Mea Kākau: Peter Berry
Lā O Ka Hana: 19 Iulai 2021
HōʻAno Hou I Ka Lā: 13 Mei 2024
Anonim
All About Darzalex (daratumumab)
Wikiō: All About Darzalex (daratumumab)

Anter

He aha ʻo Darzalex?

ʻO Darzalex kahi lāʻau lapaʻau inoa inoa inoa inoa inoa. Hoʻohana ʻia ia e mālama i ka myeloma he nui, kahi ʻano o ka maʻi ʻaʻai e pili ana i kekahi o nā hunaola keʻokeʻo i kapa ʻia nā hunaola plasma.

Aia ʻo Darzalex i daratumumab. ʻO kēia kahi ʻano lāʻau i kapa ʻia he monoclonal antibody.

ʻAʻole chemotherapy ʻo Darzalex. ʻO ia kahi ʻano o ka hoʻomōhala hoʻomāka ʻia a i kekahi manawa ua kapa ʻia ʻo immunotherapy. ʻO kēia ka mea i hoʻolālā ʻia ʻo Darzalex e hana me kāu ʻōnaehana pale (ka pale o kou kino i ka maʻi).

Hāʻawi kahi mea mālama ola iā ʻoe iā Darzalex ma ke ʻano he infravenous (IV) infusion i ke keʻena o kāu kauka a i ʻole kahi keʻena lapaʻau. ʻO ka infusion IV kahi injection i loko o kou aa i hāʻawi ʻia ma loko o kahi manawa.

Pehea e hoʻohana ai

Hiki ke kuhikuhi ʻia ʻo Darzalex hoʻokahi a i ʻole me nā lāʻau ʻē aʻe. Ua ʻae ka Food and Drug Administration (FDA) iā Darzalex e hoʻohana ʻia:

  • I nā mākua me ka myeloma hou i ʻike ʻia he nui i hiki ʻole ke loaʻa i kahi transplant cell autologous stem cell. (Me kahi transplant cell autologous stem cell, hoʻohana ʻia kāu mau cell stem.) I kēia kūlana:
    • Hiki ke hoʻohana ʻia ʻo Darzalex me nā lāʻau lenalidomide (Revlimid) a me dexamethasone.
    • Hiki ke hoʻohana pū ʻia ʻo Darzalex me nā lāʻau bortezomib (Velcade), melphalan, a me prednisone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha nā lapaʻau ma mua i holo pono ʻole a i ʻole hoʻi nona ka myeloma maha i hoʻi mai. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me lenalidomide a me dexamethasone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha mau lāʻau myeloma maha ma mua. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me ka bortezomib a me ka dexamethasone.
  • I nā mākua i loaʻa i ʻelua aʻoi aʻe paha mau lapaʻau myeloma i hala e pili ana me ka lenalidomide a me ka mea pale proteasome, kahi ʻano lāʻau. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me nā lāʻau pomalidomide (Pomalyst) a me dexamethasone.
  • I nā mākua i loaʻa he ʻekolu a ʻoi mau lāʻau lapaʻau myeloma i hala aʻe i komo i kahi mea pale proteasome a me kahi lāʻau hoʻomalu. I kēia kūlana, hoʻohana ʻia ʻo Darzalex e ia iho.
  • I nā mākua i hoʻāʻo i kahi mea pale proteasome a me kahi lāʻau hoʻomalu ākea, akā ʻaʻole hana ʻia kekahi lāʻau no ka myeloma he nui. I kēia kūlana, hoʻohana ʻia ʻo Darzalex e ia iho.

Ka hoʻokō ʻana

ʻEono mau noiʻi hoʻokolohua i nānā i ka maikaʻi o Darzalex i ka mālama ʻana i nā myeloma he nui, a hui pū ʻia me nā lāʻau ʻino e kaua ana i ka maʻi ʻaʻai.Kapa ʻia kēia mau haʻawina ʻo MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, a me SIRIUS. Ua hōʻike ʻia ka noiʻi ua ʻoi aku ka maikaʻi o ka mālama ʻana i ka myeloma maha inā ua hoʻohui ʻia ʻo Darzalex i nā ʻano maʻi ʻaʻai maʻamau ma mua o ka hāʻawi wale ʻia ʻana o kēia mau ʻano maʻamau. No ka ʻike hou aku e pili ana i ka pono, e ʻike i ka mahele ʻo "Darzalex no myeloma maha" ma lalo.


ʻO Darzalex generic

Loaʻa ʻo Darzalex ma ke ʻano he lāʻau lapaʻau inoa. ʻAʻole i loaʻa i kēia manawa i ka palapala generic.

Loaʻa iā Darzalex hoʻokahi mea hana lāʻau lapaʻau: daratumumab.

Nā hopena ʻaoʻao Darzalex

Hiki iā Darzalex ke hana i nā hopena ʻoluʻolu a koʻikoʻi paha. Loaʻa i ka papa inoa aʻe kekahi o nā hopena ʻaoʻao nui i hiki ke hana ʻia i ka wā e lawe ana iā Darzalex. ʻAʻole pili kēia papa inoa i nā hopena ʻē aʻe āpau.

No ka ʻike hou aku e pili ana i nā hopena ʻē aʻe o Darzalex, e kamaʻilio me kāu kauka a kauka paha. Hiki iā lākou ke hāʻawi iā ʻoe i nā ʻōlelo aʻoaʻo e pili ana i ka hana me nā hopena ʻē aʻe e hoʻonāukiuki paha.

Nā hopena ʻaoʻao hou aʻe

Hiki i nā hopena ʻaoʻao maʻamau o Darzalex ke hoʻopili pū:

  • luhi nei
  • nāwaliwali a nele paha i ka ikaika
  • Muscle spasms (twitches)
  • nausea a luaʻi paha
  • huhū ʻōpū me ka maʻi diarrhea a i ʻole ka paʻa paʻa
  • hoʻēmi ʻai
  • pilikia hiamoe
  • fiva
  • haʻalulu
  • pōkole o ka hanu a me ke kahe
  • maʻi hanu o luna, e like me ke anuanu
  • bronchitis, he ʻano maʻi maʻi paru
  • ʻeha ke kino
  • ʻeha puʻupuʻu a i ʻole kua
  • ʻūpā

Inā ʻoi aku ke koʻikoʻi o nā hopena ʻaoʻao a i ʻole hele aku, e kamaʻilio me kāu kauka a kauka paha.


Nā hopena hopena koʻikoʻi

ʻAʻole maʻamau nā hopena koʻikoʻi mai Darzalex, akā hiki iā lākou ke hana. Kāhea koke i kāu kauka inā loaʻa nā hopena koʻikoʻi. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Hiki i nā hopena ʻē aʻe a me kā lākou mau hōʻailona ke hoʻohui i kēia:

  • ʻO ka hopena infusion, kahi ʻano o ka hopena alerika. Hiki i nā ʻōuli ke hoʻohui pū:
    • pilikia hanu
    • ʻāʻī puʻupuʻu
    • ʻoliʻoli a poniʻula paha mai ke kahe haʻahaʻa
    • ʻū a ʻū paha
    • ihu ihu a ihu paha
    • nausea a luaʻi paha
    • haʻalulu
    • fiva
    • ʻeha poʻo
    • ʻūlili
  • ʻO ka niumonia, kahi ʻano o ka maʻi ʻaʻai. Hiki i nā ʻōuli ke hoʻohui pū:
    • ʻūhū i ka phlegm (mucus)
    • ke kuni a me ka haʻalulu
    • pokole o ka hanu
    • ʻeha ka umauma
  • Hepatitis B, inā i loaʻa iā ʻoe i ka wā ma mua. Hiki i nā ʻōuli ke hoʻohui pū:
    • mānoanoa luhi
    • melemele o kou ʻili a i ʻole ka ʻāpana keʻokeʻo o kou mau maka
  • ʻO ke neuropathy sensory peripheral (hōʻino nā nerve e hoʻonāukiuki ai, numbness, a ʻeha hoʻi). Hiki i nā ʻōuli ke hoʻohui pū:
    • numbness a i ʻole ʻūlū ʻana
    • ʻeha ʻā
    • ʻike maka
    • nāwaliwali i kou mau lima a me kou mau wāwae
  • ʻO ka edema peripheral (ka pehu ʻana o nā lima a me nā wāwae). Hiki i nā ʻōuli ke hoʻohui pū:
    • pehu o nā lima a mau wāwae paha
    • ʻili kīʻaha
    • ʻili i kuʻi (lua) ke kaomi ʻia no kekona kekona

Nā hopena ʻē aʻe koʻikoʻi, i wehewehe ʻia i nā kikoʻī ma lalo o "nā ʻaoʻao hopena pili," e hoʻopili pū me:


  • hopena maʻi ʻaʻai
  • thrombositopenia, kahi pae haʻahaʻa o nā platelet, kahi ʻano o ke koko e kōkua i ke kōkuʻu koko
  • neutropenia, kahi pae haʻahaʻa o nā neutrophil, kahi ʻano o ke koko keʻokeʻo e kōkua i ke kaua ʻana i nā maʻi
  • shingles (maʻi herpes zoster)

Nā kikoʻī hopena ʻaoʻao

Mahalo paha ʻoe i ka hopena o kekahi mau hopena ʻē aʻe me kēia lāʻau. Eia kekahi kikoʻī i nā hopena ʻino e hiki ai i kēia lāʻau.

Ka hopena hoʻowali

E like me ka nui o nā lāʻau, hiki i kekahi poʻe ke loaʻa i kahi hopena maʻi ma hope o ka lawe ʻana iā Darzalex. ʻAʻole maopopo i ka manawa pinepine o ka poʻe e hoʻohana ana iā Darzalex i ka hopena o ka maʻi ʻaʻa. Hiki i nā ʻōuli o ke ʻano ʻāpiki mālie ke hoʻopili pū i:

  • ʻili hipa a i ʻole nā ​​hives (weluwelu kawa ma kou ʻili)
  • ʻumeʻume
  • flushing (hoʻomehana a ʻulaʻula i kou ʻili)
  • fiva

Kākaʻikahi ka hopena maʻi ʻino ʻoi aku ka paʻakikī akā hiki. Hiki i nā ʻōuli o ke kūpilikiʻi ʻāpiki loa ke hoʻopili pū me

  • ʻōhū ma lalo o kou ʻili, maʻamau i kou lihilihi, lehelehe, lima, a mau wāwae paha
  • pehu o kou alelo, waha, a ʻāʻī paha
  • pilikia hanu

Kāhea koke i kāu kauka inā loaʻa iā ʻoe kahi maʻi maʻi ʻino iā Darzalex. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Pākuʻi infusion

Hāʻawi ʻia ʻo Darzalex i kahi infravenous (IV) infusion i ke keʻena o kāu kauka a i ʻole kahi keʻena lapaʻau. ʻO kēia kahi injection i loko o kou aa i hāʻawi ʻia ma kahi o kekahi manawa. E like me ka nui o nā lāʻau i hāʻawi ʻia ma ke ʻano he infusion IV, loaʻa paha iā ʻoe kahi hopena infusion ma hope o ka loaʻa ʻana o Darzalex. (ʻO kahi hopena infusion kahi ʻano o ka hopena maʻi.)

I ka wā o nā noiʻi maʻi ʻana, ua hana ʻia nā hopena infusion ma kahi o ka hapalua o nā poʻe āpau i mālama ʻia me kahi infusion Darzalex. ʻO ka maʻamau, hana ʻia nā hopena i ka wā o ka infusion mua a akahai a akahai. ʻO ka hapa nui o ka poʻe i loaʻa iā Darzalex i loaʻa i kahi hopena i loko a i ʻole ma waena o 4 mau hola o ka hopena o kahi infusion. ʻAʻole hiki ke hana ʻia nā hopena infusion me nā lāʻau e hiki mai ana. I loko o nā noiʻi, ʻaʻole i hāʻawi ʻia ka poʻe i loaʻa nā lāʻau ʻē aʻe ma mua o Darzalex i nā lāʻau i ke ʻano o nā infusions.

Inā loaʻa kāu hopena infusion i akahai a akahai paha, hiki i kāu kauka ke hoʻomaha i kāu infusion e mālama i ka hopena. Hiki iā lākou ke hoʻomaka hou i ka infusion ma kahi haʻahaʻa haʻahaʻa (wikiwiki) i mea e lohi ai ʻoe i ka lāʻau. Inā koʻikoʻi a hoʻopili ʻia kāu hopena infusion (hoʻoweliweli ola), hiki i kāu kauka ke hoʻopau loa i ka mālama ʻana me Darzalex a hoʻomaka i ka mālama olakino olakino.

