Nexium vs. Prilosec: ʻElua mau hana GERD

Anter

• No ke aha e hana ai nā PPI
• No ke aha lākou i kauoha ʻia ai
• Nā ʻokoʻa
• Ka hoʻokō ʻana
• ʻO ke kumu kūʻai
• Nā hopena ʻaoʻao
• Nā ʻōlelo aʻoaʻo a me nā launa pū
• Nā kumu weliweli
• Nā launa lāʻau
• ʻO ka lawe lawe ʻana

Hoʻopili mākou i nā huahana a mākou e manaʻo nei he pono no kā mākou poʻe heluhelu. Inā kūʻai ʻoe ma o nā loulou i kēia ʻaoʻao, loaʻa iā mākou kahi kōmike liʻiliʻi. Eia kā mākou hana.

Ka hoʻomaopopo ʻana i kāu koho

Paʻakū ka ʻūlū. Ke hoʻomaopopo nei i kāu koho lāʻau no ka maʻi reflux gastroesophageal (GERD) hiki ke lilo i mea paʻakikī loa.

ʻElua o nā mea kūpona proton pump (PPI) i kuhikuhi pinepine ʻia he omeprazole (Prilosec) a me esomeprazole (Nexium). Loaʻa nā mea ʻelua i kēia manawa ma ke ʻano he lāʻau lapaʻau over-the-counter (OTC).

E nānā pono i nā mea ʻelua e ʻike i nā mea e pono ai ke hāʻawi ʻia i kahi lāʻau i luna o kekahi.

No ke aha e hana ai nā PPI

ʻO nā pauma Proton he mau enzyme i loaʻa i nā hunaola parietal o kou ʻōpū. Hana lākou i ka waikawa hydrochloric, ka mea nui o ka waikawa ʻōpū.

Pono kou kino i ka waikawa ʻōpū no ka ʻai ʻana. Eia nō naʻe, ke pili ʻole ka mākala ma waena o kou ʻōpū a me kou esophagus, hiki i kēia acid ke hoʻopau i kāu esophagus. ʻO kēia ke kumu o ka wela i loko o kou umauma a me kou puʻu e pili ana me GERD.

Hiki iā ia ke kumu:

• hānō
• ʻūhā
• pulumonia

Hoʻoemi nā PPI i ka nui o nā waikawa i hana ʻia e nā paukū proton. Hana maikaʻi lākou ke lawe ʻoe iā lākou i hoʻokahi hola i 30 mau minuke ma mua o ka pāʻina ʻana. Pono ʻoe e lawe iā lākou no kekahi mau lā ma mua o ka hopena piha.

Hoʻohana ʻia nā PPI mai ka makahiki 1981. Ua manaʻo ʻia lākou he lāʻau lapaʻau maikaʻi loa no ka hoʻēmi ʻana i ka waikawa ʻōpū.

No ke aha lākou i kauoha ʻia ai

Hoʻohana ʻia nā PPI e like me Nexium a me Prilosec e mālama i nā kūlana pili i ka gastric acid, me:

• GERD
• puʻuwai puʻuwai
• esophagitis, ʻo ia ka mumū a me ka ʻaʻai ʻana o ka esophagus
• ʻōpū a me nā maʻi maʻi duodenal, i hoʻokumu ʻia e Helicobacter pylori (H. pylori) maʻi a i ʻole nā ​​lāʻau anti-inflammatory nonsteroidal (NSAIDs)
• ʻO Zollinger-Ellison Syndrome, kahi maʻi ia e hana ai nā tumors i ka hana ʻana o ka waikawa ʻōpū nui

Nā ʻokoʻa

ʻO Omeprazole (Prilosec) a me esomeprazole (Nexium) nā lāʻau like. Eia nō naʻe, aia kekahi mau mea ʻokoʻa iki i kā lākou mea hoʻonani kemika.

Loaʻa i loko o Prilosec nā isomers ʻelua o ka lāʻau omeprazole, ʻoiai ʻo Nexium hoʻokahi wale nō isomer.

