Nā maʻi o ka pilina pili, mai Genetic a Autoimmune

Anter

• Nā ʻano o nā maʻi maʻi hoʻopili
• Nā maʻi nā mea hoʻopili pili ma muli o nā hemahema o ka hoʻokahi-ʻaoʻao
• ʻO nā maʻi pili pili e hōʻike ʻia e ka mumū o nā aʻa
• Nā kumu a me nā ʻōuli o ka maʻi pili kikokiko
• Ehlers-Danlos maʻi
• Epidermolysis bullosa
• Maʻi ʻo Marfan
• Osteogenesis sempurnaa
• Nā kumu a me nā ʻōuli o ka maʻi ʻaʻa hoʻohui autoimmune
• Polymyositis a me dermatomyositis
• Rheumatoid arthritis
• Scleroderma
• ʻO Sjogren's Syndrome
• ʻO systemic lupus erythematosus (SLE a i ʻole lupus)
• ʻO Vasculitis
• Lapaʻau
• Nā pilikia
• Outlook

Hōʻike Overview

ʻO nā maʻi o nā mea hoʻopili e hoʻopili i kahi helu nui o nā maʻi like ʻole e hiki ke hoʻopili i ka ʻili, ka momona, nā mākala, nā hono, nā aʻa, nā ligament, ka iwi, nā iwi, a me nā maka, ke koko, a me nā kīʻaha koko. Hoʻopili pū nā mea hoʻopili i nā pūnaewele o kā mākou kino. Hāʻawi ia i ke kau ʻana o nā mea i ukali ʻia e ka hoʻi i kāna kūpikipiki mua (e like me kahi kāʻei) Hana ʻia ia me nā protein, e like me collagen a me elastin. ʻO nā mea koko, e like me nā keʻokeʻo koko keʻokeʻo a me nā cell mast, i loko o kāna mea hoʻonani.

Nā ʻano o nā maʻi maʻi hoʻopili

Nui a hewahewa nā ʻano maʻi o ka pilina paʻa. He mea pono e noʻonoʻo i nā mahele nui ʻelua. Loaʻa i ka mahele mua nā mea i hoʻoili ʻia, ma muli o ka hemahema o ka ʻaoʻao hoʻokahi i kapa ʻia he hoʻololi. ʻO ka mahele ʻelua nā mea kahi o ka pūnaewele hoʻopili ka pahuhopu o nā mea ʻāpala i kūʻē iā ia. ʻO kēia kumu ke kumu o ka ʻulaʻula, ka pehu ʻana, a me ka ʻeha (i ʻike ʻia ʻo ka palahū).

Nā maʻi nā mea hoʻopili pili ma muli o nā hemahema o ka hoʻokahi-ʻaoʻao

Pili nā maʻi maʻi ma muli o nā hemahema o ka ʻenekahi hoʻokahi i kahi pilikia i ke ʻano a me ka ikaika o nā mea hoʻopili. Eia kekahi laʻana o kēia mau ʻano:

• Ehlers-Danlos syndrome (EDS)
• Epidermolysis bullosa (EB)
• Maʻi ʻo Marfan
• Osteogenesis sempurnaa

ʻO nā maʻi pili pili e hōʻike ʻia e ka mumū o nā aʻa

Pili nā maʻi maʻi i hōʻike ʻia e ka lū o nā aʻa e nā mea ʻāpala (i kapa ʻia he autoantibodies) i hana hewa ʻole ai ke kino i kāna aʻa ponoʻī. Kapa ʻia kēia mau ʻano he maʻi autoimmune. Hoʻopili ʻia i kēia ʻano nā kūlana aʻe, i lawelawe pinepine ʻia e kekahi loea lapaʻau i kapa ʻia he rheumatologist.

• ʻO Polymyositis
• Dermatomyositis
• Rheumatoid arthritis (RA)
• Scleroderma
• ʻO Sjogren's Syndrome
• ʻErythematosis ʻōnaehana lupus
• ʻO Vasculitis

Loaʻa i nā kānaka me nā maʻi o nā mea hoʻopili i nā ʻōuli o ka maʻi ʻoi aku ma mua o hoʻokahi maʻi autoimmune. I kēia mau hihia, kuhikuhi pinepine nā kauka i ka hōʻailona he maʻi maʻi āpau i hoʻopili ʻia.