I mea e hōʻemi ai i ka manawa o kahi hopena infusion, e hāʻawi aku kāu kauka iā ʻoe i kahi hui o nā lāʻau. Hoʻokahi a ʻekolu mau hola ma mua o kēlā me kēia infusion Darzalex, e loaʻa iā ʻoe:

  • he corticosteroid (e hoʻēmi i ka pehu)
  • he antipyretic (e pale a hōʻemi paha i ke kuni)
  • kahi antihistamine (e pale a hōʻemi paha i nā ʻōuli o nā hopena maʻi)

Hiki paha iā ʻoe ke loaʻa i kahi corticosteroid 1 lā ma hope o ke kōkuhi e hōʻalo i nā hopena lohi. Akā inā ʻoe e lawe nei i kahi steroid e like me dexamethasone a prednisone paha, ʻaʻole paha ʻoe e pono i ka hoʻonui steroid hou.

Inā loaʻa iā ʻoe kahi hopena maʻi ʻino iā Darzalex ma hope o kou haʻalele ʻana i ke keʻena o kāu kauka a i ʻole ke kikowaena infusion, e kāhea koke aku i kāu kauka. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Nā maʻi maʻi koko

Hiki iā Darzalex ke hana i ka thrombositopenia, kahi hoʻoliʻiliʻi o ka pae o kāu platelet. (He ʻano ʻē aʻe ia o ke koko e kōkua ai i ke kūʻē ʻana i ke koko.)

I nā noiʻi hoʻokolohua, ma kahi o 48% a 90% o ka poʻe i lawe iā Darzalex a i ʻole Darzalex me ka maʻamau myeloma maʻamau he thrombositopenia. I ka hoʻohālikelike ʻana, 58% i ka 88% o ka poʻe i loaʻa i nā mālama maʻamau maʻamau ka thrombositopenia.

Hiki iā Darzalex ke kumu i ka neutropenia. ʻO kēia kahi hōʻemi o ke kiʻekiʻe o nā neutrophil, kahi ʻano o ke koko keʻokeʻo e kōkua i ke kaua ʻana i nā maʻi. Hiki i nā ʻōuli ke hoʻopili i ke kuni a me ka maʻi.

I nā noiʻi hoʻokolohua, ma kahi o 58% a 95% o ka poʻe i lawe iā Darzalex a i ʻole Darzalex me nā maʻamau myeloma maʻamau he neutropenia. I ka hoʻohālikelike ʻana, 40% a i 87% o ka poʻe i loaʻa he mau neutropenia maʻamau.

I kāu mālama ʻana iā Darzalex, e nānā pinepine kāu kauka i kāu platelet a me nā helu keʻokeʻo o ke koko keʻokeʻo. E nānā pū lākou iā ʻoe no nā pākī, ke kahe ʻana o ke koko, a i ʻole nā ​​maʻi. Inā hoʻomohala ʻoe i kekahi o kēia mau hōʻailona a hōʻailona paha, e haʻi i kāu kauka.

ʻO Shingles

ʻOiai ʻoe e lawe nei iā Darzalex, hiki iā ʻoe ke hoʻomohala i kahi maʻi i kapa ʻia ʻo shingles (herpes zoster). ʻO kēia no ka loaʻa ʻana o ka myeloma he nui a me ka loaʻa ʻana o nā lapaʻau myeloma he nui i hiki ke hoʻonui i kou makaʻu no ka maʻi.

Ke loaʻa ʻoe i nā shingles, loaʻa paha iā ʻoe:

  • ʻeha ʻā
  • ʻūlū
  • ʻūlili
  • kahi hū a pehu ma ka ʻaoʻao hoʻokahi o kou kino

ʻO ka mea hoʻomaʻi like i ke kumu o ka shingles hiki ke kumu i ka moa. Inā ua loaʻa ʻoe i ka pulupulu i ka wā ma mua, ʻaʻole haʻalele ka maʻi i kou kino ma hope o kou ola ʻana mai ka maʻi. Ma kahi o, e "hiamoe" wale nō ka maʻi ma loko o kou aʻa.

ʻAʻohe mea i ʻike pololei i ke kumu, akā hiki i ka maʻi hoʻomaʻemaʻe ke hoʻoulu hou a i ʻole "ala aʻe" me kekahi mau mea hoʻonāukiuki e like me kahi ʻōnaehana pale nawaliwali. (ʻO kou ʻōnaehana pale ka pale o kou kino i nā maʻi.)

Hiki i nā mālama ʻana i ke kanesa a i ʻole ke kanesa ke hoʻonāwaliwali i kou ʻōnaehana pale a hoʻoulu hou i ka maʻi herpes zoster. Ke ala aʻe, hōʻike ia iā ia iho me he shingles ma kahi o ka moa.

I nā noiʻi hoʻokolohua, ua hōʻike ʻia nā shingles ma 3% o ka poʻe i mālama ʻia me Darzalex wale nō. I ka hoʻohālikelike ʻana, ua hana ʻia nā shingles ma 2% a i 5% o ka poʻe i lawe iā Darzalex me kahi lāʻau maʻi maʻi maʻi hou.

Inā loaʻa ʻoe i ka paukū a me nā shingles i ka wā ma mua a ke lawe nei iā Darzalex, hiki i kāu kauka ke kuhikuhi i kahi lāʻau antiviral. Hiki i kēia ʻano lāʻau ke kōkua i ka pale ʻana i nā shingles mai ka hoʻomohala ʻana i kou kino. Pono ʻoe e lawe i ka lāʻau antiviral ma waena o 1 pule o ka loaʻa mua ʻana iā Darzalex. A laila e hoʻomau ʻoe i ka lawe no 3 mau mahina ma hope o kou hoʻopau ʻana i ka lāʻau me Darzalex.

Pulumonia

Lawe iā Darzalex i alakaʻi iā ʻoe e hoʻomōhala i kahi maʻi puʻupuʻu i kapa ʻia he pneumonia. ʻO kēia no ka mea inā he nui kāu myeloma, ʻoi aku paha ʻoe i ka maʻi ma mua o ka poʻe olakino.

I nā noiʻi hoʻokolohua, 11% a 26% o ka poʻe i lawe iā Darzalex i ulu i ka maʻi pneumonia. Hoʻohālikelike ʻia kēia i ka 6% a i ka 14% o ka poʻe i lawe i kahi placebo (ʻaʻohe lapaʻau).

ʻO ka maʻi Ponia ka maʻi maʻi i hōʻike pinepine ʻia. E hōʻea i ka 4% o ka poʻe ma waena o nā noi Darzalex āpau e hōʻoki i ka lawe ʻana i ka lāʻau ma muli o ka maʻi ponia. Kākaʻikahi ka make ʻana mai ka maʻi pneumonia. Akā inā ua kū ka make, no ka maʻi pneumonia a me sepsis (kahi pane hoʻoweliweli i ke maʻi).

Hiki i nā ʻōuli o ka pulumonia ke hoʻopili pū:

  • ʻūhū i ka phlegm (mucus)
  • ke kuni a me ka haʻalulu
  • pokole o ka hanu
  • ʻeha ka umauma

Inā hoʻomohala ʻoe i nā ʻōuli o ka pulumonia, e haʻi i kāu kauka. Hoʻomaha paha lākou i kāu mahele lāʻau Darzalex e mālama ai i ka niumonia. I nā noiʻi hoʻokolohua, ma kahi o 1% a i ka 4% o ka poʻe i lawe iā Darzalex a i ʻole ʻo ka hoʻomaʻamaʻa ʻana i ka maʻi ʻaʻai maʻamau e hoʻokū i kā lākou mau lāʻau no ka maʻi nui loa

Kumukūʻai ʻo Darzalex

E like me nā lāʻau āpau, hiki ke hoʻololi ke kumukūʻai o Darzalex. E ʻike ai i nā kumukūʻai o Darzalex i kēia manawa i kāu wahi, e nānā iā WellRx.com. ʻO ke kumukūʻai āu e ʻike ai ma WellRx.com ka mea āu e uku ai me ka ʻole o ka ʻinikua. ʻO ke kumukūʻai maoli āu e uku ai e hilinaʻi ia i kāu ʻinikua uhi a me ka hale kūʻai lāʻau lapaʻau āu e hoʻohana ai.

Koi paha kāu papa ʻinikua iā ʻoe e loaʻa i ka ʻae ma mua o ka ʻae ʻana i ka uhi no Darzalex. Pono kēia e hoʻouna i kāu kauka i kahi noi i kāu ʻoihana inikua e noi ana iā lākou e uhi i ka lāʻau. E nānā hou ka ʻoihana ʻinikua i ka noi a ʻike iā ʻoe a me kāu kauka inā e uhi kāu hoʻolālā iā Darzalex.

Inā ʻaʻole ʻoe e maopopo inā pono ʻoe e loaʻa i ka ʻae mua ma mua no Darzalex, e hoʻopili aku i kāu hoʻolālā ʻinikua.

Kōkua kālā a me nā ʻinikua

Inā makemake ʻoe i kākoʻo kālā e uku no Darzalex, a i ʻole inā pono ʻoe e kōkua i ka hoʻomaopopo ʻana i kāu ʻinikua uhi, loaʻa ke kōkua.

Hāʻawi ʻo Janssen Biotech, Inc., ka mea hana o Darzalex, i kahi papahana i kapa ʻia ʻo Janssen CarePath. No ka ʻike hou aku a e ʻike inā he kūpono ʻoe no ke kākoʻo, kāhea iā 844-553-2792 a i ʻole kipa i ka pūnaewele pūnaewele.

Kaha Darzalex

ʻO ka mahele Darzalex i kuhikuhi ʻia e kāu kauka e pili i nā kumu he nui. Pākuʻi ʻia kēia mau mea:

  • inā kuhi hou ʻia kāu kūlana a i ʻole ua loaʻa iā ʻoe i hoʻokahi a ʻoi paha mau lāʻau myeloma i hala (s)
  • ke loaʻa nei nā lāʻau ʻē aʻe me Darzalex e mālama ai i ka myeloma he nui
  • nā kūlana olakino ʻē aʻe āu
  • nā hopena āpau e hele ʻole

Hōʻike ka ʻikepili aʻe i nā lāʻau i hoʻohana pinepine ʻia a koi ʻia paha. E hoʻoholo kāu kauka i ke ana ʻoi loa e kūpono i kāu mau pono. No ka loaʻa ʻana o ka maikaʻi loa o kēia lapaʻau, he mea nui e hele i kāu mau koho āpau a ʻaʻole hoʻi e lele i kēlā me kēia lā.

Nā ʻano lāʻau a me nā ikaika

Hele mai ʻo Darzalex ma ke ʻano he hopena (hoʻohuihui wai) āu e loaʻa ai i ke ʻano o ka injection. He kala ʻole ka hopena i ka melemele. Loaʻa ʻo Darzalex i nā nui ʻelua:

  • 100 mg / 5 ML i loko o ka hue wai hoʻokahi
  • 400 mg / 20 mL i loko o ka hue wai hoʻokahi

E hoʻopili kahi mea mālama ola i kahi ʻāpana o Darzalex me 0.9% sodium chloride (kahi ʻano o ka wai paʻakai). A laila hāʻawi lākou iā ʻoe i kēia lāʻau ma o ke kui kele i kau ʻia i kou aa. Kapa ʻia kēia infusion intravenous (IV).

ʻO ka maʻamau, e hoʻomaka kāu kauka iā ʻoe ma kahi lāʻau i koi ʻia akā ma ka helu haʻahaʻa (wikiwiki) o ke infusion. Ma ka hala ʻana o ka manawa, hoʻoponopono lākou i ka infusion i ka helu i kūpono iā ʻoe. E hilinaʻi kēia i nā hopena infusion āu i loaʻa.

Kuhi paha kāu kuhi mua ʻana iā Darzalex ma kahi o 7 mau hola. ʻO kēia no ka hoʻokomo ʻana o kāu kauka (hāʻawi iā ʻoe) i kāu lāʻau i loko o kou aa. I ka wā e hiki mai ana, e mau ana nā infusions ma kahi o 3 a 5 mau hola no ka mea e kiʻi wikiwiki ana ʻoe i ka lāʻau. E mālama mau kahi mea mālama ola iā ʻoe i kāu mau infusions.

Nā hana no ka myeloma maha

Kau ʻia ʻo Darzalex e ia iho a i ʻole me nā ʻano maʻi ʻaukā ʻē aʻe no nā mākua me ka myeloma he nui. E hilinaʻi ka papa hana a me ka lōʻihi inā ʻike hou ʻia ʻoe a ua loaʻa paha i nā lāʻau ma mua. ʻAʻole i aʻo ʻia ʻo Darzalex i nā keiki.

ʻO ka lāʻau i koi ʻia o Darzalex he 16 milligrams / kilogram (mg / kg) o ke kino maoli ma ke ʻano he IV infusion. ʻO kahi laʻana, kaupaona kahi wahine 110-paona ma kahi o 50 kg. ʻO ia ka mea i koi ʻia ʻo Darzalex mahele lāʻau e 50 kg e hoʻonui ʻia e 16 mg / kg, ʻo ia hoʻi 800 mg.

