ʻO ka tumele pūnaewele ʻumeke Pancreatic

ʻO ka tumreatic islet cell tumulo kahi tumo laha ʻole o ka pancreas e hoʻomaka ana mai kahi ʻano o ke aʻa i kapa ʻia ka pūnaewele islet.

I loko o nā pancreas olakino, nā hunaola i kapa ʻia he mau mokupuni liʻiliʻi e hana i nā homone e hoʻoponopono i nā hana o ke kino. Hoʻopili kēia i ke kiʻekiʻe o ke kō a me ka hana ʻana o ka acid acid.

Hiki i nā tumors ke kū aʻe mai nā pūnaewele mokupuni o ka pancreas hiki ke hana i nā ʻano hormonone, i hiki ke alakaʻi ʻia i nā hōʻailona kikoʻī.

Hiki i nā tumors cell islet Pancreatic ke noncancerous (benign) a i ʻole cancerous (malignant).

Aia nā pūnana pū Islet me:

• Gastrinoma (Zollinger-Ellison maʻi pale)
• ʻO Glucagonoma
• ʻO Insulinoma
• ʻO Somatostatinoma
  
• ʻO VIPoma (Verner-Morrison Syndrome)

ʻO kahi moʻolelo ʻohana o neoplasia endocrine he nui, ʻano I (MEN I) kahi mea weliweli no ka hoʻomohala ʻana i nā tumors cell islet.

Kaukaʻi ʻia nā ʻōuli ma ke ʻano o ka hōmona e hana ʻia e ka tumo.

ʻO kahi laʻana, hana nā insulinomas i ka insulin, kahi e hoʻohaʻahaʻa ai i ke kiʻekiʻe o ke kō. Pākuʻi ʻia paha nā ʻōuli:

• Luhi a palupalu paha
• Ke luliluli a sweating paha
• ʻEha poʻo
• Pololi
• Weliweli, hopohopo, a i ʻole huhū huhū paha
• Ka noʻonoʻo pono ʻole a ʻano luhi paha
• ʻIke pālua a pohihihi paha
• Wikiwiki a kuʻi paha i ka puʻuwai puʻuwai

Inā haʻahaʻa loa kāu pae kō kō, hiki paha iā ʻoe ke maule, loaʻa ka hopu ʻana, a i ʻole hele i kahi koma.

Hana ʻo Gastrinomas i ka hormon gastrin, ka mea e haʻi i ke kino e hana i ka waikawa ʻōpū. Pākuʻi ʻia paha nā ʻōuli:

• Abdominal eha
• Pohā
• Ulcer i loko o ka ʻōpū a me ka ʻōpū liʻiliʻi
• ʻO ka luaʻi koko (i kekahi manawa)

Hana ʻo Glucagonomas i ka hormone glucagon, ka mea e kōkua i ke kino e hāpai i ka pae kō kō. Hiki i nā ʻōuli ke hoʻohui pū:

• Diabetes
• ʻUlaʻula, ʻulaʻula blistery i ke aʻa a i ʻole ka ʻūhā
• Kaumaha emi
• Urination pinepine a me ka make wai

Hana ʻo Somatostatinomas i ka hormone somatostatin. Pākuʻi ʻia paha nā ʻōuli:

• Koko kō kiʻekiʻe
• Nā Pohaku
• ʻIno melemele i ka ʻili, a me nā maka
• Kaumaha emi
• Diarrhea me nā noho ʻala hohono

Hana ʻo VIPomas i ka hormone vasoactive ʻōpū peptide (VIP) e pili ana i ka mālama ʻana i ke kaulike o nā paʻakai, ka sodium, potassium a me nā minelala ʻē aʻe i ka GI tract. Hoʻokumu paha ʻo VIPomas:

• ʻO ka diarrhea nui e hiki ai i ka make wai
• Nā pae potassium haʻahaʻa haʻahaʻa, a me nā pae calcium kiʻekiʻe
• Pākuʻi ʻōpū
• Kaumaha emi

E lawe kāu mea mālama ola i kāu mōʻaukala olakino a hana i kahi hoʻokolohua kino.

Hiki ke loli i nā hoʻāʻo koko, kaukaʻi ʻia i nā ʻōuli, akā hiki ke hoʻopili ʻia:

• ʻO ka pae kō glucose
• Pae Gastrin
• ʻO ka hoʻāʻo ahonui Glucose
• Hōʻoia hoʻonāukiuki Secretin no pancreas
• Ka pae o ka glucose koko
• ʻO ke koko insulin C-peptide
• Pae pae insulin
• ʻO ka pae ʻoihana hoʻokē ʻai somatostatin pae
• Serum vasoactive ʻōpū peptide (VIP) pae

E hana ʻia nā hoʻokolohua kiʻi:

• Scanner CT ʻōpū
• ʻO ke ultrasound ʻōpū
• Endoscopic ultrasound
• MRI o ka ʻōpū

Lawe ʻia kekahi laʻana koko mai kahi aa i ka pancreas no ka hoʻāʻo ʻana.

I kekahi manawa, pono ke ʻoki kino e hōʻoia a mālama i kēia ʻano. I loko o kēia kaʻina hana, nānā ka lāʻau lapaʻau i ka pancreas e ka lima a me ka ultrasound.

