Darunavir

Anter

• Ma mua o ka lawe ʻana i darunavir,
• Hoʻokumu ʻo Darunavir i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e hōʻoki i ka lawe ʻana i ka darunavir a kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Darunavir me ritonavir (Norvir) a me nā lāʻau ʻē aʻe e mālama ai i ka maʻi HIV (HIV) kanaka i nā mākua a me nā keiki ʻo 3 mau makahiki a ʻoi paha. Aia ʻo Darunavir i kahi papa o nā lāʻau i kapa ʻia nā protease inhibitors. Hana ia ma ka hoʻemi ʻana i ka nui o ka maʻi HIV i loko o ke koko. ʻOiai ʻaʻole hoʻōla ʻo darunavir i ka maʻi HIV, hiki iā ia ke hōʻemi i kou manawa o ka hoʻomohala ʻia ʻana o ka maʻi maʻi maʻi (AIDS) a me nā maʻi e pili ana i ka maʻi HIV e like me nā maʻi ʻino a i ʻole ka maʻi ʻaʻai. ʻO ka lawe ʻana i kēia mau lāʻau a me ka hoʻomaʻamaʻa ʻana i ka moekolohe ʻoi aku ka maikaʻi a me ka hoʻololi ʻana i ke ʻano ola ʻē aʻe e hōʻemi paha i ka lawe ʻana i ka maʻi HIV i kekahi poʻe ʻē aʻe.

Hele mai ʻo Darunavir ma ke ʻano he papa ʻaukā a me ka hoʻokuʻu waha (wai) e lawe ma ka waha. Lawe pinepine ʻia me ka meaʻai a me ka ritonavir hoʻokahi a ʻelua mau manawa i ka lā. Lawe i ka darunavir ma kahi o ka manawa like (s) i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka darunavir e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

Mai lawe i ka darunavir me ka ʻole ritonavir.

E ale i nā papa āpau me kahi mea inu e like me ka wai a waiū paha. Mai nāhelehele i nā papa.

E hoʻoluliluli maikaʻi i ka hoʻomaha ma mua o kēlā me kēia hoʻohana e kāwili kaulike i ka lāʻau. E hoʻohana i ka syringe hoʻoliʻiliʻi waha i hele mai me ka lāʻau e hoʻihoʻi i ka nui o ke kau ʻana o ka ʻōmole. Hiki iā ʻoe ke ale i ke kauā pololei mai ka ʻōʻō. E holoi i ke syringe me ka wai a ʻae e hoʻomaloʻo maloʻo ma hope o ka hoʻohana.

