Nā koho lapaʻau no CML e ka pae: Kau Kahuna, Hoʻoikaika ʻia, a me ka pae Blast

Anter

• Mahele CML
• ʻO CML pae wikiwiki
• Pāhū pahū CML
• Nā lapaʻau ʻē aʻe
• Ke nānā nei i kāu mālama ʻana
• ʻO ka lawe lawe ʻana

ʻO ka leukemia myeloid maʻi (CML) kahi i ʻike ʻia me ka leukemia myelogenous mau. I kēia ʻano maʻi ʻaʻai, hoʻopuka ka iwi iwi i nā kino koko keʻokeʻo he nui.

Inā ʻaʻole mālama maikaʻi ʻia ka maʻi, e lilo ana ia i mea ʻoi aku ka maikaʻi. Holomua paha ia mai ka pae mau, a i ka pae wikiwiki, i ka pae puhi.

Inā loaʻa iā ʻoe ka CML, pili kāu papa hana i ka ʻāpana o ka maʻi.

E heluhelu e aʻo hou aʻe e pili ana i nā koho lapaʻau no kēlā me kēia pae.

Mahele CML

Mālama ʻo CML i ka mea hiki ke mālama ʻia ke ʻike ʻia i ka wanaʻao, i ka wā mau.

No ka mālama ʻana i ka maʻa mau CML, e kauoha paha kāu kauka i kahi ʻano lāʻau i ʻike ʻia ma ke ʻano he tyrosine kinase inhibitor (TKI).

Loaʻa kekahi mau ʻano o TKI e mālama iā CML, me:

• imatinib (Gleevec)
• nilotinib (Tasigna)
• dasatinib (Spryrcel)
• bosutinib (Bosulif)
• ponatinib (Iclusig)

ʻO Gleevec ka manawa mua o TKI i kuhikuhi ʻia no CML. Eia nō naʻe, kuhikuhi ʻia ʻo Tasigna a i ʻole Spryrcel i ke ʻano o ka lālani mua.

Inā ʻaʻole maikaʻi kēlā mau ʻano TKI iā ʻoe, e hōʻoki i ka hana ʻana, a i ʻole e hoʻokumu i nā hopena i hiki ʻole ke hoʻomanawanui, hiki i kāu kauka ke kauoha iā Bosulif.

E kuhikuhi wale kāu kauka iā Iclusig inā ʻaʻole pane maikaʻi ka maʻi ʻaʻai i nā ʻano TKI ʻē aʻe a hoʻomōhala paha i kahi ʻano o ka hoʻololi ʻana o ka ʻāpana, i kapa ʻia ʻo ka hoʻololi T315I.

Inā ʻaʻole pane maikaʻi kou kino i nā TKI, hiki i kāu kauka ke kuhikuhi i nā lāʻau chemotherapy a i ʻole kekahi ʻano lāʻau i ʻike ʻia ma ke ʻano he interferon e mālama i ka maʻa mau CML.

I nā hihia maʻamau, hiki iā lākou ke ʻōlelo i kahi transplant cell stem. Eia nō naʻe, hoʻohana mau ʻia kēia lapaʻau e mālama i ka wikiwiki o ka pae CML.

ʻO CML pae wikiwiki

I ka wikiwiki o ka pae CML, hoʻomaka nā leukemia e hoʻonui i ka wikiwiki. Hoʻoulu pinepine nā hunaola i nā hoʻololi ʻana o ka ʻē aʻe e hoʻonui i ko lākou ulu a hoʻemi i ka maikaʻi o ka lāʻau.

Inā ua hoʻoholomua ʻoe i ka pae CML, e hilinaʻi ana kāu papa hana hoʻōla i kau ʻia i nā wā i hala.

Inā ʻaʻole ʻoe i loaʻa i kekahi lāʻau no CML, e kauoha paha kāu kauka i kahi TKI e hoʻomaka.

Inā ʻoe e lawe nei i kahi TKI, hiki i kāu kauka ke hoʻonui i kāu lāʻau a hoʻololi iā ʻoe i kahi ʻano TKI ʻē aʻe. Inā loaʻa i kāu mau puʻukū cancer ka hoʻololi T315I, kauoha paha lākou iā Iclusig.

Inā ʻaʻole maikaʻi ʻo TKI iā ʻoe, hiki i kāu kauka ke kuhikuhi i ka lāʻau me interferon.

I kekahi mau hihia, hiki i kāu kauka ke hoʻohui i ka chemotherapy i kāu hoʻolālā lapaʻau. Hiki i nā lāʻau Chemotherapy ke kōkua e lawe i ka maʻi ʻaʻai i loko o ke kala, akā haʻalele pinepine lākou i ka hana ʻana i ka manawa.

Inā ʻōpio a olakino ʻoe, hiki i kāu kauka ke koi aku i kahi transplant cell stem ma hope o kou hele ʻana i nā lāʻau ʻē aʻe. E kōkua kēia i mea e hoʻopiha hou ai i kāu mau keena hana koko.

I loko o kahi transplant cell autologous stem cell, e hōʻiliʻili kāu kauka i kekahi o kāu mau pūnana ponoʻī ma mua o kou loaʻa ʻana i ka lāʻau. Ma hope o ka mālama ʻana, e hoʻokomo hou lākou i kēlā mau hunaola i loko o kou kino.

I loko o kahi transplant cell allogenic stem, e hāʻawi aku kāu kauka iā ʻoe i nā pūna mai nā mea hāʻawi pono. Hiki iā lākou ke ukali i kēlā transplant me ka hoʻopili ʻana o nā hunaola keʻokeʻo keʻokeʻo mai ka mea hāʻawi.