ʻO nā mākua me ka myeloma hou i ʻike ʻia he nui i hiki ʻole ke kiʻi i kahi transplant cell autologous stem cell

Me kahi transplant cell autologous stem cell, hoʻohana ʻia kāu mau puʻukū iho. ʻO Darzalex hoʻokahi koho koho me ka lenalidomide (Revlimid) a me dexamethasone. ʻO ka papa hana papa kuhikuhi i koi ʻia:

  • Nā wiki 1 a 8: Hoʻokahi mahele lāʻau i kēlā me kēia pule (no ka nui o ʻewalu mau kau)
  • Nā wiki 9 a 24: Hoʻokahi mahele ma kēlā me kēia 2 pule (no ka nui o ʻewalu mau kau)
  • ʻO ka wiki 25 ma mua: Hoʻokahi mahele lāʻau i kēlā me kēia 4 pule

ʻO kekahi koho lapaʻau ʻo Darzalex me bortezomib (Velcade), melphalan, a me prednisone. ʻO ka papa hana papa kuhikuhi i koi ʻia:

  • Nā wiki 1 a 6: Hoʻokahi mahele lāʻau i kēlā me kēia pule (no ka nui o ʻeono mau kau)
  • Nā wiki 7 a 54: Hoʻokahi mahele ma kēlā me kēia 3 mau pule (no ka nui o 16 nā hopena)
  • ʻO ka wiki 55 ma luna: Hoʻokahi mahele lāʻau i kēlā me kēia 4 pule

Nā mākua i loaʻa i hoʻokahi a ʻoi paha nā mālama mua i holo pono ʻole a i ʻole nona ka myeloma maha i hoʻi mai

E loaʻa iā Darzalex me ka lenalidomide a me ka dexamethasone. ʻO ka papa hana papa kuhikuhi i koi ʻia:

  • Nā wiki 1 a 8: Hoʻokahi mahele lāʻau i kēlā me kēia pule (no ka nui o ʻewalu mau kau)
  • Nā wiki 9 a 24: Hoʻokahi mahele ma kēlā me kēia 2 pule (no ka nui o ʻewalu mau kau)
  • ʻO ka wiki 25 ma mua: Hoʻokahi mahele lāʻau i kēlā me kēia 4 pule

Nā mākua i loaʻa i hoʻokahi a ʻoi paha mau lāʻau myeloma maha ma mua.

E loaʻa iā Darzalex me ka bortezomib a me ka dexamethasone. ʻO ka papa hana papa kuhikuhi i koi ʻia:

  • Nā wiki 1 a 9: Hoʻokahi mahele lāʻau i kēlā me kēia pule (no ka helu ʻeiwa mau huina)
  • Nā wiki 10 a 24: Hoʻokahi mahele ma kēlā me kēia pule 3 (no ka nui o ʻelima mau kaha)
  • ʻO ka wiki 25 ma mua: Hoʻokahi mahele lāʻau i kēlā me kēia 4 pule

Nā mākua i loaʻa i ʻelua a ʻoi paha mau hanana myeloma i hala he nui, e like me ka lenalidomide a me ka mea hoʻohiwahiwa proteasome

E loaʻa iā Darzalex me pomalidomide (Pomalyst) a me dexamethasone. ʻO ka papa hana papa kuhikuhi i koi ʻia:

  • Nā wiki 1 a 8: Hoʻokahi mahele lāʻau i kēlā me kēia pule (no ka nui o ʻewalu mau kau)
  • Nā wiki 9 a 24: Hoʻokahi mahele ma kēlā me kēia 2 pule (no ka nui o ʻewalu mau kau)
  • ʻO ka wiki 25 ma mua: Hoʻokahi mahele lāʻau i kēlā me kēia 4 pule

ʻO nā mākua i loaʻa he ʻekolu a ʻoi mau lāʻau lapaʻau myeloma paha he nui ma mua, e like me ka proteasome mea kāohi a me kahi lāʻau pale

E loaʻa iā Darzalex wale nō. ʻO ka papa hana papa kuhikuhi i koi ʻia:

  • Nā wiki 1 a 8: Hoʻokahi mahele lāʻau i kēlā me kēia pule (no ka nui o ʻewalu mau kau)
  • Nā wiki 9 a 24: Hoʻokahi mahele ma kēlā me kēia 2 pule (no ka nui o ʻewalu mau kau)
  • ʻO ka wiki 25 ma mua: Hoʻokahi mahele lāʻau i kēlā me kēia 4 pule

I mea e hōʻemi ai i ka manawa o kahi hopena infusion, e hāʻawi aku kāu kauka iā ʻoe i kahi hui o nā lāʻau. Hoʻokahi i ʻekolu mau hola ma mua o kēlā me kēia infusion Darzalex, e loaʻa iā ʻoe:

  • he corticosteroid (e hoʻēmi i ka pehu)
  • he antipyretic (e pale a hōʻemi paha i kahi kuni)
  • kahi antihistamine (e pale a hōʻemi paha i nā ʻōuli o nā hopena maʻi ʻaʻai).

Hiki paha iā ʻoe ke loaʻa i kahi corticosteroid 1 lā ma hope o ke kōkuhi e hōʻalo i nā hopena lohi. Akā inā ʻoe e lawe nei i kahi steroid e like me dexamethasone a prednisone paha, ʻaʻole paha ʻoe e pono i ka hoʻonui steroid hou.

He aha inā e haʻo wau i kahi lāʻau?

Inā ʻoe e nalo i kahi manawa no kahi infusion Darzalex, e kāhea koke aku i kāu kauka e hoʻoponopono hou. E hoʻoponopono lākou i kāu papa hana hana e hōʻoia i ka loaʻa ʻana o ka helu kūpono o nā mālama ʻana i ka manawa kūpono.

Pono wau e hoʻohana i kēia lāʻau lōʻihi?

I nā noiʻi hoʻokolohua, ʻo ka manawa maʻamau no Darzalex e hoʻomaka ai i ka hana he 1 mahina.

Eia nō naʻe, hiki ke hāʻawi ʻia i kāu mau kau ma kahi o kahi manawa lōʻihi. E hilinaʻi kēia i ka pane ʻana o kou kino iā Darzalex a inā e hoʻomaka ka maikaʻi o kāu myeloma maha.

E hilinaʻi nō hoʻi ka lōʻihi o ka mālama ʻana inā ʻike hou ʻia kāu myeloma maha a i ʻole inā ua loaʻa iā ʻoe nā hana ma mua.

ʻO Darzalex no myeloma maha

Ua ʻae ka Food and Drug Administration (FDA) iā Darzalex no ka mālama ʻana i nā myeloma he nui.

ʻO kēia kahi ʻano o ka maʻi ʻaʻai e hoʻopili i kekahi o nā hunaola keokeo i kapa ʻia nā hunaola plasma. Hana nā hunaola Plasma i ʻāpana o kāu ʻōnaehana pale a kōkua i ke kaua ʻana i nā maʻi i kou kino. I ka myeloma he nui, hoʻololi ʻia nā hunaola plasma i mau hunaola myeloma maha. Ke ulu a pālahalaha nā sel myeloma he nui, hiki iā lākou ke hōʻuluʻulu i nā hunaola olakino a hōʻino i ka iwi a puni lākou.

Ua ʻae ʻia ʻo Darzalex e hoʻohana:

  • I nā mākua me ka myeloma hou i ʻike ʻia he nui i hiki ʻole ke loaʻa i kahi transplant cell autologous stem cell. (Me kahi transplant cell autologous stem cell, hoʻohana ʻia kāu mau cell stem.) I kēia kūlana:
    • Hiki ke hoʻohana ʻia ʻo Darzalex me nā lāʻau lenalidomide (Revlimid) a me dexamethasone.
    • Hiki ke hoʻohana pū ʻia ʻo Darzalex me nā lāʻau bortezomib (Velcade), melphalan, a me prednisone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha nā lapaʻau ma mua i holo pono ʻole a i ʻole hoʻi nona ka myeloma maha i hoʻi mai. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me lenalidomide a me dexamethasone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha mau lāʻau myeloma maha ma mua. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me ka bortezomib a me ka dexamethasone.
  • I nā mākua i loaʻa i ʻelua aʻoi aʻe paha mau lapaʻau myeloma i hala e pili ana me ka lenalidomide a me ka mea pale proteasome, kahi ʻano lāʻau. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me nā lāʻau pomalidomide (Pomalyst) a me dexamethasone.
  • I nā mākua i loaʻa he ʻekolu a ʻoi mau lāʻau lapaʻau myeloma i hala aʻe i komo i kahi mea pale proteasome a me kahi lāʻau hoʻomalu. I kēia kūlana, hoʻohana ʻia ʻo Darzalex e ia iho.
  • I nā mākua i hoʻāʻo i kahi mea pale proteasome a me kahi lāʻau hoʻomalu ākea akā ʻaʻole hana ʻia kekahi lāʻau no ka myeloma he nui. I kēia kūlana, hoʻohana ʻia ʻo Darzalex e ia iho.

Ka hoʻokō ʻana

ʻEono mau noiʻi hoʻokolohua i nānā i ka maikaʻi o Darzalex i ka mālama ʻana i nā myeloma he nui wale a hui pū ʻia me nā lāʻau ʻino e kaua ana i ka maʻi ʻaʻai. Kapa ʻia kēia mau haʻawina ʻo MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, a me SIRIUS. Ua hōʻike ka noiʻi ua ʻoi aku ka maikaʻi o ka mālama inā ua hoʻohui ʻia ʻo Darzalex i nā ʻano maʻi ʻaʻai maʻamau ma mua o ka hāʻawi wale ʻia ʻana o kēia mau ʻano maʻamau.

Ke aʻo MAIA

Ua nānā ka MAIA noiʻi i ka poʻe i ʻike hou ʻia me ka myeloma he nui i hiki ʻole ke loaʻa i kahi transplant cell autologous stem cell. Loaʻa i ka poʻe i ka hoʻomaʻamaʻa maʻi ʻaʻai maʻamau o lenalidomide (Revlimid) a me dexamethasone haʻahaʻa a i ʻole ka lāʻau like me Darzalex. Hoʻohālikelike ʻia i ka hui maʻamau maʻamau, ua loaʻa i ka hui Darzalex kahi 44% haʻahaʻa o ko lākou myeloma e nui ana a i ʻole ka make.

No nā mahina 42 o ke aʻo ʻana, ʻaʻole i ʻoi aku ka hewa o ka myeloma he nui i ka poʻe i lawe iā Darzalex me ka lapaʻau maʻamau. No ka poʻe i lawe i ka lapaʻau maʻamau, ma kahi o 31.9 mau mahina ma mua o ka hoʻomaka ʻana o ka myeloma maha e lilo i mea ʻino. ʻO ka helu pane pane piha he 47.6% no ka poʻe i mālama ʻia me Darzalex a me 24.9% no ka poʻe i loaʻa ka lāʻau maʻamau. (ʻO ka pane piha ʻo ia hoʻi ua pau nā maʻi ʻaʻai a ʻaʻohe hōʻailona o ka maʻi i nā hoʻokolohua lab, X-ray, a me nā hoʻokolohua hoʻokolohua.)

Ke aʻo ʻana iā ALCYONE

Ua nānā ka noiʻi ALCYONE i ka poʻe hou i ʻike ʻia me ka myeloma he nui i hiki ʻole ke loaʻa kahi transplant cell autologous stem cell. Ua loaʻa i kēia poʻe ka hoʻomaʻamaʻa ʻana o ka maʻi ʻaʻai o bortezomib (Velcade), melphalan, a me prednisone a i ʻole ia lapaʻau me Darzalex. Hoʻohālikelike ʻia i ka hui maʻamau maʻamau, loaʻa i ka hui Darzalex kahi 50% haʻahaʻa o kā lākou myeloma he nui a ʻoi paha ka make.

ʻO ka poʻe i loaʻa i ka lāʻau Darzalex, 42.6% i pane piha. Hoʻohālikelike ʻia kēia me 24.4% o ka poʻe i loaʻa i ka lāʻau maʻamau maʻamau.

Ke aʻo ʻana o POLLUX

Ua nānā ka noiʻi POLLUX i ka poʻe me ka myeloma he nui i loaʻa ma kahi o hoʻokahi lapaʻau ma mua. Lawe ka poʻe i kahi maʻamau maʻamau o lenalidomide a me dexamethasone a i ʻole ka hana like a me Darzalex. Ua hōʻike ʻia nā hopena ma kahi o 91.3% o ka poʻe i pane i ka mālama ʻana me Darzalex ma kahi o 74.6% o ka poʻe i loaʻa i ka lāʻau maʻamau maʻamau.