Pili ka mālama i ka ʻano tumo a inā he maʻi ʻaʻai.

Hiki i nā tumors cancerous ke ulu wikiwiki a pāhola i nā meaola ʻē aʻe. ʻAʻole hiki iā lākou ke mālama. Lawe pinepine ʻia nā Tumors me ke kahakaha, inā hiki.

Inā pālahalaha nā hunaola maʻi ʻaʻai i ke ake, hiki ke hoʻoneʻe ʻia kahi ʻāpana o ke ake, inā hiki. Inā ākea ka maʻi ʻaʻai, hiki ke hoʻohana ʻia i ka chemotherapy e hoʻāʻo a hōʻemi i nā tumors.

Inā hana ka hana maʻamau a nā homoni i nā ʻōuli, loaʻa paha iā ʻoe nā lāʻau e pale aku ai i ko lākou hopena. ʻO kahi laʻana, me nā gastrinomas, ʻo ka overproduction o gastrin ke alakaʻi aku ai i ka nui o ka waikawa i loko o ka ʻōpū. ʻO nā lāʻau lapaʻau nāna e ālai i ka hoʻokuʻu ʻana o ka ʻōpū ʻōpū hiki ke hōʻemi i nā ʻōuli.

Hiki iā ʻoe ke hoʻomāmā i ke koʻikoʻi o ka maʻi ma ke komo ʻana i kahi hui kākoʻo maʻi ʻaʻai. ʻO ke kaʻana ʻana me nā poʻe ʻē aʻe i loaʻa nā ʻike a me nā pilikia maʻamau e hiki ke kōkua iā ʻoe e noʻonoʻo ʻole.

E hoʻōla ʻia ʻoe inā wehe ʻia nā tumors ma mua o ka palahalaha ʻana i nā meaola ʻē aʻe. Inā maʻi kuni nā tumors, hoʻohana ʻia paha ka chemotherapy, akā ʻaʻole hiki ke hoʻōla i ka poʻe i ka maʻamau.

Hiki i nā pilikia hoʻoweliweli ke ola (e like me ke kō kō koko haʻahaʻa) ma muli o ka nui o ka hana hormone, a inā e pāhola ka maʻi ʻaʻai i loko o ke kino.

ʻO nā pilikia o kēia mau tumors nā:

• Diabetes
• Nā pilikia Hormone (inā hoʻokuʻu ka tumo i kekahi ʻano o nā hormones)
• ʻO ke kō kō haʻahaʻa haʻahaʻa (mai nā insulinomas)
• ʻO nā maʻi ulcer i loko o ka ʻōpū a me ka ʻōpū liʻiliʻi (mai gastrinomas)
• Hoʻolahalaha ka tumo i ke ake

Kāhea i kāu mea hāʻawi inā hoʻomōhala ʻoe i nā ʻōuli o kēia mau tumors, keu hoʻi inā he moʻolelo ʻohana kāu no MEN I.

ʻAʻohe pale e ʻike ʻia no kēia mau tumors.

Ka maʻi ʻaʻai - pancreas; Ka maʻi ʻaʻai - pancreatic; Maʻi ʻaʻai Pancreatic; ʻO nā kūpuna pūnaewele Islet; Mokupuni ʻo Langerhans; Nā Tumora Neuroendocrine; Peptic ulcer - maʻi ʻaʻai islet; Hypoglycemia - heʻe pūnaewele mokupuni liʻiliʻi; ʻO Zollinger-Ellison Syndrome; Verner-Morrison maʻi; Gastrinoma; Insulinoma; VIPoma; Somatostatinoma; ʻO Glucagonoma

• Nānā Endocrine
• ʻO Pancreas

Hanai DS, Norton JA. ʻO ka mālama ʻana i nā tumors cell islet pancreatic e haʻalele ana i ka gastrinoma. I: Cameron AM, Cameron JL, eds. ʻO ke kaʻoki lāʻau lapaʻau o kēia manawa. 13th ed. Piladelapia, PA: Elsevier; 2020: 581-584.

Pūnaewele ʻo National Cancer Institute. ʻO ka mālama ʻana i ka maʻi ʻaʻai Pancreatic (PDQ) - mana ʻoihana olakino. www.kanaka.gov/types/pancreatic/hp/pnet-treatment-pdq. Hoʻohou i Ianuali 2, 2020. Loaʻa iā Pepeluali 25, 2020.

Pūnaewele Pūnaewele Manuahi Manuahi. Nā papa hana hoʻomaʻamaʻa NCCN i ka oncology (nā alakaʻi NCCN). Neuroendocrine a me nā hikoko adrenal. Mana 1.2019. www.nccn.org/professionals/physician_gls/pdf/neuroendocrine.pdf. Hoʻohou ʻia Malaki 5, 2019. Loaʻa ʻia ma Pepeluali 25, 2020.

Pūnaewele Pūnaewele Manuahi Manuahi. Nā alakaʻi NCCN no nā mea maʻi. Nā Tumora Neuroendocrine. 2018. www.nccn.org/patients/guidelines/content/PDF/neuroendocrine-patient.pdf.