Minocycline no ka Rheumatoid Arthritis: E holo anei ia?

Anter

• E pili ana i ka hoʻohana lāʻau lāʻau hōʻailona
• He aha ka ʻōlelo a ka noiʻi?
• Mōʻaukala noiʻi mua
• Nā mea nui o ke aʻo ʻana me minocycline
• Pehea e hana ai ka minocycline e mālama iā RA?
• ʻO wai e pōmaikaʻi i ka minocycline no RA?
• He aha ke kaʻina hana?
• He aha nā hopena?
• ʻO ka lawe lawe ʻana

Hōʻike Overview

ʻO Minocycline kahi antibiotic i ka ʻohana tetracycline. Hoʻohana ʻia ia ma mua o ka hakakā ʻana i ka nui o nā maʻi.

, ua hōʻike nā kānaka noiʻi i kāna anti-inflammatory, immune-modulate, a me nā neuroprotective waiwai.

Mai ka, ua hoʻohana kūleʻa kekahi mau rheumatologists i nā tetracyclines no ka rheumatoid arthritis (RA). Hoʻopili kēia me minocycline. I ka loaʻa ʻana o nā papa lāʻau hou, ua hōʻole ʻia ka minocycline. I ka manawa like, ua hōʻike ʻia he maikaʻi ka minocycline no RA.

ʻAʻole ʻae ʻia ʻo Minocycline e ka US Food and Drug Administration (FDA) no ka hoʻohana me RA. Kau ʻia kēlā me kēia manawa he inoa "off-label."

ʻOiai nā hopena maikaʻi i nā hoʻokolohua, ʻaʻole hoʻohana ʻia ka minocycline e mālama iā RA i kēia lā.

E pili ana i ka hoʻohana lāʻau lāʻau hōʻailona

ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau i hōʻailona ʻia ʻo ia ka lāʻau i ʻae ʻia e ka FDA no hoʻokahi kumu i hoʻohana ʻia no kahi kumu ʻē aʻe i ʻae ʻole ʻia. Eia nō naʻe, hiki i ke kauka ke hoʻohana i ka lāʻau no ia kumu. ʻO kēia no ka mea hoʻoponopono ka FDA i ka hoʻāʻo a me ka ʻae ʻana o nā lāʻau, akā ʻaʻole pehea e hoʻohana ai nā kauka i nā lāʻau e mālama ai i kā lākou mau maʻi.No laila hiki i kāu kauka ke kuhikuhi i kahi lāʻau akā manaʻo lākou ʻoi aku ka maikaʻi no kāu mālama. E aʻo hou aʻe e pili ana i ka hoʻohana ʻana i ka lāʻau lapaʻau i waho o ka lepili.

He aha ka ʻōlelo a ka noiʻi?

mai ka hopena o 1930s pili ka bacteria i ke kumu o RA.

ʻO nā noiʻi noiʻi kālaiʻike a kāohi ʻia o ka hoʻohana minocycline no RA ma ka hopena āpau e pōmaikaʻi a palekana ʻo minocycline no nā poʻe me RA.

ʻO nā antibiotic ʻē aʻe e pili ana i nā pūhui sulfa, nā tetracyclines ʻē aʻe, a me ka rifampicin. Akā ʻo minocycline ke kumuhana o nā noi makapō makapō a me nā hoʻokolohua hoʻokolohua ma muli o kāna mau waiwai ākea.

Mōʻaukala noiʻi mua

I ka makahiki 1939, ua hoʻokaʻawale ka American rheumatologist ʻo Thomas McPherson-Brown a me nā hoapili i kahi mea koʻohune e like me ke koʻohune mai kaʻiʻo RA. Ua kapa ʻia lākou he mycoplasma.

Ma hope ua hoʻomaka ʻo McPherson-Brown i ka hoʻomaʻamaʻa hoʻokolohua ʻana iā RA me nā lāʻau ʻaloʻalo. Ua hele a ʻino kekahi poʻe ma mua. Ua hāʻawi ʻo McPherson-Brown i kēia i ka Herxheimer, a i ʻole "make-make," hopena: Ke hoʻouka ʻia nā bacteria, hoʻokuʻu lākou i nā toxins i hoʻomaka mua i nā maʻi maʻi e ʻā. Hōʻike kēia i ka hana ʻana o ka lāʻau.

I ka wā lōʻihi, ua ʻoi aku ka maikaʻi o nā mea maʻi. Nui ka poʻe i loaʻa ke kala ma hope o ka lawe ʻana i ka lāʻau antibiotic a ʻekolu mau makahiki paha.

Nā mea nui o ke aʻo ʻana me minocycline

Hoʻohālikelike ʻo A o 10 mau noiʻi i nā antibiotic tetracycline i ka lapaʻau maʻamau a i kahi placebo me RA. Ua hoʻoholo ka hoʻopaʻa ʻana ua pili ka lapaʻau tetracycline (a ʻo ka minocycline) hoʻi i ka hoʻomaikaʻi e koʻikoʻi koʻikoʻi.

Ua hōʻike ʻia kahi hoʻopaʻa ʻana i ka minocycline me ka poʻe komo he 65 i ka maikaʻi o ka minocycline no ka poʻe me RA ikaika. ʻO ka hapanui o ka poʻe i kēia noi ʻana ua holomua iā RA.

Hoʻohālikelike ʻo A o 219 poʻe me RA i ka mālama ʻana me minocycline i kahi placebo. Ua hoʻoholo nā kānaka noiʻi he maikaʻi a palekana ʻo minocycline i nā hihia akahai a kaulua o RA.