Hoʻohālikelike ʻia i ka hui lapaʻau maʻamau, ʻo ka hui i mālama ʻia me Darzalex i loaʻa kahi 63% haʻahaʻa o ka pilikia o kā lākou myeloma maha iʻoi aʻe ka maikaʻi. Ma hope o 13.5 mau mahina, ua ʻike ʻo 19% o ka hui Darzalex i ko lākou myeloma maha a ʻoi paha i hala. Ua hoʻohālikelike ʻia kēia i ka 41% o ka hui mālama maʻamau.

Ke aʻo CASTOR

Ua nānā pū ka noiʻi CASTOR i ka poʻe me ka myeloma he nui i loaʻa ma kahi o hoʻokahi lapaʻau ma mua. Lawe ka poʻe i kahi lapaʻau maʻamau o bortezomib a me dexamethasone a i ʻole ka hana like a me Darzalex. Ua like nā hopena me nā hopena o ka noiʻi POLLUX. Ma kahi o 73.9% o ka poʻe i pane i ka mālama ʻana me Darzalex i hoʻohālikelike ʻia ma kahi o 59.9% o ka poʻe i loaʻa i ka lāʻau maʻamau maʻamau.

Hoʻohālikelike ʻia i ka maʻamau maʻamau, ua hoʻopili ʻia ka mālama Darzalex i kahi 61% haʻahaʻa o ka myeloma e nui ana a i ʻole ka make. ʻO ka poʻe i lawe iā Darzalex hiki iā lākou ke noho i ke kala no ka manawa lōʻihi. (ʻO ke kala ke kumu o ka holo ʻana o ka maʻi ʻaʻai e lohi.)

Ke aʻo ʻana iā EQUULEUS

Ua nānā ka noiʻi EQUULEUS i ka poʻe 103 me ka myeloma he nui i mālama ʻia ma kahi o ʻehā mau manawa no kā lākou myeloma maha. Ua loaʻa i kēia poʻe i ʻelua mau ʻano o ka mālama ʻana: kahi proteasome mea kāohi a me kahi lāʻau hoʻomalu. Ua mālama nā kānaka āpau i kahi maʻamau maʻamau o pomalidomide (Pomalyst) a me dexamethasone a me Darzalex. ʻO ka pahuhopu nui o ke aʻo ʻana e ʻike i ka nui o ka poʻe i pane i ka lāʻau.

Ma ke ʻano holoʻokoʻa, hoʻomaka ka hana ma kahi o 1 mahina i ka hapanui o ka poʻe. Ua hana ka lapaʻau no ka awelika ma kahi o 13.6 mau mahina. Ua hōʻemi ʻia nā ʻōuli myeloma he nui e 90% a ʻoi paha i 42% o ka poʻe. ʻAʻole i koe kekahi kanesa i ka hopena o ke aʻo ʻana.

Ke aʻo SIRIUS

Ua nānā ka noiʻi SIRIUS i ka 106 poʻe me ka myeloma he nui i maʻi nui a loaʻa ka awelika o ʻelima mau lapaʻau ma mua. Ua hāʻawi ʻia nā kānaka āpau i ke aʻo ʻana ʻo Darzalex wale nō. ʻO ka pahuhopu nui o ke aʻo ʻana e ʻike i ka nui o ka poʻe i pane i ka lāʻau.

Ma ka hapanui, 31 mau kānaka i loaʻa iā Darzalex i hōʻemi ʻia ko lākou mau maʻi myeloma he nui. Ma kahi o 64.8% o ka poʻe i lawe iā Darzalex i kēia noi ʻana i ola no 12 mau mahina.

I mea e hōʻemi ai i ka manawa e loaʻa ai kahi hopena infusion, ua hāʻawi ʻia ka poʻe i kēia mau noiʻi āpau i kahi hui o nā lāʻau. Hoʻokahi i ʻekolu mau hola ma mua o kēlā me kēia Darzalex infusion, loaʻa iā lākou:

  • he corticosteroid (e hoʻēmi i ka pehu)
  • he antipyretic (e pale a hōʻemi paha i kahi kuni)
  • kahi antihistamine (e pale a hōʻemi paha i nā ʻōuli o nā hopena maʻi)

Ua loaʻa paha iā lākou kahi corticosteroid 1 lā ma hope o ke kōkuhi e hōʻalo i nā hopena lohi. Akā inā e lawe nei ka poʻe i kahi steroid e like me dexamethasone a i ʻole prednisone, ʻaʻole paha lākou e pono i ka hoʻonui steroid hou.

Darzalex no nā kūlana ʻē aʻe

Hoʻohui ʻia me ka myeloma he nui, ke hoʻopaʻa ʻia nei ʻo Darzalex ma ke ʻano he lapaʻau no ka amyloidosis kaulahao kukui immunoglobulin.

Darzalex no ka amyloidosis kaulahao immunoglobulin (ma lalo o ka hoʻopaʻa haʻawina)

ʻO ke immunoglobulin chain chain amyloidosis (AL) kahi ʻano a kahi mau protein i kapa ʻia nā kaulahao māmā e kūkulu i loko o kāu mau kino a puni kou kino. ʻO ka maʻamau, hoʻopili ʻia kou puʻuwai, hakuʻala, palolo, a me ke akepaʻa. Hiki i ka buildup protein ke hōʻino a hoʻolilo i kēia mau ʻōpala i holopono ʻole.

ʻAʻole i ʻae ʻia ʻo Darzalex e mālama iā AL. Eia nō naʻe, aia kekahi mau noiʻi liʻiliʻi e hoʻohana ana iā Darzalex off-label e mālama ai i kēia ʻano. (ʻO ka hoʻohana inoa ʻole ke hoʻohana ʻia kahi lāʻau i ʻae ʻia e mālama i hoʻokahi ʻano e hoʻohana ai i kahi ʻano ʻē aʻe.)

I hoʻokahi noi, hāʻawi ʻia ʻo Darzalex i ka poʻe me AL i loaʻa, ma ka awelika, loaʻa ʻekolu mau ʻano lapaʻau ʻokoʻa i holo ʻole. Ua hana ʻo Darzalex i kahi pane aneane piha a piha paha i 76% o ka poʻe i lawe i ka lāʻau. (Piha ka pane ʻo ia hoʻi ua pau nā maʻi āpau a ʻaʻohe hōʻailona o ka maʻi i nā hoʻokolohua lab, X-ray, nā hoʻokolohua hoʻokolohua.) I nā hihia i hōʻike ʻia, ua maikaʻi ʻo Darzalex i ka mālama ʻana iā AL a me ka hoʻomaikaʻi ʻana i ke ola o nā poʻe i lawe i ka lāʻau.

Pono nā noiʻi hou aʻe e hōʻoia i ka hana maikaʻi ʻana a Darzalex a palekana ke hoʻohana ʻia i nā poʻe me AL. A hiki i kēlā manawa, hiki i nā mea noiʻi ke hoʻohana iā Darzalex no nā poʻe me AL i loaʻa ʻole nā ​​koho koho mua ʻē aʻe, ua ʻāpono ʻia e ka FDA.

Hoʻohana ʻo Darzalex me nā lāʻau ʻē aʻe no ka myeloma maha

Kau ʻia ʻo Darzalex e ia iho a i ʻole me nā ʻano ʻano ʻē aʻe o ka mālama ʻana i ka maʻi ʻaʻai no nā mākua me ka myeloma he nui. E hilinaʻi ka papa hana a me ka lōʻihi inā ʻike hou ʻia ʻoe a ua loaʻa paha i nā lāʻau ma mua.

Ua ʻae ʻia ʻo Darzalex e hoʻohana pū ʻia me:

  • lenalidomide (Revlimid) a me dexamethasone i nā mākua me kahi myeloma hou he nui i ʻike ʻia ʻaʻole hiki ke loaʻa kahi transplant cell autologous stem cell. (Me kahi transplant cell autologous stem cell, hoʻohana ʻia kāu mau cell stem.)
  • ʻo lenalidomide a me dexamethasone i nā mākua i loaʻa i hoʻokahi a ʻoi paha mau hana ma mua i holo pono ʻole a i ʻole nona ka myeloma maha i hoʻi mai.
  • bortezomib (Velcade), melphalan, a me prednisone i nā mākua me ka myeloma hou i ʻike ʻia he nui i hiki ʻole ke loaʻa i kahi transplant cell autologous stem cell.
  • bortezomib a me dexamethasone i nā mākua i loaʻa i hoʻokahi a ʻoi paha mau lāʻau myeloma i hala.
  • pomalidomide (Pomalyst) a me dexamethasone i nā mākua i loaʻa i ʻelua aʻoi aku paha mau maʻi myeloma i hala. Pono e hoʻopili i kēia mau ʻano hana i ka lenalidomide a me ka mea hoʻohiwahiwa proteasome.

ʻEono mau noiʻi hoʻokolohua i nānā i ka maikaʻi o Darzalex i ka mālama ʻana i nā myeloma he nui, a hui pū ʻia me nā lāʻau ʻino e kaua ana i ka maʻi ʻaʻai. Kapa ʻia kēia mau haʻawina ʻo MAIA, ALCYONE, POLLUX, CASTOR, EQUULEUS, a me SIRIUS. Ua hōʻike ʻia ka noiʻi ua ʻoi aku ka maikaʻi o ka mālama ʻana i ka myeloma maha inā ua hoʻohui ʻia ʻo Darzalex i nā ʻano maʻi ʻaʻai maʻamau ma mua o ka hāʻawi wale ʻia ʻana o kēia mau ʻano maʻamau. No nā kikoʻī e pili ana i kēia mau aʻo ʻana, e ʻoluʻolu e ʻike i ka ʻāpana "Darzalex no myeloma maha" ma luna.

Nā koho ʻē aʻe iā Darzalex

Loaʻa nā lāʻau ʻē aʻe i hiki ke mālama i ka myeloma he nui. Kūpono paha kekahi iā ʻoe ma mua o nā poʻe ʻē aʻe. Inā hoihoi ʻoe i ka ʻimi ʻana i kahi koho ʻē aʻe iā Darzalex, e kamaʻilio me kāu kauka e aʻo hou e pili ana i nā lāʻau ʻē aʻe e holo pono paha iā ʻoe.

Ma lalo iho kahi papa inoa o nā lāʻau i koi ʻia e nā alakaʻi o ka National Comprehensive Cancer Network no ka mālama ʻana i nā myeloma he nui:

  • Nā lāʻau Chemotherapy, e like me:
    • bendamustine (Bendeka a i ʻole Treanda)
    • cisplatin
    • cyclophosphamide (Cytoxan)
    • doxorubicin (Doxil)
    • etoposide (Etopophos)
    • melphalan (Alkeran)
  • Nā mea kūpale protein, e like me:
    • bortezomib (Velcade)
    • carfilzomib (Kyprolis)
    • ixazomib (Ninlaro)
  • Nā monemona monoclonal, e like me:
    • elotuzumab (Empliciti)
  • Nā mea hoʻopukapuka Histone deacetylase, e like me:
    • panobinostat (Farydak)
  • Immunomodulators, e like me:
    • lenalidomide (Revlimid)
    • pomalidomide (Pomalyst)
    • thalidomide (Thalomid)
  • ʻO Corticosteroids, e like me:
    • dexamethasone (Decadron)

Kaha: Hiki ke hoʻohana ʻia kekahi o nā lāʻau i waho i ka lepili e mālama ai i ka nui o ka myeloma.

Darzalex vs. Empliciti

Mahalo paha ʻoe pehea e hoʻohālikelike ai ʻo Darzalex i nā lāʻau ʻē aʻe i kuhikuhi ʻia no nā hoʻohana like. Maanei mākou e nānā ai pehea Darzalex a me Empliciti like a ʻokoʻa hoʻi.

E pili ana i

Aia ʻo Darzalex i daratumumab, ʻoiai ʻo Empliciti kahi elotuzumab. ʻO Darzalex lāua ʻo Empliciti kahi ʻāpana o nā lāʻau i kapa ʻia he monoclonal antibodies. (ʻO ka papa o nā lāʻau lapaʻau kahi hui o nā lāʻau e hana i ke ʻano like.) Ua manaʻo ʻia ʻo Darzalex lāua ʻo Empliciti he mau mea lapaʻau i manaʻo ʻia no nā myeloma he nui.

Hoʻohana

Ua ʻae ka Food and Drug Administration (FDA) iā Darzalex a me Empliciti e mālama i nā myeloma he nui.

