ʻO Pemphigoid Gestationis i ka wā o ka hāpai ʻana

Anter

• Nā kiʻi o pemphigoid gestationis
• Nā hōʻailona Pemphigoid gestationis
• ʻO Pemphigoid gestationis ke kumu
• ʻO Pemphigoid gestationis vs. PUPPP
• ʻIkioma Pemphigoid gestationis
• Hoʻomaʻo Pemphigoid gestationis
• Nā hoʻoponopono home
• Nā hihia ʻoi loa
• Pemphigoid gestationis nā pilikia
• ʻO ka nānā aku

Hōʻike Overview

ʻO Pemphigoid gestationis (PG) kahi ʻano laha ʻole, ʻili ka pele i hana mau ʻia i ka lua a ʻekolu paha o ka hapai. Hoʻomaka pinepine ia me ka hiʻohiʻona o nā puʻupuʻu ʻulaʻula ʻili a hū paha ma kou ʻōpū a me kāu kumu, ʻoiai hiki ke hōʻike ʻia ma nā ʻāpana ʻē aʻe o kou kino.

Hoʻokumu ʻia ʻo PG e kāu ʻōnaehana pale pale kūhewa i kou ʻili iho. Hele maʻamau ia iā ia iho i loko o nā lā a i ʻole mau pule ma hope o ka lawe ʻana. I nā hihia kakaikahi, hiki ke lōʻihi ke lōʻihi.

Ua manaʻo ʻia ʻo PG e hana ʻia ma 1 o kēlā me kēia 40,000 a 50,000 mau hāpai.

ʻO ka Pemphigoid gestationis i kapa ʻia ʻo herpes gestationis, akā ua maopopo i kēia manawa ʻaʻohe ona pilina i ka maʻi herpes. Aia kekahi mau ʻano pemphigus a i ʻole nā ​​pele ʻili pemphigoid i pili ʻole i ka hāpai ʻana.

Pemphigus pili i kahi palaka a pustule paha, a haohao ʻo ia hoʻi "o ka hāpai keiki" ma ka Lākina.

Nā kiʻi o pemphigoid gestationis

Nā hōʻailona Pemphigoid gestationis

Me PG, ʻike ʻia nā puʻupuʻu ʻulaʻula a puni ka pihi ʻōpū a hohola i nā ʻāpana ʻē aʻe o ke kino i loko o kekahi mau lā a i ʻole mau pule. ʻAʻole e hoʻopili pinepine ʻia kou alo, ka ʻāʻī, nā pāma, a me nā wāwae o ka wāwae.

Ma hope o ʻelua a ʻehā mau pule, lilo nā puʻupuʻu i mau pā nui, ʻulaʻula, piha i ka wai. Hiki ke kapa ʻia kēia mau puʻupuʻu bipi. Hiki iā lākou ke hōʻoluʻolu loa.

Ma kahi o nā palapū a bulla paha, hoʻomohala kekahi poʻe i nā pāʻula ʻula i kapa ʻia he plake.

Hiki i nā pālehu ʻo PG ke hōʻemi a hele i kā lākou pono kokoke i ka hopena o kou hāpai ʻana, akā 75 a 80 mau pākēneka o nā wahine me ka PG ʻike i kahi lapalapa a puni ka manawa o ka hānau ʻana.

Hiki i ka PG ke hana hou i ka wā o ka menstruation a i ʻole nā ​​hāpai hou aʻe. Hiki paha i ka hoʻohana ʻana i nā mea pale waha ke hoʻouka hou aku.

I nā hanana kakaʻī - e pili ana - hiki i PG ke ʻike ʻia i loko o nā keiki hānau hou.

ʻO Pemphigoid gestationis ke kumu

Hoʻomaopopo ʻia ʻo Pemphigoid gestationis i kēia manawa he maʻi maʻi autoimmune. ʻO ia ka hoʻomaka o kāu ʻōnaehana pale pale i nā ʻāpana o kou kino ponoʻī. I ka PG, ʻo nā hunaola ka mea o ka placenta.

Aia nā pūnaewele Placental i nā pūnaewele mai nā mākua ʻelua. Loaʻa i nā hunaola i loaʻa mai ka makuakāne i nā mole i ʻike ʻia he haole e ka ʻōnaehana paleʻāina o ka makuahine. ʻO kēia ke kumu o ka pale ʻana o ka pale a ka makuahine e kūʻē iā lākou.

Aia nā pūnaewele Paternal i kēlā me kēia hāpai keiki, akā ʻo nā maʻi autoimmune e like me PG e kū nei i kekahi mau hihia. ʻAʻole maopopo maopopo i ke kumu e hana ai ka ʻōnaehana paleʻāina makuahine i kēia ala i kekahi mau hihia, a ʻaʻole i nā poʻe ʻē aʻe.

