Hormone therapy no ka maʻi ʻaʻai umauma

Hoʻohana ka Hormone therapy e mālama ai i ka maʻi ʻaʻai o ka umauma i nā lāʻau a i ʻole nā ​​lāʻau lapaʻau e hoʻohaʻahaʻa ai i nā pae a i ʻole ālai i ka hana o nā homone wahine (estrogen a progesterone) i ke kino o ka wahine. Kōkua kēia i ka lohi o ka ulu ʻana o nā maʻi maʻi umauma.

Hormone therapy e hoʻoliʻiliʻi iki ai ka maʻi ʻaʻai ma hope o ke kahakaha ʻana o ka maʻi ʻaʻai. Hoʻoiho hoʻi ia i ka ulu ʻana o ka maʻi ʻaʻai umauma i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino.

Hiki ke hoʻohana ʻia ʻo ka Hormone therapy e pale ai i ka maʻi ʻaʻai i nā wahine i ka makaʻu kiʻekiʻe no ka maʻi ʻaʻai umauma.

He ʻokoʻa ia mai ka hormone therapy e mālama i nā hōʻailona menopause.

ʻO nā hormones estrogen a me progesterone e ulu ai kekahi i nā maʻi maʻi umauma. Kapa ʻia lākou he mau maʻi ʻaʻai umauma ʻāʻī. ʻO ka hapa nui o nā maʻi ʻōpū o ka umauma maʻalahi i nā hormona.

Hana ʻia ka Estrogen a me ka progesterone i nā ovaries a me nā mea ʻē aʻe e like me ka momona a me ka ʻili. Ma hope o ka menopause, hoʻōki nā ovaries i ka hana ʻana i kēia mau homona. Akā hoʻomau ke kino e hana i kahi liʻiliʻi.

Hana wale ka Hormone therapy ma nā maʻi ʻaʻai maʻi hormon. E ʻike inā holo paha ka hoʻomaʻamaʻa hormone, hoʻāʻo nā kauka i kahi laʻana o ka tumo i lawe ʻia i ka wā o ke kaha e ʻike inā pili ka maʻi ʻaʻai i nā homone.

Hiki i ka Hormone therapy ke hana ma nā ʻano ʻelua:

• Ma ka pale ʻana i ka estrogen mai ka hana ʻana i nā hunaola maʻi ʻaʻai
• Ma ka hoʻohaʻahaʻaʻana i nā pae estrogen i ke kino o ka wahine

Hana kekahi mau lāʻau i ka pale ʻana i ka estrogen mai ka ulu ʻana i nā hunaola maʻi ʻaʻai.

ʻO Tamoxifen (Nolvadex) kahi lāʻau e pale aku ai i ka estrogen mai ka haʻi ʻana i nā hunaola maʻi ʻaʻai e ulu. Loaʻa iā ia he mau keu pono:

• Lawe iā Tamoxifen no 5 mau makahiki ma hope o ke kahakaha ʻana o ka maʻi ʻaʻai umauma ʻokiʻoki i ka manawa o ka maʻi ʻaʻai e hoʻi mai i ka hapalua. Hōʻike kekahi mau noiʻi e lawe ʻoi aku ia no 10 mau makahiki i ʻoi aku ka maikaʻi.
• Hoʻoemi ia ka makaʻu e ulu ai ka maʻi ʻaʻai i ka umauma ʻē aʻe.
• Hoʻohiohi ia i ka ulu a hōʻemi i ka maʻi ʻaʻai i pālahalaha.
• Hoʻoemi ia i ka makaʻu o ka loaʻa ʻana i ka maʻi ʻaʻai i nā wahine kūpilikiʻi nui.

Hoʻohana ʻia nā lāʻau ʻē aʻe e hana i kahi ala like e mālama ai i ka maʻi ʻaʻai holomua i laha:

• Toremifene (Fareston)
• ʻO Fulvestrant (Faslodex)

ʻO kekahi mau lāʻau, i kapa ʻia nā mea kāohi aromatase (AI), hoʻokū i ke kino mai ka hana ʻana i ka estrogen i loko o nā mea like me ka momona a me ka ʻili. Akā, ʻaʻole holo pono kēia mau lāʻau e hoʻopau i ka hana ʻana o nā ovaries i ka hana ʻana i ka estrogen. No kēia kumu, hoʻohana nui ʻia lākou e hoʻohaʻahaʻa i nā pae estrogen i nā wahine i loaʻa i ka menopause (postmenopausal). ʻAʻole hana hou kā lākou mau ovaries i ka estrogen.

Hiki i nā wahine Premenopausal ke lawe i nā AI ke lawe pū lākou i nā lāʻau e hōʻoki i kā lākou ovaries mai ka hana ʻana i ka estrogen.