Ua hoʻohālikelike kahi noiʻi 2001 o 60 poʻe me RA i ka mālama ʻana me minocycline i ka hydroxychloroquine. ʻO Hydroxychloroquine kahi lāʻau e hoʻololi ai i ka maʻi antirheumatic (DMARD) i hoʻohana mau ʻia e mālama iā RA. Ua ʻōlelo nā kānaka noiʻi ua ʻoi aku ka maikaʻi o ka minocycline ma mua o nā DMARD no ka RA seropositive mua.

Ua nānā ʻia kahi makahiki ʻehā mau makahiki i nā maʻi he 46 ma kahi hoʻopaʻa makapō pālua i hoʻohālikelike ʻia i ka mālama ʻana me minocycline i kahi placebo. Ua ʻōlelo ʻia he minocycline kahi lapaʻau maikaʻi no RA. ʻO ka poʻe i mālama ʻia me ka minocycline, he hapa iki kā lākou mau remission a koi lākou i ka hoʻōla kuʻuna. ʻO kēia ka hihia ʻoiai ʻo ka papa o minocycline he ʻekolu a ʻeono paha mahina.

He mea nui e hoʻomaopopo i ka hapa nui o kēia mau noiʻi i pili i ka hoʻohana pōkole o ka minocycline. Ua hoʻokūpaʻa ʻo McPherson-Brown i ke kaʻina hana e hiki ai i ke kala ʻana a i ʻole kahi hoʻomaikaʻi nui i ʻekolu mau makahiki paha.

Pehea e hana ai ka minocycline e mālama iā RA?

ʻO ke ʻano kikoʻī o ka minocycline e like me ka hoʻomaʻamaʻa RA ʻaʻole maopopo piha. Ma waho aʻe o ka hana antimicrobial, he anti-inflammatory ke ʻano o ka minocycline. ʻO ke kikoʻī, minocycline i:

• pili i ka nitric oxide synthase, i pili i ka collagen degradation
• hoʻomaikaʻi i ka interleukin-10, kahi e kāpae ai i ka cytokine pro-inflammatory i nā aʻa synovial (nā mea pili a puni nā hono)
• kāohi i ka hana B a me ka T o ke kikowaena pale

Loaʻa paha i ka Minocycline a. ʻO kēia ka mea hiki ke hoʻonui i ka mālama RA ke hui pū ʻia me nā lāʻau anti-inflammatory nonsteroidal a i ʻole nā ​​lāʻau ʻē aʻe.

ʻO wai e pōmaikaʻi i ka minocycline no RA?

Hōʻike ʻia i ka mea ʻo nā moho ʻoi loa ka poʻe i ka pae mua o RA. Akā hōʻike kekahi o ka noiʻi e pōmaikaʻi paha ka poʻe me ka RA ʻoi loa.

He aha ke kaʻina hana?

ʻO ka protocol lāʻau lapaʻau maʻamau i nā noiʻi noiʻi he 100 milligrams (mg) ʻelua manawa i kēlā me kēia lā.

Akā ʻokoʻa kēlā me kēia kanaka, a ʻokoʻa paha ka protocol minocycline. Pono paha kekahi poʻe e hoʻomaka me kahi lāʻau haʻahaʻa a hana a 100 mg a ʻoi aʻe ʻelua mau manawa i ka lā. Pono paha nā poʻe ʻē aʻe e hāhai i kahi ʻōnaehana pulsed, e lawe ana i ka minocycline i ʻekolu mau lā o ka pule a i ʻole e loli ia me nā lāʻau ʻē aʻe.

E like me ka mālama ʻana i nā lāʻau antibiotic no ka maʻi Lyme, ʻaʻohe ala hoʻokahi. Eia kekahi, ʻekolu paha makahiki e ʻike ai i nā hopena i kekahi mau hihia RA.

He aha nā hopena?

Hāʻawi maikaʻi ʻia ka Minocycline. Kūpono nā hopena ʻaoʻao a like paha me nā antibiotic ʻē aʻe. Pākuʻi ʻia lākou:

• pilikia gastrointestinal
• ʻūpā
• ʻeha poʻo
• ʻāwīwī o ka ʻili
• hoʻonui i ka ʻike i ka lā
• maʻi maʻi hū
• hyperpigmentation

ʻO ka lawe lawe ʻana

Hōʻike ʻia ka Minocycline, hoʻohana ʻia i ka wā lōʻihi, e hoʻomaikaʻi i nā hōʻailona RA a kōkua i ka waiho ʻana i ka poʻe i ke kala. ʻAʻole ia e hoʻohana ākea i kēia lā, ʻoiai kāna hōʻike i hōʻike ʻia.

ʻO nā paio maʻamau i hāʻawi kūʻē ʻia i ka minocycline no RA.

• ʻAʻole lawa nā haʻawina.
• He hopena nā Antibiotics.
• ʻOi aku ka maikaʻi o nā lāʻau ʻē aʻe.

Kūlike ʻole kekahi mau kānaka noiʻi a me nā rheumatologists i kēia mau paio a kuhikuhi i nā hopena o nā noiʻi e kū nei.

He mea nui e pili i ka hoʻolālā ʻana i kāu lapaʻau a me ka noiʻi ʻana i nā koho ʻē aʻe. Kūkākūkā me kāu kauka iʻoi aku ka maikaʻi no kāu kūlana.

Inā makemake ʻoe e hoʻāʻo i ka minocycline a hōʻole ke kauka iā ia, e nīnau ʻoe no ke aha. E kuhikuhi i ka mōʻaukala i hoʻopaʻa ʻia o ka hoʻohana minocycline. E kamaʻilio me ke kauka e pili ana i nā hopena ʻino o ka lawe ʻana i nā steroid i lōʻihi lōʻihi e hoʻohālikelike ʻia me nā hopena ʻaoʻao haʻahaʻa o minocycline. E ʻimi paha ʻoe i kahi kikowaena noiʻi i hana pū me minocycline a me RA.