ʻO ke kanulau maʻi ʻoi loa ma mua a ma hope o ka hala

Anter

• 1.He aha ka lāʻau lapaʻau mua loa no nā kanulau umauma metastatic hormone receptor-positive?
• 2. Pehea e mālama ʻia ai ka maʻi ʻaʻai umauma metastatic i nā wahine premenopausal?
• 3. He aha ka lāʻau i kuhikuhi ʻia no nā wahine postmenopausal?
• 4. I ka manawa hea e hoʻohana ʻia ai ka chemotherapy a i ʻole nā ​​lāʻau hoʻomōhala e mālama ai i nā maʻi maʻi umauma metastatic?

Hōʻike Overview

ʻO ka maʻi ʻaʻai umauma Metastatic (i kapa ʻia he maʻi ʻaʻai umauma holomua) ʻo ia hoʻi ua hoʻolaha ʻia ka maʻi ʻaʻai mai ka umauma a i nā wahi ʻē aʻe i ke kino. Manaʻo ʻia ʻo ka maʻi ʻaʻai umauma ma muli o ke ʻano like o nā metastases o nā hunaola maʻi ʻaʻai.

ʻO nā koho lapaʻau e pili i nā ʻano kikoʻī o ka tumo, e like paha me ka receptor-positive a me ka HER2-maikaʻi. ʻO nā kumu ʻē aʻe e pili ana i ke olakino o kēia manawa, nā lapaʻau āu i loaʻa ai ma mua, a pehea ka lōʻihi o ke kū ʻana o ka maʻi ʻaʻai.

Pili pū ka mālama ʻana i ka laha ʻana o ka maʻi ʻaʻai a inā ua hele ʻoe i loko o ka menopause. Eia kekahi mau nīnau e nīnau ai i kāu kauka e pili ana i ka maʻi ʻaʻai umauma holomua e pili ana i ka menopause.

1.He aha ka lāʻau lapaʻau mua loa no nā kanulau umauma metastatic hormone receptor-positive?

ʻO ka Hormonal therapy, a i ʻole endocrine therapy, ʻo ka maʻa mau ia o ka mālama ʻana no nā wahine me ka maʻi kanulau umauma metastatic maikaʻi. Kāhea ʻia ia i kekahi manawa i ka mālama anti-hormone no ka mea hana ia e like me ka ʻaoʻao ʻē aʻe o ka hoʻowalewale hōmona (HRT).

ʻO ka pahuhopu e hoʻohaʻahaʻa i nā pae o ka estrogen a me ka progesterone i loko o ke kino e pale i kēia mau hormones mai ke kiʻi ʻana i nā hunaola maʻi ʻaʻai a me ka loaʻa ʻana o ka estrogen e pono ai lākou e ulu.

Hiki ke hoʻohana ʻia ka Hormonal therapy e hōʻoki i ka mana o nā hormoni i ka ulu ʻana o nā hunaola a me ka hana holoʻokoʻa. Inā kāohi ʻia a hoʻoneʻe ʻia paha nā homone, ʻaʻole liʻiliʻi ke ola ʻana o nā hunaola maʻi ʻino.

Hoʻopau pū ʻo Hormonal therapy i nā hunaola umauma olakino mai ka loaʻa ʻana o nā hormona e hiki ke hoʻoulu i nā hunaola maʻi e ulu hou i loko o ka umauma a i ʻole nā ​​wahi ʻē aʻe

2. Pehea e mālama ʻia ai ka maʻi ʻaʻai umauma metastatic i nā wahine premenopausal?

ʻO ka mālama ʻana i ka maʻi ʻaʻai umauma Metastatic i nā wahine premenopausal me nā kanesa receptor-positive i loaʻa pinepine ʻia i ka kaomi ʻana ovarian. Hoʻoiho kēia hana i nā pae hormone i ke kino e hoʻonele i ka tumo o ka estrogen e pono ai e ulu.

Hiki ke hoʻokō ʻia ka kaomi ʻana i ka ovarian ma kekahi o nā ala ʻelua:

• Hiki i nā lāʻau ke hōʻoki i nā ovaries mai ka hana ʻana i ka estrogen, kahi e hoʻoulu ai i ka menopause no kekahi manawa.
• ʻO kahi kaʻina hana ʻoki ʻia i kapa ʻia ʻo oophorectomy hiki ke hemo i nā ovaries a hoʻōki paʻa i ka hana estrogen.