Nā kumu a me nā ʻōuli o ka maʻi pili kikokiko

ʻO nā kumu a me nā ʻōuli o ka maʻi maʻi hoʻopili i hoʻokumu ʻia e nā kīnā ʻole hoʻokahi-ʻokoʻa nā hopena o nā protein i hana maʻamau ʻia e kēlā ʻaoʻao hema.

Ehlers-Danlos maʻi

Hoʻokumu ʻia ʻo Ehlers-Danlos syndrome (EDS) e kahi pilikia hoʻokumu collagen. ʻO EDS kahi hui ʻoi aku ma luna o 10 mau maʻi, nā mea āpau e ka ʻili lōʻihi, ka ulu pono ʻole ʻana o nā ʻili maka, a me nā hono i maʻalahi. Kaukaʻi ʻia i ka ʻano o EDS, he mau kīʻaha koko nāwaliwali ko ka poʻe, kahi iwi kuamoʻo, gums a me nā pilikia me nā puʻuwai puʻuwai, nā mumū, a me ka digestion. Hōʻailona nā ʻōuli mai ke akahai a i ʻole koʻikoʻi loa.

Epidermolysis bullosa

ʻOi aku ma mua o hoʻokahi ʻano epidermolysis bullosa (EB) kū ʻia. Hiki i nā proteins aʻa pili e like me keratin, laminin, a me collagen ke ʻano ʻē. Hoʻohālikelike ʻia ʻo EB e ka ʻili palupalu keu. ʻO ka ʻili o ka poʻe me EB e palepale a waimaka paha i kahi puʻu liʻiliʻi a i kekahi manawa mai ka lole e ʻānai ana iā ia. Hoʻopili kekahi o nā ʻano EB i ka māhāhā, ka digestive tract, ka ʻai a me nā mākala.

Maʻi ʻo Marfan

Hoʻokumu ʻia ʻo Marfan Syndrome e kahi kīnā i loko o ka fibrillin protein protein i hoʻopili ʻia. Hoʻopili ia i nā ligament, nā iwi, nā maka, nā kīʻaha koko, a me ka puʻuwai. ʻO ka poʻe me Marfan Syndrome he kiʻekiʻe ka lōʻihi a wīwī hoʻi, lōʻihi loa nā iwi a me nā manamana manamana a me nā manamana wāwae. Ua loaʻa paha iā ʻAberahama Linekona. I kekahi manawa ua hoʻonui ka poʻe me ka maʻi ʻo Marfan i kahi ʻāpana o kā lākou aorta (aortic aneurysm) i hiki ke alakaʻi i ka haki ʻana o ka make (rupture).

Osteogenesis sempurnaa

ʻO ka poʻe me nā pilikia ʻokoʻa hoʻokahi a me ka pilikia i hoʻonoho ʻia ma lalo o kēia poʻo inoa āpau he collagen abnormalities a me ka nui o nā mākala haʻahaʻa, nā iwi iwi, a me nā ligament a me nā hono i hoʻomaha. ʻO nā ʻōuli ʻē aʻe o ka osteogenesis imperfecta kaukaʻi ʻia i ka kānana kikoʻī o ka osteogenesis sempurna a lākou. Pākuʻi paha kēia i ka ʻili lahilahi, kahi iwi kuamoʻo, nalo ʻana o ka pepeiao, nā pilikia hanu, nā niho e haki maʻalahi, a me ka hina hina hina i nā keʻokeʻo o nā maka.

Nā kumu a me nā ʻōuli o ka maʻi ʻaʻa hoʻohui autoimmune

ʻO nā maʻi pilikino pili ma muli o kahi kūlana autoimmune ka mea maʻamau i ka poʻe i loaʻa ka hui pū ʻana o nā gen e hoʻonui i ka manawa e iho ai lākou me ka maʻi (maʻa mau ma mua o nā mākua). Kū pinepine pinepine lākou i nā wahine ma mua o nā kāne.

