Leukoencephalopathy multifocal holomua

ʻO ka leukoencephalopathy multifocal holomua (PML) kahi maʻi laha ʻole e hōʻino i nā mea (myelin) e uhi a pale ana i nā aʻalolo i ka mea keʻokeʻo o ka lolo.

ʻO ka maʻi ʻo John Cunningham, a ʻo virus JC paha (JCV) ke kumu o ka PML. ʻIke ʻia ʻo virus JC ma ke ʻano he polyomavirus kanaka. Akā ʻo ka poʻe me ka ʻōnaehana pale nawaliwali e makaʻu i ka hoʻomōhala ʻana i ka PML. ʻO nā kumu o ka ʻōnaehana pale nawaliwali nā:

• HIV / AIDS (ʻoi aku ka liʻiliʻi o ke kumu o ka PML i kēia manawa no ka mālama maikaʻi ʻana o ka maʻi HIV / AIDS).
• ʻO kekahi mau lāʻau e kāohi i ka ʻōnaehana pale i kapa ʻia he monoclonal antibodies. Hiki ke hoʻohana ʻia ia ʻano lāʻau e pale aku ai i ka hōʻole ʻana i nā transplant a i ʻole e mālama ʻana i nā sclerosis he nui, rumatika a me nā maʻi autoimmune ʻē aʻe, a me nā kūlana e pili pū ana.
• Nā maʻi maʻi, e like me leukemia a me Hodgkin lymphoma.

Pākuʻi ʻia paha nā ʻōuli i kekahi o kēia mau mea:

• Lilo o ka hoʻohui ʻana, clumsiness
• Ka nalowale o ka hiki ʻōlelo (aphasia)
• Poho hoʻomanaʻo
• Nā pilikia ʻike
• Nāwaliwali o nā wāwae a me nā lima e ʻoi aku ana ka maikaʻi
• Hoʻololi ka pilikino

E hana ka mea mālama ola i kahi hoʻokolohua kino a nīnau e pili ana i nā ʻōuli.

E komo pū paha nā hoʻāʻo:

• ʻO Biopsy lolo (i nā manawa kakaikahi)
• ʻO ka hoʻāʻo wai Cerebrospinal no ka JCV
• CT scan o ka lolo
• Electroencephalogram (EEG)
• MRI o ka lolo

I ka poʻe me HIV / AIDS, hiki i ka mālama ʻana e hoʻoikaika i ka ʻōnaehana pale i ke ola ʻana mai nā ʻōuli o PML. ʻAʻohe mea lapaʻau ʻē aʻe i hōʻoia maikaʻi no PML.

ʻO PML kahi kūlana hoʻoweliweli i ke ola. Kaukaʻi ʻia i ka ʻino o ka maʻi, a i ka hapalua o ka poʻe i ʻike ʻia me ka PML e make i loko o nā mahina mua. E kamaʻilio i kāu mea nāna e hāʻawi e pili ana i nā hoʻoholo mālama.

PML; ʻO ka maʻi maʻi ʻo John Cunningham; JCV; Kanaka polyomavirus 2; JC virus

• ʻ Grayhinahina a keʻokeʻo mea o ka lolo
• Leukoencephalopathy

Berger JR, Nath A. Cytomegalovirus, Epstein-Barr virus, a me nā maʻi maʻi lohi o ke kikowaena pūnaewele. I: Goldman L, Schafer AI, eds. ʻO ka lāʻau lapaʻau Goldman-Cecil. 26th ed. Piladelapia, PA: Elsevier; 2020: chap 346.

Tan CS, Koralnik IJ. JC, BK, a me nā polyomavirus ʻē aʻe: leukoencephalopathy multifocal holomua (PML). I: Bennett JE, Dolin R, Blaser MJ, hua pā. ʻO Mandell, Douglas, a me Bennett's Principle a me ka hoʻomaʻamaʻa ʻana i nā maʻi kūpilikiʻi. 9th ed. Piladelapia, PA: Elsevier; 2020: chap 144.