Ua ʻae ʻia ʻo Darzalex e hoʻohana:

  • I nā mākua me ka myeloma hou i ʻike ʻia he nui i hiki ʻole ke loaʻa i kahi transplant cell autologous stem cell. (Me kahi transplant cell autologous stem cell, hoʻohana ʻia kāu mau cell stem.) I kēia kūlana:
    • Hiki ke hoʻohana ʻia ʻo Darzalex me nā lāʻau lenalidomide (Revlimid) a me dexamethasone.
    • Hiki ke hoʻohana pū ʻia ʻo Darzalex me nā lāʻau bortezomib (Velcade), melphalan, a me prednisone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha nā lapaʻau ma mua i holo pono ʻole a i ʻole hoʻi nona ka myeloma maha i hoʻi mai. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me lenalidomide a me dexamethasone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha mau lāʻau myeloma maha ma mua. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me ka bortezomib a me ka dexamethasone.
  • I nā mākua i loaʻa i ʻelua aʻoi aʻe paha mau lapaʻau myeloma i hala e pili ana me ka lenalidomide a me ka mea pale proteasome, kahi ʻano lāʻau. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me nā lāʻau pomalidomide (Pomalyst) a me dexamethasone.
  • I nā mākua i loaʻa he ʻekolu a ʻoi mau lāʻau lapaʻau myeloma i hala aʻe i komo i kahi mea pale proteasome a me kahi lāʻau hoʻomalu. I kēia kūlana, hoʻohana ʻia ʻo Darzalex e ia iho.
  • I nā mākua i hoʻāʻo i kahi mea pale proteasome a me kahi lāʻau hoʻomalu ākea akā ʻaʻole hana ʻia kekahi lāʻau no ka myeloma he nui. I kēia kūlana, hoʻohana ʻia ʻo Darzalex e ia iho.

Ua ʻae ʻia ʻo Empliciti e hoʻohana ʻia:

  • I nā mākua i loaʻa i hoʻokahi a ʻekolu mau lāʻau i hala mua no ko lākou myeloma maha. Hoʻohana ʻia ʻo Empliciti me lenalidomide (Revlimid) a me dexamethasone.
  • I nā mākua i loaʻa i ʻelua mau hana ma mua e pili ana me ka lenalidomide a me kahi mea kūpale proteasome. Hoʻohana ʻia ʻo Empliciti me pomalidomide (Pomalyst) a me dexamethasone.

ʻO ka maʻamau, hāʻawi ʻia ʻo Empliciti inā hoʻi mai kāu myeloma maha ma hope o nā ʻano lāʻau ʻē aʻe.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hāʻawi ʻia ʻo Darzalex a me Empliciti ma ke ʻano he infusion intravenous (IV). ʻO kēia kahi injection i hoʻokomo lohi ʻia i ka manawa ma o kahi nila i kau ʻia i kou aa.

No Darzalex

Hele mai ʻo Darzalex ma ke ʻano he hopena (hoʻohuihui wai) āu e loaʻa ai i ke ʻano o ka injection. Hiki ke kala ʻole i ka hopena ma ka melemele melemele. Loaʻa ka lāʻau i nā nui ʻelua:

  • 100 mg / 5 ML i loko o ka hue wai hoʻokahi
  • 400 mg / 20 mL i loko o ka hue wai hoʻokahi

I mea e hōʻemi ai i ka manawa o kahi hopena infusion, e hāʻawi aku kāu kauka iā ʻoe i kahi hui o nā lāʻau. Hoʻokahi i ʻekolu mau hola ma mua o kēlā me kēia infusion Darzalex, e loaʻa iā ʻoe:

  • he corticosteroid e hoʻēmi i ka pehu
  • kahi antipyretic e pale a hoʻēmi paha i ke kuni
  • kahi antihistamine e pale a hōʻemi paha i nā ʻōuli o nā hopena maʻi ʻaʻai

Hiki paha iā ʻoe ke loaʻa i kahi corticosteroid 1 lā ma hope o ke kōkuhi e hōʻalo i nā hopena lohi. Akā inā ʻoe e lawe nei i kahi steroid e like me dexamethasone a prednisone paha, ʻaʻole paha ʻoe e pono i ka hoʻonui steroid hou.

No Empliciti

Hele mai ʻo Empliciti ma ke ʻano he keʻokeʻo i ka pauka keʻokeʻo keʻokeʻo. E kāwili kahi mea lawelawe olakino i kēia me kahi hopena e hāʻawi iā ʻoe ma ke ʻano he injection. Loaʻa ʻo Empliciti i nā ikaika ʻelua:

  • 300 mg i kahi kīʻaha kū hoʻokahi
  • 400 mg i kahi kīʻaha kū hoʻokahi

I mea e hōʻemi ai i ka manawa o kahi hopena infusion, e hāʻawi aku kāu kauka iā ʻoe i kahi hui o nā lāʻau. Ma kahi o 45 a 90 mau minuke ma mua o ka hoʻokomo ʻana o Empliciti, e loaʻa iā ʻoe:

  • acetaminophen e pale a hōʻemi paha i ke kuni
  • diphenhydramine (Benadryl) e pale a hōʻemi paha i nā ʻōuli o nā hopena maʻi
  • ranitidine e pale a hoʻēmi paha i nā ʻōuli o nā hopena maʻi ʻaʻai
  • dexamethasone e hōʻemi i ka pehu

Nā hopena a me nā pilikia

Loaʻa iā Darzalex lāua ʻo Empliciti nā lāʻau i hana like. No laila, hiki i nā lāʻau ʻelua ke hana i nā hopena ʻaoʻao like loa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Darzalex, me Empliciti, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Darzalex:
    • nāwaliwali
    • ʻeha ke kino a ʻeha pū paha
    • nausea
    • pilikia hiamoe
    • bronchitis, he ʻano maʻi maʻi paru
    • ʻūpā
  • Hiki ke hana me Empliciti:
    • kō kō kiʻekiʻe *
    • ʻehaʻeha i kou mau lima a mau wāwae * *
  • Hiki ke hana me Darzalex a me Empliciti:
    • luhi a hemahema paha
    • huhū ʻōpū me ka maʻi diarrhea a i ʻole ka paʻa paʻa
    • hoʻēmi ʻai
    • fiva
    • haʻalulu
    • pōkole o ka hanu a me ke kahe
    • maʻi hanu o luna e like me ke anu
    • Muscle spasms (twitches)
    • ka luaʻi
    • edema peripheral, ka ʻōhū o nā lima a me nā wāwae

** Ke hoʻohana ʻia ʻo Empliciti me lenalidomide a me dexamethasone

Nā hopena hopena koʻikoʻi

Loaʻa i kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana me Darzalex, me Empliciti, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Darzalex:
    • thrombositopenia, kahi pae haʻahaʻa o nā platelet, kahi ʻano o ke koko e kōkua i ke kōkuʻu koko
    • neutropenia, kahi pae haʻahaʻa o nā neutrophil, kahi ʻano o ke koko keʻokeʻo e kōkua i ke kaua ʻana i nā maʻi
    • shingles (maʻi herpes zoster)
  • Hiki ke hana me Empliciti:
    • maʻi ʻaʻai hou
    • nā pilikia ate
  • Hiki ke hana me Darzalex a me Empliciti:
    • nā hopena infusion
    • pneumonia, he ʻano maʻi maʻi paru
    • ʻo ke neuropathy sensory peripheral, kahi ʻano o ke ʻino nerve e hiki ai i ke kani ʻana, ka helu ʻana, a me ka ʻeha

Ka hoʻokō ʻana

He ʻano ʻokoʻa kā Darzalex a me Empliciti i hoʻohana ʻia e ka FDA, akā hoʻohana ʻia lāua e mālama i nā myeloma he nui i nā mākua.

ʻAʻole hoʻohālikelike pololei ʻia kēia mau lāʻau i loko o nā noiʻi haukapila (i kapa ʻia he poʻo a he poʻo poʻo). Eia naʻe, ua nānā ʻia kahi loiloi o 13 noiʻi hoʻokolohua o Darzalex a me Empliciti ua maikaʻi nā lāʻau ʻelua i ka hoʻolohi ʻana i ka holomua (worsening) o ka myeloma he nui.

No ka poʻe nona ka myeloma he nui i hoʻi mai a hoʻomau i ka ulu ʻana ma hope o ka nui o nā mālama ʻana, kuhikuhi ka National National Comprehensive Cancer Network iā Darzalex ma mua. Inā ʻaʻole e holo ʻo Darzalex, ʻo ka mālama ʻana me Empliciti kahi koho ʻē aʻe.

Nā kumukūʻai

ʻO Darzalex lāua ʻo Empliciti nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe ʻano generic o nā lāʻau āpau i kēia manawa. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma WellRx.com, ʻoi aku ka uku o Darzalex ma mua o Empliciti. ʻO ke kumukūʻai maoli āu e uku ai no kēlā me kēia lāʻau e pili ana i kāu hoʻolālā ʻinikua a me kāu wahi.

Darzalex vs. Kyprolis

E like me Empliciti (ma luna), hoʻohana ʻo ka lāʻau Kyprolis e like me ka Darzalex. E nānā i kēia manawa pehea Darzalex a me Kyprolis like a ʻokoʻa.

E pili ana i

Aia ʻo Darzalex i ka daratumumab, ʻoiai ʻo Kyprolis kahi carfilzomib. Ua manaʻo ʻia nā lāʻau ʻelua no ka myeloma maha. Eia nō naʻe, aia nā lāʻau i loko o nā papa lāʻau ʻokoʻa. (ʻO ka papa o nā lāʻau lapaʻau kahi hui o nā lāʻau e hana ma ke ʻano like.) ʻO Darzalex kahi ʻano lāʻau i kapa ʻia he monoclonal antibody. ʻO Kyprolis kahi ʻano lāʻau i kapa ʻia he proteasome inhibitor.

Hoʻohana

Ua ʻae ka Food and Drug Administration (FDA) iā Darzalex e hoʻohana ʻia:

  • I nā mākua me ka myeloma hou i ʻike ʻia he nui i hiki ʻole ke loaʻa i kahi transplant cell autologous stem cell. (Me kahi transplant cell autologous stem cell, hoʻohana ʻia kāu mau cell stem.) I kēia kūlana:
    • Hiki ke hoʻohana ʻia ʻo Darzalex me nā lāʻau lenalidomide (Revlimid) a me dexamethasone.
    • Hiki ke hoʻohana pū ʻia ʻo Darzalex me nā lāʻau bortezomib (Velcade), melphalan, a me prednisone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha nā lapaʻau ma mua i holo pono ʻole a i ʻole hoʻi nona ka myeloma maha i hoʻi mai. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me lenalidomide a me dexamethasone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha mau lāʻau myeloma maha ma mua. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me ka bortezomib a me ka dexamethasone.
  • I nā mākua i loaʻa i ʻelua aʻoi aʻe paha mau lapaʻau myeloma i hala e pili ana me ka lenalidomide a me ka mea pale proteasome, kahi ʻano lāʻau. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me nā lāʻau pomalidomide (Pomalyst) a me dexamethasone.
  • I nā mākua i loaʻa he ʻekolu a ʻoi mau lāʻau lapaʻau myeloma i hala aʻe i komo i kahi mea pale proteasome a me kahi lāʻau hoʻomalu. I kēia kūlana, hoʻohana ʻia ʻo Darzalex e ia iho.
  • I nā mākua i hoʻāʻo i kahi mea pale proteasome a me kahi lāʻau hoʻomalu ākea akā ʻaʻole hana ʻia kekahi lāʻau no ka myeloma he nui. I kēia kūlana, hoʻohana ʻia ʻo Darzalex e ia iho.

Ua ʻae ʻia ʻo Kyprolis e hoʻohana ʻia ʻo FDA.

  • I nā mākua i loaʻa i hoʻokahi a ʻekolu mau lāʻau i hala mua no ko lākou myeloma maha. Hoʻohana ʻia ʻo Kyprolis me dexamethasone a i ʻole me lenalidomide a me dexamethasone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha nā mālama mua no kā lākou myeloma maha. Hoʻohana ʻia ʻo Kyprolis e ia iho.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hāʻawi ʻia ʻo Darzalex a me Kyprolis ma ke ʻano he infusion intravenous (IV). ʻO kēia kahi injection i hoʻokomo lohi ʻia i ka manawa ma o kahi nila i kau ʻia i kou aa.

