Hōʻike koko Pyruvate kinase

Hoʻopili ka pyruvate kinase test i ke kiʻekiʻe o ka enzyme pyruvate kinase i ke koko.

ʻO Pyruvate kinase kahi enzyme i loaʻa i nā hunaola ʻulaʻula. Kōkua ia i ka hoʻololi i ke kō i ke koko (glucose) i ka ikehu ke haʻahaʻa nā pae o ka oxygen.

Pono kahi laʻana koko. I ke keʻena hoʻokolohua, lawe ʻia nā hunaola keʻokeʻo mai ka hāpana koko no ka mea hiki iā lākou ke hoʻololi i nā hopena hōʻike. Ana ʻia ka pae o ka pyruvate kinase.

ʻAʻole pono kahi hoʻomākaukau kūikawā.

Inā ke hoʻokolohua nei kāu keiki, kōkua paha ia e wehewehe i ka ʻano o ka hoʻāʻo a hōʻike ma kahi pēpē. E wehewehe i ke kumu o ka hoʻāʻo. ʻO ka ʻike i ka "pehea a me ke kumu" e hōʻemi ai i ka hopohopo o kāu keiki.

Ke hoʻokomo ʻia ke kui kele e huki i ke koko, manaʻo kekahi poʻe i ka ʻeha kaulike. ʻIke wale kekahi i kahi ʻōniʻu a i ʻole kui. Ma hope, loaʻa paha i kahi kūpikipiki a i ʻole ka ʻūlū iki. Hele koke kēia.

Hana ʻia kēia hōʻike e huki i kahi pae haʻahaʻa pyruvate kinase ma kahi haʻahaʻa. Me ka lawa ʻole o kēia enzyme, e haki wikiwiki nā hunaola koko ma mua o ka maʻamau. Kapa ʻia kēia he hemolytic anemia.

Kōkua kēia hōʻike i ka diagnose pyruvate kinase deficit (PKD).

Hoʻololi nā hopena ma muli o ka hana hoʻāʻo i hoʻohana ʻia. Ma ka laulaha, ʻo ka waiwai maʻamau he 179 ± 16 wae no 100 mL o nā hunaola ʻulaʻula.

Hiki ke loli iki nā pae waiwai maʻamau i waena o nā hale hana ʻokoʻa. Hoʻohana kekahi mau labs i nā ana like ʻole a i ʻole nā ​​hoʻāʻo i nā laʻana like ʻole. E kamaʻilio me kāu mea mālama ola e pili ana i ke ʻano o kāu mau hopena hōʻike kikoʻī.

ʻO kahi pae haʻahaʻa o pyruvate kinase e hōʻoia iā PKD.

ʻAʻohe pilikia iki i ka lawe ʻia ʻana o kou koko. ʻOkoʻa nā aʻa a me nā aʻa i ka nui mai kekahi kanaka a i kekahi ʻē aʻe a mai kekahi ʻaoʻao o ke kino i kekahi. ʻOi aku ka paʻakikī o ka lawe ʻana i ke koko mai kekahi poʻe ma mua o nā poʻe ʻē aʻe.

ʻO nā pilikia ʻē aʻe e pili ana i ke kau ʻana o ke koko he liʻiliʻi, akā hiki ke hoʻopili ʻia:

• Kahe nui ke koko
• Pāleʻale a ʻoluʻolu paha
• Nā punctures he nui e ʻimi i nā uaua
• Hematoma (kūkulu koko ma lalo o ka ʻili)
• Maʻiʻaʻai (i iki kamepiula i kēlā me kēia manawa ka ʻili i haki)

ʻO Elghetany MT, Schexneider KI, Banki K. Nā maʻi Erythrocytic. I: McPherson RA, Pincus MR, hua. ʻO kā Henry's Clinical Diagnosis a me Management e nā Laboratory Methods. 23rd Ed. St Louis, MO: Elsevier; 2017: chap 32.

ʻO Gallagher PG. Hemolytic anemias: ʻulaʻula membrane a me nā kīnā metabolik. I: Goldman L, Schafer AI, eds. ʻO ka lāʻau lapaʻau Goldman-Cecil. 26th ed. Piladelapia, PA: Elsevier; 2020: chap 152.

Papachristodoulou D. Ka ikehu pūnao. I: Naish J, Syndercombe 'Aha D, hua. ʻEpekema Lapaʻau. ʻEkolu huaʻōlelo. Piladelapia, PA: Elsevier; 2019: chap 3.

van Solinge WW, van Wijk R. Enzymes o ke keʻena koko ʻulaʻula. I: Rifai N, ed. ʻO Tietz Textbook of Clinical Chemistry a me nā Molecular Diagnostics. ʻElua huaʻōlelo Piladelapia, PA: Elsevier; 2018: chap 30.