Protein electrophoresis - serum

Ana kēia hoʻokolohua i nā ʻano protein i loko o ka wai (serum) ʻāpana o kahi hāpana koko. Kapa ʻia kēia wai i ke serum.

Pono kahi laʻana koko.

I ka hale hana, hoʻonoho ka ʻenehana i ka laʻana koko ma kahi pepa kūikawā a hoʻopili i kahi kaila uila. Neʻe nā protein i ka pepa a hana i nā band e hōʻike i ka nui o kēlā me kēia protein.

E noi ʻia ʻoe ʻaʻole e ʻai a inu paha no 12 mau hola ma mua o kēia hōʻike.

Hiki i kekahi mau lāʻau ke hoʻololi i nā hopena o kēia hōʻike. E haʻi aku kāu mea mālama ola inā pono ʻoe e hōʻoki i ka lawe ʻana i nā lāʻau. Mai kū i kekahi lāʻau i mua o ke kamaʻilio ʻana i kāu mea hāʻawi.

Ke hoʻokomo ʻia ke kui kele e huki i ke koko, manaʻo kekahi poʻe i ka ʻeha kaulike. ʻIke wale kekahi i kahi ʻōniʻu a i ʻole kui. Ma hope, loaʻa paha i kahi kūpikipiki a i ʻole ka ʻūlū iki. Hele koke kēia.

Hana ʻia nā protein mai nā amino acid a he mau ʻāpana nui ia o nā pūnaewele a me nā aʻa. Nui a hewahewa nā ʻano protein i loko o ke kino, a he nui nā ʻano hana like ʻole. ʻO nā laʻana o nā protein e komo pū me nā enzyme, kekahi mau hormones, hemoglobin, lipoprotein haʻahaʻa (LDL, a i ʻole kolesterol maikaʻi), a me nā mea ʻē aʻe.

Hoʻonohonoho ʻia nā proteins serum ma ke ʻano he albumin a i ʻole globulins. ʻO Albumin ka protein ʻoi loa i ka serum. Hāpai ia i nā mole liʻiliʻi. He mea nui ia no ka mālama ʻana i ka wai mai ke kahe ʻana mai nā kīʻaha koko i loko o nā aʻa.

Māhele ʻia nā Globulins i nā alpha-1, alpha-2, beta, a me nā gamma globulins. Ma ka laulā, hoʻonui ka alpha a me ka gamma globulin protein i ka loaʻa ʻana o ka mumū i loko o ke kino.

Hoʻoholo ka lipoprotein electrophoresis i ka nui o nā protein i hana ʻia i loko o ka protein a me ka momona, i kapa ʻia lipoproteins (e like me LDL kolesterol).

ʻO nā pae waiwai maʻamau:

• Huina pūmua: 6.4 a 8.3 gram i kēlā me kēia deciliter (g / dL) a i ʻole 64 a 83 gramo i kēlā me kēia lita (g / L)
• Albumin: 3.5 a 5.0 g / dL a 35 a 50 g / L
• ʻO Alpha-1 globulin: 0.1 a 0.3 g / dL a i ʻole 1 a 3 g / L
• ʻO Alpha-2 globulin: 0.6 a 1.0 g / dL a i ʻole 6 a 10 g / L
• Beta globulin: 0.7 a 1.2 g / dL a i ʻole 7 a 12 g / L
• ʻO Gamma globulin: 0.7 a 1.6 g / dL a i ʻole 7 a 16 g / L

ʻO nā laʻana ma luna he ana maʻamau no nā hopena o kēia mau hoʻāʻo. Hiki ke loli iki nā pae waiwai maʻamau i waena o nā hale hana ʻokoʻa. Hoʻohana kekahi mau labs i nā ana like ʻole a i ʻole nā ​​hoʻāʻo i nā laʻana like ʻole. E kamaʻilio i kāu mea hāʻawi e pili ana i ke ʻano o kāu mau hopena kikoʻī.

