Tolvaptan (ke koko haʻahaʻa sodium)

Anter

• Ma mua o ka lawe ʻana iā tolvaptan (Samsca),
• Hiki i nā Tolvaptan (Samsca) ke hopena i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻ sectionlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka:
• Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

Hiki paha iā Tolvaptan (Samsca) ke hoʻonui i ka kiʻekiʻe o ka sodium i kou koko. ʻO kēia ke kumu o ka maʻi osmotic demyelination (ODS; hōʻino nā nerve koʻikoʻi i hoʻokumu ʻia e nā piʻi wikiwiki o nā pae sodium). E haʻi i kāu kauka inā inu ʻoe a inu paha i ka nui o ka wai ʻona, inā loaʻa ʻole kāu olakino (nele ke kino i nā meaola e pono ai no ke olakino maikaʻi), a inā ua loaʻa a loaʻa paha ʻoe i ka maʻi ate a i ʻole nā ​​pae haʻahaʻa o ka sodium i loko o kou koko. .

E mālama ʻoe a me kāu kauka i kekahi mau hana akahele e hoʻāʻo ai e pale aku iā ODS. E hoʻomaka ʻoe i kāu lāʻau lapaʻau me tolvaptan (Samsca) i ka haukapila i hiki i kāu kauka ke nānā pono iā ʻoe. Inā haʻi aku kāu kauka iā ʻoe e hoʻomau i ka lawe ʻana i ka tolvaptan (Samsca) ma hope o kou haʻalele ʻana i ka haukapila, ʻaʻole pono ʻoe e kū a hoʻomaka hou i kāu lāʻau ponoʻī. Pono ʻoe e hoʻi i ka haukapila ke hoʻomaka hou ʻoe i ka lāʻau.

Pono ʻoe e inu i ka wai i kēlā me kēia manawa āu e make wai ai e kōkua i ka pale ʻana i ka ODS i kāu mālama ʻana me tolvaptan (Samsca). ʻAʻole kauoha kāu kauka iā tolvaptan (Samsca) inā ʻaʻole hiki iā ʻoe ke ʻike he make wai ʻoe. Loaʻa iā ʻoe ka wai inu e loaʻa i nā manawa āpau i kāu mālama ʻana.

Inā ʻoe e ʻike i kekahi o nā ʻōuli o ODS, e haʻi koke aku i kāu kauka: paʻakikī i ka ʻōlelo ʻana, paʻakikī i ka ale ʻana, me ka manaʻo e paʻa ana ka meaʻai a me nā mea inu paha i kou puʻu, ka hiamoe, huikau, hoʻololi i ke ʻano, nā neʻe o ke kino e paʻakikī e kaohi, nāwaliwali. o nā lima a i ʻole nā ​​wāwae, a i ʻole ka hopu ʻana.

Pono ʻoe e ʻike i ka loaʻa ʻana o ka tolvaptan ma ke ʻano he papaha (Jynarque) e hoʻolohi i ka hōʻino ʻana o ka hana hakuʻala i nā mākua me kekahi ʻano maʻi maʻi ʻōiwi i hoʻoili ʻia. Inā loaʻa kēia maʻi maʻi ʻōpala iā ʻoe, ʻaʻole pono ʻoe e lawe i ka tolvaptan (Samsca). Ma muli o ka makaʻu o nā pilikia o ke ake me tolvaptan, loaʻa ʻo Jynarque ma o kahi papahana hoʻokaʻawale palena papaha wale nō. Hāʻawi wale kēia monograp i ka ʻike e pili ana i nā papa tolvaptan (Samsca) e mālama ai i nā pae haʻahaʻa o ka sodium i loko o ke koko. Inā ʻoe e hoʻohana ana i kēia lāʻau e hoʻolohi i ka worsening o kāu hana hakuʻala, e heluhelu i ka monograph i kapa ʻia ʻo tolvaptan (maʻi maʻi kidney).

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me tolvaptan a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i tolvaptan (Samsca).

Hoʻohana ʻia ʻo Tolvaptan (Samsca) e mālama ai i ka hyponatremia (pae haʻahaʻa o ka sodium i loko o ke koko) i ka poʻe i loaʻa ka puʻuwai puʻuwai (kahi e hiki ʻole ai i ka puʻuwai ke pauma i ke koko i nā ʻāpana āpau o ke kino), maʻi maʻi o ka hormone antidiuretic kūpono (SIADH; ke ʻano e hoʻopuka ai ke kino i nā mea kūlohelohe i hiki i ke kino ke mālama i ka wai) a i ʻole nā ​​kūlana ʻē aʻe. Aia ʻo Tolvaptan i kahi papa o nā lāʻau i kapa ʻia vasopressin V₂ ʻenemi antagonists. Hana ia ma ka hoʻonui ʻana i ka nui o ka wai i hoʻokuʻu ʻia mai ke kino e like me ka mimi. ʻO ka hemo ʻana o ka wai mai ke kino e kōkua i ka hoʻonui ʻana i ka pae o ka sodium i loko o ke koko.