Polymyositis a me dermatomyositis

Pili kēia mau maʻi ʻelua. Hoʻokumu ka Polymyositis i ka mumū o nā mākala. ʻO Dermatomyositis ke kumu o ka hoʻā o ka ʻili. Kūlike nā ʻōuli o nā maʻi ʻelua a komo pū paha me ka luhi, nāwaliwali o nā mākala, ka liʻiliʻi o ka hanu, paʻakikī i ka ale ʻana, ka pohō kaumaha, a me ke kuni. Hiki i ke kanesa ke lilo i ʻano pili i kekahi o kēia mau maʻi.

Rheumatoid arthritis

I ka rheumatoid arthritis (RA), hoʻouka ka ʻōnaehana pale i ka membrane lahilahi e kau ana i nā hono. ʻO kēia ke kumu o ka ʻoʻoleʻa, ʻeha, mehana, ʻōhū, a me ka mumū a puni ke kino. Hiki i nā ʻōuli ʻē aʻe ke komo pū me ka anemia, ka luhi, ka pau ʻole o ka makemake, a me ke kuni. Hiki iā RA ke hōʻino mau i nā hono a alakaʻi i ka palaka. Aia kekahi ʻano ʻōpio a liʻiliʻi hoʻi o kēia ʻano.

Scleroderma

Hoʻokumu ʻo Scleroderma i ka ʻili paʻa, ʻili mānoanoa, kahi kūkulu ʻana o nā ʻaʻa maka, a me nā ʻino o nā meaola. Hāʻule nā ​​ʻano o kēia ʻano i ʻelua mau pūʻulu: scleroderma kūloko a i ʻole systemic scleroderma. I nā kūlana kūloko, hoʻopaʻa ʻia ke ʻano i ka ʻili. Hoʻopili pū nā hihia ʻōnaehana i nā mea nui a me nā kīʻaha koko.

ʻO Sjogren's Syndrome

ʻO nā ʻōuli nui o ka maʻi maʻi o Sjogren he waha maloʻo a me nā maka. Hiki i nā poʻe me kēia ʻano ke loaʻa ka luhi loa a me ka ʻeha o nā hono. Hoʻonui ka hanana i ka makaʻu o ka lymphoma a hiki ke hoʻopili i nā māmā, nā puʻupaʻa, nā kīʻaha koko, ka ʻōnaehana digestive, a me nā ʻōnaehana.

ʻO systemic lupus erythematosus (SLE a i ʻole lupus)

Hoʻokumu ka Lupus i ka mumū o ka ʻili, nā hono, a me nā lālā. Hiki i nā ʻōuli ʻē aʻe ke kolo ma nā papalina a me ka ihu, nā puʻupuʻu o ka waha, ka nānā ʻana i ka lā, ka wai ma ka puʻuwai a me nā akemāmā, ka nalo ʻana o ka lauoho, nā pilikia o ka hakuʻala, ka maʻi anemia, nā pilikia hoʻomanaʻo, a me nā maʻi noʻonoʻo.

ʻO Vasculitis

ʻO Vasculitis kekahi hui o nā kūlana e hoʻopili i nā kīʻaha koko i kēlā me kēia wahi o ke kino. ʻO nā ʻōuli maʻamau e pili ana i ka nalo ʻana o ka makemake, ka pohō kaumaha, ʻeha, ke kuni, a me ka luhi.Hiki ke hahau inā hele a wela nā kīʻaha koko o ka lolo.

Lapaʻau

ʻAʻohe mea ola i kēia manawa no nā maʻi āpau e hoʻopili. Nā Breakthroughs i nā genetics therapies, kahi e hūnā ʻole ʻia ai kekahi mau genes pilikia, paʻa ka hoʻohiki no nā maʻi hoʻokahi-gen o nā mea hoʻopili.

No nā maʻi autoimmune o nā mea hoʻopili, pili ka mālama ʻana i ke kōkua ʻana e hōʻemi i nā ʻōuli. Hiki i nā hoʻoponopono hou hou aʻe no nā kūlana e like me ka psoriasis a me ka arthritis ke hoʻopau i ka maʻi pale e hoʻonā ai i ka mumū.

