IgA nephropathy

ʻO IgA nephropathy kahi maʻi kīʻaha kahi i kūkulu ʻia ai nā mea ʻino i kapa ʻia ʻo IgA i loko o nā puʻupaʻa. ʻO ka nephropathy ka mea hōʻino, maʻi, a i ʻole nā ​​pilikia ʻē aʻe me ka puʻupaʻa.

Kāhea ʻia ʻo IgA nephropathy ʻo Berger maʻi.

ʻO ka IgA kahi protein, i kapa ʻia he antibody, i kōkua i ke kino e hakakā i nā maʻi. Hana ʻia kahi nephropathy IgA ke waiho ʻia ka nui o kēia protein i loko o nā puʻupaʻa. Kūkulu ʻo IgA i loko o nā kīʻaha koko liʻiliʻi o ka puʻupaʻa. ʻO nā hanana i ka puʻuwai i kapa ʻia ʻo glomeruli e lilo i mea wela a hōʻino ʻia.

Hiki ke ʻike ʻole ʻia ka maʻi (ʻāpiki), a i ʻole hele a lohi paha i ka hala o nā makahiki he nui (glomerulonephritis mau).

ʻO nā kumu pilikia me:

• ʻO kahi moʻolelo pilikino a ʻohana paha o IgA nephropathy a i ʻole Henoch-Schönlein purpura, kahi ʻano o ka vasculitis e pili ana i nā ʻāpana o ke kino.
• ʻO ka lāhui keʻokeʻo a ʻĀkia paha

Hiki i ka nephropathy IgA ke hana i nā poʻe o nā makahiki āpau, akā pili pinepine ia i nā kāne i kā lākou ʻōpio a hiki i ka hopena o 30.

ʻAʻohe paha hōʻailona no nā makahiki he nui.

Ke loaʻa nā ʻōuli, pili pū paha lākou:

• Mimi koko e hoʻomaka i ka wā a ma hope koke paha o kahi maʻi hanu
• Nā māhele hou o ka mimi ʻeleʻele a koko paha
• ʻO ka pehu ʻana o nā lima a me nā wāwae
• Nā ʻōuli o ka maʻi maʻi kō

ʻIke pinepine ʻo IgA nephropathy ke kanaka me ka ʻole o nā ʻōuli ʻē aʻe o nā pilikia puʻupaʻa he hoʻokahi a ʻoi paha nā ʻāpana o ka mimi ʻeleʻele a koko paha.

ʻAʻohe mau hoʻololi kikoʻī i ʻike ʻia i ka wā o ka hoʻokolokolo kino. I kekahi manawa, kiʻekiʻe paha ke koko a i ʻole ke pehu paha o ke kino.

Loaʻa i nā hoʻāʻo:

• Hoʻokolohua urea nitrogen (BUN) e ana i ka hana o ka hakuʻala
• Hoʻokolohua ke koko Creatinine e ana i ka hana o ka hakuʻala
• ʻO ka biopsy kidney e hōʻoia i ka hōʻoia
• Urinalysis
• Mīkini immunoelectrophoresis

ʻO ka pahuhopu o ka mālama ʻana e hōʻoluʻolu i nā ʻōuli a pale a hoʻolohi paha i ka hōʻino ʻole o ke kīnā ʻole mau loa.

Hoʻopili paha ka lāʻau:

• Angiotensin-hoʻololi i ka enzyme (ACE) mea kāohi a me nā angiotensin receptor blockers (ARBs) e kaohi i ke kiʻekiʻe o ke koko a me ka pehu (edema)
• ʻO Corticosteroids, nā lāʻau ʻē aʻe e kāohi i ka ʻōnaehana pale
• ʻAilā iʻa
• Lapaʻau e hoʻohaʻahaʻa i ka kolesterol

Hiki ke kapu ʻia ka paʻakai a me nā wai e kāohi ai i ka pehu. Kuhi ʻia kahi papaʻai protein haʻahaʻa a haʻahaʻa i kekahi mau hihia.

ʻO ka hope loa, pono e mālama ʻia nā kānaka he nui no ka maʻi maʻi kōkō mau a pono paha i ka dialysis.

Lohi mālie ʻo IgA nephropathy. I nā manawa he nui, ʻaʻole e ʻino iki. Eʻoi aku paha ka maikaʻi o kou kūlana inā loaʻa iā ʻoe:

• Piʻi koko kiʻekiʻe
• ʻO ka nui o nā protein i ka mimi
• Hoʻonui ʻia ka BUN a i ʻole nā ​​pae creatinine

Kāhea i kāu kahu mālama ola inā he mimi koko kou a i ʻole e hana ana ʻoe i ka mimi liʻiliʻi ma mua o ka maʻamau.

ʻO Nefropathy - IgA; Maʻi maʻi Berger

• Anatomia hakuʻala

ʻO Feehally J, Floege J. Immunoglobulin He nephropathy a me IgA vasculitis (Henoch-Schönlein purpura). I: Feehally J, Floege J, Tonelli M, Johnson RJ, eds. Nā Nephrology Haumāna piha. ʻElua huaʻōlelo Piladelapia, PA: Elsevier; 2019: chap 23.

Saha MK, Pendergraft WF, Jennette JC, Falk RJ. Maʻi glomerular mua. I: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. ʻO Brenner a me Rector's The Kidney. 11th hua. Piladelapia, PA: Elsevier; 2020: chap 31.