Mea Kākau: Clyde Lopez
Lā O Ka Hana: 22 Iulai 2021
HōʻAno Hou I Ka Lā: 19 Nowemapa 2024
Anonim
Efficacy and safety of adjunctive lacosamide in the treatment of PGTCS
Wikiō: Efficacy and safety of adjunctive lacosamide in the treatment of PGTCS

Anter

Hoʻohana ʻia ʻo Lacosamide e kaohi i ka hopu ʻana i ka ʻāpana hoʻomaka (ka hopu ʻana e hoʻopili wale i hoʻokahi ʻāpana o ka lolo) i nā mākua a me nā keiki ʻo 4 mau makahiki a ʻoi paha. Hoʻohana pū ʻia ʻo Lacosamide me ka hui pū me nā lāʻau ʻē aʻe e kāohi i ka hopu ʻia ʻana o nā tonic-clonic kumu nui (ʻike ʻia ma ke ʻano he kuʻi nui. Aia ʻo Lacosamide i kahi papa o nā lāʻau i kapa ʻia anticonvulsants. Hana ia ma ka hoʻemi ʻana i ka hana uila uila ʻole i ka lolo.

Hele mai ʻo Lacosamide ma ke ʻano he papaha a ma ke ʻano he solution (wai) e lawe ma ka waha. Lawe ʻia ia i ʻelua mau manawa i ka lā me ka ʻai ʻole. E lawe i ka lacosamide ma nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka lacosamide e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā papa holoʻokoʻa; mai nau, mahele. aiʻole e haki iā lākou.


Inā ʻoe e lawe i ka hopena waha, e hoʻohana i ka puna i ana i ka puna ai ʻole ka syringe waha e ana i ka nui kūpono o ka wai e pono ai no kēlā me kēia kau. Mai hoʻohana i ka puna o ka home mau. Inā loaʻa iā ʻoe kahi nasogastric (NG) a i ʻole gastric Tube, e wehewehe kāu kauka a kauka paha pehea e hoʻomākaukau ai i ka lacosamide e lawelawe iā ia.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi lāʻau lacosamide haʻahaʻa a hoʻonui iki i kāu lāʻau, ʻaʻole pinepine ma mua o hoʻokahi manawa i ka pule.

Hiki i ka Lacosamide ke kōkua i ke kaohi i kou ʻano akā ʻaʻole e hoʻōla iā ia. He mau pule paha ka lōʻihi a ʻoi paha ma mua o kou ʻike ʻana i ka pono piha o ka lacosamide. E hoʻomau i ka lawe ʻana i ka lacosamide ʻoiai inā maikaʻi ʻoe. Mai hōʻoki i ka lawe ʻana i ka lacosamide me ke kamaʻilio ʻole ʻana me kāu kauka, ʻoiai inā ʻike ʻoe i nā hopena ʻē aʻe e like me nā loli maʻamau i ka lawena a i ʻole ke ʻano. Inā kū koke ʻoe i ka lawe ʻana i ka lacosamide, hiki pinepine pinepine kāu mau hopu ʻana. E hoʻoliʻiliʻi paha kāu kauka i kāu lāʻau.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.