Hiki ke kuhikuhi ʻia kahi mea hoʻohālua aromatase i nā wahine premenopausal i ka hui pū ʻia me ka kaomi ovarian. Pākuʻi ʻia paha nā mea hoʻopā Aromatase:

• anastrozole (Arimidex)
• exemestane (Aromasin)
• letrozole (Femara)

ʻO Tamoxifen, kahi antiestrogen, hoʻohana mau ʻia e mālama i ka maʻi ʻaʻai umauma metastatic i nā wahine premenopausal. Hiki iā ia ke pale aku i ka maʻi ʻaʻai mai ka hoʻi ʻana a hoʻolaha paha i kahi ʻē aʻe.

ʻAʻole paha he koho ʻo Tamoxifen inā holomua ke kanesa i ka wā o ka mālama tamoxifen mua. ʻO ka hoʻohui ʻana i ka kaomi ovarian a me ka tamoxifen ua loaʻa e hoʻomaikaʻi i ke ola ke hoʻohālikelike ʻia me tamoxifen wale nō.

3. He aha ka lāʻau i kuhikuhi ʻia no nā wahine postmenopausal?

ʻAʻole pono ka kāohi ʻana ʻo Ovarian no nā wahine postmenopausal. Ua pau kā lākou ovaries i ka hana ʻana i ka nui o ka estrogen. Hana lākou i kahi mea liʻiliʻi i kā lākou momona momona a me nā adrenal glands.

Hoʻokomo pinepine ʻia ʻo ka lāʻau hoʻomaʻamaʻa postmenopausal i kahi mea kāohi aromatase. Hoʻoemi kēia mau lāʻau i ka nui o ka estrogen i loko o ke kino e ka hoʻokū ʻana i nā aʻa a me nā mea ʻokoʻa ma waho o nā ovaries mai ka hana ʻana i ka estrogen.

ʻO nā hopena ʻaoʻao āpau o nā mea kāohi aromatase e komo pū:

• uila uila
• nausea
• ka luaʻi
• iwi ʻeha a ʻeha paha

ʻO nā hopena ʻē aʻe e pili ana i nā iwi lahilahi a me ka hoʻonui ʻana o ka cholesterol.

Kau ʻia nā wahine Postmenopausal i tamoxifen no kekahi mau makahiki, ʻelima a ʻoi paha. Inā hoʻohana ʻia ka lāʻau lapaʻau ma lalo o ʻelima mau makahiki, hāʻawi pinepine ʻia kahi mea kāohi lāʻau aromatase no nā makahiki i koe.

ʻO nā lāʻau ʻē aʻe i kuhikuhi ʻia e laʻa me CDK4 / 6 mea kāohi a i ʻole fulvestrant.

4. I ka manawa hea e hoʻohana ʻia ai ka chemotherapy a i ʻole nā ​​lāʻau hoʻomōhala e mālama ai i nā maʻi maʻi umauma metastatic?

ʻO Chemotherapy ke koho lapaʻau nui loa no nā maʻi maʻi umauma triple-maikaʻi (receptor-maikaʻi ʻole a me HER2-maikaʻi ʻole). Hiki ke hoʻohana pū ʻia ʻo Chemotherapy me ka hoʻopili ʻia me nā HER2 i hoʻolālā ʻia no nā maʻi maʻi umauma HER2-maikaʻi.

Hiki ke hoʻohana ʻia ʻo Chemotherapy i nā hihia ʻoi aku ka koʻikoʻi no ka receptor-positive, HER2-maʻi maʻi maʻi maʻi ʻole.

Inā ʻo ka lāʻau chemotherapy mua, a i ʻole ka hui ʻana o nā lāʻau, kū i ka hana a pālahalaha ka maʻi ʻaʻa, hiki ke hoʻohana ʻia ka lua a ʻekolu paha ka lāʻau.

Ke ʻimi nei i ka lāʻau kūpono kūpono e hoʻokolokolo ai a me ka hewa. ʻAʻole kūpono ka mea kūpono no kekahi mea ʻē aʻe nāu. E hāhai i kāu hoʻolālā lapaʻau a kamaʻilio i kāu kauka. E hoʻomaopopo iā lākou ke hana nei kekahi mea a hana paha.

He mau lā paʻakikī paha kāu ma mua, akā kōkua ia e makaʻala i kāu mau koho lapaʻau a pau.