Mea Kākau: Eugene Taylor
Lā O Ka Hana: 15 Aukake 2021
HōʻAno Hou I Ka Lā: 14 Nowemapa 2024
Anonim
New HCV Therapy Harvoni (Ledipasvir and Sofosbuvir) FDA Approved
Wikiō: New HCV Therapy Harvoni (Ledipasvir and Sofosbuvir) FDA Approved

Anter

He aha ʻo Harvoni?

ʻO Harvoni kahi lāʻau lapaʻau inoa inoa inoa inoa e hoʻohana ʻia e mālama ai i ka maʻi hepa C. He ʻelua mau lāʻau i loaʻa ʻo Harvoni: ledipasvir a me sofosbuvir. Hele mai ia ma ke ʻano he papa i lawe mau ʻia i kēlā me kēia lā no 12 mau pule.

ʻO Harvoni kahi ʻano lāʻau i kapa ʻia he antiviral hana pololei (DAA). Ua ʻae ʻia e ka FDA ma 2014 e mālama i nā genotypes ʻokoʻa, a i ʻole nā ​​ʻano, o ka maʻi hepa C.

Ua ʻae ʻia ʻo Harvoni e mālama i ka maʻi hepatitis C:

  • i ka poʻe me nā genotypes hepatitis C 1, 4, 5, a me 6
  • i ka poʻe me ka ʻole cirrhosis
  • i ka poʻe i loaʻa i ka hoʻoliʻiliʻi ate
  • i nā mākua a i ʻole nā ​​keiki he 12 mau makahiki a ʻoi paha a i kaupaona ma ka liʻiliʻi 77 paona

I ka hapanui o nā noiʻi maʻi no Harvoni, ʻoi aku ka nui o ka helu holomua no ka hoʻōla ʻana i ka maʻi hepa C ma mua o 90 pākēneka. ʻO kēia ka ʻaneʻane kokoke i nā poʻe āpau i lawe iā Harvoni i loaʻa kahi pane virologic kākoʻo (SVR). ʻO ka manaʻo ʻo SVR ʻaʻohe o lākou virus i ʻike ʻia i ko lākou kino he 12 mau pule a ʻoi paha ka lōʻihi ma hope o ka pau ʻana o ka lāʻau.


ʻO Generic Harvoni

Loaʻa iā Harvoni nā lāʻau i loko o hoʻokahi papa: ledipasvir a me sofosbuvir. ʻAʻohe ʻano generic o kēia manawa ka lāʻau hoʻohui a i ʻole nā ​​lāʻau āpau. Loaʻa ʻo Harvoni ma ke ʻano he lāʻau lapaʻau inoa inoa inoa inoa.

Eia nō naʻe, e manaʻo ʻia e hoʻokuʻu ʻia kahi mana mana o Harvoni i ka hoʻomaka mua o 2019.

Nā hopena ʻaoʻao Harvoni

Hiki iā Harvoni ke hana i nā hopena ʻoluʻolu a koʻikoʻi paha. Aia i ka papa inoa aʻe kekahi o nā hopena ʻaoʻao nui i hiki ke hana ʻia ke lawe ʻo Harvoni. ʻAʻole pili kēia papa inoa i nā hopena ʻaoʻao āpau.

No ka ʻike hou aku e pili ana i nā hopena ʻē aʻe o Harvoni a i ʻole nā ​​ʻōlelo aʻoaʻo e pili ana i ka hopena me ka hopena pilikia, e kamaʻilio me kāu kauka a kauka paha.

Inā kēnā kāu kauka iā ribavirin e lawe ʻoe me Harvoni, loaʻa paha iā ʻoe nā hopena ʻē aʻe. (E nānā iā "Harvoni a me ribavirin" ma lalo.)

Nā hopena ʻaoʻao hou aʻe

ʻO nā hopena ʻē aʻe i ʻike pinepine ʻia o Harvoni hiki ke hoʻopili ʻia:

  • luhi
  • ʻeha poʻo
  • nausea
  • pāhoehoe
  • hiamoe (pilikia hiamoe)
  • ʻūhā
  • nāwaliwali
  • ʻeha ʻeha
  • dyspnea (ka pōkole o ka hanu)
  • ukiuki
  • ʻūpā

I kekahi mau hihia, hiki i Harvoni ke hana i kahi hopena maʻi ahonui. Hiki i nā ʻōuli ke hoʻopili i ka ʻili o ka ʻili, ʻili, a me ka pīpī (ka mahana o ka ʻili a me ka ʻulaʻula, maʻamau i kou alo a me kou ʻāʻī).


E hala paha ka hapa nui o kēia mau hopena i loko o kekahi mau lā a i ʻole ʻelua mau pule. Inā ʻoi aku ke koʻikoʻi a i ʻole hele aku, e kamaʻilio me kāu kauka a kauka paha.

Nā hopena hopena koʻikoʻi

ʻAʻole maʻamau nā hopena koʻikoʻi mai Harvoni, akā hiki iā lākou ke hana. Kāhea koke i kāu kauka inā loaʻa nā hopena koʻikoʻi. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Hiki i nā hopena ʻē aʻe a me kā lākou mau hōʻailona ke hoʻohui i kēia:

  • Hepatitis B reactivation i ka poʻe coinfected me ka maʻi hepa C a me ka hepitis B. ʻO kekahi poʻe i loaʻa i ka maʻi hepitis C a me ka maʻi hepitis B ua loaʻa kahi reactivation o ka maʻi hepitis B i ka wā i hoʻomaka ai lākou e mālama me Harvoni. Hoʻopaʻa hou ke ʻano o ka virus i hana hou. ʻO ka hoʻoulu hou ʻana o ka maʻi hepatitis B hiki ke alakaʻi i ka hōʻino o ke ake, ka maikaʻi ʻole o ke ake, a i ʻole ka make. Ma mua o kou hoʻomaka ʻana me Harvoni, e hoʻāʻo kāu kauka iā ʻoe no ka maʻi hepitis B. Pono paha ʻoe e lawe i ka lāʻau e mālama ai i ka maʻi hepitis B.
  • ʻO ka hopena maʻi ʻino. I nā hihia maʻamau, hiki iā Harvoni ke hana i kahi hopena maʻi kūpilikiʻi. Hiki i nā ʻōuli ke hoʻohui pū:
    • angioedema (hāhā ma lalo o kou ʻili, maʻamau i kou mau lihilihi, nā lehelehe, nā lima, a me nā wāwae)
    • pehu o kou puʻu, waha, a me kou alelo
    • pilikia hanu
  • Nā manaʻo Suicidal. I nā hihia maʻamau, hiki i Harvoni ke hana i nā manaʻo suicidal a i ʻole nā ​​hana ke lawe ʻia me ka ribavirin a i ʻole pegylated interferon / ribavirin.

Kāohi ʻana i ke ola

  • Inā ʻike ʻoe i kahi mea e makaʻu koke ana i ka hōʻeha ponoʻī, pepehi kanaka ʻana, a i ʻole hōʻeha ʻana i kekahi kanaka.
  • Kāhea iā 911 a i ʻole ka helu kūloko kūloko.
  • Noho me ke kanaka a hiki i ka hōʻea ʻana mai o ke kōkua ʻoihana.
  • Wehe i nā mea kaua, nā lāʻau, a i ʻole nā ​​mea ʻino ʻino ʻē aʻe.
  • E hoʻolohe i ke kanaka me ka hoʻokolokolo ʻole.
  • Inā ʻoe a i ʻole kekahi mea āu e ʻike nei e noʻonoʻo nei i ka pepehi kanaka, hiki i kahi laina pale pale ke kōkua. Loaʻa ka National Suicide Prevention Lifeline 24 mau lā i ka lā ma 1-800-273-8255.

Nā hopena ʻaoʻao lōʻihi

ʻAʻole i hōʻike ʻia nā hopena ʻaoʻao lōʻihi me ka hoʻohana ʻana iā Harvoni.


Eia nō naʻe, hiki i ka poʻe me ka cirrhosis (scarring ate) ke hoʻomau i ka loaʻa ʻana o nā ʻōuli o ka hōʻino o ke ake ma hope o ka hoʻōla ʻia ʻana o ko lākou hepatitis C. Inā loaʻa ʻoe i ka cirrhosis, makemake kāu kauka e nānā pinepine i kāu hana ate i ka wā a ma hope o ka mālama ʻana me Harvoni.

Nā hopena ma hope o ka mālama ʻana

ʻAʻole i hōʻike ʻia nā hopena ʻaoʻao ma hope o ka mālama ʻana ʻo Harvoni i nā noiʻi maʻi.

Eia nō naʻe, ma hope o ka pau ʻana o ka lāʻau me Harvoni, ʻike paha kekahi poʻe i nā ʻōuli e like me ka flu, e like me ka ʻeha ʻana i nā mākala, nā haʻalulu, nā luhi, a me nā pilikia e hiamoe ana. Hoʻokumu ʻia kēia mau hopena ʻaoʻao e ke ola ʻana o kou kino ma hope o ka hoʻomaʻemaʻe ʻia o ka maʻi hepatitis C.

Inā loaʻa iā ʻoe nā hōʻailona like flu ma hope o kou hoʻopau ʻana i ka lāʻau me Harvoni, e kamaʻilio me kāu kauka.

Ka hōʻemi kaumaha a i ʻole loaʻa waiwai

ʻAʻole i hōʻike ʻia nā loli i ke kaumaha i ka wā o Harvoni i nā noiʻi maʻi ʻana. Eia nō naʻe, ua lilo ka kaumaha o kekahi poʻe ma ke ʻano he hōʻailona o ka maʻi hepa C. Inā he nui nā loli i ke kaupaona ʻana, e kamaʻilio pū me kāu kauka.

ʻO nā ʻōuli haʻalele

ʻO ka kū ʻana o ka lapaʻau ʻana me Harvoni ʻaʻole ia i kumu e haʻalele i nā hōʻailona ma nā noiʻi maʻi.

Hiki paha i kekahi poʻe ke ʻike i nā ʻōuli e like me ka haʻalele ʻana, e like me ke kuni e like me ke kuni, ka maʻi ʻeha, a me nā ʻehaʻeha. Eia naʻe, maopopo ʻole inā pili kēia mau ʻōuli i ka hōʻoki ʻana i ka lāʻau ʻo Harvoni.

ʻEha hui

ʻAʻole ka ʻeha hui ka hopena o Harvoni i ka noiʻi maʻi.

He nui ka poʻe me ka maʻi hepitis C e ʻike i ka ʻeha hui ma ke ʻano he hōʻailona o ka maʻi. Hiki i kēia ke hopena o ka mumū mau a i ʻole ke kaʻina hana autoimmune e hoʻouka nei i kou mau hui.

Inā loaʻa iā ʻoe ka ʻeha ma kou mau ami, e kamaʻilio me kāu kauka e pili ana i nā ala e hoʻokele ai.

Nā hopena maka

I nā noiʻi olakino o Harvoni, ʻaʻole i ʻike ka poʻe e lawe nei i ka lāʻau i nā pilikia o ka maka. Akā aia hoʻokahi hōʻike o ka nalo ʻana o ka hihiʻo pokole ma hope o ka hoʻohana ʻana iā Harvoni me ka lāʻau ribavirin. A hōʻike kekahi kanaka i ka mumū o ka maka a me ka hihi o ka maka ma hope o ka hoʻohana ʻana i ka sofosbuvir (kekahi o nā lāʻau i Harvoni) a me ka ribavirin.

Eia naʻe, ʻaʻole maopopo inā ʻo Harvoni a i ʻole nā ​​mea hana i hoʻokumu i nā pilikia o ka maka i kēia mau hihia. Eia kekahi, ua loaʻa kahi noiʻi 2019 ʻaʻole kēia mau lāʻau like i kumu i nā pilikia o ka maka i ka poʻe me ka maʻi hepitis C.

I kekahi hihia, inā ʻike ʻoe i nā hopena o ka maka ke lawe ʻoe iā Harvoni, e kamaʻilio koke i kāu kauka.

Lilo ka lauoho

ʻAʻole i hōʻike ʻia ka lilo o ka lauoho ma ke ʻano he ʻaoʻao i ka noiʻi olakino ʻo Harvoni. Ua hōʻike kekahi poʻe i ka lilo ʻana o ka lauoho i ka wā e lawe ana i ka lāʻau, akā ʻaʻole maopopo inā ʻo Harvoni ke kumu o ko lākou lauoho lilo.

