Nā Tumors Stromal Gastrointestinal: Nā Hōʻailona, ​​Nā Kumu, a me nā kumu pilikia

Anter

• Nā ʻōuli
• Nā Kumu
• Nā kumu weliweli
• Makahiki
• ʻO Genes

ʻO nā tumors stromal Gastrointestinal (GISTs) he mau tumors, a i ʻole nā ​​huhui o nā hunaola i ulu nui ʻia, i ka tract gastrointestinal (GI). Nā ʻōuli o nā ʻōpū GIST:

• noho noho koko
• ʻeha a hōʻoluʻolu ʻole i loko o ka ʻōpū
• nausea a me ka luaʻi
• ālai ʻōpū
• kahi nui i loko o ka ʻōpū hiki iā ʻoe ke noʻonoʻo
• luhi a luhi paha
• piha piha ka manaʻo ma hope o ka ʻai ʻana i nā mea liʻiliʻi
• ʻeha a paʻakikī paha i ka ale ʻana

ʻO ke ala GI ka ʻōnaehana no ke kūpulu ʻana a me ka omo ʻana i ka meaʻai a me nā meaʻai. Hoʻopili pū ʻia me ka esophagus, ʻōpū, ʻōpū liʻiliʻi, a me ke kolona.

Hoʻomaka ka GISTs i nā hunaola kūikawā i ʻāpana o ka ʻōnaehana autonomic. Aia kēia mau hunaola i loko o ka paia o ka palapala GI, a hoʻoponopono lākou i ka neʻe ʻana o nā mākala no ka ʻai ʻana.

ʻO ka hapa nui o nā GIST i loko o ka ʻōpū. I kekahi manawa hana lākou i loko o ka ʻōpū liʻiliʻi, akā ʻoi aku ka liʻiliʻi o nā GIST i ka kolona, ​​esophagus, a me ke kīhā. Hiki i nā GIST ke hōʻino a me ka maʻi ʻaʻai a maikaʻi ʻole a ʻaʻole maʻi maʻi maʻi.

Nā ʻōuli

Pili nā ʻōuli i ka nui o ka tumo a ma hea kahi e waiho ai. Ma muli o kēia, ʻokoʻa pinepine lākou i ka paʻakikī a mai kekahi kanaka a i kekahi. ʻO nā ʻōuli e like me ka ʻeha o ka ʻōpū, nausea, a me ka luhi e hoʻopili ʻia me nā kūlana a me nā maʻi ʻē aʻe.

Inā ʻoe e ʻike nei i kekahi o kēia a i ʻole nā ​​ʻōuli ʻē aʻe, pono ʻoe e kamaʻilio me kāu kauka. Kōkua lākou i ke kumu o kāu hōʻailona.

Inā loaʻa iā ʻoe kekahi mau pilikia no GIST a i ʻole kekahi ʻano ʻē aʻe i hiki ke kumu i kēia mau ʻōuli, e haʻi pono i kāu kauka.

Nā Kumu

ʻAʻole ʻike ʻia ke kumu kikoʻī o GIST, ʻoiai aia he pilina e pili ana i kahi mutation i ka hōʻike o ka protein KIT. Hoʻomohala ka maʻi ʻaʻai ke hoʻomaka ka ulu ʻana o nā pūnaewele i waho o ka kaohi. Ke hoʻomau nei ka ulu ulu ʻana o nā pūnaewele, kūkulu lākou e hana i kahi nuipa i kapa ʻia he tumo.

Hoʻomaka ʻo GISTs i ka palapala GI a hiki ke ulu i waho i nā hale kokoke a i ʻole nā ​​kino. Hoʻolahalaha pinepine lākou i ke akepaʻa a me ka peritoneum (ka uhi o ka membrane o ka lua o ka ʻōpū) akā ʻaʻole iki i nā lymph node kokoke.

Nā kumu weliweli

Aia wale kekahi mau mea ʻike pilikia no nā GIST.

Makahiki

ʻO ka makahiki maʻamau e hoʻomohala i kahi GIST ma waena o 50 a 80. ʻOiai ʻo GIST hiki ke hana ʻia i ka poʻe ʻōpio ma mua o 40, paʻakikī loa lākou.

ʻO Genes

Kū ka hapanui o nā GIST a ʻaʻohe kumu maopopo. Eia nō naʻe, ua hānau ʻia kekahi poʻe me ka hoʻololi kūlohelohe i hiki ke alakaʻi iā GISTs.

ʻO kekahi o nā ʻāpana a me nā ʻano e pili pū ana me nā GIST.

Neurofibromatosis 1: ʻO kēia maʻi genetical, i kapa ʻia ʻo ka maʻi ʻo Von Recklinghausen (VRD), he kumu ia na ka hemahema i loko o ka NF1 ʻāpana Hiki ke hoʻoili ʻia ke ʻano mai ka makua a ke keiki akā ʻaʻole hoʻoilina mau. ʻO ka poʻe me kēia ʻano aia i ka hoʻonui i ka makaʻu e hoʻomōhala i nā puʻupuʻu benign i nā aʻa i ka wā ʻōpio. Hiki i kēia mau tumors ke hana i nā kiko ʻeleʻele i ka ʻili a freckling i ke aʻa a i ʻole underarms. Hoʻonui pū kēia kūlana i ka makaʻu no ka hoʻomohala ʻana i kahi GIST.

Familial gastrointestinal stromal tumor maʻi pale: Hoʻokumu pinepine ʻia kēia maʻi maʻi e kahi ʻāpana KIT ʻokoʻa i hala ʻia mai ka makua a ke keiki. Hoʻonui kēia ʻano maʻamau i ka makaʻu o nā GIST. Hiki i kēia mau GIST ke hana i kahi makahiki ʻōpio ma mua o ka lehulehu. Hiki i nā poʻe me kēia ʻano ke loaʻa nā GIST he nui i ko lākou wā e ola nei.

ʻO nā hoʻololi i nā genes succinate dehydrogenase (SDH): ʻO ka poʻe i hānau ʻia me nā hoʻololi ʻana i nā genes SDHB a me SDHC i ka nui o ka makaʻu no ka hoʻomohala ʻana i nā GIST. Hoʻonui pū kekahi lākou i ka makaʻu no ka hoʻomohala ʻana i kahi ʻano tumo nerve i kapa ʻia he paraganglioma.