No Darzalex

Hele mai ʻo Darzalex ma ke ʻano he hopena (hoʻohuihui wai) āu e loaʻa ai i ke ʻano o ka injection. Hiki ke kala ʻole i ka hopena ma ka melemele melemele. Loaʻa ka lāʻau i nā nui ʻelua:

  • 100 mg / 5 ML i loko o ka hue wai hoʻokahi
  • 400 mg / 20 mL i loko o ka hue wai hoʻokahi

I mea e hōʻemi ai i ka manawa o kahi hopena infusion, e hāʻawi aku kāu kauka iā ʻoe i kahi hui o. lāʻau. Hoʻokahi i ʻekolu mau hola ma mua o kēlā me kēia infusion Darzalex, e loaʻa iā ʻoe:

  • he corticosteroid e hoʻēmi i ka pehu
  • kahi antipyretic e pale a hoʻēmi paha i ke kuni
  • kahi antihistamine e pale a hōʻemi paha i nā ʻōuli o nā hopena maʻi ʻaʻai

Hiki paha iā ʻoe ke loaʻa i kahi corticosteroid 1 lā ma hope o ke kōkuhi e hōʻalo i nā hopena lohi. Akā inā ʻoe e lawe nei i kahi steroid e like me dexamethasone a prednisone paha, ʻaʻole paha ʻoe e pono i ka hoʻonui steroid hou.

No Kyprolis

Hele mai ʻo Kyprolis i kahi keke a i ʻole ka pauka i loko o kahi kīʻaha kū hoʻokahi. Hele mai ia i loko o ʻekolu mau ikaika: 10 mg, 30 mg, a me 60 mg.

I mea e hōʻemi ai i ka manawa e loaʻa ai kahi hopena infusion, e hāʻawi kāu kauka iā ʻoe i kahi steroid. E loaʻa iā ʻoe ka mea hoʻokalakupua 30 mau minuke i 4 mau hola ma mua o kou hoʻokomo ʻana iā Kyprolis. Akā inā ʻoe e lawe nei i kahi steroid e like me dexamethasone, ʻaʻole pono kāu kauka e hāʻawi iā ʻoe i ka lāʻau keu.

Nā hopena a me nā pilikia

Hiki iā Darzalex lāua ʻo Kyprolis ke hana i nā hopena ʻaoʻao like loa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻē aʻe i hiki ke hana ʻia me Darzalex, me Kyprolis, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Darzalex:
    • nāwaliwali a nele paha i ka ikaika
    • bronchitis, he ʻano maʻi maʻi paru
    • ʻeha ke kino a ʻeha pū paha
  • Hiki iā Kyprolis ke hana:
    • helu ʻulaʻula koko haʻahaʻa
    • helu keʻokeʻo haʻahaʻa keʻokeʻo haʻahaʻa
    • pilikia hanu
    • hoʻemi i nā pae potassium
  • Hiki iā Darzalex lāua ʻo Kyprolis ke hana.
    • Muscle spasms (twitches)
    • pilikia hiamoe
    • luhi nei
    • huhū ʻōpū me ka maʻi diarrhea a i ʻole ka paʻa paʻa
    • fiva
    • haʻalulu
    • pokole o ka hanu
    • ʻūhā
    • maʻi hanu o luna, e like me ke anuanu
    • nausea a luaʻi paha
    • hoʻēmi ʻai
    • edema peripheral, ka ʻōhū o nā lima a me nā wāwae
    • ʻūpā

Nā hopena hopena koʻikoʻi

Loaʻa i kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana ʻia me Darzalex, me Kyprolis, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Darzalex:
    • neutropenia, kahi pae haʻahaʻa o nā neutrophil, kahi ʻano keokeo keʻokeʻo e kōkua i ke kaua ʻana i nā maʻi
    • shingles (maʻi herpes zoster)
    • ʻo ke neuropathy sensory peripheral, kahi ʻano o ke ʻino nerve e hiki ai i ke kani ʻana, ka helu ʻana, a me ka ʻeha
  • Hiki iā Kyprolis ke hana:
    • ʻinoʻino o ka hū e like me ke kahe ʻana o ke koko, nā huʻa o ke koko, ka pehu ʻana, a i ʻole nā ​​maʻi ma nā akemāmā
    • poino puʻuwai a i ʻole hake puʻuwai
    • nā pilikia o ke ake, e like me ka hoʻonui ʻana i ke kiʻekiʻe o nā proteins ate a i ʻole ke kō ʻana o ke ake
    • hakuʻala ʻole
    • maʻi maʻi lysis syndrome, kahi ʻano kahi e make koke ai nā hunaola maʻi ʻaʻai a ninini ʻia kā lākou mea i loko o kou koko
    • posterior hiki ke hoʻohuli ʻia ka encephalopathy maʻi, kahi maʻi o nā ʻāʻī i ka lolo
    • kahe koko kiʻekiʻe
    • pulmonary hypertension, ʻo ia ke kiʻekiʻe o ke koko i nā akemāmā
    • huʻi koko
    • nā pilikia kahe nui e like me ke kahe ʻana i ka ʻōpū, nā māmā, a me ka lolo
  • Hiki iā Darzalex lāua ʻo Kyprolis ke hana.
    • nā hopena infusion
    • thrombositopenia, kahi pae haʻahaʻa o nā platelet, kahi ʻano o ke koko e kōkua i ke kōkuʻu koko
    • pneumonia, he ʻano maʻi maʻi paru

Ka hoʻokō ʻana

He ʻano ʻokoʻa kā Darzalex a me Kyprolis i hoʻohana ʻia e ka FDA, akā hoʻohana ʻia lāua ʻelua e mālama i nā myeloma he nui.

ʻAʻole i hoʻohālikelike pololei ʻia ka hoʻohana ʻana o Darzalex a me Kyprolis no nā myeloma he nui i nā noiʻi hoʻokolohua. Eia nō naʻe, ua ʻike ʻia kahi noiʻi e like me Darzalex a me Kyprolis e maikaʻi no ka mālama ʻana i nā myeloma he nui.

Ke hoʻopaʻa nei nā mea noiʻi i ka hoʻohana ʻana o nā lāʻau ʻelua me ka dexamethasone e mālama ai i kēia ʻano maʻi ʻaʻai. Ua hōʻike nā hopena i ka poʻe i mālama mua ʻia no ka myeloma he nui i pane maikaʻi i ka lāʻau hoʻohui. Akā pono nā ho'āʻo hou aʻe ma mua o ka hiki i ka FDA ke ʻae i kahi kuʻikahi o Darzalex a me Kyprolis no nā myeloma he nui.

Nā kumukūʻai

ʻO Darzalex lāua ʻo Kyprolis nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe ʻano generic o nā lāʻau āpau i kēia manawa. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā koho ma WellRx.com, ʻoi aku ka uku o Darzalex ma mua o Kyprolis. ʻO ke kumukūʻai maoli āu e uku ai no kēlā me kēia lāʻau e pili ana i kāu hoʻolālā ʻinikua a me kāu wahi.

Pehea ʻo Darzalex e hana ai

ʻO ka myeloma maha he maʻi ʻaʻai e hoʻomaka i kahi ʻano o ke keʻokeʻo keʻokeʻo i kapa ʻia he huna wai plasma. Hana nā hunaola Plasma i ʻāpana o kāu ʻōnaehana pale a kōkua i ke kaua ʻana i nā maʻi i kou kino.

I kekahi manawa hoʻololi koke i kāu mau gen, i kapa ʻia he mutation, hiki ke hoʻolilo i nā hunaola olakino i mau maʻi ʻaʻai. (ʻO Genes kahi mau ʻōkuhi e kōkua i ke kaohi ʻana i ke ala e ulu a hana ai kāu mau pūnaewele). Ke hoʻololi aʻe nā hunaola plasma i mau hunaola myeloma he nui, hoʻomaka lākou e kūkulu i ka iwi iwi (ka ʻaoʻao o kou mau iwi). Ke ulu a pālahalaha nā sel myeloma he nui, hiki iā lākou ke hōʻuluʻulu i nā hunaola olakino a hōʻino i ka iwi a puni lākou.

ʻO Darzalex kahi lāʻau i hana ʻia e ke kanaka i kapa ʻia he monoclonal antibody. (ʻO nā monoclonal antibodies nā protein i loko o kāu ʻōnaehana pale. Hoʻonohonoho ʻia lākou e māka a hoʻouka i kahi ʻāpana kikoʻī o kahi cell cancer.

Ke lilo nā hunaola plasma i mau hunaola myeloma he nui, hoʻomohala lākou i kahi nui o ka protein i kapa ʻia ʻo CD38 ma ko lākou ʻili. Hana ka antibody monoclonal Darzalex ma ka hoʻopili ʻana i ka protein CD38 ma ka cell myeloma maha. Ma ka hana ʻana i kēia, make pololei a kōkua paha ʻo Darzalex i kāu ʻōnaehana pale ʻole e luku i ka cell myeloma maha.

Pehea ka lōʻihi o ka hana?

I nā noiʻi lapaʻau, ʻo ka manawa maʻamau i lawe ʻia ʻo Darzalex e hoʻomaka i ka hana he 1 mahina. Eia nō naʻe, hiki ke hāʻawi ʻia i kāu mau kau ma kahi o kahi manawa lōʻihi. Aia kēia i ka pane a kou kino iā Darzalex a inā e hoʻomaka ka maikaʻi o kāu myeloma maha. Pili pū ka lōʻihi o ka mālama ʻana inā ʻike hou ʻia kāu myeloma maha a i ʻole inā ua loaʻa mua iā ʻoe nā lāʻau ma mua.

Darzalex a me ka waiʻona

ʻAʻohe mea i ʻike ʻia ma waena o Darzalex a me ka waiʻona. Akā koi ʻia ʻoe e hōʻalo i ka inu ʻana i ka waiʻona i ka wā e lawe ana iā Darzalex. Pili kēia i ka lōʻihi o ka loaʻa ʻana o ka lāʻau.

Hāʻawi ʻia ʻo Darzalex ma ke ʻano he infravenous (IV) infusion. ʻO kēia kahi injection i loko o kou aa i hāʻawi ʻia ma kahi o kekahi manawa. Hiki ke hala nā infusions o Darzalex mai 3 a 7 mau hola. No laila he mea nui e noho hydrate ma mua a i ka wā o kāu infusions. Hiki i nā mea inu ʻona ke hoʻoinu iā ʻoe, no laila e hōʻalo i ka waiʻona i ka wā e lawe ana iā Darzalex.

Inā he mau nīnau kāu e pili ana i ka wai ʻona a me Darzalex, e nīnau i kāu kauka.

Nā hana a Darzalex

Ma mua o ka lawe ʻana iā Darzalex, e hoʻomaopopo pono e haʻi aku i kāu kauka a me ka kauka lāʻau e pili ana i nā lāʻau āpau, over-the-counter, a me nā lāʻau ʻē aʻe āu e lawe ai. E haʻi pū iā lākou e pili ana i nā wikamina, nā mea kanu, a me nā mea hoʻopiha āu e hoʻohana ai. Hiki ke kōkua i ka hāʻawi ʻana i kēia ʻike iā ʻoe e hōʻalo i nā launa ʻole.

Inā he mau nīnau kāu e pili ana i nā launa lāʻau e hoʻopili iā ʻoe, e nīnau i kāu kauka a kauka paha.

ʻO Darzalex a me nā hoʻokolohua laboratory

Hiki i ka lawe ʻana iā Darzalex ke hoʻololi i nā hopena o kekahi mau hoʻokolohua lab.

Nā hewa o ke keʻena ʻano koko

Inā lawe ʻoe iā Darzalex a loaʻa i kahi hoʻokolohua koko e kūlike i kāu ʻano koko, ʻaʻole pololei paha nā hopena. Hiki i nā hewa ma kēia mau hoʻāʻo ke hala i 6 mau mahina ma hope o kāu hopena hope loa o Darzalex.

Hana ʻo Darzalex e ka hoʻopili ʻana i ka protein CD38 ma ka ʻili o kahi cell myeloma maha a e hōʻino ana hoʻi i ka protein. I kekahi manawa hiki i nā hunaola ʻulaʻula ke loaʻa nā protein CD38 ma luna o lākou. Hiki iā Darzalex ke hoʻopili pono iā ia iho i kahi protein CD38 ma kahi hunaʻulaʻula ma kahi o kahi cell myeloma maha. Ke hiki mai kēia, hoʻololi ia i ke ʻano o ka nānā ʻana o ke koko ʻulaʻula i nā hōʻike koko. Eia naʻe, ʻaʻole e hoʻopili ʻo Darzalex i kou ʻano koko.

I mea e hōʻalo ai i nā hewa kuhi koko, e hoʻāʻo kāu kauka i kāu ʻano koko ma mua o kāu kau mua o Darzalex. E hana lākou i kēia inā pono ʻoe i kahi kōpuni i ka wā e hiki mai ana.

Pehea e hāʻawi ʻia ai ʻo Darzalex

No ka loaʻa ʻana o kāu lāʻau o Darzalex, e hele ʻoe i ke keʻena o kāu kauka a i ʻole kahi kikowaena infusion. Hele mai ka lāʻau lapaʻau ma ke ʻano he hopena (hoʻohuihui wai). E hoʻopili kahi mea mālama ola iā Darzalex me 0.9% sodium chloride (kahi ʻano o ka wai paʻakai). A laila e hāʻawi lākou iā ʻoe i kēia lāʻau i ka manawa ma o ka nila kuʻina i kau ʻia i kou aa. Kapa ʻia kēia infusion intravenous (IV). Hiki iā ʻoe ke loaʻa iā Darzalex e ʻoe iho a i ʻole me nā lāʻau lapaʻau ʻē aʻe.