He mea nui e hoʻomaopopo he hiki i ka nalo ʻana o ka lauoho ke lilo i hōʻailona o ka maʻi hepitis C. ʻO ka maʻi hepatitis C (HCV) kaohi i kou ake mai ka hana kūpono. Pono ʻoe i ke akepaʻa olakino e loaʻa nā meaʻai mai ka meaʻai āu e ʻai ai. No laila inā ʻaʻole hiki iā ʻoe ke loaʻa nā mea momona e pono ai i kou kino, ʻike paha ʻoe i ka nalo ʻana o ka lauoho.

Inā hopohopo ʻoe i ka nalo ʻana o ka lauoho, e kamaʻilio me kāu kauka.

ʻĀlapa / ʻānō

Ua hōʻike ʻia nā ʻili o ka ʻili i kekahi poʻe i lawe iā Harvoni i loko o nā noiʻi maʻi, akā ʻaʻole maopopo leʻa pehea ka maʻamau. I kekahi mau hihia, loaʻa i nā kānaka ka pehu a me ka pehu ʻana o ka ʻili. Hiki ke kumu ʻia kēia mau mea e nā hopena maʻi ʻino iā Harvoni.

ʻO ka ʻili ʻili a me nā ʻino hoʻi nā ʻōuli o ka maʻi hepatitis C. Hoʻohui ʻia, hiki iā lākou ke hōʻailona o ka hōʻino nui o ke ake. E kamaʻilio me kāu kauka inā loaʻa ʻoe i ka huhū a i ʻole ka ʻili huʻu.

Pohā

I nā noiʻi olakino o Harvoni, ma waena o 3 pākēneka a me 7 pākēneka o ka poʻe i ʻike i ka palahī i ka wā o ka mālama ʻana. Hele paha ka maʻi palahē me ka hoʻohana mau ʻana o ka lāʻau.

Inā loaʻa ʻoe i ka maʻi nui loa, a i ʻole ka diarrhea e ʻoi aku ana ma mua o ʻelua mau lā, e kamaʻilio koke me kāu kauka.

Kaumaha

ʻO ke kaumaha loa kahi hopena maʻamau o Harvoni. I nā noiʻi hoʻokolohua, ma lalo o 5 pākēneka o ka poʻe i lawe iā Harvoni ʻike i ke kaumaha. Hoʻohui ʻia, ua kū mai nā manaʻo suicidal ma lalo o ka 1 pākēneka o ka poʻe i lawe iā Harvoni me ka ribavirin a i ʻole pegylated interferon / ribavirin.

Hiki i nā poʻe he nui me ka hepatitis C ke kaumaha no ko lākou ʻike. Inā kaumaha ʻoe, e kamaʻilio me kāu kauka e pili ana i nā ala e hoʻomaikaʻi ai i kou ʻano. A inā he manaʻo kou e hōʻeha iā ʻoe iho, e kāhea koke i kāu kauka.

Ka luhi

ʻO ka luhi, a i ʻole nele i ka ikaika, kahi hopena ʻaoʻao maʻamau o Harvoni. I nā noiʻi maʻi, a hiki i ka 18 pākēneka o ka poʻe i lawe iā Harvoni i ka luhi.

Hele paha ka luhi me ka hoʻomau o ka hoʻohana ʻana iā Harvoni. Eia nō naʻe, inā koʻikoʻi kou luhi a hoʻololi i kou ola, e kamaʻilio me kāu kauka.

ʻO Insomnia (pilikia e hiamoe ana)

I nā noiʻi hoʻokolohua, ua hiki mai ka hiamoe a i 6 pakeneka o ka poʻe i lawe iā Harvoni. E hele aku paha kēia hopena me ka hoʻohana mau ʻana o ka lāʻau.

ʻO nā ala e hoʻomaikaʻi ai i kou hiamoe pū me ka ukali ʻana i ka papa manawa hiamoe maʻamau a me ka mālama ʻana i nā uila uila, e like me nā kelepona, ma waho o kou lumi moe. Inā pilikia kāu hiamoe a hele ʻole, e kamaʻilio me kāu kauka e pili ana i nā ala ʻē aʻe e kōkua ai iā ʻoe e hiamoe.

ʻEha poʻo

ʻO ka Headache kahi hopena ʻaoʻao maʻamau o Harvoni. I nā noiʻi hoʻokolohua, a hiki i ka 29 pākēneka o ka poʻe i lawe iā Harvoni ʻike i ka maʻi poʻo. Inā loaʻa ʻoe i ka maʻi poʻo i ka wā e lawe ana iā Harvoni, e kamaʻilio me kāu kauka e pili ana i nā ala e kōkua ai iā ʻoe e hoʻokele iā lākou.

Ka maʻi ʻaʻai / maʻi ʻaʻai

ʻO Harvoni kahi lāʻau i kapa ʻia he antiviral hana pololei (DAA). ʻO ka mālama ʻana i ka maʻi hepa C me nā DAA e kōkua i ka pale ʻana i nā hopena lōʻihi, e like me ka maʻi ʻaʻai ate. Eia nō naʻe, aia kekahi mau hōʻike e pili ana i ka maʻi ʻaʻai ate i nā poʻe i hoʻōla ʻia e ka maʻi hepatitis C me ka mālama ʻana iā Harvoni.

Ua ʻike ʻia kahi noiʻi hoʻokolohua ua loaʻa i ka poʻe me ka cirrhosis i mālama ʻia me ka DAA ka nui o ka makaʻu o ka ulu ʻana i ka maʻi ʻaʻai akepau ke hoʻohālikelike ʻia me ka poʻe me ka ʻole cirrhosis. Eia nō naʻe, hiki i ka poʻe me ka ʻole cirrhosis ke loaʻa i ka maʻi ʻaʻai ate.

Inā hopohopo ʻoe i kou makaʻu i ka ulu ʻana i ka maʻi ʻaʻai ake, e kamaʻilio me kāu kauka.

Uku Harvoni

E like me nā lāʻau āpau, hiki ke hoʻololi ke kumukūʻai o Harvoni.

E hilinaʻi kāu kumukūʻai maoli i kāu ʻinikua.

Kōkua kālā a me nā ʻinikua

Inā makemake ʻoe i kākoʻo kālā e uku no Harvoni, a i ʻole inā ʻoe e kōkua i ka hoʻomaopopo ʻana i kāu ʻinikua uhi, loaʻa ke kōkua.

Hāʻawi ʻo Gilead Science, Inc., ka mea hana o Harvoni, i kahi papahana i kapa ʻia ʻo Harvoni Support Path. No ka ʻike hou aku a e ʻike inā he kūpono ʻoe no ke kākoʻo, kāhea iā 855-769-7284 a i ʻole kipa i ka pūnaewele pūnaewele.

Hoʻohana ʻo Harvoni

Ua ʻae ka Food and Drug Administration (FDA) i nā lāʻau i kuhikuhi ʻia e like me Harvoni e mālama ai i kekahi mau ʻano.

Ua ʻae ʻia ʻo Harvoni no ka mālama ʻana i ka maʻi hepatitis C (HCV). Hiki ke kuhikuhi ʻia ʻo Harvoni no:

  • Nā mākua a me nā keiki (ʻo 12 mau makahiki a ʻoi a ʻoi paha e kaupaona ma ka liʻiliʻi 77 mau paona) ʻo wai:
    • loaʻa iā HCV genotype 1, 4, 5, a i ʻole 6. ʻO nā genotypes he mau ʻano ʻokoʻa, a me nā ʻano, o ka maʻi.
    • loaʻa a i ʻole loaʻa ka cirrhosis uku. Hoʻoweliweli koʻikoʻi ʻo Cirrhosis i ke ake e pale iā ia mai ka hana kūpono. ʻO ka cirrhosis Compensated ka cirrhosis ʻaʻole i kū i ka hopena nā ʻōuli.
  • Nā mākua nāna:
    • i genotype 1 a me decompensated cirrhosis. ʻO ka cirrhosis decompensated ke hiki ʻole ke ake ʻana a me ke kumu o nā pilikia olakino koʻikoʻi. Pono nā kānaka me ka cirrhosis decompensated e lawe iā Harvoni me kahi lāʻau ʻelua, ribavirin (Rebetol).
    • loaʻa ka genotype 1 a i ʻole 4 a ua loaʻa kahi hoʻoliʻiliʻi ate.

Hōʻike kēia pākaukau i ka mea i kūpono no ka mālama ʻana iā Harvoni:

Genotype 1Genotype 2Genotype 3Genotype 4Genotype 5Genotype 6
Me ka ʻole cirrhosisYYYY
ʻO cirrhosis ukuYYYY
Hoʻopau i ka cirrhosisY (nā mākua wale nō)
Loaʻa ka lawe aku o ka akeY (nā mākua wale nō)Y (nā mākua wale nō)

Kukuna Harvoni

Kau ʻia ʻo Harvoni ma ke ʻano he hoʻokahi ana: He papa i piha i 90 mg o ledipasvir a me 400 mg o sofosbuvir, i lawe ʻia i hoʻokahi lā i ka lā.

I kekahi mau hanana, hiki i kāu kauka ke kuhikuhi i kahi lāʻau ʻelua e lawe me Harvoni. ʻO kahi laʻana, kauoha ʻia paha ʻoe i ka ribavirin (Rebetol) i hui pū ʻia me Harvoni.

Hiki paha kēia inā ua decompensated ʻoe i ka cirrhosis (nā ʻōuli koʻikoʻi mai ka maʻi ʻoi loa) a i ʻole inā ua lawe ʻoe i kekahi mau lāʻau e mālama ai i ka maʻi hepitis C i ka wā ma mua. Kaukaʻi ʻia kāu mea hana ribavirin i kou kaupaona, hana ʻōpala, a me nā kūlana olakino ʻē aʻe.

Hōʻike ka ʻikepili aʻe i ke ana i koi ʻia o Harvoni.

Nā ʻano lāʻau a me nā ikaika

Loaʻa ʻo Harvoni i hoʻokahi ikaika. Hele mai ia i loko o ka papa hoʻohui i loaʻa iā 90 mg o ledipasvir a me 400 mg o sofosbuvir.

Nā hana no ka maʻi hepitis C

ʻO ke ana e mālama ai i ka maʻi hepitis C hoʻokahi papa (90 mg ledipasvir / 400 mg sofosbuvir), lawe hoʻokahi ʻia i kēlā me kēia lā.

Duration o ka lapaau

Pehea ka lōʻihi e lawe ai iā Harvoni e kaukaʻi ʻia i kāu genotype hepatitis C (ke ʻano o ka maʻi virus). E hilinaʻi ʻia ia i kāu hana o ke ake, a me nā ʻano hepatitis C āu i hoʻāʻo ai i ka wā i hala.

Lawe ka hapa nui o nā kānaka iā Harvoni no 12 mau pule, akā hiki ke mālama i 8 a 24 mau pule paha. E hoʻoholo kāu kauka i ka lōʻihi kūpono o ka mālama ʻana iā ʻoe.

He aha inā e haʻo wau i kahi lāʻau?

He mea nui e lawe iā Harvoni i kēlā me kēia lā no ka manawa holoʻokoʻa i kau ʻia e kāu kauka. ʻO ka nalo ʻana a i ʻole ka hōʻalo ʻana i nā lāʻau hiki ke hoʻonā i ka maʻi maʻi iā Harvoni. ʻO ke kūpaʻa ʻo ia ka hana ʻole o ka lāʻau iā ʻoe.

Ke hoʻohana nei i kahi mea hana hoʻomanaʻo hiki ke kōkua iā ʻoe e hoʻomanaʻo e lawe iā Harvoni i kēlā me kēia lā.

Inā haʻalele ʻoe i kahi lāʻau, lawe iā ia ke hoʻomanaʻo ʻoe. Inā ʻaʻole ʻoe e hoʻomanaʻo a hiki i ka lā aʻe, mai lawe i ʻelua mau kaha o Harvoni i ka manawa hoʻokahi. Hiki i kēia ke hoʻonui i ka hopena o nā hopena ʻaoʻao. E lawe wale i kāu mahele lāʻau maʻamau o Harvoni.

Hoʻopili i kāu hoʻolālā mālama Harvoni

He mea nui ia e lawe i kāu papa Harvoni e like me kā ke kauka i kauoha ai. ʻO kēia no ka mea ʻo ka mālama ʻana i kāu papa hana e hoʻonui ai i kou manawa e hoʻōla ai i kou maʻi hepa C (HCV). Kōkua pū ia ia e hoʻoliʻiliʻi i kāu hopena o nā hopena lōʻihi o ka HCV, e pili ana i ka cirrhosis a me ka maʻi ʻaʻai ate.