Mālama ʻo Darunavir iā HIV akā ʻaʻole ia e hoʻōla iā ia. E hoʻomau i ka lawe ʻana i darunavir ʻoiai inā maikaʻi ʻoe. Mai hōʻoki i ka lawe ʻana i ka darunavir me ke kamaʻilio ʻole ʻana me kāu kauka. Inā kū ʻoe i ka lawe ʻana i ka darunavir a i ʻole lele i nā lāʻau, e ʻoi aku ka paʻakikī o kou ʻano e mālama. Ke hoʻomaka haʻahaʻa kāu lako o darunavir, e kiʻi hou mai kāu kauka a kauka paha.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i darunavir,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka darunavir, ritonavir, nā lāʻau sulfa, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa darunavir a i ʻole ka hoʻomaha ʻana. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui a i ʻole inā kānalua ʻoe inā ʻo kahi lāʻau āu e maʻi ai he lāʻau sulfa ia.
• e haʻi i kāu kauka inā lawe ʻoe i kekahi o nā lāʻau aʻe: alfuzosin (Uroxatral); cisapride (Propulsid) (ʻaʻole loaʻa ma ka U.S.); dronedarone (Multaq); elbasvir / grazoprevir (Zepatier); nā lāʻau lapaʻau ergot-type e like me dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, ma Cafergot, ma Migergot), a me methylergonovine (Methergine); lomitapide (Juxtapid); lovastatin (Mevacor, i Advicor); lurasidone (Latuda), midazolam (hāʻawi ʻia e ka waha); pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, ma Rifamate, ma Rifater); sildenafil (ʻo ka inoa Revatio wale nō i hoʻohana ʻia no ka maʻi puʻupuʻu); simvastatin (Zocor, i Vytorin); St. John's wort; aiʻole triazolam (Halcion). E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka darunavir. Eia kekahi, inā loaʻa ʻoe i ka maʻi puʻupaʻa a ate paha a ke lawe nei ʻoe i ka colchisin (Colcrys, Mitigare, ma Col-Probenecid), e ʻōlelo paha kāu kauka iā ʻoe mai lawe i ka darunavir.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, a me nā mea hoʻopihaʻai pono ʻole āu e lawe nei a hoʻolālā paha e lawe. E hoʻomaopopo pono e ʻōlelo i kekahi o kēia mau mea: anticoagulants ('blood thinners') e like me apixaban (Eliquis), rivaroxaban (Xarelto), a me warfarin (Coumadin, Jantoven); nā antifungals e like me itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), a me voriconazole (Vfend); artemether / lumefantrine (Coartem); beta blockers e like me carvedilol (Coreg), metoprolol (Lopressor, Toprol XL, ma Dutoprol, ma Lopressor HCT), a me timolol (Betimol, Istalol, ma Combigan, ma Cosopt, a me nā mea ʻē aʻe); betamethasone; boceprevir (ʻaʻole loaʻa hou i ka US; Victrelis); bosentan (Tracleer); budesonide (Entocort, Pulmicort, Uceris, nā mea ʻē aʻe); buprenorphine (Belbuca, Buprenex, Butrans, ma Suboxone, nā mea ʻē aʻe); buprenorphine / naloxone (Bunavail, Suboxone, Zubsolv); buspirone; nā poloka kalipuna e like me amlodipine (Norvasc, ma Caduet), diltiazem (Cardizem CD, Cartia, XT, Diltzac, a me nā mea ʻē aʻe), felodipine (Plendil), nicardipine (Cardene), nifedipine (Adalat CC, Afebitab CR, Procardia), a verapamil (Calan, Covera, Verelan, ma Tarka); kekahi mau lāʻau chemotherapy e like me dasatinib (Sprycel), nilotinib (Tasigna), vinblastine, a me vincristine (Marqibo Kit); nā lāʻau hoʻohaʻahaʻa kolesterol (statins) e like me atorvastatin (Lipitor, ma Caduet), pravastatin (Pravachol), a me rosuvastatin (Crestor); ciclesonide (Alvesco); clarithromycin (Biaxin, i Prevpac); kekahi mau lāʻau no ke kaumaha e like me amitriptyline, desipramine (Norpramin), imipramine, nortriptyline, paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), a me trazodone; dexamethasone; diazepam (Diastat, Valium); estazolam; fentanyl (Abstral, Duragesic, Subsys); fluticasone (Flonase, Flovent, ma Advair); kekahi mau lāʻau no ka maʻi hepitis C (HCV) e like me glecaprevir / pibrentasvir (Mavyret) a me simeprevir (ʻaʻole loaʻa hou ma U.S.; Olysio); nā lāʻau lapaʻau ʻē aʻe no HIV e like me indinavir (Crixivan), lopinavir / ritonavir (Kaletra), maraviroc (Selzentry), a me saquinavir (Invirase); nā kaola hormonal (estrogen) (nā lāʻau kaohi hānau, nā pāhili, nā apo, nā implants, a i ʻole nā ​​injection); nā lāʻau no ke kuʻi puʻuwai ʻole e like me amiodarone (Nexterone, Pacerone), bepridil (ʻaʻole loaʻa hou ma US), digoxin (Lanoxin), disopyramide (Norpace), flecainide, tutupocaine (Xylocaine), mexiletine, propafenone (Rythmol), a me quinidine ); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Carbatrol, Equetro, Tegretol, a me nā mea ʻē aʻe), clonazepam (Klonopin), phenobarbital, a me phenytoin (Dilantin, Phenytek); kekahi mau lāʻau e kāohi i ka ʻōnaehana pale e like me cyclosporine (Gengraf, Neoral, Sandimmune), everolimus (Afinitor, Zortress), sirolimus (Rapamune), a me tacrolimus (Astagraf XL, Prograf); methadone (Dolophine, Methadose); methylprednisolone; mometasone (Asmanex); omeprazole (Prilosec); ʻoxycodone (Xtampza); kekahi mau mea hoʻopale phosphodiesterase (PDE-5 mea hoʻopukapuka) i hoʻohana ʻia no ka hana erectile e like me avanafil (Stendra), sildenafil (Viagra), tadalafil (Cialis), a me vardenafil (Levitra, Staxyn); perphenazine; prednisone (Rayos); quetiapine (Seroquel); rifabutin (Mycobutin); rifapentine (Priftin); risperidone (Risperdal); salmeterol (Serevent, ma Advair); tadalafil (Adcirca); thioridazine; ticagrelor (Brilinta); tramadol (Conzip); triamcinolone (Nasacort); a me zolpidem (Ambien, Edluar, Intermezzo). Nui paha nā lāʻau ʻē aʻe e launa pū paha me darunavir, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• inā ʻoe e lawe ana i ka didanosine (Videx), lawe ia i hoʻokahi hola ma mua a i ʻole 2 mau hola ma hope o kou lawe ʻana i ka darunavir.
• e haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi diabetes a i ʻole ke kō i ke koko kiʻekiʻe. hemophilia (ke kahe o ke kahe o ke koko kahi e ʻole pono ai ke kō ʻana o ke koko); hepatitis (puhū o ke akepaʻa i hoʻokumu ʻia e kahi maʻi), cirrhosis (kahi maʻi e ʻāʻī ai i nā maʻi o ke ake), a i ʻole nā ​​ʻano maʻi ʻē aʻe ʻē aʻe; a i ʻole kahi maʻi i hele ʻole a i hele mai a hele e like me cytomegalovirus (CMV; kahi maʻi viral e hiki ai ke hōʻeha i nā hōʻailona ma nā mea maʻi me nā ʻōnaehana pale nawaliwali), mycobacterium avium complex maʻi (MAC; kahi maʻi bacteria i hiki ke kumu i nā ʻōuli koʻikoʻi i ka poʻe me ka maʻi AIDS), ka niumonia, a i ʻole ka tuberculosis (TB; kahi ʻano o ka maʻi ʻaʻai.
• e haʻi i kāu kauka inā hāpai ʻoe, hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka darunavir, e kāhea i kāu kauka. Mai hānai i ka hānai inā loaʻa ʻoe i ka maʻi HIV a i ʻole ke lawe nei i ka darunavir.
• pono ʻoe e ʻike i ka darunavir hiki ke hoʻemi i ka pono o nā kaola pale hormonal (nā lāʻau kaohi hānau, nā pāhili, nā apo, nā inikū, a me nā implants). E kamaʻilio me kāu kauka e pili ana i kahi kaohi hānau ʻole hormonal e like me ke ʻano pale (kahi mea e ālai i ka sperm mai ke komo ʻana i ka pūpū e like me ka condom a i ʻole diaphragm) e pale ai i ka hāpai keiki ʻoiai ʻoe e lawe nei i kēia lāʻau. E noi i kāu kauka e kōkua iā ʻoe e koho i kahi hana o ka kaohi hānau e holo pono nāu.
• pono ʻoe e ʻike e hoʻonui a neʻe paha kou momona o ke kino i nā wahi like ʻole o kou kino e like me kou umauma, luna o luna, ʻāʻī, umauma, a me kou wahi ʻōpū. ʻO ka nalowale o ka momona mai nā wāwae, nā lima, a me ka helehelena hiki ke hana pū kekahi.
• pono ʻoe e ʻike e ʻike paha ʻoe i ka hyperglycemia (hoʻonui i kāu kō kō) ʻoiai ʻoe e lawe nei i kēia lāʻau, ʻoiai inā ʻaʻohe ou diabetes. E haʻi koke i kāu kauka inā loaʻa iā ʻoe kekahi o nā ʻōuli aʻe ke lawe nei ʻoe i ke darunavir: make wai loa, mimiki pinepine, pololi loa, ʻike maka ʻole a nāwaliwali paha. He mea nui ia e kāhea aku i kāu kauka ke loaʻa koke iā ʻoe kekahi o kēia mau ʻōuli, no ka mea, ʻaʻole mālama ʻia ke kō koko kiʻekiʻe e mālama ʻia ai i kahi ʻano koʻikoʻi i kapa ʻia ʻo ketoacidosis. Lilo paha ʻo Ketoacidosis i mea hoʻoweliweli i ke ola ke mālama ʻole ʻia ia i ka wā mua. ʻO nā ʻōuli o ketoacidosis e komo pū me: waha maloʻo, nausea a me ka luaʻi, ka hanu o ka hanu, ka hanu e ʻaʻala i ka hua, a me ka emi o ka ʻike.
• pono ʻoe e ʻike ʻoiai ʻoe e lawe nei i nā lāʻau e mālama ai i ka maʻi HIV, e ikaika paha kou ʻōnaehana pale a hoʻomaka e hakakā i nā maʻi ʻē aʻe i loko o kou kino. Hiki iā ʻoe ke hoʻomohala i nā ʻōuli o kēlā mau maʻi. Inā loaʻa iā ʻoe nā hōʻailona hou a pōʻino paha i kēlā me kēia manawa i kāu mālama ʻana me darunavir, e haʻi pono i kāu kauka.

