Pehea e hiki ai iaʻu ke kōkua i kaʻu mea i aloha ai e hoʻoholo i ka ʻike hou aʻe e pili ana i kā lākou mālama ʻana iā Parkinson.

Anter

• Nā lāʻau Dopamine
• Carbidopa-levodopa
• ʻO nā agonists Dopamine
• Nā mea hoʻopuka MAO B
• Nā mea kāohi COMT
• Nā lāʻau a Parkinson ʻē aʻe
• Nā Anticholinergics
• ʻO Amantadine
• Hoʻopili i ka papa hana lapaʻau
• He aha ka hana ke pau ka hana a nā lāʻau a Parkinson
• Lawe aku

ʻAʻole nō i loaʻa i nā kānaka noiʻi ka lāʻau lapaʻau no ka maʻi ʻo Parkinson, akā ua hele lōʻihi loa nā mālama ʻana i nā makahiki i hala iho nei. I kēia lā, loaʻa nā lāʻau lapaʻau like ʻole a me nā lāʻau ʻē aʻe e kāohi i nā ʻōuli e like me ka haʻalulu a me ka ʻoʻoleʻa.

He mea nui i kāu mea i aloha ai e lawe i kā lākou lāʻau e like me kā ke kauka i kuhikuhi ai. Hiki iā ʻoe ke hāʻawi i ke kākoʻo a me nā hoʻomanaʻo hoʻomanaʻo akahai.

I mea kōkua, pono ʻoe e ʻike i nā lāʻau e mālama ai i ka maʻi o Parkinson, a pehea e holo ai.

Nā lāʻau Dopamine

Loaʻa ka nele o ka dopamine i ka poʻe me Parkinson, kahi kemika lolo e kōkua i ka mālama i nā neʻe. ʻO kēia ke kumu e hele mālie ai ka poʻe me ke ʻano a paʻa nā ʻūʻī paʻa. ʻO nā lāʻau nui i hoʻohana ʻia e mālama i ka hana a Parkinson ma ka hoʻonui ʻana i ka nui o ka dopamine i ka lolo.

Carbidopa-levodopa

ʻO kahi lāʻau i kapa ʻia ʻo levodopa, a i ʻole L-DOPA, ʻo ia ka lapaʻau nui loa no ka maʻi ʻo Parkinson mai ka hopena o 1960. Ke hoʻomau nei ia e lilo i lāʻau lapaʻau maikaʻi loa no ka mea pani ia i ka nalo ʻana o ka dopamine i ka lolo.

ʻO ka hapa nui o nā poʻe me ka maʻi ʻo Parkinson e lawe iā levodopa i kekahi manawa i ka wā o kā lākou lapaʻau. Hoʻohuli ʻia ʻo Levodopa i dopamine i ka lolo.

Hoʻohui nā lāʻau he nui i ka levodopa me ka carbidopa. Kāohi ʻo Carbidopa iā levodopa mai ka haki ʻana i loko o ka ʻōpū a i ʻole nā ​​ʻāpana ʻē aʻe o ke kino a hoʻohuli iā ia i ka dopamine ma mua o ka hiki ʻana i ka lolo. Kōkua pū ka hoʻohui ʻana i ka carbidopa i ka pale ʻana i nā hopena ʻē aʻe e like me ka nausea a me ka luaʻi.

Hele mai ʻo Carbidopa-levodopa i kekahi mau ʻano like ʻole:

• papa (Parcopa, Sinemet)
• papa e hoʻokuʻu me ka lohi no laila lōʻihi ka hopena o kāna hopena (Rytary, Sinemet CR)
• infusion i hāʻawi ʻia i loko o ka ʻōpū ma o kahi Tube (Duopa)
• inhaled pauka (Inbrija)

Nā hopena ʻē aʻe mai kēia mau lāʻau e:

• nausea
• ʻūpā
• dizziness ke kū i luna (orthostatic hypotension)
• hopohopo
• tics a i ʻole nā ​​neʻeneʻa ʻē aʻe ʻē aʻe (dyskinesia)
• huikau
• ʻike a lohe ʻana paha i nā mea ʻaʻole maoli (hallucination)
• hiamoe

ʻO nā agonists Dopamine

ʻAʻole hoʻololi kēia mau lāʻau i ka dopamine i ka lolo. Akā, hana lākou e like me ka dopamine. Lawe kekahi poʻe i nā agonists dopamine me ka levodopa e pale ai i kā lākou mau hōʻailona mai ka hoʻi ʻana i nā wā ke pau ka levodopa.