ʻO Isomer kahi manawa no kahi mole e hoʻopili i nā kemika like, akā hoʻonohonoho ʻia i kahi ʻano ʻokoʻa.No laila, hiki iā ʻoe ke ʻōlelo aʻe ua hana ʻia ka omeprazole a me ka esomeprazole i nā poloka hale like, akā hoʻohui like ʻia.

ʻOiai he mea liʻiliʻi nā ʻokoʻa i nā isomers, hiki iā lākou ke hopena i nā ʻokoʻa i ka holo ʻana o nā lāʻau.

ʻO kahi laʻana, ʻo ka isomer i Nexium e hana lohi ma mua o Prilosec i kou kino. ʻO kēia ke kiʻekiʻe o nā kiʻekiʻe o ka lāʻau i loko o kou kahe o ke koko, a hiki i ka esomeprazole ke hoʻemi i ka hana waikawa no kahi manawa lōʻihi.

E holo wikiwiki paha ia e mālama i kāu mau ʻōuli ke hoʻohālikelike ʻia i ka omeprazole. Ua wāwahi ʻia ʻo Esomeprazole i kāu ʻokoʻa, no laila e alakaʻi ʻia ai i ka liʻiliʻi o ka launa lāʻau ma mua o ka omeprazole.

Ka hoʻokō ʻana

Hōʻike kekahi mau noiʻi e hiki i nā ʻokoʻa ma waena o ka omeprazole a me ka esomeprazole ke hāʻawi i kekahi mau mea maikaʻi i ka poʻe me kekahi ʻano.

Ua ʻike ʻia kahi noiʻi kahiko mai ka 2002 i ka hāʻawi ʻana o ka esomeprazole i ka kaohi maikaʻi o ka GERD ma mua o ka omeprazole ma nā kaupaona like.

Wahi a kahi noiʻi ma hope ma 2009, ua hāʻawi ka esomeprazole i ke kōkua wikiwiki ma mua o ka omeprazole i ka pule mua o ka hoʻohana. Ma hope o hoʻokahi pule, ua like ka hoʻomaha o ka hōʻailona.

Eia nō naʻe, i loko o kahi ʻatikala 2007 ma ʻAmelika Kauka Lapaʻau, ua nīnau nā kauka i kēia a me nā noiʻi ʻē aʻe e pili ana i nā PPI. Ua ʻōlelo lākou i nā hopohopo e like me:

• ʻokoʻa i ka nui o nā mea hana i hāʻawi ʻia i loko o nā noiʻi
• ka nui o nā haʻawina
• nā ʻano hana lapaʻau i hoʻohana ʻia e ana i ka pono

Ua kālailai nā mea kākau i ka 41 mau noiʻi e pili ana i ka pono o nā PPI. Ua hoʻoholo lākou he wahi liʻiliʻi iki ka maikaʻi o nā PPI.

No laila, ʻoiai aia kekahi mau ʻikepili e hōʻike ana he ʻoi aku ka maikaʻi o ka esomeprazole i ka hoʻomaha ʻana i nā ʻōuli, ʻo ka hapa nui o ka poʻe loea e ʻae he ʻano like nā hopena o nā PPI ma ka laulā.

Ua ʻōlelo ke Kulanui ʻAmelika ʻo Gastroenterology ʻaʻohe ʻokoʻa nui i ka maikaʻi o ka hana a nā PPI ʻokoʻa no ka mālama ʻana iā GERD.

ʻO ke kumu kūʻai

ʻO ka ʻokoʻa nui loa ma waena o Prilosec a me Nexium ka uku ke nānā ʻia.

A hiki i Malaki 2014, loaʻa wale ʻo Nexium e ke kuhikuhi a ma ke kumu kūʻai kiʻekiʻe loa. Ke hāʻawi nei ʻo Nexium i kahi huahana over-the-counter (OTC) i uku hoʻokūkū ʻia me Prilosec OTC. Eia naʻe, ʻoi aku ka liʻiliʻi o ka pipiʻi omeprazole generic ma mua o Prilosec OTC.

