Hōʻike antigen histocompatibility

Nānā kahi ho'āʻo koko antigen histocompatibility i nā protein i kapa ʻia ʻo antigens leukocyte kanaka (HLAs). Loaʻa kēia i ka papa o ka ʻaneʻane o nā hunaola a pau i ke kino o ke kanaka. Loaʻa nā HLA i nā nui ma ka ʻili o nā hunaola keokeo. Kōkua lākou i ka ʻōnaehana pale pale e haʻi i ka ʻokoʻa ma waena o nā kino o ke kino a me nā mea ʻaʻole mai kou kino ponoʻī.

Kuhi ʻia ke koko mai kahi aa. Hiki paha iā ʻoe ke ʻeha iki a i ʻole ke kuʻi ke hoʻokomo ʻia o ka nila. Ma hope, aia paha kekahi ʻōkā.

ʻAʻole pono ʻoe e hoʻomākaukau no kēia hōʻike.

Hiki ke hoʻohana i nā hopena mai kēia hoʻokolohua e ʻike i nā kūlike maikaʻi no nā grafts a me nā transplant o nā meaola. Pākuʻi paha kēia i ke kāhili a i ʻole ka hoʻoneʻe iwi o ka iwi.

Hoʻohana ʻia paha ia i:

• Nānā i kekahi mau maʻi autoimmune. ʻO kahi hypersensitivity i hoʻokomo ʻia i ka lāʻau lapaʻau kahi laʻana.
• E hoʻoholo i nā pilina ma waena o nā keiki a me nā mākua ke nīnau ʻia ia ʻano pilina.
• Nānā i ka mālama ʻana me kekahi mau lāʻau.

He kau liʻiliʻi kāu o nā HLA i hoʻoili ʻia mai kou mau mākua mai. ʻO nā keiki, ma ka awelika, e loaʻa ka hapalua o kā lākou HLA i ka hapalua o ko lākou makuahine a me ka hapalua o kā lākou HLA i ka hapalua o ko lākou makuakāne.

ʻAʻole paha e loaʻa i nā poʻe pili ʻole ʻelua ka makeup HLA like. Eia nō naʻe, kūlike paha nā māhoe like.

ʻO kekahi mau ʻano HLA i ʻike pinepine ʻia i kekahi mau maʻi autoimmune. ʻO kahi laʻana, loaʻa ka antigen HLA-B27 i nā poʻe he nui (akā ʻaʻole āpau) me ka ankylosing spondylitis a me Reiter syndrome.

ʻAʻohe pilikia iki i ka lawe ʻia ʻana o kou koko. ʻOkoʻa nā aʻa a me nā aʻa i ka nui mai kekahi kanaka a i kekahi ʻē aʻe a mai kekahi ʻaoʻao o ke kino i kekahi. ʻOi aku ka paʻakikī o ka lawe ʻana i ke koko mai kekahi poʻe ma mua o nā poʻe ʻē aʻe.

ʻO nā pilikia ʻē aʻe e pili ana i ke kau ʻana o ke koko he liʻiliʻi, akā hiki ke hoʻopili ʻia:

• Pāleʻale a ʻoluʻolu paha
• Nā punctures he nui e ʻimi i nā uaua
• Hematoma (kūkulu koko ma lalo o ka ʻili)
• Kahe nui ke koko
• Maʻiʻaʻai (i iki kamepiula i kēlā me kēia manawa ka ʻili i haki)

Kikowaena HLA; Kikū kikokiko

• Hōʻaʻo koko
• Māhele iwi

Fagoaga OR. Antigen leukocyte kanaka: ka paʻakikī histocompatibility nui o ke kanaka. I: McPherson RA, Pincus MR, hua. ʻO kā Henry's Clinical Diagnosis a me Management e nā Laboratory Methods. 23rd Ed. St Louis, MO: Elsevier; 2017: chap 49.

Monos DS, Winchester RJ. ʻO ka paʻakikī histocompatibility nui. I: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Kakaʻu AJ, Weyand CM, hua. ʻO Immunology Haumāna: Nā Kumu a me nā Haʻawina. 5th lā. Piladelapia, PA: Elsevier; 2019: chap 5.

Wang E, Adams S, Stroncek DF, Marincola FM. Antigen leukocyte kanaka a me nā ʻōnaehana antigen neutrophil kanaka. I: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Nā Kumumanaʻo a me ka Hoʻomeheu. ʻEpekema 7 Piladelapia, PA: Elsevier; 2018: chap 113.