Hele mai ʻo Tolvaptan (Samsca) ma ke ʻano he papa e lawe ma ka waha. Lawe ʻia ia i hoʻokahi manawa i ka lā me ka ʻai a me ka ʻole o ka meaʻai no ka ʻoi aku o 30 mau lā. I ka hoʻomaka o kāu lapaʻau ʻana, e hāʻawi ʻia ʻoe i ke tolvaptan (Samsca) i kahi manawa i hoʻonohonoho ʻia i ka haukapila. Inā haʻi ʻia ʻoe e lawe i ka tolvaptan (Samsca) ma ka home ma hope o kou hoʻokuʻu ʻia ʻana, pono ʻoe e lawe ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono iā tolvaptan (Samsca) e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi haʻahaʻa o tolvaptan (Samsca) a hoʻonui iki i kāu lāʻau, ʻaʻole pinepine ma mua o hoʻokahi manawa i kēlā me kēia 24 mau hola.

E kamaʻilio me kāu kauka e pili ana i ka mea āu e hana ai ma hope o kou hōʻoki ʻana i ka lawe tolvaptan (Samsca). E palena paha ʻoe i ka wai āu e inu ai, a e nānā pono kāu kauka iā ʻoe i kēia manawa.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana iā tolvaptan (Samsca),

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka tolvaptan (Samsca, Jynarque), nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa tolvaptan. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka inā lawe ʻoe i kekahi antifungals e like me ketoconazole (Nizoral) a i ʻole itraconazole (Sporanox); clarithromycin (Biaxin); kekahi mau lāʻau no ka HIV e like me indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), a i ʻole saquinavir (Invirase); desmopressin (dDAVP, Stimate); nefazodone; aiʻole telithromycin (Ketek). ʻ telllelo paha kāu kauka iā ʻoe ʻaʻole e lawe i ka tolvaptan (Samsca) inā ʻoe e lawe nei i hoʻokahi aʻoi aku paha o kēia mau lāʻau.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, a me nā mea hoʻopihaʻai pono ʻole āu e lawe nei a hoʻolālā paha e lawe. E hoʻomaopopo pono e haʻi i kekahi o kēia mau mea: angiotensin-hoʻololi i ka enzyme (ACE) mea kāohi e like me benazepril (Lotensin, ma Lotrel), captopril, enalapril (Vasotec, ma Vaseretic), fosinopril, lisinopril (Prinivil, Zestril, ma Zestoretic), moexipril , perindopril, (quinapril (Accupril, in Accuretic, in Quinaretic), ramipril (Altace), and trandolapril (Tarka); angiotensin II receptor blockers like candesartan (Atacand), eprosartan, irbesartan (Avapro, in Avalide), losartan (Cozaar , ma Hyzaar), olmesartan (Benicar, ma Benicar HCT, ma Tribenzor), telmisartan (Micardis, ma Twynsta), a me valsartan (Diovan, Prexxartan, i Entresto, i Exforge); aprepitant (Emend); barbiturates e like me phenobarbital; carbamazepine (Carbatrol, Equetro, Tegretol); cyclosporine (Gengraf, Neoral, Sandimmune); desmopressin (dDAVP, Minirin, Noctiva), digoxin (Lanoxin); diltiazem (Cardizem, Diltzac, Tiazac); diuretics (water pills); Erythrom ERYC, Erythrocin, PCE); fluconazole (Diflucan); phenytoin (Dilant i); pākuʻi potassium; rifabutin (Mycobutin); rifampin (Rimactane, Rifadin, ma Rifater, ma Rifamate); rifapentine (Priftin); a me ka verapamil (Calan, Verelan, ma Tarka). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Hiki paha i nā lāʻau ʻē aʻe ke launa pū me tolvaptan (Samsca), no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe, ʻo ka wort ʻo St John.
• e haʻi i kāu kauka inā loaʻa ʻoe i ka maʻi puʻupaʻa a hana ʻole i ka mimi, inā he luaʻi koʻikoʻi a i ʻole diarrhea, a inā ua lilo ka nui o ka wai mai kou kino a ʻano paupauaho a maʻule paha. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe iā tolvaptan (Samsca). ʻAʻole paha e kau kauka i ke kauka tolvaptan (Samsca) inā pono e hoʻonui wikiwiki ʻia kāu pae sodium.
• e haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe kahi pae kiʻekiʻe o ka potassium i loko o kou koko.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i tolvaptan (Samsca), e kāhea i kāu kauka.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i nā Tolvaptan (Samsca) ke hopena i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• make wai
• waha maloo
• pinepine, urination nui loa
• kōpaʻa

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻ sectionlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka:

• nalo ʻai ʻole
• nausea
• ka luaʻi
• fiva
• manaʻo maikaʻi ʻole
• luhi ʻole a nawaliwali paha
• ʻūlili
• melemele o ka ʻili a me nā maka
• mimi ʻeleʻele
• ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū
• pāhoehoe
• hiki ʻole ke inu maʻamau
• ʻūpā
• maule
• luaʻi ka mea koko a nānā paha e like me nā kahua kope
• nā noho koko a ʻeleʻele a tarry
• ka pehu o ka maka, ka ʻāʻī, ke alelo, nā lehelehe, nā maka, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
• hulahula
• hives
• hūwī

Hiki i Tolvaptan (Samsca) ke hana i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

• urination nui loa
• make wai nui loa
• ʻūpā
• maule

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino iā tolvaptan (Samsca).

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Samsca^®