He maʻi ʻo Autoimmune ʻo Psoriasis?

Anter

• Hōʻike Overview
• Ka hoʻomaopopo ʻana i nā maʻi maʻi autoimmune
• ʻO nā kūlana autoimmune maʻamau
• ʻO Psoriasis kahi maʻi maʻi autoimmune
• Nā hana i kuhikuhi i ka ʻōnaehana paleʻea
• Nā lāʻau kahiko
• ʻO Biologics
• Nā mea kūʻē TNF
• ʻO nā meaolaolaola hou
• Psoriasis a me ka makaʻu no nā kūlana autoimmune ʻē aʻe
• ʻO ka nānā aku

Hōʻike Overview

ʻO ka Psirus kahi maʻi ʻili hoʻāhu e hōʻike ʻia e nā ʻāpana ʻulaʻula ʻili o ka ʻili i uhi ʻia me nā unahi keʻokeʻo keʻokeʻo. He kūlana mau. Hiki i nā ʻōuli ke hele a hele, a hiki ke laulā i ka paʻakikī.

He kūlana maʻamau ka Psoriasis, e aneane kokoke ana i ka 3 pakeneka o ko ka honua heluna. Ma kahi o 7.4 miliona mau kānaka ma ʻAmelika Hui Pū ʻIa i loaʻa ka psoriasis.

ʻAʻole maopopo ke kumu kikoʻī o ka psoriasis. Manaʻo ʻia he hui pū ʻana o nā genetics, nā mea pili i ke kaiapuni, a me kāu ʻōnaehana pale.

Ma muli o nā hoʻomohala noiʻi i nā makahiki i hala iho nei, ua hoʻohālikelike ʻia ʻo psoriasis ma ke ʻano he maʻi autoimmune. ʻO kēia ke kumu o kāu mau ʻōnaehana pale pale, i kapa ʻia nā pūnaewele T, kuhi hewa i kāu mau ʻili ʻili ponoʻī ma ke ʻano he poʻe hoʻouka haole. ʻO kēia ke kumu e hoʻonui nui ai i nā hunaola o kou ʻili, e alakaʻi nei i nā leona ʻili psoriasis ʻano.

ʻAʻole nā ​​mea noiʻi āpau e noʻonoʻo he maʻi maʻi autoimmune ka psoriasis. ʻAe kekahi poʻe ʻo ka psoriasis kahi ʻano pale pale. Akā ko lākou kumumanaʻo ʻo ia ka hopena o ka psoriasis mai nā hopena maikaʻi ʻole e pili ana i ka gen i ka bacteria bacteria.

Ka hoʻomaopopo ʻana i nā maʻi maʻi autoimmune

ʻO ka maʻamau ʻike kāu ʻōnaehana pale i kāu mau pūnaewele ponoʻī a ʻaʻole hoʻouka iā lākou. ʻO nā maʻi Autoimmune ke hōʻewa hewa kāu ʻōnaehana pale i nā pūnaewele olakino me he mea lā aia i waho nā mea komo hewa e hoʻouka nei i kou kino.

Aia ma mua o 100 nā maʻi autoimmune. Hoʻopili kekahi mau maʻi autoimmune i hoʻokahi ʻāpana o kou kino - e like me kou ʻili i psoriasis. He ʻōnaehana nā poʻe ʻē aʻe, e pili ana i kou kino holoʻokoʻa.

ʻO nā mea āpau nā maʻi autoimmune āpau ka mea i hoʻokumu ʻia e ka hui pū ʻana o nā gen a me nā mea pili i ke kaiapuni.

ʻO ke kikoʻī ʻana pehea e launa pū ai nā genes a me nā mea e pili ana i ke kaiapuni e hana i nā maʻi like ʻole he kumuhana o ka noiʻi mau.

I kēia manawa, ʻo ka mea i ʻike ʻia ʻo ka poʻe me ka predisposition genetical i ka autoimmunity e loaʻa paha iā 2 a 5 mau manawa ka manawa o ka hoʻomohala ʻana i kahi maʻi autoimmune ma ke ʻano he poʻe i loaʻa ʻole kahi predisposition genetical.

ʻO ka hui o nā gen e pili ana i kapa ʻia ʻo ia ka kompleks histocompatibility, i kapa ʻia ʻo HLA. ʻOkoʻa ʻo HLA i kēlā me kēia.