Akā ʻo kekahi mau molekiola i ʻike ʻia ma ke ʻano he MHC II i loaʻa ʻole ma ka placenta i loaʻa i nā wahine me PG. Ke ʻike ka ʻōnaehana pale o ka wahine hāpai i kēia mau mole, hoʻomaka ia i kahi hoʻouka.

ʻO nā mole molekole MHC II ke kuleana o ka pili pū ʻana o kāu mau ʻili o ka ʻili. Ke hoʻomaka nei kāu ʻōnaehana pale pale e hoʻouka iā lākou, hiki i ka hopena i nā palapū a me ka pālau kahi hōʻailona nui o PG.

ʻO kahi ana o kēia hopena autoimmune ka loaʻa ʻana o kahi protein i ʻike ʻia ʻo Collagen XVII (i kapa ʻia ʻo BP180).

ʻO Pemphigoid gestationis vs. PUPPP

ʻO kekahi pahū ʻili i ʻike ʻia ʻo PUPPP (pruritic urticarial papules a me nā pā o ka hāpai keiki) hiki ke like me pemphigoid gestationis. E like me ka inoa e hōʻike nei, ʻūlū ʻo PUPPP (pruritic) a like me ka hive (urticarial).

Kū pinepine ʻo PUPPP i ke kolu o ka trimester, a he manawa maʻamau nō hoʻi ia e hōʻike ʻia ʻo PG. A e like me ka PG, ʻike pinepine ʻia ia ma ka ʻōpū e like me ka huehue ʻulaʻula a i ʻole nā ​​pahu.

Akā ʻaʻole holomua ʻo PUPPP i ka wā i nā pā nui a piha i ka wai e like me PG. A ʻokoʻa ʻo PG, hoʻolaha pinepine i nā wāwae a i kekahi manawa nā underarms.

Mālama ʻia ʻo PUPPP me nā kalima anti-itch a me nā hamo, a i kekahi manawa me nā papa antihistamine. Nalo pinepine ka ʻōpala iā ia iho i loko o ʻeono pule ma hope o ka lawe ʻana.

Hana ʻia ʻo PUPPP ma kahi o 1 i kēlā me kēia 150 hāpai keiki, e hana ana i ka mea maʻamau ma mua o ka PG. ʻOi aku ka maʻamau o ka PUPPP i nā hāpai mua, a i nā wahine e hāpai ana i nā māhoe, ʻekolu, a i ʻole nā ​​mea ʻoi aku ke kiʻekiʻe.

ʻIkioma Pemphigoid gestationis

Inā kānalua kāu kauka iā PG, e kuhikuhi paha lākou iā ʻoe i kahi dermatologist no kahi biopsy o ka ʻili. Hoʻopili kēia i ka hoʻopili ʻana i kahi anesthetic kūloko a i ʻole ka paukū i kahi wahi ʻili o ka ʻili a ʻokiʻoki i kahi mea liʻiliʻi e hoʻouna ʻia i ka hale hana.

Inā loaʻa i ka hale hana nā hōʻailona o pemphigoid ma lalo o ka microscope, e hana lākou i kahi hoʻokolohua hou aʻe i ʻike ʻia ma ke ʻano he loiloi immunofluorescence e hiki ai ke hōʻoia iā PG.

Lawe pū kāu kauka i nā laʻana koko e hoʻoholo i nā pae o ka pemphigoid antigen Collagen XVII / BP180 i ke koko. Hiki i kēia ke kōkua iā lākou e nānā i ka hana maʻi.

Hoʻomaʻo Pemphigoid gestationis

Inā akahai kāu mau ʻōuli, hiki i kāu kauka ke kuhikuhi i nā kalima anti-itch i ʻike ʻia ʻo topic corticosteroids. Hoʻomaha kēia mau mea i ka ʻili ma ka hōʻemi ʻana i ka pae o ka hana ʻōnaehana pale pale ma ke kahua o nā pehu.

Hiki ke kōkua i nā lāʻau āpau āpau loa (antihistamines). Hoʻopili kēia i nā huahana non-drowsy:

• cetirizine (Zyrtec)
• fexofenadine (Allegra)
• loratadine (Claritin)

Hoʻokomo ka Diphenhydramine (Benadryl) i ka hiamoe a lawe maikaʻi ʻia i ka pō. A laila lawelawe ia ma ke ʻano he kōkua kōkua hiamoe me ka hoʻohui ʻana i kāna mau waiwai ma ke ʻano he mea ʻemi itch.