Hiki i nā nalo ke nalo ke hana iā Harvoni e hoʻēmi iki i ka mālama ʻana i kāu HCV. I kekahi mau hihia, inā ʻoe e nalo i nā kau, ʻaʻole e hoʻōla ʻia kāu HCV.

E mālama pono i nā ʻōlelo aʻoaʻo a kāu kauka a lawe i hoʻokahi papa Harvoni i kēlā me kēia lā no ka lōʻihi o kāu lapaʻau ʻana. Hiki ke kōkua iā ʻoe me ka hoʻohana ʻana i kahi mea hana hoʻomanaʻo e lawe iā Harvoni i kēlā me kēia lā.

Inā he mau nīnau a hopohopo paha kāu e pili ana i kāu lāʻau, e kamaʻilio me kāu kauka. Hiki iā lākou ke kōkua i ka hoʻoponopono ʻana i nā pilikia iā ʻoe a kōkua iā ʻoe e loaʻa i ka lāʻau lapaʻau maikaʻi loa no kāu hepatitis C.

Harvoni a me ka waiʻona

ʻO ka inu ʻana i ka waiʻona i ka wā e lawe ana iā Harvoni hiki ke hoʻonui i ka hopena o kekahi mau hopena ʻaoʻao mai Harvoni. ʻO kēia mau hopena ʻaoʻao:

  • luhi
  • ʻeha poʻo
  • nausea
  • pāhoehoe

Eia kekahi, ʻo ka hepatitis C a me ka hoʻohana nui ʻana i ka waiʻona e hana i ka scarring a me ka mumū i kou ake. ʻO ka hui pū ʻana i nā mea ʻelua e hoʻonui i kou makaʻi o ka cirrhosis a me ke kō ʻole o ke ake.

Hiki paha i ka waiʻona ke hoʻoemi iā ʻoe i ka lawe ʻana i kāu lāʻau i kuhikuhi ʻia e kāu kauka. ʻO kahi laʻana, hana iā ʻoe e hoʻopoina i ka lawe ʻana i kāu lāʻau i ka manawa kūpono. ʻO nā nalo o Harvoni e nalo nei hiki ke hoʻemi ia i ka lawelawe ʻana i kāu HCV.

No kēia mau kumu āpau, pono ʻoe e hōʻalo i ka inu waiʻona ke loaʻa ʻoe i ka maʻi hepitis C. He ʻoiaʻiʻo nō kēia ke mālama ʻia ʻoe me Harvoni. Inā loaʻa iā ʻoe kahi pilikia e hōʻalo i ka ʻalekohola, e kamaʻilio me kāu kauka.

ʻO Harvoni me ka ribavirin

Lawe pinepine ʻia ʻo Harvoni e mālama pono i ka maʻi hepatitis C. Eia nō naʻe, i kekahi mau hihia, lawe ʻia me kahi lāʻau ʻē aʻe i kapa ʻia ʻo ribavirin (Rebetol).

Kauoha paha kāu kauka i ka ribavirin me Harvoni inā ʻoe:

  • ua decompensated cirrhosis
  • ua loaʻa he hoʻoliʻiliʻi ate
  • ʻaʻole i kūleʻa ka mālama ʻana me kekahi mau lāʻau hepatitis C ʻē aʻe i ka wā i hala

Hoʻohana pū ʻia ʻo Harvoni a me ribavirin i ka poʻe i kēia mau hanana no ka mea ua hōʻike nā noiʻi hoʻokolohua i kahi helu hoʻōla kiʻekiʻe me ka hoʻohuihui hoʻohui ʻia ma mua o Harvoni wale nō.

ʻO ka mālama ʻana me ka ribavirin he 12 mau pule ka lōʻihi. Hele mai ʻo Ribavirin ma ke ʻano he pilala āu e lawe ai i ʻelua mau manawa i ka lā. E hoʻokumu ʻia ka mahele lāʻau āu e lawe ai i kāu kaupaona. Hoʻokumu ʻia ia paha i kāu hana hakuʻala a me nā pae hemoglobin.

Nā hopena ʻaoʻao Ribavirin

Hiki iā Ribavirin ke kumu i nā hopena ʻino a koʻikoʻi hoʻi. Hele pū mai me nā ʻōlelo aʻoaʻo koʻikoʻi.

ʻLelo aʻoaʻo pane

He ʻōlelo aʻoaʻo kā Ribavirin mai ka FDA. ʻO kahi ʻōkuhi pahu ka ʻoi loa o ka ʻōlelo aʻoaʻo e koi ai ka FDA. Kūkala ka ʻōlelo aʻoaʻo a Ribavirin i pahu ʻia:

  • ʻAʻole pono e hoʻohana hoʻokahi ʻo Ribavirin e mālama i ka maʻi hepitis C no ka mea ʻaʻole ia e hoʻokō pono iā ia iho.
  • Hiki i ka Ribavirin ke kumu i kahi ʻano o ke koko i kapa ʻia ʻo hemolytic anemia. Hiki i kēia ʻano ke alakaʻi i ka puʻuwai puʻuwai a make paha. Ma muli o kēia pilikia, ʻaʻole pono nā kānaka i loaʻa i nā maʻi puʻuwai koʻikoʻi a paʻa ʻole paha e lawe i ka ribavirin.
  • Ke hoʻohana ʻia ka ribavirin i nā wahine hāpai, hiki ke hōʻeha a make paha i ka fetus. ʻAʻole pono e lawe ʻia ʻo Ribavirin e nā wahine hāpai a i ʻole kā lākou mau kāne moekolohe kāne i ka wā hāpai. Pono hoʻi e hōʻalo i ka hāpai ʻana no ʻeono mau mahina ma hope o ka pau ʻana o ka mālama ʻana i ka ribavirin. I kēia manawa, e noʻonoʻo e hoʻohana i kahi ʻano kope o ka pale keiki (kaohi hānau).

Nā hopena ʻē aʻe

Hiki i ka Ribavirin ke hana i kekahi mau hopena ʻaoʻao maʻamau, e like me:

  • luhi
  • hopohopo
  • fiva
  • ʻeha poʻo
  • huhū
  • nalo ʻai ʻole
  • ʻehaʻeha a nāwaliwali paha
  • nausea
  • ka luaʻi

ʻO nā hopena ākea akā koʻikoʻi i ʻike ʻia i loko o nā noiʻi maʻi e pili ana i ka anemia, ka maʻi maʻi, a me ka pancreatitis. Hoʻopili pū lākou i nā pilikia o ka maka, e like me nā maʻi a me ka hihi ʻike.

Ribavirin a me ka hāpai keiki

E ʻike iā "Boxed warn" ma luna.

Ribavirin a me ka waiū hānai

ʻAʻole maopopo inā hele ʻo ribavirin i ka waiū umauma kanaka. Hōʻike nā noiʻi i nā holoholona i ka ribavirin i lawe ʻia e ka makuahine hiki ke hōʻeha i ka hānai ʻōpio. Eia naʻe, ʻaʻole wānana pinepine nā noiʻi holoholona i nā mea e hiki i nā kānaka.

Inā ʻoe e noʻonoʻo i ka mālama ʻana i ka ribavirin ʻoiai ʻoe e hānai ana i ka waiū, e kamaʻilio me kāu kauka. Paipai paha lākou iā ʻoe e hōʻoki i ka hānai ʻana a hōʻalo paha i ka mālama ʻana i ka ribavirin.

Nā launa pū ʻo Harvoni

Hiki iā Harvoni ke launa pū me nā lāʻau ʻē aʻe. Hiki iā ia ke launa pū me kekahi mau mea hoʻopihapiha a me nā meaʻai.

Hiki i nā launa like ʻole ke kumu i nā hopena like ʻole. ʻO kahi laʻana, hiki i kekahi ke hoʻopilikia i ka maikaʻi o ka hana ʻana o ka lāʻau, ʻoiai ʻo kekahi e hoʻonui i nā hopena ʻē aʻe.

Harvoni a me nā lāʻau ʻē aʻe

Ma lalo ka papa inoa o nā lāʻau i hiki ke launa pū me Harvoni. ʻAʻole i loko o kēia papa inoa nā lāʻau āpau e launa pū paha me Harvoni.

Ma mua o ka lawe ʻana iā Harvoni, e pono e haʻi aku i kāu kauka a me ka kauka lāʻau e pili ana i nā kauka, over-the-counter, a me nā lāʻau ʻē aʻe āu e lawe ai. E haʻi pū iā lākou e pili ana i nā wikamina, nā mea kanu, a me nā mea hoʻopiha āu e hoʻohana ai. Hiki ke kōkua i ka hāʻawi ʻana i kēia ʻike iā ʻoe e hōʻalo i nā launa ʻole.

Inā he mau nīnau kāu e pili ana i nā launa lāʻau e hoʻopili iā ʻoe, e nīnau i kāu kauka a kauka paha.

ʻAnakini

Lawe iā Harvoni me nā antacids, e like me Mylanta a i ʻole Tums, hiki ke hōʻemi i ka nui o Harvoni i lawe ʻia e kou kino. Hiki i kēia ke hōʻemi i ka Harvoni. I mea e pale aku ai i kēia pilina, hoʻokaʻawale i ka mahele lāʻau o Harvoni a me nā antacids ma kahi o ʻehā mau hola.

Nā poloka H2

ʻO ka lawe ʻana iā Harvoni me nā lāʻau i kapa ʻia ʻo H2 blockers hiki ke hoʻemi i ka nui o Harvoni i komo i loko o kou kino. Hiki i kēia ke kumu iā Harvoni e liʻiliʻi i ka hakakā ʻana i ka maʻi hepatitis C.

Inā pono ʻoe e lawe i kahi H2 blocker me Harvoni, pono ʻoe e lawe iā lākou i ka manawa like a lawe iā lākou i 12 mau hola ma ke kaʻawale. Lawe iā lākou i ka manawa like e hiki ai ke hoʻoheheʻe i nā lāʻau a lawe ʻia i loko o kou kino ma mua o ka hopena o ka H2 blocker i kiki i loko. ʻO ka lawe ʻana iā lākou i 12 mau hola ka lōʻihi e hiki ai i kēlā me kēia lāʻau ke hoʻopili i kou kino me ka launa ʻole ʻana me ka lāʻau ʻē aʻe

ʻO nā laʻana o nā poloka H2 e pili ana i ka famotidine (Pepcid) a me ka cimetidine (Tagamet HB).

Amiodarone

Lawe iā Harvoni me amiodarone (Pacerone, Nexterone) hiki ke hana i kahi puʻuwai puʻuwai weliweli weliweli, i kapa ʻia ʻo bradycardia. Ua ʻōlelo ʻia kekahi mau hōʻike e pili ana ka poʻe i lawe amiodarone a me Harvoni pū i kahi pacemaker e mālama i ka helu o ka puʻuwai maʻa mau. Ua hōʻike pū lākou i ka hōʻeha puʻuwai make ʻana o kekahi poʻe ʻē aʻe.

ʻO ka lawe amiodarone a me Harvoni ʻaʻole i koi ʻia. Inā pono ʻoe e lawe pū iā Harvoni a me amiodarone, e nānā pono kāu kauka i kāu hana puʻuwai.

Digoxin

Lawe iā Harvoni me digoxin (Lanoxin) hiki ke hoʻonui i ka nui o ka digoxin i kou kino. Hiki i nā pae Digoxin ke kiʻekiʻe ke alakaʻi i nā hopena ʻaoʻao weliweli.

Inā pono ʻoe e lawe pū iā Harvoni a me digoxin, e nānā pono kāu kauka i kāu pae digoxin. Hiki iā lākou ke hoʻololi i kāu mahele digoxin e hoʻohaʻahaʻa i ka hopena o nā hopena ʻaoʻao.

Lapaʻau hopu

Lawe iā Harvoni me kekahi mau lāʻau i hopu ʻia hiki ke hoʻemi i ka nui o Harvoni i lawe ʻia e kou kino. Hiki i kēia ke hōʻemi i ka hopena o Harvoni. No kēia kumu, ʻaʻole pono ʻoe e lawe iā Harvoni me kēia mau lāʻau hopu.

