ʻO Crizotinib

Anter

• Ma mua o ka lawe ʻana i crizotinib,
• Hoʻokumu paha ʻo Crizotinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Crizotinib e mālama i kekahi ʻano o nā maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi (NSCLC) i pālahalaha ʻia i nā mea kokoke a i ʻole nā ​​ʻāpana ʻē aʻe o ke kino. Hoʻohana ʻia ia e mālama i kekahi ʻano o ka lymphoma nui anaplastic (ALCL) i hoʻi a pane ʻole paha i nā ʻano lāʻau ʻē aʻe i kekahi mau mākua a me nā keiki ʻo 1 mau makahiki a ʻoi paha. Aia ʻo Crizotinib i kahi papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kekahi mea kūlohelohe e pono ai e kōkua i nā hunaola maʻi ʻaʻai e hoʻonui.

Hele mai ʻo Crizotinib ma ke ʻano he capsule e lawe ma ka waha. Lawe mau ʻia me ka ʻai ʻole a i ʻole ʻelua mau manawa i ka lā. Lawe iā crizotinib ma nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono iā crizotinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā capsule holoʻokoʻa; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou. Mai hoʻopā i nā capsule i haki a haki paha.

Hiki i kāu kauka ke hoʻopau i kahi manawa kūloko a paʻa paha i kāu lāʻau lapaʻau, hoʻoliʻiliʻi i ka lāʻau, a i ʻole e haʻi iā ʻoe e lawe i kāu lāʻau i ka manawa pinepine inā ʻike ʻoe i nā hopena koʻikoʻi o crizotinib. E haʻi i kāu kauka i kou ʻano i kou wā e mālama ai.

E hoʻomau i ka lawe ʻana iā crizotinib inā ʻoe e manaʻo maikaʻi. Mai hōʻoki i ka lawe ʻana i crizotinib me ke kamaʻilio ʻole ʻana me kāu kauka.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i crizotinib,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka crizotinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o ka crizotinib capsules. E noi i kāu kauka lāʻau a nānā paha i ka ʻike hoʻomanawanui o ka mea hana no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, a me nā mea hoʻopihaʻaiʻai āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: amiodarone (Cordarone, Pacerone); kekahi mau antibiotic e like me clarithromycin (Biaxin); kekahi mau lāʻau lapaʻau antifungal e like me itraconaozole (Sporanox), ketoconazole (Nizoral), a me voriconazole (Vfend); kekahi mau lāʻau lapaʻau koko; chloroquine (Aralen); chlorpromazine (Thorazine); citalopram (Celexa); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); dihydroergotamine (D.H.E. 45, Migranal); disopyramide (Norpace); dofetilide (Tikosyn); droperidol (Inapsine); ergotamine (Ergomar, ma Cafergot, ma Migergot); erythromycin (E.E.S., Erythrocin); fentanyl (Abstral, Actiq, Fentora, Lazanda, Onsolis); flecainide (Tambocor); kekahi mau lāʻau no ka maʻi pale maʻi (HIV) e like me atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ma Kaletra), a me saquinavir (Invirase); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, a me phenytoin (Dilantin); mesoridazine (Serentil); methadone (Dolophine); moxifloxacin (Avelox); nefazodone; pentamidine (NebuPent, Pentam); pimozide (Orap); procainamide (Pronestyl); quinidine (i Nuedexta); rifabutin (Mycobutin), rifampin (Rimactane, Rifadin, ma Rifater); sirolimus (Rapamune); sotalol (Betapace); tacrolimus (Prograf); telithromycin (Ketek); thioridazine (Mellaril); a vandetanib (Caprelsa). Hiki ke launa pū kekahi me nā lāʻau ʻē aʻe he nui me crizotinib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi aku i kāu kauka inā loaʻa a i ʻole loaʻa paha iā ʻoe kahi QT maʻi lōʻihi (kahi pilikia puʻuwai laha ʻole e hiki ai ke hōʻeha i ka puʻuwai ʻole, maʻule, a make koke paha), ka puʻuwai puʻuwai, ka maikaʻi ʻole o ka puʻuwai, nā pilikia ʻike maka, nā pilikia o ka mumū ma mua o ka maʻi ʻaʻa maʻi, a i ʻole ke ake. a maʻi maʻi ʻōpae paha.
• e haʻi i kāu kauka inā hāpai ʻoe, hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Pono ʻoe e loaʻa i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau me crizotinib. Inā he wahine ʻoe, pono ʻoe e hoʻohana i ka kaohi hānau i kāu wā e mālama ai a no 45 mau lā ma hope o kāu hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā wahine e hoʻohana i ka kaohi hānau ma kāu wā e mālama ai a no 90 mau lā ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i ke ʻano hana o ka kaohi hānau āu e hoʻohana ai. Inā hāpai ʻoe i ka lawe ʻana iā crizotinib, e kāhea koke i kāu kauka. Hiki iā Crizotinib ke hōʻeha i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. Mai hānai i ka waiū i kou wā e mālama ai a no 45 mau lā ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne a me nā wahine. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana i crizotinib.
• inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe nei ʻoe iā crizotinib.
• pono ʻoe e ʻike i ka crizotinib ke kumu o nā pilikia o ka hihiʻo, ka luhi, a me ka luhi nui. Mai hoʻokele i kahi kaʻa a hana i nā mīkini a ʻike ʻoe i ka hopena o kēia lāʻau iā ʻoe.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā ʻoi aku ia ma mua o 6 mau hola ma mua o ka hoʻonohonoho ʻia ʻana e lawe i kāu kaukana aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Crizotinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• pāhoehoe
• kōpaʻa
• ʻeha ka ʻōpū
• ʻeha ma ka waha
• hoʻololi i ka hiki ke ʻono i ka meaʻai
• puʻuwai puʻuwai
• ʻeha poʻo
• numbness, puhi ʻana, a i ʻole ka ʻūlū ʻana i nā lima a me nā wāwae paha
• paʻakikī e hiamoe a hiamoe paha

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• pokole o ka hanu
• ʻūhā
• fiva
• ka pehu ʻana o nā lima, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a i nā wāwae lalo
• ʻeha ka umauma
• ʻūlū puʻuwai
• hūwī
• nāwaliwali
• luhi nui loa
• ʻeha ma ka ʻaoʻao ʻākau i luna o ka ʻōpū
• nausea
• ka luaʻi
• paʻakikī i ka ale ʻana
• melemele o ka ʻili a me nā maka
• mimi ʻeleʻele
• ʻūlili
• fiva
• kahe koko ʻole ʻana a palapū paha
• ʻike hihi pālua a pohō paha
• nā hoʻololi i ka hihiʻo
• ʻike i ka mālamalama
• ke ʻike maka ʻana i ke kukui uila
• ke ʻike nei i nā float hou a hoʻonui paha (nā wahi i kāu hihiʻo)

Hoʻokumu paha ʻo Crizotinib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kahi hoʻokolohua hoʻokolohua ma mua o kou hoʻomaka ʻana i kāu lāʻau e ʻike ai hiki ke mālama ʻia i kou maʻi ʻaʻai me crizotinib a e kauoha pū kekahi i nā hoʻokolohua lab i kou wā e mālama ai e nānā i ka pane o kou kino iā crizotinib. E nānā pū kāu kauka i ka helu o kou puʻuwai a me ke kahe o ke koko i nā manawa a pau i kāu mālama ʻana.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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