Hiki ke holo i kahi predisposition genetical i ka autoimmunity i loko o nā ʻohana, akā hiki i nā lālā o ka ʻohana ke hoʻomohala i nā ʻano autoimmune ʻokoʻa. Eia kekahi, inā loaʻa iā ʻoe kekahi maʻi autoimmune, ʻoi aku kou kiʻekiʻe i ka loaʻa ʻana i kekahi.

ʻAʻoleʻike iki ʻia e pili ana i nā ʻano pilikino e pili ana i kahi maʻi autoimmune i kekahi mea i loaʻa i ka genetic predisposition i ka autoimmunity.

ʻO nā kūlana autoimmune maʻamau

Eia kekahi o nā maʻi autoimmune maʻamau.

• maʻi celiac (kahi hopena i ka gluten)
• ʻano diabetes 1
• nā maʻi ʻōpū, me Crohn's
• lupus (systemic lupus erythematosus, ka mea e hoʻopili ai i ka ʻili, nā puʻupaʻa, nā hono, ka lolo, a me nā mea ʻē aʻe)
• rheumatoid arthritis (hoʻohaunaele o nā hono)
• ʻO Sjögren's Syndrome (maloʻo i kou waha, maka, a me nā wahi ʻē aʻe)
• vitiligo (nalo o ka ʻili pigment, i kumu i keʻokeʻo keʻokeʻo)

ʻO Psoriasis kahi maʻi maʻi autoimmune

Manaʻo ka hapanui o nā ʻepekema i kēia lā ʻo psoriasis he maʻi autoimmune. Ua ʻike lōʻihi ʻia e pili ana ka ʻōnaehana pale i ka psoriasis. Akā ʻaʻole maopopo leʻa kikoʻī.

I nā makahiki he ʻelua i hala aku nei, ua hoʻokumu ʻia kahi noiʻi e hōʻike ʻia nā ʻāpana a me nā hui pū kekahi e pili ana i ka psoriasis me nā maʻi autoimmune i ʻike ʻia. Ua hoʻokumu pū ʻia kahi noiʻi e hana pono nā lāʻau hou i ka lāʻau pale maʻi no ka lāʻau. Hana kēia mau lāʻau i ke kāohi ʻana i ka ʻōnaehana pale maʻi e hoʻouka nei i nāʻiʻo olakino.

Ke hoʻomau nei ka noiʻi ʻana ma ke ʻano o nā pūnaewele T o ke ʻano pale i ka psoriasis. ʻO nā pūnaewele T nā "koa" o ka ʻōnaehana pale e hakakā maʻamau i nā maʻi. Ke misfire nā pūnaewele T a hoʻouka kaua i ka ʻili olakino, hoʻokuʻu lākou i nā protein kūikawā i kapa ʻia he cytokines. ʻO kēia ke kumu o ka hoʻonui ʻana o nā hunaola o ka ʻili a kūkulu aʻe ma luna o kou ʻili, e hopena ana i nā leona psoriatic.

Ua hōʻike ʻia kahi ʻatikala 2017 e pili ana i ka noiʻi hou i ʻike ʻia i ka launa pū ʻana o nā hunaola T kikoʻī a me nā interleukins i ʻike ʻia e pili ana i ka ulu ʻana o ka psoriasis. E like me nā ʻike kikoʻī e ʻike ʻia, lilo paha i mea hiki ke hoʻomohala i nā lāʻau lapaʻau hou e mākaukau ʻia.

Nā hana i kuhikuhi i ka ʻōnaehana paleʻea

ʻO ka mālama ʻana no ka psoriasis kaukaʻi ʻia i ke ʻano a me ke koʻikoʻi o ke ʻano, kou olakino ākea, a me nā kumu ʻē aʻe.

Eia nā ʻano lapaʻau like ʻole i kuhi i nā kumuhana kikoʻī i loko o ka ʻōnaehana paleʻaleʻa e hoʻonā ai i ka mumū. Hoʻohana ʻia kēia mau mea ke ʻano lōkahi kāu mau hōʻailona psoriasis a koʻikoʻi. E hoʻomaopopo he ʻoi aku ka pipiʻi o nā lāʻau hou.

Nā lāʻau kahiko

ʻElua mau lāʻau lapaʻau i hoʻohana ʻia e kāohi i ka ʻōnaehana pale a hoʻomaʻemaʻe i nā ʻōuli o ka psoriasis he methotrexate a me cyclosporine. He maikaʻi kēia mau mea ʻelua, akā loaʻa nā hopena ʻona ke hoʻohana ʻia i ka wā lōʻihi.

