Mea Kākau: Joan Hall
Lā O Ka Hana: 4 Pepeluali 2021
HōʻAno Hou I Ka Lā: 1 Iulai 2024
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Dabigatran (Pradaxa) Mechanism of action 【USMLE, Biochemistry】
Wikiō: Dabigatran (Pradaxa) Mechanism of action 【USMLE, Biochemistry】

Anter

Inā loaʻa iā ʻoe ka fibrillation atrial (kahi ʻano e kuʻi mau ka puʻuwai, e hoʻonui ana i ka manawa o ke kō ʻana o ke kino i loko o ke kino, a hiki paha ke hahau) a ke lawe nei ʻoe i ka dabigatran e pale aku i nā hahau a i ʻole nā ​​maʻi koko koʻikoʻi, aia ʻoe i kahi kiʻekiʻe kiʻekiʻe o ke loaʻa i kahi hahau ma hope o kou hooki ʻana i ka lawe ʻana i kēia lāʻau. Mai hōʻoki i ka lawe ʻana i ka dabigatran me ke kamaʻilio ʻole ʻana me kāu kauka. E hoʻomau i ka lawe ʻana i ka dabigatran ʻoiai inā maikaʻi ʻoe. E hoʻopihapiha hou i kāu kuhikuhi ma mua o ka pau ʻana o kāu lāʻau i ʻole ʻoe e nalo i nā kaha o dabigatran. Inā pono ʻoe e haʻalele i ka lawe ʻana i ka dabigatran, hiki i kāu kauka ke kuhikuhi i kekahi anticoagulant ('blood thinner') e kōkua ai i ka pale ʻana i ke kūpē ʻana o ke koko a loaʻa iā ʻoe kahi maʻi hahau.

Inā loaʻa ʻoe i ka epidural a i ʻole ka lāʻau anesthesia a i ʻole ka puncture ʻōiwi i ka wā e lawe ana i kahi 'mea lahilahi o ke koko' e like me dabigatran, makaʻu ʻoe i ka loaʻa ʻana o kahi ʻano koko i loko a puni paha o kou kuamoʻo i hiki ai iā ʻoe ke maʻi lōlō. E haʻi i kāu kauka inā loaʻa iā ʻoe kahi catheter epidural i koe i loko o kou kino a i ʻole ua hana pinepine paha i nā epidural a i ʻole nā ​​punctures spinal, deformity spinal, a i ʻole ke kaʻi ʻōiwi. E haʻi i kāu kauka a me kāu kauka lāʻau inā ʻoe e lawe i kekahi o kēia mau mea: anagrelide (Agrylin), aspirin a me nā lāʻau anti-inflammatory nonsteroidal (NSAIDs) e like me ibuprofen (Advil, Motrin), indomethacin (Indocin, Tivorbex), ketoprofen, a me naproxen (Aleve, Anaprox, kekahi poʻe), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine), eptifibatide (Integrilin), heparin, prasugrel (Effient), ticagrelor (Brilinta), ticlopidine, tirofiban (Aggrastat) ʻO Coumadin, Jantoven). Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: ʻehaʻeha o ke kua, nāwaliwali o nā mākala (ʻoi aku i kou mau wāwae a me kou mau wāwae), numbness a i ʻole ke kaniʻu ʻana (ʻoi aku i kou mau wāwae), a i ʻole ka nalowale o ka kaohi o kou ʻōpū a i ʻole ka waiū.


E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino iā dabigatran.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka ʻikepili ʻike hoʻomanawanui o ka mea hana (Ke alakaʻi alakaʻi) ke hoʻomaka ʻoe i ka lāʻau me dabigatran a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Hoʻohana ʻia ʻo Dabigatran e mālama i ka thrombosis hohonu (DVT; kahi kīʻaha koko, maʻamau i ka wāwae) a me ka pulmonary embolism (PE; kahi kīʻaha koko i ka akemāmā) i ka poʻe i mālama ʻia me kahi anticoagulant i hoʻokomo ʻia ('ka mea lahilahi'). Hoʻohana ʻia ia e hōʻemi i ka makaʻu o kahi DVT a me PE mai ka hana hou ʻana ma hope o ka pau ʻana o ka lapaʻau mua. Hoʻohana ʻia ʻo Dabigatran e pale aku i ka DVT a me ka PE i ka poʻe i loaʻa i ka ʻoki pani pani. Hoʻohana ʻia ʻo Dabigatran i mea e pale aku ai i nā hahau a i ʻole nā ​​maʻi koko koʻikoʻi i ka poʻe i loaʻa i ka fibrillation atrial (kahi ʻano e kuʻi pinepine ka puʻuwai, e hoʻonui ana i ka manawa o nā clots i hana ʻia i loko o ke kino, a hiki paha ke hōʻeha) me ka ʻole o ka maʻi puʻuwai puʻuwai. Aia ʻo Dabigatran i kahi papa o nā lāʻau anticoagulant i kapa ʻia nā mea hoʻopukapuka thrombin pololei. Hana ia ma ka pale ʻana i nā kahe koko mai ka hana ʻana i ke kino.