Loaʻa kēia mau mea āpau ma luna o ka pā. Kūlike like nā mana Generic i ka hana i nā inoa inoa, a ʻoi aku ka liʻiliʻi o ke kumukūʻai.

E kamaʻilio mau i kāu kauka ma mua o ka lawe ʻana i nā lāʻau, ʻo nā huahana ʻoi loa aku, i ka wā hāpai.

Nā hoʻoponopono home

E kuhi paha kāu kauka i nā hoʻoponopono home e hakakā i ka makaʻu a me ka hōʻoluʻolu ʻole o kahi hihia ʻoluʻolu o PG. Hiki i kēia mau mea ke:

• mālama i ka ʻili me ka hau a i ʻole nā ​​kaomi anu
• ke noho nei i kahi anuanu a ʻoluʻolu lewa
• ʻauʻau ʻana i ka paʻakai ʻo Epsom a i ʻole hoʻomākaukau oatmeal
• e ʻaʻahu ana i ka lole pulupulu maikaʻi

Nā hihia ʻoi loa

Ke ʻoi aku ka ʻeha a me ka huhū, e kauoha paha kāu kauka i nā lāʻau corticosteroids. Ke hana nei kēia mau lāʻau i ka hoʻohaʻahaʻa ʻana i ka hana o ka ʻōnaehana paleʻea, pono e hoʻohana mau ʻia ka lāʻau liʻiliʻi pono.

E noʻonoʻo kāu kauka i nā hopena ma luna o ʻolua a me kāu pēpē, a mālama i nā ana a me ka lōʻihi o ka mālama ʻana i kahi liʻiliʻi.

Hiki ke hoʻohana pū ʻia nā lāʻau Immunosuppressive e like me azathioprine a i ʻole cyclosporine e kōkua ai i ka hōʻemi ʻana i ka aniani a me ka hōʻoluʻolu ʻole. Pono ka nānā pono ʻana i nā hopena ʻaoʻao. Hoʻopili paha kēia:

• ke nānā nei i ke kaomi koko hoʻokahi a i ʻole ʻelua mau manawa o ka pule no ka malama mua o ka hoʻohana
• ke nānā nei i nā hana o ke kīʻaha me nā hoʻokolohua koko a me ka mimi
• ke kiaʻi ʻana i ka hana ate, uric acid, a me ka wikiwiki o ka lipid pae

Pemphigoid gestationis nā pilikia

Ua ʻike ʻia kahi noiʻi ma 2009 i ka laha ʻana o nā blister o PG i ka ʻekolu a ʻelua paha o ka trimester e alakaʻi i nā hopena maikaʻi ʻole o ka hāpai ʻana.

Ua nānā ka noiʻi i nā moʻolelo hihia o 61 mau wahine hāpai me PG mai United Kingdom a me Taiwan. ʻO nā hopena maikaʻi ʻole i loaʻa i nā wahine me ka hoʻomaka mua (ʻekahi a ʻelua paha trimester) me PG:

• hānau mua
• kaumaha hānau haʻahaʻa
• liʻiliʻi no ka makahiki hāpai

ʻOi aku ka maʻamau o ka hōʻike ʻana o PG ma hope o ka hāpai ʻana. Ke hiki i ka ʻekahi a ʻelua paha trimester, paipai nā mea kākau noiʻi e mālama iā ia ma ke ʻano he hāpai kiʻekiʻe kiʻekiʻe me ka nānā pono a me ka nānā pono ʻana.

Ma ka ʻaoʻao maikaʻi, ua ʻike pū ʻia nō hoʻi ka noiʻi ʻana i ka mālama ʻana me nā ʻōnaehana (oral) corticosteroids ʻaʻole ia e hoʻopili i ka hopena o ka hāpai ʻana.

ʻO ka nānā aku

ʻO Pemphigoid gestationis kahi maʻi ʻili laha ʻole i ka hopena o ka hāpai ʻana. Māmā a ʻoluʻolu ʻole ia, akā ʻaʻole hoʻoweliweli iā ʻoe a i ʻole kāu pēpē.

Ke hiki wawe i ka hāpai keiki kahi hoʻonui iki o nā manawa kūpono no ka hānau mua a i ʻole kahi pēpē haʻahaʻa. ʻO ke kiaʻi kokoke ʻana e kāu kauka OB-GYN a me ka hoʻohui ʻana o ka mālama ʻana me kāu dermatologist.

E makemake paha ʻoe e launa pū me ka International Pemphigus a me Pemphigoid Foundation, he mau hui kūkā kamaʻilio a me nā hoa aʻo no nā poʻe me PG.