Pākuʻina antibody antinuclear

ʻO ka antinuclear antibody panel kahi hōʻike koko e nānā i nā antinuclear antibodies (ANA).

ʻO ANA nā mea pale i hana ʻia e ka ʻōnaehana pale e hoʻopili ai i nā kino o ke kino. Ke nānā nei ka antinuclear antibody test i nā mea ʻāpili e hoʻopaʻa ai i kahi ʻāpana o ke kele i kapa ʻia ka nucleus. Hoʻoholo ka hōʻike loiloi inā paha aia nā mea ʻino. Ana nō hoʻi ka hoʻāʻo i ka pae, i kapa ʻia ʻo ka titer, a me ke kumu, hiki ke kōkua.Inā maikaʻi ka hoʻāʻo, hiki ke hana ʻia kahi papa o nā hoʻokolohua e ʻike ai i nā pahuhopu antigen kikoʻī. ʻO kēia ka panalā antibody ANA.

Kuhi ʻia ke koko mai kahi aa. ʻO ka pinepine, hoʻohana ʻia kahi aa i loko o ka kuʻe lima a i ʻole ke kua o ka lima. Hoʻomaʻemaʻe ʻia ka pūnaewele me nā lāʻau make-germ (antiseptic). Hoʻopili ka mea mālama ola i kahi kāʻei elastis a puni ka lima luna e hoʻopili i ka kaomi i ka wahi a pehu ke aʻa me ke koko.

A laila, hoʻokomo mālie ka mea hāʻawi i kahi nila i ke aa. Hōʻiliʻili ke koko i loko o kahi kīʻaha ea a i ʻole ka paipu e pili ana i ka nila. Wehe ʻia ke kāʻei elastik mai kou lima aku.

Ke hōʻiliʻili ʻia ke koko, hemo ka nila, a uhi ʻia ka pūnaewele puncture e hoʻōki i ke kahe ʻana o ke kahe.

I nā pēpē a i ʻole nā ​​keiki ʻōpio, hiki ke hoʻohana ʻia kahi mea ʻoi i kapa ʻia he lancet e hou i ka ʻili a hoʻokahe ke koko. Hōʻiliʻili ke koko i loko o kahi pahu aniani liʻiliʻi i kapa ʻia he pipette, a i kahi pāheʻe a i ʻole ka papa hoʻāʻo. Hiki ke hoʻokau ʻia kahi kapa ma luna o ka wahi inā he kahe kekahi.

Kaukaʻi ʻia i ka keʻena hoʻokolohua, hana paha ka hōʻike ma nā ʻano like ʻole. Pono kahi hana i kahi loea e nānā i kahi laʻana koko ma lalo o kahi microscope e hoʻohana ana i nā kukui ultraviolet. Hoʻohana ka mea ʻē i kahi mea hana automate e hoʻopaʻa i nā hopena.

ʻAʻole pono kahi hoʻomākaukau kūikawā. Eia nō naʻe, kekahi mau lāʻau lapaʻau, e like me nā lāʻau kaohi hānau, procainamide, a me nā diuretics thiazide, e hoʻopili i ka pololei o kēia hōʻike. E ʻike pono ka ʻike o kāu mea lawelawe e pili ana i nā lāʻau āpau āu e lawe ai.

Ke hoʻokomo ʻia ke kui kele e huki i ke koko, manaʻo kekahi poʻe i ka ʻeha kaulike. ʻO ka manaʻo ʻē aʻe wale nō he prick a i ʻole sensation stinging paha. Ma hope, aia paha kekahi ʻōkā.

Pono paha ʻoe i kēia hōʻoia inā loaʻa iā ʻoe nā hōʻailona o kahi maʻi autoimmune, ʻo ia hoʻi ʻo lupus erythematosus ʻōnaehana. E hana ʻia paha kēia hōʻike inā loaʻa iā ʻoe kahi mau ʻōuli ʻaʻole i wehewehe ʻia e like me ka rumitis, rashes, a me ka ʻeha o ka umauma.

Loaʻa i kahi poʻe maʻamau ka pae haʻahaʻa o ANA. No laila, ʻaʻole kūleʻa ke alo o kahi pae haʻahaʻa o ANA.

Hōʻike ʻia ʻo ANA ma ke ʻano he "titer". Aia nā titer haʻahaʻa ma ke kaha o 1:40 a 1:60. ʻOi aku ka mea nui o kahi hōʻike ANA maikaʻi inā loaʻa iā ʻoe nā pūpona e kūʻē i ka ʻano papālua o DNA.

ʻAʻole hōʻoia ka hiki ʻana o ANA i kahi kuhi o ka ʻōnaehana lupus erythematosus (SLE). Eia nō naʻe, ʻo ka nele o ANA e hoʻoliʻiliʻi loa i ka hōʻailona.