Nā laʻana o ka hopu ʻana i nā lāʻau e hōʻalo i ka lawe ʻana iā Harvoni e hoʻopili ʻia:

  • carbamazepine (Carbatrol, Equetro, Tegretol)
  • phenytoin (Dilantin, Phenytek)
  • phenobarbital
  • oxcarbazepine (Trileptal)

Nā Antibiotics

Hiki i kekahi mau lāʻau antibiotic ke hoʻemi i nā kiʻekiʻe Harvoni i kou kino. Hiki i kēia ke hōʻemi i ka Harvoni. I mea e pale aku ai i kēia pilina, pale i ka lawe ʻana iā Harvoni me nā antibiotic e hiki mai ana:

  • rifabutin (Mycobutin)
  • rifampin (Rifadin, Rimactane)
  • rifapentine (Priftin)

Nā lāʻau HIV

ʻO ka lawe ʻana iā Harvoni me kekahi mau lāʻau HIV e hiki ke hoʻololi i nā pae o kou kino o Harvoni a i ʻole nā ​​lāʻau HIV. Hiki i kēia mau launa pū ke hana i nā lāʻau i ʻoi aku ka maikaʻi a hoʻonui i kou makaʻu i nā hopena ʻaoʻao.

Tenofovir disoproxil fumarate

Lawe iā Harvoni me nā lāʻau i loaʻa i ka tenofovir disoproxil fumarate hiki ke hoʻonui i nā pae o tenofovir i kou kino. E hoʻonui kēia i ka hopena o nā hopena mai tenofovir, e like me ka hōʻino ʻana o ka puʻupaʻa. Inā pono ʻoe e lawe iā Harvoni me nā lāʻau i loaʻa ka tenofovir disoproxil fumarate, e nānā pono ke kauka iā ʻoe no nā hopena ʻaoʻao.

Nā laʻana o nā lāʻau i loaʻa i loko o tenofovir disoproxil fumarate me:

  • tenofovir (Viread)
  • tenofovir a me emtricitabine (Truvada)
  • tenofovir, elvitegravir, cobicistat, a me emtricitabine (Stribild)
  • tenofovir, emtricitabine, a me rilpivirine (Complera)

ʻO Tipranavir a me ritonavir

Lawe iā Harvoni me nā lāʻau lapaʻau HIV tipranavir (Aptivus) a i ʻole ritonavir (Norvir) hiki ke hōʻemi i nā kiʻekiʻe o Harvoni i kou kino. Hiki i kēia ke hōʻemi i ka Harvoni. ʻO ka lawe ʻana iā Harvoni me tipranavir a me ritonavir ʻaʻole e koi ʻia.

Nā lāʻau Cholesterol

Lawe iā Harvoni me nā lāʻau kolesterol i kapa ʻia he statins hiki ke hoʻonui i nā pae o nā statins i kou kino. Hoʻonui kēia i kou makaʻi i nā hopena ʻaoʻao statin, e like me ka ʻeha o ka mākala a me ka hōʻino.

Aia nā Statins i nā lāʻau e like me rosuvastatin (Crestor), atorvastatin (Lipitor), a me simvastatin (Zocor). Inā ʻoe e lawe iā Harvoni me kahi statin, e nānā pono kāu kauka iā ʻoe no nā hōʻailona o ka rhabdomyolysis (ka haʻihaʻi ʻana o nā mākala).

ʻAʻole pono e lawe pū ʻia ʻo Rosuvastatin lāua ʻo Harvoni. Pono e hoʻohana akahele nā ​​statins ʻē aʻe me Harvoni.

Warfarin

Hiki paha i ka Harvoni ke hoʻopili i ka hiki i kou kino ke hana i nā clots koko. Inā pono ʻoe e lawe i warfarin (Coumadin) ʻoiai ke mālama ʻia ʻoe me Harvoni, hiki i kāu kauka ke hōʻoia pinepine i kou koko. Pono paha lākou e hoʻonui a hōʻemi paha i kāu lāʻau warfarin.

Harvoni a me ribavirin

ʻAʻohe pilina ma waena o Harvoni a me ribavirin (Rebetol). Palekana ʻo Harvoni e lawe me ribavirin. I ka ʻoiaʻiʻo, ʻae ʻia ʻo Harvoni e ka FDA e lawe ʻia me ribavirin no nā poʻe me kekahi moʻolelo olakino.

Kauoha paha kāu kauka i ka ribavirin e lawe ai ʻoe iā Harvoni inā ʻoe:

  • ua decompensated cirrhosis
  • ua loaʻa he hoʻoliʻiliʻi ate
  • ua holo pono ʻole ʻia me kekahi mau lāʻau hepatitis C ʻē aʻe i ka wā i hala

Hoʻohana pū ʻia ʻo Harvoni a me ribavirin i ka poʻe me kēia mau ʻano no ka mea ua hōʻike nā noiʻi hoʻokolohua i kahi kiʻekiʻe o ka hoʻōla kiʻekiʻe me ka hoʻohuihui lapaʻau.

ʻO Harvoni a me ka omeprazole a i ʻole nā ​​PPI ʻē aʻe

ʻO ka lawe ʻana iā Harvoni me ka omeprazole (Prilosec) a i ʻole nā ​​mea hana hoʻomakee proton pump (PPI) hiki ke hōʻemi i ka nui o Harvoni i kou kino. Hiki i kēia ke hōʻemi i ka Harvoni.

Inā hiki, pale i ka lawe ʻana iā Harvoni me kēia papa o nā lāʻau. Inā makemake ʻoe i kahi PPI ke lawe nei ʻoe iā Harvoni, pono ʻoe e lawe iā Harvoni a me ka PPI i ka manawa like ma kahi ʻōpū nele.

Eia kekahi laʻana o nā PPI ʻē aʻe:

  • esomeprazole (Nexium)
  • lansoprazole (Prevacid)
  • pantoprazole (Protonix)

ʻO Harvoni a me nā mea kanu a me nā mea hoʻopili

ʻO ka lawe ʻana iā Harvoni me ka wort a St. John hiki ke hoʻemi i ka nui o Harvoni i kou kino. Hiki i kēia ke hōʻemi i ka Harvoni. I mea e hōʻalo ai i kēia pilina, mai lawe iā Harvoni me ka wort o St.

ʻO nā mea kanu ʻē aʻe a i ʻole nā ​​mea hoʻopili e hōʻemi ai i ka nui o Harvoni i kou kino e komo pū ana:

  • kava kava
  • kakalaioa waiū
  • ʻaloe
  • glucomannan

I kou wā e mālama ai me Harvoni, e nānā me kāu kauka ma mua o ka lawe ʻana i nā mea kanu a i ʻole nā ​​mea hoʻohui.

Harvoni a me kope

ʻAʻole i hōʻike ʻia nā pilina ma waena o Harvoni a me kope. Eia nō naʻe, e ʻinoʻino paha kekahi o nā hopena a Harvoni inā ʻoe e ʻai nui i ke kofe a i ʻole ka caffeine. ʻO kahi laʻana, inu inu kope i ke awakea a i ʻole ahiahi hiki ke hōʻeha i kou pilikia hiamoe. A hiki i ka caffeine ke hoʻonāukiuki i ka maʻi poʻo.

Inā inu ʻoe i ka kofe a ʻai pinepine paha i ka caffeine, e kamaʻilio me kāu kauka no ka palekana inā ʻaʻole paha kēia iā ʻoe i kou wā e mālama ai me Harvoni.

Nā koho ʻē aʻe iā Harvoni

Loaʻa nā lāʻau ʻē aʻe i hiki ke mālama i ka hepatitis C. Ua kūpono paha kekahi iā ʻoe ma mua o kekahi. Inā makemake ʻoe i ka ʻimi ʻana i kahi ʻē aʻe iā Harvoni, e kamaʻilio me kāu kauka e aʻo hou e pili ana i nā lāʻau ʻē aʻe e holo pono paha iā ʻoe.

Hiki ke mālama ʻia ka Hepatitis C me ka hoʻohana ʻana i nā lāʻau ʻē aʻe a i ʻole ka hui pū ʻana o ka lāʻau. ʻO ka lāʻau lapaʻau āu e koho ai i kāu kauka e pili ana i kāu genotype hepatitis C, kāu hana ate, a inā ua loaʻa iā ʻoe ka lāʻau no ka maʻi hepatitis C i ka wā ma mua.

Nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e mālama ai i ka maʻi hepa C me:

  • Epclusa (velpatasvir, sofosbuvir)
  • Mavyret (glecaprevir, pibrentasvir)
  • ʻO Viekira Pak (paritaprevir, ombitasvir, ritonavir, dasubuvir)
  • ʻO Vosevi (velpatasvir, sofosbuvir, voxilaprevir)
  • Zepatier (elbasvir, grazoprevir)
  • Rebetol (ribavirin), hoʻohana ʻia me ka hui pū me nā lāʻau ʻē aʻe

He lāʻau lapaʻau kahiko nā Interferons i hoʻohana pinepine ʻia e mālama i ka maʻi hepitis C. Eia nō naʻe, ʻo nā lāʻau hou e like me Harvoni ke kumu o ka liʻiliʻi o nā hopena a ʻoi aku ka nui o ka nui o ka hōʻola ma mua o nā interferons. No kēia mau kumu, i kēia lā ʻaʻole hoʻohana pinepine ʻia nā interferons e mālama i ka maʻi hepitis C.

Harvoni vs. nā lāʻau ʻē aʻe

Mahalo paha ʻoe pehea Harvoni e hoʻohālikelike ai i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Ma lalo nā hoʻohālikelike ma waena o Harvoni a me kekahi mau lāʻau.

Harvoni vs. Epclusa

Loaʻa iā Harvoni nā lāʻau i loko o hoʻokahi pila: ledipasvir a me sofosbuvir. Hoʻokomo pū ʻia ʻo Epclusa i nā lāʻau i loko o hoʻokahi pila: velpatasvir a me sofosbuvir.

Loaʻa nā lāʻau ʻelua i ka lāʻau sofosbuvir, i manaʻo ʻia he "iwi ʻaoʻao" o ka lapaʻau. ʻO kēia ke kumu o ka hoʻolālā hoʻomalu e pili ana i ka lāʻau kua o ka iwi hope, me nā lāʻau ʻē aʻe i hoʻohui pū ʻia.

Hoʻohana

Ua ʻae ʻia ʻo Harvoni lāua ʻo Epclusa e hoʻomaʻamaʻa i ka hepatitis C. Hiki iā Harvoni ke mālama i nā genotypes hepatitis C 1, 4, 5, a me 6, ʻoiai ʻo Epclusa hiki ke mālama i nā genotypes ʻeono.

Ua ʻae ʻia nā lāʻau ʻelua e mālama i ka poʻe me ka ʻole cirrhosis, a i ʻole me ka cirrhosis compensated a decompensated paha. Aia kekahi mau ʻokoʻa iki i ka mea a lākou e kuhikuhi ai, kaukaʻi ʻia i ka genotype, ka hana ate, a me ka mōʻaukala olakino.

Ua ʻae ʻia ʻo Harvoni e mālama i ka maʻi hepitis C i nā keiki he 12 a ʻoi paha mau makahiki a i ʻole kaupaona ʻana ma ka liʻiliʻi 77 paona. ʻAʻole ʻae ʻia ʻo Epclusa e mālama i ka maʻi hepatitis C i nā keiki.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Lawe ʻia ʻo Harvoni lāua ʻo Epclusa i hoʻokahi papa i hoʻokahi manawa i kēlā me kēia lā. Hiki iā lākou ke lawe ʻia me ka meaʻai a i ʻole ma ka ʻōpū hakahaka.

ʻO ka lōʻihi o ka mālama ʻana no Harvoni ʻo 8, 12, a i ʻole 24 mau pule. Pehea ka lōʻihi e lawe ai iā Harvoni e hilinaʻi ai i kāu genotype, a i ʻole ʻano hepatitis C a me kāu hana ate. E hilinaʻi ʻia ia i kāu mālama ʻana i ka maʻi hepatita C i hala.

ʻO ka lōʻihi o ka mālama ʻana iā Epclusa he 12 mau pule.