Ma ka maʻamau, ʻaʻole uhi nā ʻoihana ʻinikua i nā huahana OTC. Eia naʻe, ua alakaʻi ka mākeke PPI i nā mea he nui e hoʻoponopono i kā lākou uhi ʻana o Prilosec OTC a me Nexium OTC. Inā ʻaʻole uhi kāu ʻinikua iā OTC PPI, ʻo kahi kuhikuhi no ka omeprazole generic a i ʻole esomeprazole paha kāu koho maikaʻi loa.

Kāhea ʻia ʻo Nexium i kekahi manawa he lāʻau "me aʻu" hoʻi no ka mea like ia me Prilosec, kahi lāʻau i loaʻa. Manaʻo kekahi poʻe ʻo "ʻo wau pū kekahi" nā lāʻau he ala wale no nā ʻoihana lāʻau e loaʻa kālā ai ma ke kope ʻana i nā lāʻau i loaʻa mua. Akā ua hoʻopaʻapaʻa kekahi e hiki i nā lāʻau "ʻo wau kekahi" ke hōʻemi maoli i nā kumukūʻai lāʻau, no ka mea, paipai lākou i ka hoʻokūkū ma waena o nā ʻoihana lāʻau.

Hana pū me kāu kauka a kauka paha e hoʻoholo i kahi PPI maikaʻi loa nāu. Ma waho aʻe o ke kumukūʻai, e noʻonoʻo i nā mea e like me:

• nā hopena ʻaoʻao
• nā kūlana olakino ʻē aʻe
• nā lāʻau ʻē aʻe āu e lawe nei

Nā hopena ʻaoʻao

ʻAʻohe o ka hapa nui o ka poʻe i nā hopena ʻaoʻao mai nā PPI. ʻO ka pinepine, ʻike paha ka poʻe:

• pāhoehoe
• nausea
• ka luaʻi
• ʻeha poʻo

ʻOi aku paha ka hopena o kēia mau hopena me ka esomeprazole ma mua o ka omeprazole.

Manaʻo ʻia he hiki i kēia mau PPI ke hoʻonui i ka makaʻu o:

• ʻO ka haki o ka iwi kuamoʻo a me ka pulima i nā wahine postmenopausal, keu hoʻi inā lawe ʻia nā lāʻau no hoʻokahi makahiki a ʻoi a i ʻole nā ​​kaupaona kiʻekiʻe
• huʻi koʻohune o ke kolona, ​​keu hoʻi ma hope o ka haukapila
• pulumonia
• nā pono kīnā ʻole, e like me ka wikamina B-12 a me nā hemahema magnesium

Ua hōʻike ʻia kahi loulou i ka pilikia dementia i ka makahiki 2016, akā ʻo kahi noiʻi hōʻoia nui aʻe ma 2017 i hoʻoholo ʻia ʻaʻohe piʻi nui o ka dementia mai ka hoʻohana ʻana i nā PPI.

ʻIke ka hapa nui o ka poʻe i ka hana waikawa ke oki lākou i ka hoʻohana ʻana i nā PPI. Eia naʻe, no ke aha e maopopo ʻole ai kēia.

No ka hapanui o nā pilikia waikawa ʻōpū, pono ʻoe e lawe i nā PPI ma mua o ʻehā a ʻewalu mau pule ke ʻole e hoʻoholo kāu kauka i kahi lōʻihi o ke olakino e pono ai.

I ka pau ʻana o ka lōʻihi o ka lāʻau i pono ai, pono ʻoe e hoʻopau i ka lāʻau. Hana pū me kāu kauka e hana pēlā.

Nā ʻōlelo aʻoaʻo a me nā launa pū

Ma mua o ka lawe ʻana i kekahi lāʻau, e kamaʻilio me kāu kauka e aʻo e pili ana i nā pilikia a me nā launa lāʻau e pili pū ana me lākou.