Ma mua o ka lawe ʻana i ka lacosamide,

  • e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka lacosamide, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i ka papa lacosamide a i ʻole ka hopena waha. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻike pono i kekahi o kēia mau mea: beta blockers e like me atenolol (Tenormin, ma Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), a me propranolol (Hemangeol, Inderal); calcium blockers blockers e like me amlodipine (Norvasc, ma Caduet, ma Lotrel, ma Exforge, a me nā mea ʻē aʻe), diltiazem (Cardizem, Cartia, Tiazac, a me nā mea ʻē aʻe), felodipine, isradipine, nicardipine, nifedipine (Procardia), nimodipine (Nymalize), nisoldipine ( Sular), a me verapamil (Calan, Verelan, ma Tarka); a me nā lāʻau no ke kuʻi puʻuwai ʻole e like me amiodarone (Nexterone, Pacerone), digoxin (Lanoxin), dronedarone (Multaq), flecainide (Tambocor), propafenone (Rythmol), quinidine (i Nuedexta), a me sotalol (Betapace, Sorine, Sotylize). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Pili pū paha nā lāʻau ʻē aʻe he nui me ka lacosamide, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
  • e haʻi i kāu kauka inā inu ʻoe i kēia manawa a i ʻole inu nui paha i ka ʻalekohola, nā lāʻau lapaʻau i hoʻohana ʻia i ke alanui, a i ʻole nā ​​lāʻau lapaʻau i hoʻohana nui ʻia. E haʻi aku i kāu kauka inā loaʻa ʻoe a i ʻole loaʻa paha iā ʻoe ke kaumaha, nā pilikia o ke ʻano, nā manaʻo suicidal a i ʻole ka lawena. he puʻuwai puʻuwai kūpono ʻole, kahi puʻuwai puʻuwai, pacemaker, puʻuwai puʻuwai, ai ʻole nā ​​pilikia puʻuwai ʻē aʻe; neuropathy diabetic (hōʻino nā aʻa i hoʻokumu ʻia e ka maʻi kō); aiʻole ka ate a me nā maʻi pākī.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka lacosamide, e kāhea i kāu kauka.
  • pono ʻoe e ʻike i ka lacosamide e hoʻohoka ai ʻoe a hiamoe ai paha a lilo ai i mea ʻike ʻole a i ʻole nā ​​pilikia me ka laulima a me ke kaulike. Mai kalaiwa i ke kaʻa, hana i nā mīkini, a i ʻole e komo i nā hana e koi ai i ka makaʻala a i ʻole ka hoʻohui ʻana a ʻike ʻoe i ka hopena o kēia lāʻau iā ʻoe.
  • pono ʻoe e ʻike e loli paha kou olakino noʻonoʻo i nā ala i manaʻo ʻole ʻia a lilo ʻoe i suicidal (e noʻonoʻo e pili ana i ka hōʻeha a pepehi paha iā ʻoe iho a hoʻolālā paha a hoʻāʻo paha e hana pēlā) ʻoiai ʻoe e lawe nei i ka lacosamide. ʻO kahi liʻiliʻi o nā mākua a me nā keiki he 5 mau makahiki a ʻoi paha (ma kahi o 1 ma 500 mau kānaka) i lawe i nā anticonvulsants e like me lacosamide e mālama i nā ʻano like ʻole i ka manawa o nā noiʻi maʻi ʻana i lilo i suicidal i kā lākou mālama ʻia. Ua hoʻomohala kekahi o kēia poʻe i nā manaʻo suicidal a me ka lawena e like me 1 mau pule ma hope o ka hoʻomaka ʻana e lawe i ka lāʻau. Aia kekahi pilikia e ʻike paha ʻoe i nā loli i kou olakino noʻonoʻo inā ʻoe e lawe i kahi lāʻau anticonvulsant e like me lacosamide, akā aia paha paha kahi pilikia e ʻike ʻoe i nā loli i kou olakino noʻonoʻo inā ʻaʻole mālama ʻia kāu ʻano. E hoʻoholo ʻoe a me kāu kauka inā ʻoi aku ka nui o nā makaʻi o ka lawe ʻana i kahi lāʻau anticonvulsant ma mua o nā makaʻu o ka lawe ʻole ʻana i ka lāʻau. ʻO ʻoe, kou ʻohana, a i ʻole kāu mea mālama e kāhea koke aku i kāu kauka inā ʻike ʻoe i kekahi o nā ʻōuli penei: weliweli weliweli; hoʻonāukiuki a hoʻomaha ʻole paha; hoʻonāukiuki hou a i ʻole ke kaumaha paha; hana ana i nā manaʻo hoʻoweliweli; paʻakikī e hiamoe a hiamoe paha; hana hoʻomāinoino, huhū, a kolohe paha; mania (pīhoihoi, ʻano hauʻoli ʻole); ke kamaʻilio a noʻonoʻo paha e pili ana i ka makemake e hōʻeha iā ʻoe iho a i ʻole hoʻopau i kou ola; a i ʻole nā ​​hoʻololi ʻē aʻe i ke ʻano a me ke ʻano. E ʻike pono i kou ʻohana a mea mālama paha e ʻike i nā hōʻailona e koʻikoʻi paha i hiki iā lākou ke kāhea i ke kauka inā ʻaʻole hiki iā ʻoe ke ʻimi iā ʻoe lāʻau ponoʻī.
  • pono ʻoe e ʻike ʻo ka lacosamide ke kumu o ka puʻupuʻu, ka ʻūlū ʻana, ka maule ʻana, a me ka puʻuwai puʻuwai ʻole, ʻoiai ke ala koke ʻoe mai kahi kūlana wahaheʻe. Inā hoʻomohala ʻoe i kēia mau ʻōuli, moe i lalo me kou mau wāwae i hāpai ʻia a hiki i kou wā e maikaʻi ai, a kāhea koke aku i kāu kauka.
  • inā loaʻa iā ʻoe ka phenylketonuria (PKU, kahi ʻano hoʻoilina e pono ai e ukali ʻia kahi papaʻai kūikawā e pale ai i ka lolo o ka noʻonoʻo), pono ʻoe e ʻike he waiwa wai aspartame ka lacosamide i hana i phenylalanine.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Lacosamide i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • nausea
  • ka luaʻi
  • pāhoehoe
  • ʻike hihi ʻole a pālua paha
  • neʻe ʻole o ka maka o ka maka
  • ʻūpā
  • ʻeha poʻo
  • hiamoe
  • luliluli ʻole ʻana i kahi ʻāpana o ke kino
  • nā pilikia me ka laulima, ke kaulike, a me ka hele wāwae paha
  • nāwaliwali
  • ʻūlili

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka:

  • wikiwiki a kuʻi paha i ka puʻuwai a i ʻole ka pāhawewe
  • pokole o ka hanu
  • ʻūlū puʻuwai
  • ʻeha ka umauma
  • maule ana
  • pehu o ka maka, puʻu, alelo, lehelehe, a me nā maka
  • fiva
  • hūwī
  • luhi
  • melemele o ka ʻili a me nā maka
  • mimi ʻeleʻele

Hoʻokumu paha ʻo Lacosamide i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua. Mai hoʻopili i ka hopena waha. E hoʻolei i nā hāʻina waha i hoʻohana ʻole ʻia i 7 mau pule ma hope o ka wehe mua ʻana i ka ʻōmole.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Mālama i nā manawa āpau me kāu kauka.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. ʻO Lacosamide kahi lāʻau i kāohi ʻia. Hiki ke hoʻopiha hou ʻia nā kuhikuhi ma nā helu kau palena wale nō; e noi i kāu kauka lāʻau inā he nīnau kāu.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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