E hoʻāʻo paha kāu kauka e lawe i ka maʻi ʻaʻai i loko o ke kala ʻana me nā lāʻau ma mua o ka ʻōlelo ʻana i kahi transplant cell stem.

Pāhū pahū CML

I ka pae blast CML, hoʻonui wikiwiki nā hunaola maʻi a hoʻonui i nā ʻōuli i ʻike ʻia.

Kūpono ʻole ka maikaʻi o nā mālama ʻana i ka wā puhi, ke hoʻohālikelike ʻia me nā pae mua o ka maʻi. ʻO ka hopena, ʻaʻole hiki ke hoʻōla ʻia ka hapa nui o ka poʻe me ka pae blast CML i ka maʻi ʻaʻai.

Inā hoʻomohala ʻoe i ka pae blast CML, e noʻonoʻo kāu kauka i kāu mōʻaukala lapaʻau ma mua.

Inā ʻaʻole i loaʻa iā ʻoe kekahi lapaʻau ma mua no CML, kauoha paha lākou i nā koina kiʻekiʻe o kahi TKI.

Inā ʻoe e lawe nei i kahi TKI, e hoʻonui paha lākou i kāu lāʻau a ʻōlelo paha iā ʻoe e hoʻololi i kahi ʻano TKI ʻē aʻe. Inā loaʻa i kāu mau huna leukemia ka hoʻololi T315I, kauoha paha lākou iā Iclusig.

Kau kauka paha kau kauka i ka chemotherapy e kōkua i ka hōʻemi ʻana i ka maʻi ʻaʻai a i ʻole ke hōʻoluʻolu i nā ʻōuli. Eia nō naʻe, ʻoi aku ka liʻiliʻi o ka hopena o ka chemotherapy i ka pae blast ma mua o nā pae mua.

Inā pane maikaʻi kāu kūlana i ka mālama ʻana me nā lāʻau, hiki i kāu kauka ke koi aku i kahi transplant cell stem. Eia nō naʻe, lilo kēia hana i mea maikaʻi ʻole i ka wā puhi.

Nā lapaʻau ʻē aʻe

Ma waho aʻe o nā hana i hōʻike ʻia ma luna, hiki i kāu kauka ke kuhikuhi i nā lāʻau hoʻomalu e kōkua ai e hōʻoluʻolu i nā hōʻailona a mālama paha i nā pilikia kūpono o CML.

ʻO kahi laʻana, kauoha paha lākou:

• kahi hana i ʻike ʻia ʻo leukapheresis e hemo i nā hunaola keokeo mai kou koko
• ulu nā mea e hāpai i ka hoʻihoʻi ʻana o ka iwi iwi, inā hele ʻoe ma o chemotherapy
• ʻoki kino e hemo i kou manamana, inā e hoʻonui ʻia
• radiation therapy, inā hoʻomohala ʻoe i kahi spleen hoʻonui a ʻeha iwi paha
• antibiotic, antiviral, a i ʻole nā ​​lāʻau antifungal, inā hoʻomohala ʻoe i nā maʻi āpau
• ke koko a me ka hoʻoliʻiliʻi plasma

Paipai pū paha lākou i ka ʻōlelo aʻoaʻo aʻe a i ʻole ke kākoʻo olakino noʻonoʻo ʻē aʻe, inā he paʻakikī ʻoe e kāpae i nā hopena o ka nohona a i ʻole ke ʻano o kou ʻano.

I kekahi mau hihia, paipai paha lākou iā ʻoe e kākau inoa i kahi hoʻokolohua hoʻokolohua e loaʻa ai ka hoʻomaʻamaʻa hoʻokolohua no CML. Ke hoʻomohala ʻia nei a mālama ʻia nā mālama ʻana hou no kēia maʻi.

Ke nānā nei i kāu mālama ʻana

Ke mālama nei ʻoe i ka lāʻau no CML, kauoha paha kāu kauka i nā hoʻokolohua koko maʻamau e nānā i ka pane ʻana o kou kino.

Inā maikaʻi kāu papa hana o kēia manawa, e ʻōlelo paha kāu kauka iā ʻoe e hoʻomau me kēlā hoʻolālā.

Inā ʻaʻole maikaʻi ka maikaʻi o kāu mālama ʻana i kēia manawa a i ʻole ua emi iho ka maikaʻi o ka holo ʻana o ka manawa, hiki i kāu kauka ke kuhikuhi i nā lāʻau like ʻole a i ʻole nā ​​ʻano lāʻau ʻē aʻe.

Pono ka hapa nui o ka poʻe me CML e lawe i kahi TKI no kekahi mau makahiki a mau loa paha.

ʻO ka lawe lawe ʻana

Inā loaʻa iā ʻoe ka CML, pili ka hoʻolālā lapaʻau a kāu kauka i ka pae o ka maʻi, a me kou makahiki, ke olakino holoʻokoʻa, a me ka mōʻaukala o nā hana i hala.

Loaʻa nā ʻano lapaʻau e kōkua i ka lohi o ka ulu ʻana o ka maʻi ʻaʻai, hoʻēmi i nā hikoko, a me ka hoʻomaha ʻana i nā ʻōuli. Hoʻomaʻemaʻe ka hoʻomaʻemaʻe i ka maikaʻi o ka holo ʻana o ka maʻi.

E kamaʻilio me kāu kauka e aʻo hou aʻe e pili ana i kāu koho lapaʻau, e like me nā pōmaikaʻi kūpono a me nā pilikia o nā ʻano lapaʻau like ʻole.