Hōʻike ka hōʻemi ʻana o ka protein i:

• ʻO ka nalo maʻamau o ka protein mai ka digestive tract a i ʻole hiki ʻole o ka tract digestive ke komo i nā proteins (protein-lilo enteropathy)
• Kaʻai pono ʻole
• ʻO ka maʻi kīwī i kapa ʻia ʻo nephrotic Syndrome
• Scarring o ke akepaʻa a me ka hana maikaʻi ʻole ate (cirrhosis)

ʻO ka hoʻonui ʻia o ka protein alpha-1 globulin ma muli o:

• Maʻi maʻi kūpilikiʻi
• Kanesa
• ʻO ka maʻi hōʻeha mau (e laʻa me, rheumatoid arthritis, SLE)

ʻO ka hōʻemi alpha-1 globulin proteins i hōʻailona o:

• Ka nele o Alpha-1 antitrypsin

Hoʻonui ka alpha-2 globulin proteins i kahi:

• Huʻi huʻi
• Pāhū mau

Hiki i nā alpha-2 globulin protein i hōʻemi ke hōʻike:

• Ka haki ʻana o nā hunaola ʻulaʻula (hemolysis)

Hoʻonui ka protein beta globulin i hōʻike ʻia:

• ʻO kahi maʻi kahi e pilikia ai ke kino i ka haki ʻana i nā momona (ʻo kahi laʻana, hyperlipoproteinemia, hypercholesterolemia ʻohana)
• Hoʻoikaika Estrogen

Hōʻike ka hōʻemi beta globulin protein i:

• ʻO ka haʻahaʻa haʻahaʻa haʻahaʻa o LDL kolesterol
• Kaʻai pono ʻole

Hiki i nā proteins gamma globulin i hoʻonui ʻia ke hōʻike:

• Nā maʻi maʻi koko, me myeloma maha, Waldenström macroglobulinemia, lymphomas, a me nā leukemias lymphocytic mau.
• Maʻi maʻi kūpikipiki (e laʻa me, rheumatoid arthritis)
• Maʻi ʻaʻai
• Maʻi maʻi ʻōiwi

ʻAʻohe pilikia iki i ka lawe ʻia ʻana o kou koko. ʻOkoʻa nā aʻa a me nā aʻa i ka nui mai kekahi kanaka a i kekahi, a mai kekahi ʻaoʻao o ke kino i kekahi ʻē aʻe. ʻOi aku ka paʻakikī o ka lawe ʻana i ke koko mai kekahi poʻe ma mua o nā poʻe ʻē aʻe.

ʻO nā pilikia ʻē aʻe e pili ana i ke kau ʻana o ke koko he liʻiliʻi, akā hiki ke hoʻopili ʻia:

• Kahe nui ke koko
• Pāleʻale a ʻoluʻolu paha
• Nā punctures he nui e ʻimi i nā uaua
  
• Hematoma (kūkulu koko ma lalo o ka ʻili)
• Maʻiʻaʻai (i iki kamepiula i kēlā me kēia manawa ka ʻili i haki)

SPEP

• Hōʻaʻo koko

Chernecky CC, Berger BJ. Protein electrophoresis - serum. I: Chernecky CC, Berger BJ, hua. Nā Hoʻokolohua Laboratory a me nā kaʻina hana Diagnostic. ʻElua huaʻōlelo St Louis, MO: Elsevier Saunders; 2013: 917-920.

Munshi NC, Jagannath S. Plasma pūnaewele neoplasms. I: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Nā Kumumanaʻo a me ka Hoʻomeheu. ʻEpekema 7 Piladelapia, PA: Elsevier; 2018: chap 86.

ʻO Warner EA, Herold AH. Ka wehewehe ʻana i nā hoʻokolohua hoʻokolohua. I: Rakel RE, Rakel DP, eds. Puke aʻo o ka lāʻau lapaʻau ʻohana. 9th ed. Piladelapia, PA: Elsevier; 2016: chap 14.