E hoʻoholo kāu kauka i ka nui a Darzalex e hāʻawi ai iā ʻoe e pili ana i kou kaupaona a me kāu hoʻolālā mālama pilikino. E mālama mau kahi mea mālama ola iā ʻoe i ka manawa e hoʻokomo ai.

I ka manawa hea e lawe ai

E hoʻoholo kāu kauka i ka manawa ma waena o nā lāʻau a pehea ka nui o nā lāʻau āu e pono ai. E hoʻokumu ʻia kēia inā e lawe hoʻokahi ʻoe iā Darzalex a i ʻole me nā lāʻau ʻē aʻe. E noi i kāu kauka e koi i ka lā a me ka manawa ʻoi loa e hoʻokumu i kāu infusions e pili ana i kāu hana o kēlā me kēia lā.

Ehia mau manawa e loaʻa ai iā Darzalex a e hoʻemi ana ka lōʻihi o ka manawa i ka manawa. Kuhi paha kāu kuhi mua ʻana iā Darzalex ma kahi o 7 mau hola. ʻO kēia no ka mea e hoʻokomo haʻahaʻa kāu kauka i ka lāʻau i loko o kou aa. ʻO nā infusions i ka wā e hiki mai ana e lawe i ka manawa liʻiliʻi a hala ma kahi o 3 a 5 mau hola no ka mea e wikiwiki ana ʻoe i ka lāʻau.

Lawe iā Darzalex me ka meaʻai

Hiki i nā manawa infus Darzalex ke kuhi mai 3 a 7 mau hola, ke kaukaʻi ʻia i kāu papa hoʻolālā. ʻO ia ke kumu he manaʻo maikaʻi e hele mākaukau me nā meaʻai māmā a me nā mea inu ke maikaʻi inā maikaʻi me kāu kauka.

ʻO Darzalex a me ka hāpai keiki

ʻAʻole i aʻo ʻia ʻo Darzalex i nā wahine hāpai a holoholona paha. Akā ʻo Darzalex kahi antibody monoclonal, kahi ʻano lāʻau e kuhikuhi i nā hunaola maʻi ʻaʻai. A ʻike ʻia nā antibodies monoclonal e hele i ka placenta. (ʻO ka placenta kahi mea i loko o kou ʻōpū e hāʻawi i nā meaʻai mai kou kino i kāu pēpē.)

Ma muli o ke ʻano o ka hana ʻana a Darzalex, hiki i ka lāʻau ke hoʻemi i ka nui o ka iwi i loko o kahi pēpē i hānau ʻole ʻia. Hiki iā ia ke hoʻemi i ka nui o ke koko a me nā hunaola i hana ʻia e ka pēpē ulu.

Ma mua o kou hoʻomaka ʻana e lawe iā Darzalex, e hoʻomaopopo pono e haʻi aku i kāu kauka inā hāpai ʻoe, hāpai paha, a i ʻole hoʻolālā e hāpai.

ʻO Darzalex me ka lenalidomide a i ʻole ka pomalidomide

Lawe ʻia ʻo Darzalex i kekahi manawa me kahi lāʻau i kapa ʻia ʻo lenalidomide (Revlimid) a i ʻole pomalidomide (Pomalyst) no ka myeloma he nui. Loaʻa iā Lenalidomide a me pomalidomide i kahi ʻōlelo aʻoaʻo pahu pahu * no nā ʻino hānau hānau weliweli a weliweli hoʻi. Inā he wahine ʻoe a ua kau kauka iā Darzalex me ka lenalidomide a i ʻole ka pomalidomide, ʻaʻole pono ʻoe e hāpai.

  • no 4 mau pule ma mua o ka hoʻomaka ʻana o ka lāʻau
  • ʻoiai e hana ana i ka lāʻau
  • i ka wā hoʻomaha iki i ka lapaʻau ʻana
  • no 4 mau pule ma hope o ka hoʻōki ʻana i ka lenalidomide a i ʻole ka pomalidomide

Inā he mau nīnau kāu e pili ana i ka lawe ʻana iā Darzalex, lenalidomide, a i ʻole pomalidomide i ka wā hāpai, e kamaʻilio me kāu kauka.

Darzalex a me ka kaohi hānau

Inā loaʻa kahi manawa e hāpai ai ʻoe, ua ʻōlelo ʻia e hoʻohana ʻoe i ka kaohi hānau ʻoiai e lawe ana iā Darzalex. E mālama ʻoe i ka kaohi hānau no 3 mau mahina ma hope o ka pau ʻana o kāu mālama Darzalex. ʻO kēia no ka mea hiki i ka lāʻau ke noho i kāu ʻōnaehana no kekahi manawa pōkole ma hope o kou hoʻōki ʻana i ka lawe ʻana.

Inā he kāne ʻoe a ke moekolohe nei me ka wahine, aia kahi manawa kūpono e hāpai ai. E noʻonoʻo e hoʻohana i kahi ʻano pale o ka kaohi hānau, e like me ka condom, ʻoiai inā e hoʻohana pū ana kāu kāne moekolohe i ka kaohi hānau.

ʻO Darzalex me ka lenalidomide a i ʻole ka pomalidomide

I kekahi mau hihia, lawe paha ʻoe iā Darzalex me nā lāʻau i kapa ʻia ʻo lenalidomide (Revlimid) a i ʻole pomalidomide (Pomalyst). Inā he wahine ʻoe a ke lawe nei iā Darzalex me ka lenalidomide a i ʻole ka pomalidomide, pono ʻoe e ʻae e hoʻohana i ʻelua ʻano o ka kaohi hānau. Pono ʻoe e hoʻomaka e hoʻohana i ka kaohi hānau ma ka liʻiliʻi he 4 mau pule ma mua o kou hoʻomaka ʻana i ka lāʻau me nā lāʻau. E hoʻomau i ka hoʻohana ʻana i ka kaohi hānau ʻoiai e lawe ana iā Darzalex a me lenalidomide a i ʻole pomalidomide, a i ka wā hoʻomaha iki o ka lapaʻau. Pono ʻoe e hoʻomau i ka hoʻohana ʻana i ka kaohi hānau no 4 mau pule ma hope o kou hōʻoki ʻana i ka lawe ʻana i ka lenalidomide a i ʻole ka pomalidomide.

Hiki i ka Lenalidomide a me ka pomalidomide ke hele i loko o ke ʻano o ke kanaka. No laila, pono i nā kāne āpau ke hoʻohana i ka latex a synthetic condom ke hana kolohe me kahi wahine i hiki ke hāpai. Pono nā kāne e hoʻohana i kēia ʻano hana o ka kaohi hānau no ka manawa like o ka lawe ʻia ʻana o kā kā lāua hoa moekolohe.

Inā hana kolohe ʻoe a hiki i ʻoe a i ʻole kāu pakanā wahine ke hāpai, e kamaʻilio me kāu kauka. Hiki iā lākou ke kōkua iā ʻoe e hoʻoholo i kāu pono hanau hānau ʻoiai ʻoe e hoʻohana ana iā Darzalex.

Darzalex a me ka waiū hānai

ʻAʻole ʻike ʻia inā hiki iā Darzalex ke hele i ka waiū umauma a i ʻole pehea e hoʻopili ai ka lāʻau i ka waiū umauma. ʻAʻole nō i ʻike ʻia inā hiki iā Darzalex ke hoʻopili i kahi keiki umauma.

ʻO Darzalex me ka lenalidomide a i ʻole ka pomalidomide

I kekahi mau hihia, lawe paha ʻoe iā Darzalex me nā lāʻau i kapa ʻia ʻo lenalidomide (Revlimid) a i ʻole pomalidomide (Pomalyst). Inā he wahine wahine hānai ʻoe, ʻaʻole pono ʻoe e hoʻohana i ka lenalidomide a i ʻole ka pomalidomide. ʻAʻole maopopo inā hiki i kēia lāʻau ke hele i loko o kāu waiū umauma a hōʻeha i kāu pēpē.

Inā makemake ʻoe e hānai i kāu keiki a noʻonoʻo e pili ana i ka lawe ʻana iā Darzalex, e kamaʻilio me kāu kauka. Hiki iā lākou ke haʻi iā ʻoe e pili ana i nā maikaʻi a me nā maikaʻi ʻole o ka hoʻohana ʻana i kēia lāʻau i ka wā e hānai ana i ka waiū.

Nā nīnau e pili ana iā Darzalex

Eia nā pane i kekahi o nā nīnau e nīnau pinepine ʻia e pili ana iā Darzalex.

No ke aha e pono ai wau e lawe i nā steroid a me nā lāʻau ʻē aʻe i kaʻu mau koho no Darzalex infusions?

Ke loaʻa iā Darzalex, loaʻa paha iā ʻoe kahi hopena maʻi ʻaʻai. I mea e pale aku ai i kēia, hāʻawi paha kāu kauka iā ʻoe i nā lāʻau i kapa ʻia ʻo corticosteroids a me nā lāʻau ʻē aʻe.

Hāʻawi kahi mea mālama ola iā ʻoe iā Darzalex ma ke ʻano he infravenous (IV) infusion i ke keʻena o kāu kauka a i ʻole kahi keʻena lapaʻau. ʻO kēia kahi injection i loko o kou aa i hāʻawi ʻia ma kahi o kekahi manawa. Hoʻokahi i ʻekolu mau hola ma mua o kēlā me kēia infusion Darzalex, e loaʻa mau iā ʻoe nā lāʻau aʻe:

  • he corticosteroid (e hoʻēmi i ka pehu)
  • he antipyretic (e pale a hōʻemi paha i ke kuni)
  • kahi antihistamine (e pale a hōʻemi paha i nā ʻōuli o nā hopena maʻi)

Hiki paha iā ʻoe ke loaʻa i kahi corticosteroid 1 lā ma hope o ke kōkuhi e hōʻalo i nā hopena lohi. Akā inā ʻoe e lawe nei i kahi steroid e like me dexamethasone a prednisone paha, ʻaʻole paha ʻoe e pono i ka hoʻonui steroid hou.

Inā he mau nīnau kāu e pili ana i kekahi o nā lāʻau i hāʻawi ʻia me Darzalex infusions, e nīnau i kāu kauka.

Hiki iaʻu ke hoʻokele iaʻu iho i ka home ma hope o kaʻu infusion Darzalex?

Paipai ʻole ʻia. ʻO kēia no ka mea maʻamau ka luhi ma hope o kahi infusion a i ʻole loaʻa kahi hopena infusion. (E nānā i nā "hopena Infusion" i ka ʻaoʻao "Nā ʻaoʻao pili ʻaoʻao" ma luna e aʻo hou ai.) No laila e palekana, e loaʻa i kahi ʻohana, a me kou hoa aloha, a i ʻole mea mālama iā ʻoe e hoʻokele ai iā ʻoe a mai kāu mau infusion.

E nānā i kou ʻano ma hope o kāu infusions a mālama i kahi diary o kāu mau hōʻailona. Hiki i kēia ke kōkua iā ʻoe e hoʻoholo inā hiki iā ʻoe ke hoʻokele iā ʻoe iho, inā ʻoe e pono.

Inā ʻaʻole hiki iā ʻoe ke loaʻa kahi kalaiwa, hiki iā Janssen Biotech, Inc., ka mea hana a Darzalex, ke kōkua. Hiki iā ʻoe ke kamaʻilio me kahi mea hoʻonohonoho ʻo Janssen CarePath e pili ana i ka hele ʻana mai a i kāu mau koho a loaʻa ke kōkua me ke kumukūʻai o ka huakaʻi. No ke aʻo hou ʻana, e kāhea iā 844-553-2792 a i ʻole kipa i ka pūnaewele Darzalex.

Hiki iaʻu ke hoʻohana iā Darzalex inā ua loaʻa iaʻu nā shingles?

ʻAe, hiki iā ʻoe ke hoʻohana iā Darzalex inā loaʻa ʻoe i kahi maʻi i kapa ʻia ʻo shingles. Akā ma mua o kou lawe ʻana iā Darzalex, he mea nui e haʻi aku i kāu kauka inā loaʻa iā ʻoe kahi shingles a i ʻole ka moa. (ʻO ka maʻi hoʻomaʻemaʻe like e kumu ai i ka shingles hiki ke kumu i ka moa moa.)

Inā ua loaʻa ʻoe i ka pulupulu i ka wā ma mua, ʻaʻole haʻalele ka maʻi i kou kino ma hope o kou ola ʻana mai ka maʻi. Ma kahi o, e "hiamoe" wale nō ka maʻi ma loko o kou aʻa.

