ʻO Zollinger-Ellison Syndrome

ʻO Zollinger-Ellison Syndrome kahi kūlana kahi e hoʻonui ai ke kino i ka nui o ka hormone gastrin. ʻO ka hapa nui o ka manawa, kahi tumo liʻiliʻi (gastrinoma) i ka pancreas a i ʻole ka ʻōpū liʻiliʻi ke kumu o ka gastrin keu i ke koko.

Hoʻokumu ʻia ʻo Zollinger-Ellison Syndrome e nā tumors. ʻIke pinepine ʻia kēia mau ulu ʻana i ke poʻo o ka pancreas a me ka ʻōpū liʻiliʻi o luna. Kapa ʻia nā tumors ʻo gastrinomas. ʻO nā kiʻekiʻe kiʻekiʻe o ka gastrin ka mea e hana ai i ka nui o ka waikawa ʻōpū.

Hana ʻia ʻo Gastrinomas ma ke ʻano he hoʻokahi tumors a i ʻole kekahi mau tumors. ʻO ka hapalua i ka ʻelua hapakolu o nā gastrinomas hoʻokahi he maʻi ʻaʻa maʻi (malignant). Hoʻolahalaha pinepine kēia mau tumors i ke akepaʻa a me nā pūnana lymph kokoke.

He nui nā kānaka me ka gastrinomas i kekahi mau tumors ma ke ʻano he ʻāpana i kapa ʻia he endocrine neoplasia type I (MEN I). Hiki i nā tumors ke hoʻomohala i ka pituitary gland (lolo) a me ka parathyroid gland (ʻāʻī) a me ka pancreas.

Pākuʻi ʻia paha nā ʻōuli:

• Abdominal eha
• Pohā
• ʻO ka luaʻi ke koko (i kekahi manawa)
• ʻO nā ʻōuli reflux esophageal nui (GERD)

Pākuʻi ʻia nā ʻōuli i ka ʻōpū a me ka ʻōpū liʻiliʻi.

Loaʻa i nā hoʻāʻo:

• Scanner CT ʻōpū
• Hōʻike hoʻāʻo kalipuna
• Endoscopic ultrasound
• ʻOki kino exploratory
• Pae pae Gastrin
• Scan NineManga.com
• Hōʻike hoʻonāukiuki Secretin

ʻO nā lāʻau i kapa ʻia nā protitors pump proton (omeprazole, lansoprazole, a me nā mea ʻē aʻe) i hoʻohana ʻia no ka mālama ʻana i kēia pilikia. Hoʻoemi kēia mau lāʻau i ka hana ʻana i ka waikawa e ka ʻōpū. Kōkua kēia i ka maʻi hānai ma ka ʻōpū a hoʻōla i ka ʻōpū liʻiliʻi. Hoʻoiho kēia mau lāʻau i ka ʻeha o ka ʻōpū a me ka diarrhea.

Hiki ke hana i kahi ʻoki e wehe i hoʻokahi gastrinoma inā ʻaʻole pālahalaha nā tumors i nā meaola ʻē aʻe. ʻO ke keʻoki ʻana ma ka ʻōpū (gastrectomy) e kāohi ai i ka hana ʻana i ka waikawa ʻaʻole makemake iki ʻia.

Haʻahaʻa ka nui o ka hōʻola, ʻoiai ke loaʻa mua a hemo ka tumo. Eia nō naʻe, ulu mālie nā gastrinomas.Hiki i nā poʻe me kēia ʻano ke noho no nā makahiki he nui ma hope o ka loaʻa ʻana o ka tumo. Hana maikaʻi nā lāʻau hoʻomake-ʻakika e kaohi i nā ʻōuli.

Komo pū nā pilikia:

• ʻO ka loaʻa ʻole o ka loaʻa o ka tumo i ka wā o ke ʻoki kino
• ʻO ke kahe ʻana o ka Intestinal a i ʻole ka lua (perforation) mai ka maʻi ulcer i loko o ka ʻōpū a i ʻole duodenum
• ʻO ka diarrhea nui a me ka pohō kaumaha
• Hoʻolahalaha i ka tumo i nā meaola ʻē aʻe

Kāhea i kāu mea mālama ola inā loaʻa iā ʻoe ka ʻeha o ka ʻōpū nui ʻaʻole e hele, keu hoʻi inā kū ʻia me ka maʻi diarrhea.

Maʻi maʻi Z-E; Gastrinoma

• Nānā Endocrine

ʻO Jensen RT, ʻo Norton JA, ʻo Oberg K. Neuroendocrine tumors. I: Feldman M, Friedman LS, Brandt LJ, eds. ʻO Sleisenger a me Fordtran's Gastrointestinal a me ka maʻi ate. 10 o ka lā. Piladelapia, PA: Elsevier Saunders; 2016: chap 33.

ʻO Vella A. Gastrointestinal hormones a me nā ʻōpū endocrine ʻōpū. I: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, eds. ʻO Williams Textbook of Endocrinology. 13th ed. Piladelapia, PA: Elsevier; 2016: chap 38.