ʻO Biologics

Nā mea kūʻē TNF

Hoʻopaʻa ʻia kahi lāʻau lapaʻau hou loa i kahi waiwai e kumu i ka mumū i kapa ʻia ʻo tumor nekrosis factor (TNF). ʻO TNF kahi cytokine i hana ʻia e nā ʻōnaehana pale pale e like me nā pūnaewele T. Kapa ʻia kēia mau lāʻau hou i nā antagonist TNF.

Kūpono nā lāʻau anti-TNF, akā ʻoi aku ka liʻiliʻi ma mua o nā biologics hou. ʻO nā lāʻau antagonist TNF pū kekahi:

• adalimumab (Humira)
• etanercept (Enbrel)
• infliximab (Remicade)
• certolizumab pegol (Cimzia)

ʻO nā meaolaolaola hou

ʻO nā pahuhopu biologics hou aku nei e pale a pale i nā pūnaewele T a me nā ala interleukin e pili ana i ka psoriasis. ʻEkolu mau biologics i hoʻokumu i ka IL-17 i ʻae ʻia mai ka 2015:

• secukinumab (Cosentyx)
• ixekizumab (Taltz)
• brodalumab (Siliq)

Hoʻopaʻa nā lāʻau ʻē aʻe i ka pale ʻana i kekahi ala interleukin (I-23 a me IL-12):

• ustekinuman (Stelara) (IL-23 a me IL-12)
• guselkumab (Tremfya) (IL-23)
• tildrakizumab-asmn (Ilumya) (IL-23)
• risankizumab-rzaa (Skyrizi) (IL-23)

Ua hōʻoia kēia mau biologics i ka palekana a me ka maikaʻi.

Psoriasis a me ka makaʻu no nā kūlana autoimmune ʻē aʻe

Ke loaʻa nei i kahi maʻi autoimmune e like me psoriasis e hoʻokau iā ʻoe no ka hoʻomohala ʻana i kahi maʻi autoimmune. Hoʻonui ʻia ka makaʻi inā koʻikoʻi kāu psoriasis.

ʻO nā hui o nā gen e koho mua iā ʻoe e hoʻomohala i kahi maʻi autoimmune e like me nā ʻano like ʻole o nā maʻi autoimmune. ʻO kekahi o nā kaʻina hana hoʻomālamalama a me nā ʻano kaiapuni kahi like like.

ʻO nā maʻi autoimmune nui e pili ana me psoriasis:

• psoriatic arthritis, kahi e hoʻopili ai i ka 30 a i ka 33 pakeneka o ka poʻe i loaʻa i ka maʻi kō
• rumatika
• maʻi celiac
• ʻO ka maʻi o Crohn a me nā maʻi ʻōpū ʻē aʻe
• sclerosis maha
• lupus (systemic lupus erythematosus a i ʻole SLE)
• maʻi thyroid autoimmune
• ʻO Sjögren's syndrome
• poho lauoho autoimmune (alopecia areata)
• bullous pemphigoid

ʻO ka me ka psoriasis me ka rumatika rumati.

ʻO ka pilina o psoriasis i nā maʻi autoimmune ʻē aʻe kahi kumuhana o ke aʻo mau. Ke aʻo ʻia nei hoʻi ka hui pū ʻana o psoriasis me a me nā helu make ʻoi aku ke kiʻekiʻe mai kēlā mau maʻi.

ʻO ka nānā aku

ʻO ka nānā aku no ka poʻe me ka psoriasis maikaʻi loa. ʻAʻole hiki ke hoʻōla ʻia ke ʻano, akā hiki i nā mālama ʻana i kēia manawa ke mālama mau i nā ʻōuli ma lalo o ka kaohi.

Ke hoʻomau nei ka noiʻi lāʻau lapaʻau e ʻike i nā kikoʻī hou aʻe e pili ana i nā kumu o ka psoriasis a me nā maʻi autoimmune ʻē aʻe. A laila kōkua kēia mau mea hou i ka hoʻomohala ʻana i nā lāʻau hou e kuhikuhi pono a pale i nā ala maʻi.

ʻO kahi laʻana, aia kekahi mau lāʻau hou e pili ana i ka interleukin-23 i kēia manawa i nā hoʻokolohua hoʻokolohua. E puka paha kekahi mau ala hou ʻē aʻe i ka noiʻi mau ʻana e pili ana i nā maʻi autoimmune i ka laulā.

E kamaʻilio me kāu kauka e pili ana i ke komo ʻana i nā hoʻokolohua hoʻokolohua e hoʻomau nei a e pili ana i nā hanana hou. E makemake paha ʻoe e hui pū me kahi hui kākoʻo psoriasis / PsA pūnaewele.