Nā kumu weliweli

• no ka moʻokūʻauhau Asia, no ka mea ʻoi aku ka lōʻihi o kou kino e hana i nā PPI a pono ʻoe i kahi lāʻau ʻokoʻa
• he maʻi ate
• ua loaʻa nā pae magnesium haʻahaʻa
• hapai a hoʻolālā paha e hāpai
• hānai waiū

Nā launa lāʻau

E haʻi mau i kāu kauka e pili ana i nā lāʻau āpau, nā mea kanu, a me nā wikamina āu e lawe ai. Hiki iā Prilosec a me Nexium ke launa pū me nā lāʻau ʻē aʻe āu e lawe nei.

Ua hoʻolaha aku ka U.S. Food and Drug Administration (FDA) i kahi ʻōlelo aʻoaʻo e hōʻemi ana ka lāʻau i Prilosec i ka maikaʻi o ke kahe o ke koko clopidogrel (Plavix).

ʻAʻole pono ʻoe e lawe pū i nā lāʻau ʻelua. ʻAʻole hoʻokomo ʻia nā PPI ʻē aʻe i ka ʻōlelo aʻoaʻo no ka mea ʻaʻole lākou i hoʻāʻo no kēia hana.

ʻAʻole pono e lawe i kēia mau lāʻau me Nexium a i ʻole Prilosec:

• klopidogrel
• delavirdine
• nelfinavir
• rifampin
• rilpivirine
• kuakea
• John's wort

Hiki i nā lāʻau ʻē aʻe ke launa pū me Nexium a i ʻole Prilosec, akā lawe ʻia paha me kekahi lāʻau. E haʻi i kāu kauka inā lawe ʻoe i kekahi o kēia mau lāʻau i hiki iā lākou ke loiloi i kou makaʻi:

• amphetamine
• aripiprazole
• atazanavir
• bisphosphonates
• bosentan
• kalaiwa
• cilostazol
• citalopram
• clozapine
• cyclosporine
• dextroamphetamine
• escitalopram
• lāʻau antifungal
• fosphenytoin
• hao
• hydrocodone
• mesalamine
• methotrexate
• methylphenidate
• phenytoin
• raltegravir
• saquinavir
• ʻākena
• warfarin a i ʻole nā ​​mea ʻenemi vitamin K ʻē aʻe
• vicalonazole

ʻO ka lawe lawe ʻana

ʻO ka maʻamau, hiki iā ʻoe ke koho i ka PPI e loaʻa koke a me nā kumu kūʻai e emi ai. Akā e hoʻomanaʻo i nā PPI e mālama wale i nā ʻōuli o GERD a me nā maʻi ʻē aʻe. ʻAʻole lākou e mālama i ke kumu a hōʻike wale ʻia no ka hoʻohana manawa pōkole ke ʻole e hoʻoholo kāu kauka i kahi ʻē aʻe.

Pono nā loli o ke ola i kāu mau hana mua i ka kaohi ʻana iā GERD a me ka puʻuwai. Makemake ʻoe e hoʻāʻo:

• hoʻokele kaumaha
• e hōʻalo nei i nā pāʻina nui ma mua pono o kou hiamoe ʻana
• ke haʻalele a pale paha i ka paka ʻana, inā ʻoe e hoʻohana

I ka hala ʻana o ka manawa, hiki i ka GERD wā lōʻihi ke alakaʻi i ka maʻi ʻaʻai esophageal. ʻOiai he kakaikahi ka poʻe me GERD i loaʻa i ka maʻi ʻaʻai esophageal, he mea nui e makaʻala i ka pilikia.

E holo mālie nā PPI, no laila ʻaʻole paha lākou ka pane no ka ʻāʻī ʻana o ka puʻuwai a i ʻole ka reflux.

Hiki i nā koho ʻē aʻe ke hāʻawi i ke kōkua no kekahi manawa, e like me:

• papa ʻaukā pākahō
• nā wai e like me ka hydroxide alumini a me ka magnesium hydroxide (Maalox) a i ʻole ke alumini / makanekiuma / simethicone (Mylanta)
• ʻo nā lāʻau hoʻoliʻiliʻi acid e like me famotidine (Pepcid) a i ʻole cimetidine (Tagamet)

Loaʻa kēia mau mea āpau e like me nā lāʻau OTC.