Nā hopena a me nā pilikia

ʻO Harvoni lāua ʻo Epclusa nā lāʻau ʻelua i kapa ʻia he antivirals pololei a loaʻa nā hopena like i ke kino. Ma muli o kēia, kumu lākou i nā hopena like he nui. Ma lalo iho nei kekahi mau hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

ʻO nā hopena ʻē aʻe i hiki ke hana ʻia me Harvoni a me Epclusa pū me:

ʻO Harvoni lāua ʻo EpclusaHarvoniEpclusa
Nā hopena ʻaoʻao hou aʻe
  • luhi
  • ʻeha poʻo
  • nausea
  • hiamoe (pilikia hiamoe)
  • nāwaliwali o nā mākala
  • ukiuki
  • pāhoehoe
  • ʻūhā
  • ʻeha ʻeha
  • dyspnea (ka pōkole o ka hanu)
  • ʻūpā
(mau hopena ʻaoʻao ʻokoʻa like ʻole)

Nā hopena hopena koʻikoʻi

Nā hopena ʻē aʻe hiki ke kū ʻia me Harvoni a me Epclusa pū me:

  • hepatitis B reactivation (ke hele a maʻi hou kahi maʻi ma mua), a hiki i ke kīnā ʻole o ke ake a i ʻole ka make (e ʻike i nā ʻōlelo aʻoaʻo "Booted" ma lalo)
  • nā hopena kūpilikiʻi koʻikoʻi, me nā ʻōuli e hiki ke komo pū me ka hanu pilikia a me ka angioedema (ʻōhū ma lalo o kou ʻili, maʻamau i kou lihilihi, nā lehelehe, nā lima, a me nā wāwae)

Nā ʻōlelo aʻoaʻo a ka pahu

He ʻōlelo hoʻolaha kā Harvoni lāua ʻo Epclusa mai ka FDA. ʻO kahi ʻōlelo aʻoaʻo i pahu ʻia ka ʻōlelo aʻo ikaika a ka FDA e koi ai.

Hōʻike ka ʻōlelo aʻoaʻo i ka pilikia o ka hana hou ʻana o ka maʻi hepatitis B ma hope o ka hoʻomaka ʻana i ka lāʻau me nā lāʻau ʻelua. ʻO ka hoʻoulu hou ʻana o ka maʻi hepatitis B hiki ke alakaʻi i ka hōʻino nui o ke ake, ka ʻole o ke ake, a me ka make.

E hoʻāʻo kāu kauka iā ʻoe no ka maʻi hepa B ma mua o kou hoʻomaka ʻana e lawe iā Harvoni a i ʻole Epclusa. Inā hōʻoia ʻoe i ka maikaʻi no ka maʻi hepatitis B, pono paha ʻoe e lawe i nā lāʻau e mālama iā ia.

Ka hoʻokō ʻana

Wahi a nā kulekele lapaʻau, ʻo Harvoni a me Epclusa nā koho lāʻau koho mua ʻelua no ka mālama ʻana i nā genotypes hepatitis C 1, 4, 5, a me 6. Eia kekahi mau ʻōlelo aʻoaʻo hou aʻe e like me kēia:

  • ʻO Harvoni kahi koho mua loa no ka mālama ʻana i nā genotypes 1, 4, 5, a me 6 i nā keiki o nā makahiki 12 a keu (a he 77 paona a ʻoi paha ke kaumaha).
  • ʻO Epclusa kahi koho koho mua loa no ka mālama ʻana i nā genotypes 2 a me 3.

Ua hoʻohālikelike ʻia ʻo Harvoni lāua ʻo Epclusa i nā noiʻi maʻi. Ua ʻike ʻia ka maikaʻi o nā mea ʻelua i ka hoʻōla ʻana i ka maʻi hepitis C. Eia naʻe, hiki i ka Epclusa ke hoʻōla i ka hapa haneri o ka poʻe ma mua o Harvoni.

I hoʻokahi hoʻokolohua hoʻokolohua, ʻoi aku ma mua o 93 pākēneka o ka poʻe i loaʻa ka ledipasvir a me sofosbuvir, nā ʻāpana o Harvoni, i hoola ʻia e ka maʻi hepitis C. ʻO ka nui o ka hōʻola no ka poʻe i loaʻa ka velpatasvir a me ka sofosbuvir, nā ʻāpana o Epclusa, ʻoi aku ma mua o 97 pākēneka.

Ua loaʻa kahi noiʻi ʻelua i nā hopena like i ka poʻe me ka cirrhosis o ka ate i uku ʻia. Ua ʻike ʻia kekahi noiʻi ʻē aʻe ua hoʻōla ʻo Epclusa i ka maʻi hepatita C ma kahi pākēneka o ka poʻe ma mua o Harvoni.

I loko o nā haʻawina ʻekolu, ua kiʻekiʻe iki ka SVR no Epclusa ma mua o Harvoni. Kū ʻo SVR no ka pane virologic i kākoʻo ʻia, ʻo ia hoʻi ʻaʻole hiki ke ʻike hou ʻia ka maʻi ma kou kino.

Nā kumukūʻai

ʻO Harvoni lāua ʻo Epclusa nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe ʻano generic o nā lāʻau āpau i kēia manawa. ʻOi aku ka uku o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma GoodRx.com, ʻoi aku ka nui o ke kumukūʻai ʻo Harvoni ma mua o Epclusa. ʻO ke kumukūʻai maoli āu e uku ai no nā lāʻau ʻelua e pili ana i kāu hoʻolālā ʻinikua a me ka hale kūʻai āu e hoʻohana ai.

Kaha: E hoʻokuʻu ʻia nā mana mana o nā lāʻau ʻelua i ka mua o ka makahiki 2019. Kuhi ka mea hana i ke kumukūʻai no kahi papa o kēlā me kēia lāʻau e $ 24,000. ʻOi aku ka emi o kēia kumukūʻai ma mua o ke kumukūʻai o nā mana inoa inoa.

Harvoni vs. Mavyret

Loaʻa iā Harvoni nā lāʻau i loko o hoʻokahi pila: ledipasvir a me sofosbuvir. Aia i loko o Mavyret nā lāʻau i loko o hoʻokahi pila: glecaprevir a me pibrentasvir.

Hoʻohana

Ua ʻae ʻia ʻo Harvoni lāua ʻo Mavyret e ka FDA e mālama i ka maʻi hepitis C. Eia naʻe, hoʻohana ʻia lāua e mālama i nā genotypes like ʻole i nā ʻano like ʻole:

  • Ua ʻae ʻia ʻo Harvoni e mālama i nā genotypes hepatitis C 1, 4, 5, a me 6. Ua ʻae ʻia ʻo Mavyret e mālama i nā genotypes nui ʻeono.
  • Hoʻohana ʻia nā lāʻau ʻelua e mālama i ka poʻe i uku i ka cirrhosis. Hiki ke hoʻohana pū ʻia ʻo Harvoni i ka poʻe me ka cirrhosis decompensated, akā ʻaʻole hiki iā Mavyret.
  • Hiki ke hoʻohana ʻia nā mea ʻelua i ka poʻe i loaʻa i ka hoʻoliʻiliʻi ate.
  • Hiki ke hoʻohana ʻia ʻo Mavyret i ka poʻe me nā maʻi puʻuwai koʻikoʻi a i ʻole ma hope o ke kuʻi ʻana o ka puʻuwai, akā ʻaʻole ʻae ʻia ʻo Harvoni no kēia mau hoʻohana.
  • Ua ʻae ʻia ʻo Harvoni e mālama i ka maʻi hepatitis C i nā keiki he 12 mau makahiki a ʻoi paha a i kaupaona ma 77 paha mau paona. ʻAe wale ʻia ʻo Mavyret no ka hoʻohana i nā mākua.
  • Ua ʻae ʻia nā lāʻau ʻelua e mālama i ka poʻe i hoʻāʻo i kekahi mau lāʻau hepatitis C i ka wā i hala.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Harvoni lāua ʻo Mavyret ma ke ʻano he mau papa e lawe ʻoe i hoʻokahi manawa i ka lā. Eia nō naʻe, ʻoiai ʻoe e lawe i hoʻokahi papa ʻo Harvoni i kēlā me kēia lā, lawe ʻoe i ʻekolu papa ʻo Mavyret i kēlā me kēia lā.

Hiki ke kiʻi ʻia ʻo Harvoni me ka ʻole o ka meaʻai, akā lawe ʻia ʻo Mavyret me kahi pāʻina.

Kau ʻia ʻo Harvoni no 8, 12, a i ʻole 24 mau pule o ka mālama ʻana. ʻO ka lōʻihi o ka mālama ʻana iā Mavyret he 8, 12, a i ʻole 16 mau pule. ʻO ka lōʻihi o ka mālama ʻana a kāu kauka e kuhikuhi ai e pili ana i kāu genotype hepatitis C, ka hana ate, a me ka mōʻaukala o nā hana hepatitis C i hala.

Nā hopena a me nā pilikia

Loaʻa nā hopena like ʻo Harvoni lāua ʻo Mavyret i ke kino. ʻO kēia ke kumu o ka hopena o ka hopena. Ma lalo nā hiʻohiʻona o kekahi o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

ʻO nā hopena ʻē aʻe i hiki ke hana ʻia me Harvoni a me Mavyret pū me:

ʻO Harvoni lāua ʻo MavyretHarvoniʻO Mavyret
Nā hopena ʻaoʻao hou aʻe
  • ʻeha poʻo
  • luhi
  • nausea
  • pāhoehoe
  • nāwaliwali
  • ʻōlohelohe
  • ʻūhā
  • ʻeha ʻeha
  • pilikia hanu
  • ukiuki
  • ʻūpā
  • ʻili ʻili (i ka poʻe ma ka dialysis)

Nā hopena hopena koʻikoʻi

Nā hopena ʻē aʻe i hiki ke kū ʻia me Harvoni a me Mavyret pū me:

  • hepatitis B reactivation (ke hele a maʻi hou kahi maʻi ma mua), hiki ke alakaʻi ʻia i ka hōʻeha o ke ake nui, ka maikaʻi ʻole o ke ake, a i ʻole ka make (e ʻike i nā ʻōlelo aʻoaʻo "Booted" ma lalo)
  • ke kūpilikiʻi kūpilikiʻi koʻikoʻi, me nā ʻōuli e hiki ke komo pū me ka hanu pilikia a me ka angioedema (ʻōhū ma lalo o kou ʻili, maʻamau i kou lihilihi, nā lehelehe, nā lima, a me nā wāwae)

Nā ʻōlelo aʻoaʻo a ka pahu

Ua hoʻolaha ʻia ʻo Harvoni lāua ʻo Mavyret i nā ʻōlelo aʻoaʻo mai ka FDA. ʻO kahi ʻōlelo aʻoaʻo i pahu ʻia ka ʻōlelo aʻo ikaika a ka FDA e koi ai.

Hōʻike ka ʻōlelo aʻoaʻo i ka pilikia o ka hana hou ʻana o ka maʻi hepatitis B ma hope o ka hoʻomaka ʻana i ka lāʻau me nā lāʻau ʻelua. Hiki i ka Hepatitis B reactivation ke alakaʻi i ka hōʻino nui o ke ake, ka ʻole o ke ake, a i ʻole ka make.

E hoʻāʻo kāu kauka iā ʻoe no ka maʻi hepa B ma mua o kou hoʻomaka ʻana e lawe iā Harvoni a i ʻole Mavyret. Inā hōʻoia ʻoe i ka maikaʻi no ka maʻi hepatitis B, pono paha ʻoe e lawe i nā lāʻau e mālama iā ia.

Ka hoʻokō ʻana

ʻAʻole hoʻohālikelike ʻia ʻo Harvoni lāua ʻo Mavyret i nā noiʻi maʻi, akā maikaʻi nā mea ʻelua no ka mālama ʻana i ka maʻi hepitis C.

Wahi a nā kulekele lapaʻau, ʻo Harvoni lāua ʻo Mavyret nā koho lapaʻau koho ʻelua no nā genotypes hepatitis C 1, 4, 5, a me 6. ʻO Mavyret kekahi koho mua loa no nā genotypes 2 a me 3. Ma waho o kēia mau manaʻo, aia kekahi kekahi mau kūlana olakino kahi e koi ʻia ai kahi lāʻau ma luna o kekahi.