Hoʻopili nā mea hoʻopā Aromatase:

• Anastrozole (Arimidex)
• Letrozole (Femara)
• Exemestane (Aromasin)

Hana wale kēia ʻano lapaʻau i nā wahine premenopausal nāna ka ovaries e holo nei. Hiki iā ia ke kōkua i kekahi ʻano o ka hoʻomaʻamaʻa hormone e hana ʻoi aku ka maikaʻi. Hoʻohana ʻia ia e mālama i ka maʻi ʻaʻai i laha.

ʻEkolu ala e hoʻohaʻahaʻa ai i nā pae estrogen mai nā ovaries:

• Keʻokiʻoki e wehe i nā ovaries
• ʻO ka uila e hōʻino ai i nā ovaries no laila ʻaʻole lākou e hana hou, kahi paʻa mau
• ʻO nā lāʻau e like me goserelin (Zoladex) a me leuprolide (Lupron) e kū iki i nā ovaries mai ka hana ʻana i ka estrogen.

ʻO kekahi o kēia mau ʻano hana e hoʻokau i ka wahine i ka menopause. ʻO kēia ke kumu o nā ʻōuli o ka menopause:

• ʻO nā kukuna wela
• Hoʻoulu ka pō
• Maloʻo maloʻo
• Swings hāhuli
• Kaumaha
• Loaʻa ka hoihoi i ka moekolohe

ʻO nā hopena ʻē aʻe o ka hoʻomaʻamaʻa hormone e hilinaʻi ʻia i ka lāʻau. ʻO nā hopena ʻē aʻe e pili pū me nā uila wela, ka sweats o ka pō, a me ka maloʻo liʻiliʻi.

Hiki i kekahi mau lāʻau ke hōʻemi i nā hopena ākea akā ʻoi aku ka hopena o ka hopena, e like me:

• ʻO Tamoxifen. ʻO ke kahe o ke koko, ka hahau ʻana, ka cataract, nā maʻi ʻoki endometrial a me ka uterine, ka loli o ke ʻano, ke kaumaha, a me ka nalo ʻole o ka hoihoi i ka moekolohe.
• Nā mea kāohi ʻo Aromatase. ʻO ke koleke kiʻekiʻe, ka puʻuwai puʻuwai, ka pohō o ka iwi, ka ʻeha pū, ka loli o ke ʻano, a me ke kaumaha.
• ʻO Fulvestrant. ʻO ka nele o ka makemake, kahoʻi, ka luaʻi, ka paʻa, ka maʻi kō, ka ʻōpū o ka ʻōpū, nāwaliwali, a me ka ʻeha.

ʻO ka hoʻoholo ʻana i ka hoʻokalakupua hormonal no ka maʻi ʻaʻai umauma hiki ke lilo i hoʻoholo paʻakikī a paʻakikī hoʻi. ʻO ke ʻano o ka therapy i loaʻa iā ʻoe e kaukaʻi inā ʻoe i hele i loko o ka menopause ma mua o ka mālama ʻana no ka maʻi ʻaʻai umauma. Pili paha ia inā makemake ʻoe e hānau keiki. ʻO ke kamaʻilio pū ʻana me kāu kauka olakino e pili ana i kāu koho a me nā pōmaikaʻi a me nā pilikia no kēlā me kēia lapaʻau hiki ke kōkua iā ʻoe e hoʻoholo pono loa iā ʻoe.

Hormonal therapy - ka maʻi ʻaʻai umauma; Hormone lapaʻau - umauma maʻi 'aʻai; Endocrine therapy; Maʻi ʻaʻai Hormone-sensitive - therapy; ER maikaʻi - therapy; Nā mea kāohi aromatase - ka maʻi ʻaʻai umauma

Pūnaewele ʻAmelika Hui Pū ʻIa ʻAmelika. Hormone therapy no ka maʻi ʻaʻai umauma. www.cancer.org/cancer/breast-cancer/treatment/hormone-therapy-for-breast-cancer.html. Hoʻohou i Kepakemapa 18, 2019. Loaʻa iā Nowemapa 11, 2019.

ʻO Henry NL, Shah PD, Haider I, Freer PE, Jagsi R, Sabel MS. Kanesa o ka umauma. I: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. ʻO Oncology Clinical ʻo Abboff. ʻElua huaʻōlelo Piladelapia, PA: Elsevier; 2020: chap 88.

Pūnaewele ʻo National Cancer Institute. Hormone therapy no ka maʻi ʻaʻai umauma. www.cancer.gov/types/breast/breast-hormone-therapy-fact-sheet. Hoʻohou i Pepeluali 14, 2017. Loaʻa iā Nowemapa 11, 2019.

Rugo HS, Rumble RB, Macrae E, et al. Endocrine therapy for cancer receptor-positive metastatic cancer cancer: ʻAhahui ʻAmelika Hui Pū ʻIa Oncology Clinical. ʻO J Clin Oncol. 2016; 34 (25): 3069-3103. PMID: 27217461 www.ncbi.nlm.nih.gov/pubmed/27217461.

• Ka maʻi ʻaʻai umauma