Hele mai ʻo Dabigatran ma ke ʻano he capsule e lawe ma ka waha. Ke hoʻohana ʻia ka dabigatran e mālama a pale aku iā DVT a i ʻole PE a i ʻole e pale aku i nā hahau a i ʻole ke kōkō ʻana o ke koko koʻikoʻi i ka poʻe i loaʻa i ka fibrillation atrial, lawe mau ʻia ia i ʻelua mau lā i ka lā. Ke hoʻohana ʻia ka dabigatran i mea e pale aku ai i kahi DVT a i ʻole PE ma hope o ke kahakaha hope e lawe pinepine ʻia i 1 a 4 mau hola ma hope o ke kaha ʻana, a laila hoʻokahi manawa i ka lā no 28 a 35 mau lā hou. Lawe ʻia ʻo Dabigatran me ka ʻole o ka meaʻai. E lawe i ka dabigatran ma nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe iā dabigatran e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā capsule a pau me ke aniani holoʻokoʻa o ka wai; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou. Mai wehe i nā capsule a kāpīpī i ka mea i loko o ka meaʻai a i ʻole i nā mea inu.

E kōkua ʻo Dabigatran i ka pale ʻana i nā hahau a me nā kahe koko ke hoʻomau ʻoe i ka lawe. E hoʻomau i ka lawe ʻana i ka dabigatran ʻoiai inā maikaʻi ʻoe. E nānā pono e hoʻopihapiha i kāu kuhikuhi ma mua o ka pau ʻana o kāu lāʻau i ʻole ʻoe e nalo i nā kaha o dabigatran. Mai hōʻoki i ka lawe ʻana i ka dabigatran me ke kamaʻilio ʻole ʻana me kāu kauka. Inā kū koke ʻoe i ka lawe ʻana i ka dabigatran, piʻi a nui aʻe ka makaʻu e loaʻa iā ʻoe i ka ʻūlū a i ʻole ka hahau.


Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka dabigatran,

  • e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka dabigatran, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o nā capsule dabigatran. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻai, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe E haʻi pono i kekahi o kēia mau mea: dronedarone (Multaq), ketoconazole (Nizoral), a me rifampin (Rifadin, Rimactane, ma Rifamate, ma Rifater). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi aku i kāu kauka inā loaʻa ʻoe i kahi kolo i loko o kou puʻuwai i pani a i ʻole inā ʻike koke ʻoe i kahi ʻeha a me ke kahe koko ʻole. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka dabigatran.
  • e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha iā ʻoe kahi pilikia kahe o ke kahe, ke kahe ʻana a i ʻole ka maʻi ulcer i kou ʻōpū a i ʻole kou ʻōpū a maʻi maʻi ʻōpae paha.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka dabigatran, e kāhea i kāu kauka. Lawe paha ka lawe ʻana i ka dabigatran i ka makaʻu e ʻike ʻoe i ke kahe nui ʻana i ka wā o ka hana a me ka lawe ʻana.
  • e kamaʻilio me kāu kauka e pili ana i nā pilikia a me nā pono o ka lawe ʻana i ka dabigatran inā he 75 ou mau makahiki a ʻoi paha.
  • inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe ana ʻoe i ka dabigatran.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia naʻe, inā ʻoe e hoʻomanaʻo i ka mahele lāʻau i hala ma mua o 6 mau hola ma mua o kāu kau palena hope e hoʻolālā ʻia, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Dabigatran i nā hopena ʻaoʻao. E haʻi i kāu kauka inā loaʻa kekahi o kēia mau ʻōuli.

  • ʻeha ka ʻōpū
  • hoʻohuhū ʻōpū
  • puʻuwai puʻuwai
  • nausea

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻARlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • ʻāpā ʻaʻano ʻole a hoʻokahe koko paha
  • mimi ʻākala a ʻeleʻele paha
  • ʻulaʻula a ʻeleʻele, noho aliʻi
  • kahe ana ke koko
  • luaʻi i nā mea koko a ʻano like paha me nā papa kope
  • e kahe ana ke kahe mai ka gums
  • ihu ihu pinepine
  • kahe nui ke haehae
  • kahe kahe mai kahi ʻoki i ʻoi aku ka lōʻihi ma mua o ka maʻamau
  • ʻeha puʻupuʻu a huʻi paha
  • ʻeha poʻo
  • ʻūpī a palupalu paha
  • nāwaliwali
  • hives
  • hūwī
  • ʻūlili
  • pilikia i ka hanu ʻana a i ʻole ke ale ʻana
  • ʻeha o ka umauma a i ʻole ke kūiki
  • pehu o ka maka, ʻāʻī, elelo, lehelehe, maka, lima, lima, wāwae, kuʻekuʻe wāwae, a i ʻole nā ​​wāwae lalo

Hoʻokumu paha ʻo Dabigatran i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. Mai mālama i ka dabigatran i kahi pahu pahu a mea hoʻokele pila paha. E mālama iā ia i ka mahana wela a mamao aku mai ka wela a me ka ona mau. E wehe i hoʻokahi ʻōmole o dabigatran i ka manawa. E hoʻopau i kāu ʻōmole i wehe ʻia o dabigatran ma mua o ka wehe ʻana i kahi ʻōmole hou). E hoʻolei i nā lāʻau i waiho ʻia i loko o ka ipu 4 mau mahina ma hope o kou wehe ʻana.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

  • ʻāpā ʻaʻano ʻole a hoʻokahe koko paha
  • mimi ʻākala a ʻeleʻele paha
  • ʻulaʻula a ʻeleʻele, noho aliʻi
  • luaʻi i nā mea koko a ʻano like paha me nā papa kope
  • kahe ana ke koko

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • Pradaxa®
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