  • ʻO nā keiki ma ka makahiki 12 a ʻoi a ʻoi paha he 77 paona a ʻoi paha ke kaumaha: ʻO Harvoni kahi koho mua loa no ka mālama ʻana i kēia mau keiki me nā genotypes 1, 4, 5, a me 6. ʻAʻole ʻōlelo ʻia ʻo Mavyret e hoʻohana i nā keiki.
  • Maʻi maʻi ʻino nui: ʻO Mavyret kahi koho mua loa no ka mālama ʻana i ka maʻi hepitis C i ka poʻe me kēia ʻano. ʻAʻole koi ʻia ʻo Harvoni no nā poʻe me nā maʻi puʻuwai koʻikoʻi.
  • Hoʻopau i ka cirrhosis: No ka poʻe me ka cirrhosis decompensated, ua ʻōlelo ʻia ʻo Harvoni e hoʻohana ʻia me ka ribavirin. ʻAʻole koi ʻia ʻo Mavyret no ka poʻe me kēia ʻano.
  • Ke kuʻi ʻōhua: No ka poʻe i loaʻa i kahi transplan kidney, ʻōlelo ʻia nā lāʻau ʻelua ma ke ʻano he laina mua no ka poʻe me nā genotypes 1 a i ʻole 4. (hoʻohana ʻia ʻo Harvoni i ka lepili no kēia kumu.) Paipai ʻia ʻo Mavyret no ka poʻe me nā genotypes 2 , 3, 5, a i ʻole 6 i loaʻa i kahi transplant kidney, akā ʻaʻole ʻo Harvoni.
  • Ka hoʻoliʻiliʻi ate: ʻO nā ʻōlelo aʻoaʻo lapaʻau no ka hoʻohana ʻana o Harvoni a me Mavyret he ʻokoʻa ia no ka poʻe me ka hoʻoliʻiliʻi ate. Hoʻokumu ʻia lākou i ka genotype a me ka hana ate.

Nā kumukūʻai

ʻO Harvoni lāua ʻo Mavyret nā lāʻau lapaʻau inoa inoa ʻelua. ʻAʻohe o nā ʻano laulā o kekahi lāʻau i loaʻa. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma GoodRx.com, ʻoi aku ka nui o ke kumukūʻai ʻo Harvoni ma mua o Mavyret. ʻO ke kumukūʻai maoli āu e uku ai no nā lāʻau ʻelua e pili ana i kāu hoʻolālā ʻinikua a me ka hale kūʻai āu e hoʻohana ai.

Kaha: Kuhi ʻia kahi mana mana o Harvoni i ka hoʻomaka mua o ka makahiki 2019. Kuhi ka mea hana i ke kumukūʻai no kahi papa lāʻau e $ 24,000. ʻOi aku ka emi o kēia kumukūʻai ma mua o ke kumukūʻai o ka mana inoa mana.

Harvoni vs. Sovaldi

Hoʻohana ʻia ʻo Harvoni lāua ʻo Sovaldi e mālama ai i ka maʻi hepitis C. ʻO Harvoni kahi papa hoʻohui i loaʻa nā lāʻau ʻelua: ledipasvir a me sofosbuvir. Loaʻa iā Sovaldi hoʻokahi lāʻau: sofosbuvir.

Hoʻohana

Ua ʻae ʻia ʻo Harvoni e mālama i ka hepatitis C i nā mākua me nā genotypes 1, 4, 5, a i ʻole 6. Hiki nō ke hoʻohana ʻia e mālama ai i nā keiki me kēia mau genotypes mai ka makahiki 12 a ʻoi a kaupaona paha ma ka liʻiliʻi 77 paona.

Ua ʻae ʻia ʻo Sovaldi e mālama i ka hepatitis C, akā hoʻohana ʻia ia i nā mākua me nā genotypes 1, 2, 3, a i ʻole 4. Hiki nō ke hoʻohana ʻia i nā keiki me nā genotypes 2 a i ʻole 3 mau makahiki he 12 a ʻoi paha a i kaupaona he 77 paona a ʻoi paha. .

Hoʻohana ʻia ʻo Sovaldi me ka hui pū me nā lāʻau ʻē aʻe e mālama ai i ka maʻi hepitis C. ʻAʻole ʻae ʻia e FDA e hoʻohana ʻia e ia iho.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Harvoni lāua ʻo Sovaldi ma ke ʻano he mau papa e lawe ai ʻoe ma ka waha. Lawe ʻia ʻo Harvoni i kēlā me kēia lā no 8, 12, a i ʻole 24 mau pule. Lawe pū ʻia ʻo Sovaldi i hoʻokahi manawa i kēlā me kēia lā, akā no 12 a 24 mau pule paha.

Loaʻa nā lāʻau ʻelua i ka sofosbuvir, akā ʻo Harvoni kahi lāʻau hoʻohui e hiki ke hoʻohana ʻia e ia iho no kekahi poʻe. ʻAʻole hoʻohana ʻo Sovaldi iā ia iho e mālama i ka hepatitis C. Kau ʻia ia me nā lāʻau ʻē aʻe, e like me pegylated interferon a me ribavirin (Rebetol). Loaʻa ke ʻano generic o Sovaldi i loko o nā lāʻau hepatitis C hui pū ʻia.

Nā hopena a me nā pilikia

Loaʻa nā lāʻau ʻelua i ka sofosbuvir, no laila e hana lākou i nā hopena ʻaoʻao like. Eia nō naʻe, lawe mau ʻia ʻo Sovaldi me ka hoʻohui pū ʻana me nā lāʻau ʻē aʻe, i hana ʻokoʻa paha ia Harvoni. Ma muli o kēia, nā hopena ʻino i ʻike ʻia me ka lāʻau Sovaldi e pili ana i ka lāʻau i hoʻohana ʻia.

ʻO nā hopena āpau a koʻikoʻi hoʻi no Harvoni a me Sovaldi e hōʻike ʻia ma lalo. ʻIke ʻia nā hopena ʻaoʻao ʻo Sovaldi ke hoʻohana ʻia ʻo Sovaldi me nā lāʻau hepatitis C ʻē aʻe e like me ribavirin a me pegylated interferon.

ʻO Harvoni lāua ʻo SovaldiHarvoniLapaʻau hoʻohui Sovaldi
Nā hopena ʻaoʻao hou aʻe
  • luhi
  • ʻeha poʻo
  • nausea
  • hiamoe (pilikia hiamoe)
  • nāwaliwali o nā mākala
  • pāhoehoe
  • ʻeha ʻeha
  • ukiuki
  • ʻūhā
  • dyspnea (ka pōkole o ka hanu)
  • ʻili ʻili
  • hūwī
  • emi i ka makemake
  • haʻalulu
  • nā ʻōuli like flu
  • fiva
Nā hopena hopena koʻikoʻi
  • hepatitis B reactivation *
  • ʻino kūpikipikiʻi reaksi, me angioedema (loa pehu)
(kekahi mau hopena ʻaoʻao koʻikoʻi koʻikoʻi)
  • haʻahaʻa kehena o ke koko (anemia)
  • helu keʻokeʻo haʻahaʻa keʻokeʻo haʻahaʻa (neutropenia)
  • kaumaha loa

* ʻO Harvoni lāua ʻo Sovaldi i kahi ʻatikala i pahu ʻia mai ka FDA no ka hana hou ʻana i ka maʻi hepitis B. ʻO kahi ʻōlelo aʻoaʻo i pahu ʻia ka ʻōlelo aʻo ikaika a ka FDA e koi ai. Hoʻomaopopo ia i nā kauka a me nā mea maʻi e pili ana i nā hopena lāʻau e weliweli paha.

Ka hoʻokō ʻana

He ʻano ʻokoʻa nā Harvoni a me Sovaldi i ʻae ʻia e ka FDA, akā hoʻohana ʻia lāua ʻelua e mālama i ka maʻi hepitis C. Maikaʻi ʻo Harvoni e kūʻē i ka maʻi ke hoʻohana wale ʻia a i ʻole me ka ribavirin. He maikaʻi ʻo Sovaldi i ka mālama ʻana i ka maʻi hepa C ke hoʻohana wale ʻia me nā lāʻau ʻē aʻe, e like me ribavirin a me pegylated interferon.

Wahi a nā kulekele lapaʻau, ʻo Harvoni kahi koho mua loa e mālama ai i ka maʻi hepitis C i ka poʻe me nā genotypes 1, 4, 5, a i ʻole 6. He koho koho mua nō hoʻi ia i nā keiki mai ka makahiki 12 a ʻoi a i ʻole ka mea kaupaona ma kahi o 77 paona.

ʻAʻole koi ʻia ʻo Sovaldi e nā ʻōkuhi lapaʻau ma ke ʻano he koho mua loa e mālama ai i ka maʻi hepitis C. ʻO kēia no ka mea ʻoi aku ka maikaʻi o nā lāʻau hou e like me Harvoni. Hoʻokumu pū nā lāʻau hou i nā hopena ʻē aʻe.

Eia nō naʻe, koi ʻia ʻo Sovaldi i kekahi manawa ma ke ʻano he koho lua-koho no kekahi poʻe, akā pono ia e hoʻohana pū ʻia me nā lāʻau ʻē aʻe.

Nā kumukūʻai

ʻO Harvoni lāua ʻo Sovaldi nā lāʻau lapaʻau inoa inoa. ʻAʻohe o nā ʻano laulā i loaʻa i kekahi lāʻau paha.

Wahi a nā koho ma GoodRx.com, ʻoi aku ke kumukūʻai ʻo Harvoni ma mua o Sovaldi. ʻO ke kumukūʻai maoli āu e uku ai no nā lāʻau āpau e hilinaʻi ia i kāu ʻinikua a me ka hale kūʻai āu e hoʻohana ai.

Kaha: Kuhi ʻia kahi mana mana o Harvoni i ka hoʻomaka mua o ka makahiki 2019. Kuhi ka mea hana i ke kumukūʻai no kahi papa lāʻau e $ 24,000. ʻOi aku ka emi o kēia kumukūʻai ma mua o ke kumukūʻai o ka mana inoa mana.

Harvoni vs. Zepatier

Loaʻa iā Harvoni nā lāʻau ledipasvir a me sofosbuvir i hoʻokahi pila. Aia pū kekahi ʻo Zepatier i nā lāʻau i loko o hoʻokahi pila: elbasvir a me grazoprevir.

Hoʻohana

Ua ʻae ʻia ʻo Harvoni lāua ʻo Zepatier e hoʻomaʻamaʻa i ka maʻi hepitis C i nā mākua me nā genotypes 1 a i ʻole 4. ʻAe ʻia ʻo Harvoni no ka mālama ʻana i nā genotypes 5 a me 6 i nā mākua, a me nā genotypes 1, 4, 5, a i ʻole 6 i nā keiki he 12 a ʻoi paha mau makahiki. a ʻo ka mea kaupaona ma ka liʻiliʻi 77 paona. ʻAʻole ʻae ʻia ʻo Zepatier no ka hoʻohana i nā keiki.

Ua ʻae ʻia ʻo Harvoni e mālama i ka maʻi hepatitis C i ka poʻe mākua me ka cirrhosis decompensated a i ʻole ka mea i loaʻa i kahi neʻe o ke ake. Me kēia mau kūlana, e kauoha paha kāu kauka i ka ribavirin me Harvoni.

ʻAʻole ʻae ʻia ʻo Zepatier no ka hoʻohana ʻana i ka poʻe me ka maʻi kaulike a koʻikoʻi paha, cirrhosis decompensated, a ma hope paha o ke kaʻe ʻana o ke ake.

Ua ʻae ʻia ʻo Zepatier e hoʻohana i nā kānaka me nā genotypes 1 a me 4 i loaʻa kahi ʻano i kapa ʻia he polymorphism. Me kēia kūlana, loaʻa i kekahi kanaka kekahi ʻano loli (mutation) e pale aku ai i ka maʻi virus i kekahi mau lāʻau. Ke kūpaʻa nei kahi virus, paʻakikī e mālama me kekahi mau lāʻau.

E hana ana kāu kauka i kahi hoʻokolohua koko inā loaʻa iā ʻoe kekahi o kēia mau ʻano. Inā hana ʻoe, pono ʻoe e lawe i ka ribavirin me Zepatier.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Harvoni lāua ʻo Zepatier ma kahi papa hoʻokahi i lawe ʻia i hoʻokahi manawa i kēlā me kēia lā. Hiki ke lawe ʻia i kēlā me kēia me ka ʻai ʻole.

ʻO ka mālama ʻana ʻo Harvoni no 8, 12, a i ʻole 24 mau pule. Kū ka mālama Zepatier no 12 a 16 mau pule. ʻO ka lōʻihi o ka mālama ʻana a kāu kauka e kuhikuhi ai e pili ana i kāu genotype, ka hana ate, a me ka mōʻaukala o nā hana hepatitis C i hala.

Nā hopena a me nā pilikia

ʻO Harvoni lāua ʻo Zepatier nā lāʻau like a like ko lāua hopena ma ke kino. No laila, kumu lākou i nā hopena like like. Ma lalo iho nei kekahi mau hiʻohiʻona o kā lākou hopena ʻaoʻao.

