Mea Kākau: Gregory Harris
Lā O Ka Hana: 8 Apelila 2021
HōʻAno Hou I Ka Lā: 21 Nowemapa 2024
Anonim
Methotrexate Toxicity and Acute Kidney Injury
Wikiō: Methotrexate Toxicity and Acute Kidney Injury

Anter

Hoʻohana ʻia ʻo Glucarpidase e pale i nā hopena weliweli o ka methotrexate (Rheumatrex, Trexall) i nā mea maʻi me nā maʻi puʻupaʻa e loaʻa nei i ka methotrexate e mālama i kekahi ʻano maʻi ʻaʻai. Aia ʻo Glucarpidase i ka papa o nā lāʻau i kapa ʻia nā enzymes. Hana ia ma ke kōkua ʻana e haki a hoʻoneʻe i ka methotrexate mai ke kino.

Hele mai ʻo Glucarpidase e like me ka pauka e hoʻopili ʻia me ka wai a injected i loko o ka aa (i loko o kahi aa koko). Hāʻawi pinepine ʻia ma luna o 5 mau minuke ma ke ʻano he mahele manawa hoʻokahi. Hāʻawi ʻia ʻo Glucarpidase me ka leucovorin (kekahi lāʻau i hoʻohana ʻia e pale aku ai i nā hopena ʻino o ka methotrexate) a hiki i ka hōʻike ʻana o nā hōʻike keʻena hoʻokolohua ʻaʻole pono ka lapaʻau.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka glucarpidase,

  • e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka glucarpidase, i nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka injection glucarpidase. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻōlelo pono i kekahi o kēia mau mea: folic acid (Folicet, i nā multivitamins); levoleucovorin (Fusilev); aiʻole pemetrexed (Alimta). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • inā loaʻa iā ʻoe ka leucovorin, pono e hāʻawi ʻia ma kahi o 2 mau hola ma mua a i ʻole 2 mau hola ma hope o ka glucarpidase.
  • e haʻi i kāu kauka inā hāpai ʻoe, hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka glucarpidase, e kāhea i kāu kauka.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


Hiki i ka Glucarpidase ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • nausea
  • ka luaʻi

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • fiva
  • haʻalulu
  • hoʻomālamalama a wela paha
  • hūwī
  • hives
  • ʻūlili
  • ʻāʻī puʻupuʻu a paʻakikī i ka hanu ʻana
  • manaʻo o ka ʻōlohelohe, ʻūlū ʻana, pricking, puhi ʻana, a i ʻole ke kolo ʻana i ka ʻili
  • ʻeha poʻo

Hiki i ka Glucarpidase ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino i ka glucarpidase.


E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka glucarpidase.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • ʻO Voraxaze®
Nānā Hou - 02/15/2013

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