E kamaʻilio me kāu kauka e pili ana i ka ʻai ʻana i ka huaʻulu a me ka inu ʻana i ka wai momona i ka wā e lawe ana i kēia lāʻau.

Inā ʻoe e lawe i ka darunavir i hoʻokahi manawa i ka lā a hala ʻoe i kahi mahele ma lalo o 12 mau hola, e lawe i ka lāʻau i hala i kou hoʻomanaʻo ʻana iā ia a laila lawe i ka lāʻau aʻe i ka manawa i hoʻopaʻa ʻia. Eia nō naʻe, inā ʻoe e nalo i kahi mahele ma mua o 12 mau hola, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Inā ʻoe e lawe i ka darunavir i ʻelua mau manawa i ka lā a hala ʻoe i kahi mahele ma lalo o 6 mau hola, e lawe i ka lāʻau i hala i kou hoʻomanaʻo ʻana iā ia a laila lawe i ka lāʻau aʻe i ka manawa i hoʻopaʻa ʻia. Eia nō naʻe, inā ʻoe e nalo i kahi mahele ma mua o 6 mau hola, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu ʻo Darunavir i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻeha poʻo
• pāhoehoe
• ka luaʻi
• ʻeha ka ʻōpū
• kōpaʻa

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e hōʻoki i ka lawe ʻana i ka darunavir a kāhea koke aku i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• hūwī
• ʻili a ʻili paha i ka ʻili
• ʻeha nā waha
• ʻulaʻula, pehu, ʻāʻī, a i ʻole nā ​​maka haehae
• ʻeha a ʻeha pū paha
• fiva
• pehu, palupalu, ʻulaʻula, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• nausea
• luhi loa
• nalo ʻai ʻole
• ʻeha ma ka ʻaoʻao ʻākau o luna o ka ʻōpū
• melemele o ka ʻili a me nā maka
• ʻūlū pale a ʻeleʻele paha

Hoʻokumu paha ʻo Darunavir i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua e ʻike pono he palekana no ʻoe e lawe i darunavir a e nānā i ka pane o kou kino iā darunavir.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Prezista^®
• Prezcobix^® (me Darunavir, Cobicistat)

• TMC-114