ʻO Harvoni lāua ʻo ZepatierHarvoniZepatier
Nā hopena ʻaoʻao hou aʻe
  • luhi
  • ʻeha poʻo
  • ukiuki
  • pāhoehoe
  • nausea
  • hiamoe (pilikia hiamoe)
  • ʻūhā
  • nāwaliwali
  • ʻeha ʻeha
  • paʻakikī i ka hanu ʻana
  • ʻūpā
  • ʻeha ka ʻōpū
Nā hopena hopena koʻikoʻi
  • hepatitis B reactivation *
  • koʻikoʻi nā hopena maʻi, me angioedema (ʻōhū nui)
(kekahi mau hopena ʻaoʻao koʻikoʻi koʻikoʻi)
  • hoʻokiʻekiʻe kiʻekiʻe akeakamai (alanine aminotransferase)

* ʻO Harvoni lāua ʻo Zepatier he ʻelua ʻōlelo aʻoaʻo mai ka FDA no ka hana hou ʻana i ka maʻi hepitis B. ʻO kahi ʻōlelo aʻoaʻo i pahu ʻia ka ʻōlelo aʻo ikaika a ka FDA e koi ai. Hoʻomaopopo ia i nā kauka a me nā mea maʻi e pili ana i nā hopena lāʻau e weliweli paha.

Ka hoʻokō ʻana

ʻAʻole hoʻohālikelike ʻia ʻo Harvoni lāua ʻo Zepatier i nā noiʻi maʻi, akā maikaʻi nā mea ʻelua no ka mālama ʻana i ka maʻi hepitis C.

Wahi a nā kulekele lapaʻau, ua ʻōlelo ʻia ʻo Harvoni a me Zepatier e like me nā koho mua loa e mālama ai i ka hepatitis C i nā mākua me nā genotypes 1 a me 4. ʻO Harvoni kekahi koho mua loa no ka mālama ʻana i nā genotypes 5 a me 6, akā ʻaʻole ʻo Zepatier.

ʻOkoʻa nā ʻōlelo aʻoaʻo no ke alakaʻi ʻana no Harvoni a me Zepatier i nā ʻano aʻe:

  • ʻO nā keiki ma ka makahiki 12 a ʻoi a ʻoi paha he 77 paona a ʻoi paha ke kaumaha: ʻO Harvoni kahi koho koho mua loa no ka mālama ʻana i kēia mau keiki i loaʻa nā genotypes 1, 4, 5, a me 6. ʻAʻole pono ʻo Zepatier e hoʻohana i nā keiki.
  • Maʻi maʻi ʻino nui: Koi ʻia ʻo Zepatier ma ke ʻano he koho mua loa no ka poʻe me kēia ʻano, ʻoiai ʻaʻole ʻo Harvoni.
  • Hoʻopau i ka cirrhosis: I ka poʻe me ka cirrhosis decompensated, ua ʻōlelo ʻia ʻo Harvoni ma ke ʻano he koho mua. ʻAʻole koi ʻia ʻo Zepatier no ka poʻe me kēia ʻano.
  • Ka hoʻoneʻe ʻana o ka ake a me ke kōkō: ʻO Harvoni kahi koho mua loa loa no ka mālama ʻana i ka maʻi hepitis C i ka poʻe i loaʻa i ka hoʻoliʻiliʻi o ke ake a me nā puʻupaʻa. ʻAʻole koi ʻia ʻo Zepatier no ka poʻe me kēia ʻano.

Nā kumukūʻai

ʻO Harvoni lāua ʻo Zepatier nā lāʻau lapaʻau inoa inoa. ʻAʻohe o nā ʻano generic i kēia manawa no kekahi lāʻau. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma GoodRx.com, ʻoi aku ke kumukūʻai ʻo Harvoni ma mua o Zepatier. ʻO ke kumukūʻai maoli āu e uku ai no nā lāʻau ʻelua e pili ana i kāu hoʻolālā ʻinikua a me ka hale kūʻai āu e hoʻohana ai.

Kaha: Kuhi ʻia kahi mana mana o Harvoni i ka hoʻomaka mua o ka makahiki 2019. Kuhi ka mea hana i ke kumukūʻai no kahi papa lāʻau e $ 24,000. ʻOi aku ka emi o kēia kumukūʻai ma mua o ke kumukūʻai o ka mana inoa mana.

Pehea e lawe ai iā Harvoni

Pono ʻoe e lawe iā Harvoni e like me nā kuhikuhi a kāu kauka.

Manawa

Hiki ke kiʻi ʻia ʻo Harvoni i kēlā me kēia manawa o ka lā. Eia nō naʻe, pono ʻoe e hoʻāʻo e lawe iā Harvoni i ka manawa like i kēlā me kēia lā. Hiki i kēia ke kōkua iā ʻoe e hoʻomanaʻo e lawe a kōkua i ka mālama ʻana i ka nui o ka lāʻau i loko o kāu ʻōnaehana.

Inā ʻoe e ʻike i ka luhi i kou wā lapaʻau me Harvoni, e hoʻāʻo e lawe i ka lāʻau i ka pō. Kōkua paha kēlā iā ʻoe e hōʻalo i kēlā hopena ʻaoʻao.

Lawe iā Harvoni me ka meaʻai

Hiki ke kiʻi ʻia ʻo Harvoni me ka ʻole o ka meaʻai. Inā ʻike ʻoe i ka nausea ma hope o ka lawe ʻana iā Harvoni, hiki iā ʻoe ke pale i kēlā hopena ʻaoʻao e ka lawe ʻana i ka lāʻau me ka meaʻai.

Hiki iā Harvoni ke haki?

ʻAʻole maopopo inā he palekana ka haki ʻana i nā papa ʻo Harvoni, no laila ʻoi aku ka maikaʻi o ka hōʻalo ʻana iā lākou. Inā loaʻa iā ʻoe kahi pilikia e ale i nā papa Harvoni, e kamaʻilio me kāu kauka e pili ana i nā lāʻau ʻē aʻe e ʻoi aku ka maikaʻi iā ʻoe.

Pehea ʻo Harvoni e hana ai

Hoʻohana ʻia ʻo Harvoni e mālama i ka maʻi me ka maʻi hepatitis C (HCV).

E pili ana i ka maʻi hepa C

Hoʻouna ʻia ʻo HCV ma o ke koko a i ʻole nā ​​wai o ke kino. Hoʻopuka mua ka virus i nā hunaola i loko o kou akepaʻa a hoʻokumu i ka pehu. Alakaʻi kēia i nā ʻōuli e like me:

  • ʻeha ma kou ʻōpū (ʻōpū)
  • fiva
  • mimi ʻeleʻele
  • ʻeha pū
  • jaundice (melemele o kou ʻili a i ʻole nā ​​keʻokeʻo o kou mau maka)

Hiki i nā ʻōnaehana pale pale o kekahi poʻe ke hakakā me HCV me ka ʻole o ka lāʻau. Eia nō naʻe, pono i nā poʻe he nui i ka lāʻau e hoʻomaʻemaʻe i ka maʻi a hoʻemi i nā hopena lōʻihi. ʻO nā hopena koʻikoʻi, wā lōʻihi o ka hepatitis C me ka cirrhosis (scarring ate) a me ka maʻi ʻaʻai ate.

Pehea ʻo Harvoni e mālama ai i ka maʻi hepitis C?

ʻO Harvoni kahi antiviral hana pololei (DAA). Mālama kēia ʻano lāʻau i HCV ma ke kāpae ʻana i ka maʻi mai ka hana kope ʻana (hana kope ʻana iā ia iho). ʻO nā virus ʻaʻole hiki ke hana kope i ka hopena make a hoʻomaʻemaʻe ʻia mai ke kino.

ʻO ka hoʻomaʻemaʻe ʻana i ka maʻi mai kou kino e hoʻēmi ai i ka mumū o ka ate a pale i ka hōʻeha ʻana o ke ake.

Pehea ka lōʻihi o ka hana?

Hoʻomaka kekahi poʻe e ʻoi aku ka maikaʻi i loko o kekahi mau lā a i ʻole mau pule o ka hoʻomaka ʻana me ka Harvoni. Eia nō naʻe, pono ʻoe e lawe iā Harvoni no ka manawa holoʻokoʻa a ke kauka i kau ai.

I nā noiʻi maʻi, ʻoi aku ma mua o 86 ka pākēneka o ka poʻe i lawe iā Harvoni i hoʻōla ʻia ma hope o ʻekolu mau mahina o ka lapaʻau ʻana.

E hoʻāʻo kāu kauka i kou koko no ka maʻi ma mua a i ka wā o ka mālama. E hōʻoia lākou iā ia ma hope o 12 mau pule ma hope o kou hoʻopau ʻana i ka lāʻau. Inā ʻaʻohe virus ʻike ʻia i kou kino he 12 mau pule ma hope o ka pau ʻana o kāu lāʻau, ua loaʻa iā ʻoe ka pane virologic i kākoʻo ʻia (SVR). ʻO ka loaʻa ʻana o ka SVR manaʻo ʻoe ua hoʻōla ʻia ka maʻi hepatitis C.

Harvoni a me ka hāpai keiki

ʻAʻole lawa nā noiʻi i loko o nā kānaka e ʻike inā palekana ʻo Harvoni e lawe i ka wā hāpai. I nā noiʻi holoholona, ​​ʻaʻohe mea ʻino i ka ʻōpū i ʻike ʻia i ka wā i loaʻa ai ka makuahine iā Harvoni. Eia naʻe, ʻaʻole wānana pinepine nā noiʻi holoholona i nā mea e hiki i nā kānaka.

Inā hāpai ʻoe a hoʻolālā paha ʻoe e hāpai, e kamaʻilio me kāu kauka inā kūpono ʻo Harvoni iā ​​ʻoe.

Kaha: Inā lawe ʻoe iā Harvoni me ka ribavirin, ʻaʻole palekana kēlā lawelawe i ka wā hāpai (e ʻike iā "Harvoni a me ribavirin" ma luna).

Harvoni a me ka waiū hānai

ʻAʻole ʻike ʻia inā hele ʻo Harvoni i ka waiū umauma kanaka. I loko o nā noiʻi holoholona, ​​ua loaʻa ʻo Harvoni i ka waiū umauma akā ʻaʻole i hoʻokumu i nā hopena maikaʻi ʻole i nā keiki. Eia naʻe, ʻaʻole wānana pinepine nā noiʻi holoholona i nā mea e hiki i nā kānaka.

Inā hānai ʻoe a hoʻolālā paha ʻoe i ka waiū, e kamaʻilio me kāu kauka e pili ana i nā pilikia a me nā pono o ka lawe ʻana iā Harvoni i ka wā e hānai ana.

Hoʻomaopopo: Inā lawe ʻoe iā Harvoni me ka ribavirin, pono ʻoe e kamaʻilio me kāu kauka inā hiki iā ʻoe ke hoʻomau palekana i ka hānai ʻana i ka waiū (e ʻike iā "Harvoni a me ribavirin" ma luna).

Nā nīnau e pili ana iā Harvoni

Eia nā pane i kekahi o nā nīnau e nīnau pinepine ʻia e pili ana iā Harvoni.

Pono wau e ukali i kahi papaʻai kūikawā ke lawe nei wau iā Harvoni?

ʻAʻole, ʻaʻohe meaʻai kūikawā koi ʻia ke lawe ʻoe iā Harvoni.

Eia nō naʻe, inā ʻike ʻoe i ka ʻeha a i ʻole ka ʻeha o ka ʻōpū ma ke ʻano he ʻaoʻao o Harvoni, kōkua paha e ʻai i nā meaʻai liʻiliʻi a hōʻalo i nā meaʻai momona, ʻona, a ʻawaʻawa hoʻi. ʻO ka lawe ʻana iā Harvoni me kahi meaʻai liʻiliʻi hiki ke hoʻoliʻiliʻi hoʻi i ka nausea.

Pehea ka lōʻihi o Harvoni e hoʻopau ai i koʻu maʻi hepa C?

E hoʻomaka koke ʻo Harvoni e hakakā me ka maʻi virus. Eia nō naʻe, i mea e hoʻopau ai i ka maʻi hepa C, pono ʻoe e lawe iā Harvoni no ka lōʻihi o ka manawa a ke kauka e kuhikuhi ai. ʻO 8, 12, a i ʻole 24 mau pule paha kēia, kaukaʻi ʻia i kāu moʻolelo olakino.

I nā noiʻi hoʻokolohua, kokoke i nā poʻe āpau i lawe iā Harvoni i loaʻa iā SVR pane hoʻomau virologic ma hope o ka hoʻoponopono piha. ʻO ka manaʻo ʻo SVR ʻaʻole ʻike hou ʻia ka maʻi i loko o kā lākou koko. Ke loaʻa i kahi kanaka ka SVR, manaʻo ʻia lākou ua hoʻōla ʻia ʻo hepatitis C.