ʻAʻohe mea i ʻike pololei i ke kumu, akā hiki i ka maʻi hoʻomaʻemaʻe ke hoʻoulu hou a i ʻole "ala aʻe" me kekahi mau mea hoʻonāukiuki e like me kahi ʻōnaehana pale nawaliwali. (ʻO kou ʻōnaehana pale ka pale o kou kino i nā maʻi.)

Hiki i nā mālama ʻana i ka maʻi ʻaʻai e like me Darzalex ke hoʻonāwaliwali i kou ʻōnaehana pale a hoʻoulu hou i ka maʻi. Ke ala aʻe, hōʻike ia iā ia iho me he shingles ma kahi o ka moa.

No laila inā he shingles a i ʻole ka paukū, e kauoha ana kāu kauka i kahi lāʻau antiviral e pale aku ai i nā shingles e ulu hou i kou kino. Pono ʻoe e lawe i ka lāʻau antiviral ma waena o 1 pule o ka hoʻomaka ʻana e lawe iā Darzalex. A laila e mālama ʻoe i ka antiviral no 3 mau mahina ma hope o kou hoʻopau ʻana i ka lāʻau me Darzalex.

Inā ʻaʻole ʻoe e maopopo inā he shingles a i ʻole ka moa kaʻi, e kamaʻilio me kāu kauka.

Hoʻola ʻo Darzalex i ka myeloma maha?

I kēia manawa, ʻaʻohe lāʻau no ka myeloma maha. Akā ʻo ka mea a Darzalex e hana ai e hoʻomaikaʻi i kou maikaʻi a me kou lōʻihi o ke ola, e hilinaʻi ana i kāu ʻike. Hiki i kāu kauka ke haʻi hou aku iā ʻoe.

Nā hana hoʻomalu a Darzalex

Ma mua o ka lawe ʻana iā Darzalex, e kamaʻilio me kāu kauka e pili ana i kāu mōʻaukala olakino. ʻAʻole kūpono paha ʻo Darzalex iā ʻoe inā loaʻa iā ʻoe kekahi ʻano olakino a i ʻole nā ​​mea ʻē aʻe e hoʻopili i kou olakino. Pākuʻi ʻia kēia mau mea:

  • Hepatitis B. Inā loaʻa paha iā ʻoe ka maʻi hepitis B a i ʻole ma mua, lawe paha iā Darzalex e hana hou ia. Ma mua o kou hoʻomaka ʻana e lawe iā Darzalex, e nānā kāu kauka iā ʻoe no ka maʻi hepitis B. E nānā pū lākou iā lākou ma hope o kou hoʻopau ʻana i kāu lāʻau. ʻO nā ʻōuli o ka maʻi hepitis B me ka luhi e ʻoi aku ana ka maikaʻi, a me ke kala melemele o kou ʻili a me ke keʻokeʻo o kou mau maka. Inā ʻoe e ʻike i kēia mau hōʻailona, ​​e haʻi i kāu kauka.
  • ʻO Shingles. ʻOiai ʻoe e lawe nei iā Darzalex, hiki iā ʻoe ke hoʻomohala i kahi maʻi i kapa ʻia ʻo shingles. ʻO ka mea hoʻomaʻi like i ke kumu o ka shingles hiki ke kumu i ka moa. No laila inā ua loaʻa ʻoe i ka paukū a i ʻole nā ​​shingles i ka wā ma mua a ke lawe nei iā Darzalex, hiki i kāu kauka ke kuhikuhi i kahi lāʻau antiviral. Hiki i kēia ʻano lāʻau ke kōkua i ka pale ʻana i nā shingles mai ka hoʻomohala ʻana i kou kino.
  • ʻO ka maʻi pulmonary obstructive maʻi (COPD). Inā loaʻa iā ʻoe kahi moʻolelo o kahi maʻi hanu i kapa ʻia ʻo ka maʻi pulmonary obstructive maʻi (COPD), e haʻi i kāu kauka ma mua o kou hoʻomaka ʻana e lawe iā Darzalex. Hāʻawi paha lākou iā ʻoe i kahi mea inhaler e kōkua iā ʻoe e hanu maʻalahi a me nā corticosteroids e kōkua i ka hōʻemi ʻana i ka pehu i loko o kou mau māmā.
  • Hapai keiki. ʻAʻole i aʻo ʻia ʻo Darzalex i nā wahine hāpai. Akā he ʻano lāʻau hiki keʻaʻa i ka placenta. (ʻO ka placenta kahi ʻona i loko o kou ʻōpū e hāʻawi i nā meaʻai mai kou kino i kāu pēpē.) No ka ʻike hou aku, e ʻoluʻolu e ʻike i ka ʻāpana ʻo "Darzalex and hāpai" ma luna.
  • Hānai umauma. ʻAʻole ʻike ʻia inā palekana ka hānai ʻana i ka umauma ʻoiai e lawe ana iā Darzalex. No ka ʻike hou aku, e ʻoluʻolu e ʻike i ka ʻāpana ʻo "Darzalex a me ka waiū hānai" ma luna.

E haʻi i kāu kauka inā ʻoe e hoʻomōhala i kekahi o kēia mau ʻano i ka wā a ma hope paha o ka mālama ʻana me Darzalex.

Kaha: No ka ʻike hou aku e pili ana i nā hopena maikaʻi ʻole o Darzalex, e ʻike i ka ʻāpana "Darzalex Side Effects" ma luna.

ʻO ka ʻike ʻoihana no Darzalex

Hāʻawi ʻia ka ʻike aʻe no nā kauka lapaʻau a me nā ʻoihana ola.

Nā Hōʻike

Ua ʻae ka Food and Drug Administration (FDA) a hōʻike iā Darzalex e hoʻohana ai:

  • I nā mākua me ka myeloma hou i ʻike ʻia he nui i hiki ʻole ke loaʻa i kahi transplant cell autologous stem cell. (Me kahi transplant cell autologous stem cell, hoʻohana ʻia kāu mau cell stem.) I kēia kūlana:
    • Hiki ke hoʻohana ʻia ʻo Darzalex me nā lāʻau lenalidomide (Revlimid) a me dexamethasone.
    • Hiki ke hoʻohana pū ʻia ʻo Darzalex me nā lāʻau bortezomib (Velcade), melphalan, a me prednisone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha nā lapaʻau ma mua i holo pono ʻole a i ʻole hoʻi nona ka myeloma maha i hoʻi mai. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me lenalidomide a me dexamethasone.
  • I nā mākua i loaʻa i hoʻokahi a ʻoi paha mau lāʻau myeloma maha ma mua. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me ka bortezomib a me ka dexamethasone.
  • I nā mākua i loaʻa i ʻelua aʻoi aʻe paha mau lapaʻau myeloma i hala e pili ana me ka lenalidomide a me ka mea pale proteasome, kahi ʻano lāʻau. I kēia kūlana, hoʻohana ʻia ʻo Darzalex me nā lāʻau pomalidomide (Pomalyst) a me dexamethasone.
  • I nā mākua i loaʻa he ʻekolu a ʻoi mau lāʻau lapaʻau myeloma i hala aʻe i komo i kahi mea pale proteasome a me kahi lāʻau hoʻomalu. I kēia kūlana, hoʻohana ʻia ʻo Darzalex e ia iho.
  • I nā mākua i hoʻāʻo i kahi mea pale proteasome a me kahi lāʻau hoʻomalu ākea akā ʻaʻole hana ʻia kekahi lāʻau no ka myeloma he nui. I kēia kūlana, hoʻohana ʻia ʻo Darzalex e ia iho.

Mekanism o ka hana

ʻO Darzalex kahi antibody monoclonal a kāohi a hōʻino paha i ka ulu ʻana o ka cell tumel o nā pūnaewele myeloma he nui. Ke lilo nā hunaola plasma i mau hunaola myeloma he nui, hoʻomohala lākou i ka nui o nā protein o luna i kapa ʻia ʻo CD38. Hoʻokumu a hoʻopili ʻo Darzalex iā ia iho i kēia mau protein CD38. Ma o nā immune-mediated a kuhikuhi pololei i nā hana tum-tumo, pāpā ʻo Darzalex i ka ulu ʻana o ka cell myeloma maha a hoʻomaka i ke kaʻina hana o ka apoptosis (make o ke kelepona)

Pharmacokinetics a me ka metabolism

ʻAʻohe ʻokoʻa nui o ka lāʻau i loko o nā pharmacokinetics o Darzalex ma ke ʻano he monotherapy a i ʻole me ke ʻano he therapy hoʻohui ʻia e pili ana i nā heluna kikoʻī.

Ma hope o ka hoʻokomo ʻia ʻana o ka lāʻau i koi ʻia o Darzalex wale nō a i ʻole me ke ʻano he therapy hoʻohui ʻia, kokoke ʻekolu mau manawa ke kiʻekiʻe o ke koko ma Darzalex i ka pau ʻana o ka hana o ka pule ma ka hoʻohālikelike ʻana i ka lāʻau mua.

ʻO ka hoʻokaʻawale ʻana i ka mahele mua o Darzalex ka hopena i nā kūpikipiki ʻokoʻa ma mua o ka mea i loaʻa i kahi kanaka kahi piha piha. Eia nō naʻe, ua ʻike ʻia a wānana ʻia nā piko like a me nā ʻāpana o ke kūpikipikiʻi ma hope o ka loaʻa ʻana o kahi mahele hoʻokaʻawale ʻelua i ka pule 1, lā 2 o ka mālama

I ka wā i hāʻawi ʻia ai ʻo Darzalex wale nō, ua loaʻa kahi pae paʻa koko paʻa (kūlana paʻa) ma kahi o 5 mau mahina i loko o kēlā me kēia pule he 4 mau pule (e ka 21 infusion). Ma ka mokuʻāina paʻa, ʻo Darzalex ke ʻano o ka hōʻiliʻili no ka piʻi kiʻekiʻe o ke koko he 1.6.

Hoʻokaʻina:

  • monotherapy: 4.7 ± 1.3 L
  • hoʻohui hoʻohui: 4.4 ± 1.5 L

ʻO ka hoʻopau hapa hapalua o ka monotherapy a me ka hoʻohuihui hoʻohui ʻia he 18 ± 9 mau lā. Ua hoʻēmi ʻo Darzalex clearance me ka hoʻonui ʻana i ka lāʻau a me nā hana he nui. Ua koho ʻia ka hoʻomaʻemaʻe ma 171.4 ± 95.3 mL / lā. Ke piʻi nei ke kaumaha o ke kino, hoʻonui ka nui o ka mahele a me ka helu i lawe ʻia ai ʻo Darzalex mai ke kino.

Nā Kūʻai Kūʻai

Hoʻopiʻi ʻia ʻo Darzalex i nā mea maʻi me ka moʻaukala o nā hopena anaphylactic koʻikoʻi i daratumumab a i ʻole kekahi o nā mea e loaʻa ana i ka lāʻau lapaʻau. ʻO nā hihia koʻikoʻi o ka neutropenia, thrombositopenia, a i ʻole nā ​​hopena infusion ma muli o ka mālama ʻana e koi paha iā Darzalex e hoʻokū a paʻa mau paha.

Waihona

Pono e mālama ʻia ʻo Darzalex i loko o ka pahu hau ma 36 ° F a 46 ° F (2 ° C a i 8 ° C).

Mai hoʻoluliluli a paʻa iā Darzalex. Pono e pale ʻia ka lāʻau mai ka malamalama. ʻAʻohe i loko o Darzalex nā mālama mālama.

Hoʻolaha: Ua hana ʻo Nūhou Lapaʻau i kēia mau lā e hōʻoia i ka pololei, ka laulā, a me ka lā hou o nā ʻike āpau. Eia nō naʻe, ʻaʻole pono e hoʻohana i kēia ʻatikala i pani no ka ʻike a me ka mākaukau o kahi loea mālama ola laikini. E nīnau mau ʻoe i kāu kauka a i ʻole ʻoihana olakino ʻē aʻe ma mua o ka lawe ʻana i nā lāʻau. Hiki ke loli i ka ʻike o ka lāʻau i loko a ʻaʻole i manaʻo ʻia e uhi i nā hoʻohana a pau, nā kuhikuhi, ka mālama ʻana, nā ʻōlelo aʻoaʻo, nā launa lāʻau, nā hopena maʻi ʻaʻai, a me nā hopena maikaʻi ʻole. ʻO ka loaʻa ʻole o nā ʻōlelo aʻoaʻo a i ʻole nā ​​ʻike ʻē aʻe no kahi lāʻau i hāʻawi ʻia ʻaʻole ia e hōʻike i ka palekana o ka lāʻau a lāʻau paha i kūpono no nā mea maʻi āpau a i ʻole nā ​​hoʻohana kikoʻī āpau.

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