ʻO nā agonists Dopamine pū kekahi:

• pramipexole (Mirapex, Mirapex ER), pākaukau a me ka papa hoʻolōʻihi lōʻihi
• ropinirole (Koi, Pono XL), pākaukau a me ka papa hoʻolōʻihi lōʻihi
• apomorphine (Apokyn), hana hoʻopōkole
• rotigotine (Neupro), kāpili

Hoʻokumu kēia mau lāʻau i kekahi o nā hopena ʻē aʻe e like me carbidopa-levodopa, e like me ka nausea, dizziness, a me ka hiamoe. Hiki iā lākou ke kumu i nā hana koi, e like me ka piliwaiwai a me ka ʻai nui.

Nā mea hoʻopuka MAO B

Hana ʻokoʻa kēia hui lāʻau i mua o ka levodopa e hoʻonui i nā pae dopamine i ka lolo. Paʻa lākou i kahi enzyme e wāwahi i ka dopamine, kahi e hoʻolōʻihi ai i nā hopena o ka dopamine i loko o ke kino.

ʻO nā mea pāpā ʻo MAO B:

• selegiline (Zelapar)
• rasagiline (Azilect)
• safinamide (Xadago)

Hiki i kēia mau lāʻau ke hana i nā hopena ʻē aʻe e like me:

• pilikia hiamoe (hiamoe)
• ʻūpā
• nausea
• kōpaʻa
• huhū ka ʻōpū
• neʻe ʻole (dyskinesia)
• nā ʻōlelo hoʻohiwahiwa
• huikau
• ʻeha poʻo

Hiki i nā mea pāpā ʻo MAO B ke launa pū me kekahi:

• mea ʻai
• lāʻau lapaʻau over-the-counter
• lāʻau lapaʻau kuhikuhi
• pākuʻi

E ʻike pono i kāu kauka e pili ana i nā lāʻau āpau a me nā mea hoʻopihapiha a kāu mea i aloha ai.

Nā mea kāohi COMT

Hoʻopili nā lāʻau entacopine (Comtan) a me tolcapone (Tasmar) i kahi enzyme e wāwahi i ka dopamine i ka lolo. ʻO Stalevo kahi lāʻau hoʻohui i hoʻopili pū ʻia me carbidopa-levodopa a me kahi mea hōʻoki COMT.

Hoʻokumu nā mea hoʻokipa COMT i nā hopena like i like me carbidopa-levodopa. Hiki iā lākou ke hōʻino i ke ake.

Nā lāʻau a Parkinson ʻē aʻe

ʻOiai ʻo nā lāʻau e hoʻonui ana i nā kiʻekiʻe dopamine nā mea nui o ka mālama ʻana iā Parkinson, kōkua pū kekahi mau lāʻau ʻē aʻe i ka mālama ʻana i nā ʻōuli.

Nā Anticholinergics

ʻO Trihexyphenidyl (Artane) a me benztropine (Cogentin) e hōʻemi i nā haʻalulu mai ka maʻi o Parkinson. ʻO kā lākou hopena ʻaoʻao:

• maka maloʻo a waha
• kōpaʻa
• pilikia e hoʻokuʻu i ka mimi
• pilikia pilikia hoʻomanaʻo
• kaumaha
• nā ʻōlelo hoʻohiwahiwa

ʻO Amantadine

Hiki i kēia lāʻau ke kōkua i ka poʻe me ka maʻi o Parkinson ma ka wanaʻao i loaʻa nā ʻōuli palupalu wale nō. Hiki ke hoʻohui pū ʻia me ka lapaʻau carbidopa-levodopa i nā pae hope o ka maʻi.