He aha ka helu hōʻola no Harvoni?

ʻO ka helu hoʻōla no Harvoni hilinaʻi ʻia ma kekahi mau ʻano o kāu hepatitis C. Kēia pū inā loaʻa iā ʻoe he cirrhosis a i ʻole, he aha nā hana hepatitis C āu i hoʻāʻo ai i ka wā i hala, a he aha nā genotype o ka maʻi i loaʻa iā ʻoe.

ʻO kahi laʻana, i nā noiʻi olakino o Harvoni, 96 pākēneka o ka poʻe i hālāwai me kēia ʻano wehewehe i hoola ʻia o ka hepatitis C ma hope o 12 mau pule.

  • he genotype 1
  • ʻaʻohe cirrhosis
  • ʻaʻohe mōʻaukala o nā hana hepatitis C ʻē aʻe

I nā noiʻi hoʻokolohua like, ma waena o 86 pakeneka a me 100 pākēneka o nā kānaka me nā moʻolelo olakino ʻokoʻa i hoola ʻia e ka hepatitis C.

Hiki i ka hepatitis C ke hoʻi mai ma hope o ka lawe ʻana iā Harvoni?

Inā lawe ʻoe iā Harvoni i kēlā me kēia lā e like me ke kuhikuhi a kāu kauka a mālama ʻoe i kahi nohona olakino, ʻaʻole pono e hoʻi ka virus.

Eia nō naʻe, hiki ke hoʻi hou (loaʻa hou ka maʻi ʻaʻai). Hana ʻia kēia i ka wā i hōʻola ai kahi lāʻau i ke kanaka o ka hepatitis C, akā ʻike hou nā hōʻike koko i ka maʻi ma hope o ka mālama ʻia ʻana. I nā hoʻokolohua hoʻokolohua, a i 6 pakeneka o ka poʻe i mālama ʻia me Harvoni ua hoʻi hou.

Eia kekahi, inā pili hou ʻoe i ka maʻi hepitis C ma hope o kou lawe ʻana i nā lāʻau hepatitis C, me Harvoni, hiki iā ʻoe ke lilo hou i ka maʻi. Hiki i ka Reinfection ke hana i ke ala like i ʻaelike ʻia ai ka maʻi kumu.

ʻO nā nila kele i hoʻohana ʻia no ka hoʻōla ʻana i nā lāʻau a me ka moekolohe ʻana me ka ʻole o ka pale condom. Ke pale nei i kēia mau hana hiki ke pale i ka hoʻopili hou ʻana me ka hepatitis C.

He aha ka genotype hepatitis C?

Aia he ʻeono mau ʻano ʻokoʻa, a i ʻole nā ​​ʻano, o nā maʻi hepitis C i ʻike ʻia e hoʻopili ʻia i ka poʻe. Kapa ʻia kēia mau ʻāpana nā genotypes.

Hoʻomaopopo ʻia nā genotypes e nā ʻokoʻa i ka code genetic o nā virus. ʻO ka maʻi hepatitis C maʻamau i ʻAmelika Hui Pū ʻIa ʻo ia ka genotype 1, akā ʻike ʻia nā ʻano ʻē aʻe ʻaneʻi.

E hāʻawi aku kāu kauka iā ʻoe i kahi hōʻoia koko e hoʻoholo ai i kahi genotype āu. E kōkua kāu genotype hepatitis C i kāu kauka e hoʻoholo i nā lāʻau kūpono no ʻoe.

Harvoni overdose

Inā lawe nui ʻoe iā Harvoni, hoʻonui ʻoe i kou makaʻu i nā hopena ʻino.

Nā hōʻailona overdose

Hiki i nā ʻōuli o ka overdose o Harvoni ke hoʻopili pū ʻia:

  • luhi
  • ʻeha poʻo poʻo
  • nausea a me ka luaʻi
  • nāwaliwali o nā mākala
  • hiamoe (pilikia hiamoe)
  • ukiuki

He aha e hana ai inā he overdose

Inā manaʻo ʻoe ua lawe nui ʻoe i kēia lāʻau, e kāhea i kāu kauka a i ʻole e ʻimi i ke alakaʻi mai ka ʻAmelika Hui Pū ʻIa Poison Control ma 800-222-1222 a i ʻole ma o kā lākou mea pono pūnaewele. Akā inā koʻikoʻi kāu mau ʻōuli, e kāhea iā 911 a i ʻole e hele koke i kahi lumi pilikia kokoke.

Nā ʻōlelo aʻoaʻo a Harvoni

Hele mai kēia lāʻau lapaʻau me nā ʻōlelo aʻoaʻo.

Ka hoʻolaha ʻana a FDA: Hoʻoulu hou ʻana i ka maʻi hepatitis B

Aia kēia lāʻau i ka ʻōlelo aʻoaʻo a ka pahu. ʻO kēia ka ʻōlelo aʻo koʻikoʻi loa mai ka Food and Drug Administration (FDA). ʻO ka leka hoʻomaopopo e hōʻike i nā kauka a me nā mea maʻi e pili ana i nā hopena lāʻau e weliweli paha.

  • Ke hoʻomaka ka poʻe i coinfected me nā hepatitis C a me ka hepatitis B e lawe iā Harvoni, aia kahi pilikia o ka hoʻoulu hou ʻana i ka maʻi hepatitis B (HBV). Hoʻopaʻa hou ke ʻano o ka virus i hana hou. ʻO ka hoʻoulu hou ʻana o HBV hiki ke alakaʻi i ka ʻole o ke ake a i ʻole ka make. E hoʻāʻo kāu kauka iā ʻoe no HBV ma mua o kou hoʻomaka ʻana i ka lāʻau me Harvoni. Inā loaʻa ʻoe he HBV, pono paha ʻoe e lawe i ka lāʻau e mālama ai.

Nā ʻōlelo aʻoaʻo ʻē aʻe

Ma mua o ka lawe ʻana iā Harvoni, e kamaʻilio me kāu kauka e pili ana i kāu mōʻaukala olakino. ʻAʻole kūpono paha ʻo Harvoni iā ​​ʻoe inā loaʻa iā ʻoe kekahi ʻano olakino.

ʻAʻole ʻike ʻia inā palekana a maikaʻi paha ʻo Harvoni i ka poʻe me nā maʻi puʻuwai koʻikoʻi. Hoʻopili pū kēia me nā kānaka me ka hōʻino kīwī koʻikoʻi a i ʻole me nā maʻi puʻukū hopena e pono ai ka hemodialysis. Eia nō naʻe, mālama maikaʻi ʻia ka poʻe me nā maʻi puʻupuʻu koʻikoʻi nāna i lawe iā Harvoni i kahi noi hoʻokolohua 2018 a ʻaʻohe o lākou hopena maikaʻi ʻole.

Inā loaʻa ʻoe i ka maʻi puʻuwai koʻikoʻi, e kamaʻilio me kāu kauka e pili ana inā kūpono ʻo Harvoni iā ​​ʻoe.

Pau ʻole ʻo Harvoni

Ke haʻalele ʻia ʻo Harvoni mai ka hale kūʻai lāʻau, e hoʻohui ka kauka i kahi lā palena pau i ka lepili ma ka ʻōmole. ʻO kēia lā maʻamau hoʻokahi makahiki mai ka lā i hāʻawi ʻia ai ka lāʻau.

ʻO ke kumu o kēlā mau lā palena pau e hōʻoia i ka hopena o nā lāʻau i kēia manawa. ʻO ke kūlana o ka Food and Drug Administration (FDA) i kēia manawa e hōʻalo i ka hoʻohana ʻana i nā lāʻau i make.

Pehea ka lōʻihi o ka maikaʻi o ka lāʻau e hiki ai ke hilinaʻi i nā kumu he nui, me ke ʻano a me kahi e mālama ʻia ai ka lāʻau. Pono e mālama ʻia nā papa Harvoni ma lalo o 86⁰F (30⁰C) a mālama ʻia i loko o ka pahu i komo ai lākou.

Inā loaʻa iā ʻoe kahi lāʻau i hoʻohana ʻole ʻia i hala i ka lā palena pau, e kamaʻilio me kāu kauka lāʻau e pili ana inā hiki paha iā ʻoe ke hoʻohana.

ʻO ka ʻike ʻoihana no Harvoni

Hāʻawi ʻia ka ʻike aʻe no nā kauka lapaʻau a me nā ʻoihana ola.

Mekanism o ka hana

Loaʻa iā Harvoni nā lāʻau ʻelua: ledipasvir a me sofosbuvir.

Ua pāpā ʻo Ledipasvir i ka protein HCV NS5A, i koi ʻia no ka phosphorylation maikaʻi o ka RNA viral. Ka pāpā ʻana o NS5A ālai i ka hoʻopili hou ʻana o RNA a me ka ʻākoakoa.

ʻO Sofosbuvir kahi mea kāohi iā HCV NS5B polymerase me kahi metabolite hana (kahi triposphateate analog nukleoide) i hoʻokomo ʻia i HCV RNA. Hana ka metabolite hana ma ke ʻano he terminator kaulahao, e hoʻoki ana i ka hoʻopili ʻana o HCV.

Loaʻa ka hana a Harvoni e kūʻē i nā genotypes HCV 1, 4, 5, a me 6.

Pharmacokinetics a me ka metabolism

Loaʻa iā Harvoni nā mea hana ʻelua: ledipasvir a me sofosbuvir.

Ua hōʻea ʻo Ledipasvir i ka piʻi piko ma kahi o ʻehā mau hola a aneane paʻa loa i nā protein plasma. Hana ʻia ka metabolism ma o ka hoʻowali ʻia ma o kahi ʻano ʻike ʻole. ʻO ka hapalua o ke ola ma kahi o 47 mau hola. ʻO ka lāʻau loli ʻole a me kāna metabolites oxidative e kāpae mua ʻia i nā feces.

Kū ka pae kiʻekiʻe o Sofosbuvir i 45 mau minuke i hoʻokahi hola. ʻO ka paʻa ʻana o ka protein protein no 65 pakeneka o ka lāʻau kaapuni. ʻO Sofosbuvir kahi prodrug i hoʻohuli ʻia i metabolite hana (GS-461203) e ka hydrolysis a me ka phosphorylation i ke ake. Hoʻopau hou ʻia ʻo GS-461203 i kahi metabolite hana ʻole.

A i ka 80 pākēneka o ka mahele e hoʻopau ʻia i ka mimi. ʻO ka hapalua o ke ola o ka lāʻau makua he 30 mau minuke, a ʻo ka hapalua o ka ola o ka metabolite hana ʻole ma kahi o 27 mau hola.

Nā Kūʻai Kūʻai

ʻAʻohe mea kū'ē i ka Harvoni e hoʻohana ai. E kuhikuhi i ka ribavirin e kuhikuhi nei i ka ʻikepili no ka contraindications no ka poʻe e loaʻa ana iā Harvoni me ka ribavirin.

Waihona

Pono e mālama ʻia ʻo Harvoni i loko o kāna ipu kumu ma nā mahana i lalo o 86⁰F (30⁰C).

Hoʻolaha: Ua hana ʻo MedicalNewsToday i nā hana āpau e hōʻoia i ka pololei, ka laulā, a me ka lā hou o nā ʻike āpau. Eia nō naʻe, ʻaʻole pono e hoʻohana i kēia ʻatikala i pani no ka ʻike a me ka mākaukau o kahi loea mālama ola laikini. E nīnau mau ʻoe i kāu kauka a i ʻole ʻoihana olakino ʻē aʻe ma mua o ka lawe ʻana i nā lāʻau. Hiki ke loli i ka ʻike o ka lāʻau i loko a ʻaʻole i manaʻo ʻia e uhi i nā hoʻohana a pau, nā kuhikuhi, ka mālama ʻana, nā ʻōlelo aʻoaʻo, nā launa lāʻau, nā hopena maʻi ʻaʻai, a me nā hopena maikaʻi ʻole. ʻO ka loaʻa ʻole o nā ʻōlelo aʻoaʻo a i ʻole nā ​​ʻike ʻē aʻe no kahi lāʻau i hāʻawi ʻia ʻaʻole ia e hōʻike i ka palekana o ka lāʻau a lāʻau paha i kūpono no nā mea maʻi āpau a i ʻole nā ​​hoʻohana kikoʻī āpau.

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