ʻOiai ʻike pinepine ʻia ʻo ANA me SLE, hiki i kahi hōʻike ANA maikaʻi ke hōʻailona o nā maʻi autoimmune ʻē aʻe.

Hiki ke loli iki nā pae waiwai maʻamau i waena o nā hale hana ʻokoʻa. E kamaʻilio i kāu mea hāʻawi e pili ana i ke ʻano o kāu mau hopena hōʻike.

Hōʻike nā hiʻohiʻona ma luna i nā ana maʻamau no nā hopena no kēia mau hoʻāʻo. Hoʻohana kekahi mau keʻena hoʻokolohua i nā ana like ʻole a i ʻole hoʻokolohua i nā hoʻohālikelike like ʻole.

Hiki ke holo i nā hoʻokolohua hou aʻe ma ke koko me kahi hōʻike ANA maikaʻi e loaʻa ai ka ʻike hou aku.

E hana i ke kuhi o SLE, pono e ʻike ʻia kekahi mau hiʻohiʻona maʻi e like me ANA. Eia hou, kōkua kekahi mau antibodies ANA kikoʻī e hōʻoia i ke kuhi.

ʻO ke kū ʻana o ANA i loko o ke koko ma muli o nā maʻi ʻē aʻe he ʻokoʻa ʻo SLE. Pākuʻi ʻia kēia mau mea:

NA MAI AUTOIMMUNE

• Maʻi maʻi hoʻopili
• Hoʻokomo ʻia ka lāʻau lupus erythematosus
• Myositis (maʻi hōʻeha kino)
• Rheumatoid arthritis
• ʻO Sjögren maʻi
• ʻŌnaehana sclerosis (scleroderma)
• Maʻi thyroid
• ʻO ka hepatitis autoimmune
• ʻO Lymphomas

INFECTIONS

• EB mea hoʻomaʻi
• Hepatitis C
• HIV
• Parvovirus

ʻOkoʻa nā aʻa a me nā aʻa i ka nui mai kekahi kanaka a i kekahi, a mai kekahi ʻaoʻao o ke kino i kekahi ʻē aʻe. ʻOi aku ka paʻakikī o ka loaʻa ʻana o ke koko mai kekahi poʻe ma mua o nā poʻe ʻē aʻe.

ʻO nā pilikia ʻē aʻe e pili ana i ke kau ʻana o ke koko he liʻiliʻi, akā hiki ke hoʻopili ʻia:

• Kahe nui ke koko
• Pāleʻale a ʻoluʻolu paha
• Hematoma (hōʻiliʻili koko ma lalo o ka ʻili)
• Maʻiʻaʻai (i iki kamepiula i kēlā me kēia manawa ka ʻili i haki)

E hoʻohana kāu mea hāʻawi i nā hopena o ka panela ANA e kōkua i ka hana ʻana i kahi kuhi. Loaʻa i nā poʻe āpau me ka SLE hana he ANA maikaʻi. Eia nō naʻe, ʻaʻole lawa ka ANA maikaʻi e hōʻike ai i ka maʻi o SLE a i ʻole nā ​​maʻi autoimmune ʻē aʻe. Pono e hoʻohana i nā hoʻokolohua ANA me kāu mōʻaukala olakino, hoʻāʻo kino a me nā hoʻokolohua hoʻokolohua ʻē aʻe.

Hiki i ka ANA ke lilo i mea maikaʻi i nā ʻohana o ka poʻe me SLE ʻaʻole SLE iā lākou iho.

Aia kahi haʻahaʻa haʻahaʻa loa e hoʻomohala iā SLE i kekahi manawa ma hope o ke ola inā loaʻa kahi loaʻa he titer haʻahaʻa o ANA.

ANA; ANA panela; ANA reflexive panel; SLE - ANA; ʻO ka lupus erythematosus ʻōnaehana - ANA

• Hōʻaʻo koko

ʻO Alberto von Mühlen C, Fritzler MJ, ʻo Chan EKL. Lapaʻau a me keʻena hoʻokolohua loiloi o nā ʻōnaehana rheumatic maʻi. I: McPherson RA, Pincus MR, hua. ʻO kā Henry's Clinical Diagnosis a me Management e nā Laboratory Methods. 23rd Ed. St Louis, MO: Elsevier; 2017: chap 52.

Pūnaewele ʻAmelika Hui Pū ʻIa o Rheumatology. Antinuclear antibodies (ANA). www.rheumatology.org/I-Am-A/Patient-Caregiver/Diseases-Conditions/Antinuclear-Antibodies-ANA. Hoʻohou Malaki Malaki 2017. Loaʻa iā ʻApelila 04, 2019.

ʻO Reeves WH, Zhuang H, Han S. Autoantibodies i ka lupus erythematosus ʻōnaehana. I: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. ʻEpekema 7 Piladelapia, PA: Elsevier; 2019: chap 139.