Nā hopena pili me:

• pehu wāwae
• ʻūpā
• nā kiko ma ka ʻili
• huikau
• maka maloʻo a waha
• kōpaʻa
• hiamoe

Hoʻopili i ka papa hana lapaʻau

ʻO ka mālama mua ʻana no ka maʻi ʻo Parkinson e ukali ana i kahi papa maʻalahi maʻalahi. Lawe kāu mea aloha i ka carbidopa-levodopa i kekahi mau manawa i ka lā ma kahi hoʻonohonoho hoʻonohonoho.

Ma hope o kekahi mau makahiki i ka mālama ʻana, ua lilo ka lolo i ka hiki ke mālama i ka dopamine a lilo i mea maʻalahi i ka lāʻau. ʻO kēia paha ke kumu o ka pau ʻana o ka lāʻau mua o ka lāʻau i hana ai ma mua o ka hiki ʻana no ka lā aʻe, i kapa ʻia ʻo "maloʻo."

Ke kū kēia, e hana pū ke kauka o kāu mea aloha me lākou e hoʻomaʻa i ka lāʻau lapaʻau a i ʻole e hoʻohui i kahi lāʻau e pale ai i nā wā "off". Hiki iā ia ke lawe i kahi manawa a me ke ahonui e kiʻi pololei i ka ʻano lāʻau a me ka lāʻau.

ʻO ka poʻe me ka maʻi ʻo Parkinson e lawe nei i ka levodopa no kekahi mau makahiki he hiki ke hoʻomohala hoʻi i ka dyskinesia, i kumu e neʻe ai i ka neʻe ʻole. Hiki i nā kauka ke hoʻoponopono i nā lāʻau e hōʻemi i ka diskinesia.

He mea koʻikoʻi ka manawa ke lawe i nā lāʻau a Parkinson. No ka mālama ʻana i nā ʻōuli, pono i kāu mea aloha e lawe i kā lākou lāʻau i ka lāʻau kūpono a i ka manawa kūpono i kēlā me kēia lā. Hiki iā ʻoe ke kōkua i ka wā o ka loli ʻana o ka lāʻau i ka hoʻomanaʻo ʻana iā lākou e lawe i kā lākou pila i ka manawa hou, a i ʻole ke kūʻai ʻana iā lākou i kahi dispenser pill automated e maʻalahi ai ka hana.

He aha ka hana ke pau ka hana a nā lāʻau a Parkinson

I kēia lā, nui nā kauka i nā kauka e kāohi ai i nā ʻōuli o Parkinson. Maliʻa paha e ʻike kāu mea aloha i hoʻokahi lāʻau - a i ʻole ka hui ʻana o nā lāʻau - holo pono ia.

Loaʻa nā ʻano lapaʻau ʻē aʻe, e komo pū me ka stimulate o ka lolo hohonu (DBS). I kēia mālama ʻana, waiho ʻia kahi uea i kapa ʻia kēpau i kahi ʻoki o ka lolo e kaohi ana i ka neʻe. Hoʻopili ka uea i kahi mea pacemaker-like i kapa ʻia he impulse generator i hoʻokomo ʻia ma lalo o ka iwi iwi. Hoʻouna ka mea i nā uila uila e hoʻonāukiuki i ka lolo a hoʻōki i nā manaʻo lolo ʻole e kū i nā ʻōuli o Parkinson.

Lawe aku

Maikaʻi loa nā hana a Parkinson i ka kaohi ʻana i nā ʻōuli. Pono e hoʻoponopono ʻia nā ʻano lāʻau a me nā lāʻau i lawe ʻia e kāu mea aloha i loko o nā makahiki. Hiki iā ʻoe ke kōkua me kēia kaʻina hana ma ke aʻo ʻana e pili ana i nā lāʻau i loaʻa, a me ka hāʻawi ʻana i ke kākoʻo e kōkua i kāu mea i aloha ai e hoʻopili i kāna papa hana maʻamau.