Hoʻohana ʻia nā lāʻau i hoʻohana ʻia i ka mālama ʻana i nā maʻi ʻaʻa autoimmune:

• Corticosteroids. Kōkua kēia mau lāʻau i ka pale ʻana i ka ʻōnaehana pale maʻi i ka hoʻouka ʻana i kāu mau hunaola a pale i ka palahū.
• Immunomodulators. Hoʻomaikaʻi kēia mau lāʻau i ka ʻōnaehana pale.
• Nā lāʻau Antimalarial. Hiki i nā Antimalarials ke kōkua ke akahai nā ʻōuli, hiki iā lākou ke pale i nā ahi uila.
• Nā poloka ʻauana kalipuna. Kōkua kēia mau lāʻau i ka hoʻomaha ʻana i nā mākala i nā paia o nā kīʻaha koko.
• Methotrexate. Kōkua kēia lāʻau i ka mālama ʻana i nā ʻōuli o ka rheumatoid arthritis.
• ʻO nā lāʻau hypertension pulmonary. Wehe ʻia kēia mau lāʻau i nā kīʻaha koko i loko o nā akemāe i hoʻopili ʻia e ka mumuna autoimmune, e ʻae ana i ke kahe o ke koko e maʻalahi.

ʻO Surgically, kahi hana ma kahi aneurysm aortic no kahi mea maʻi me Ehlers Danlos a i ʻole ʻo Marfan's syndrome hiki ke hoʻopakele. Kūleʻa pono kēia mau ʻoki ʻana inā hana ʻia ma mua o ka haki.

Nā pilikia

Hiki i nā maʻi ke hoʻopili pinepine i nā maʻi autoimmune.

ʻO ka poʻe me ka maʻi ʻo Marfan hiki ke loaʻa i kahi aneurysm aortic ruptured.

Hiki i nā mea maʻi o Osteogenesis Imperfecta ke hoʻomohala i ka hanu ma muli o ka pilikia o ka iwi kuamoʻo a me ka iwi iwi ʻaoʻao.

ʻO ka poʻe maʻi me ka lupus pinepine ka loaʻa ʻana o ka wai a puni ka puʻuwai i hiki ke make. Hiki i kēlā mau mea maʻi ke loaʻa i ka maʻi lele ma muli o ka vasculitis a i ʻole ka mumū lupus.

ʻO ka maikaʻi ʻole o ke kīhāpai kahi pilikia maʻamau o ka lupus a me ka scleroderma. Hiki i kēia mau maʻi ʻelua a me nā maʻi pili pili autoimmune ke alakaʻi i nā pilikia me nā ake māmā. Hiki i kēia ke alakaʻi i ka pōkole o ka hanu, ka puʻu, paʻakikī ka hanu ʻana, a me ka luhi nui loa. I nā hihia koʻikoʻi, hiki i nā pilikia pulmonary o kahi maʻi āpau e make.

Outlook

Loaʻa ka laulā ākea i ka hana a nā mea maʻi me ka gen-single a i ʻole ka autoimmune pili maʻi maʻi i ka holo lōʻihi. ʻOiai me ka mālama ʻana, ʻoi aku ka maʻi o nā maʻi pili. Eia nō naʻe, ʻaʻohe mea pono i kekahi poʻe me nā ʻano ʻoluʻolu o Ehlers Danlos syndrome a i ʻole Marfan syndrome a hiki ke ola i ka wā elemakule.

Mahalo i nā hoʻoponopono pale pale hou no nā maʻi autoimmune, hiki i nā kānaka ke ʻoliʻoli i nā makahiki he nui o ka hana maʻi liʻiliʻi a hiki ke pōmaikaʻi ke "wela" ka mumū me ka nui o ka makahiki.

Ma ke ʻano holoʻokoʻa, e ola ka hapanui o ka poʻe me nā maʻi pili pili no 10 mau makahiki ma hope o kā lākou hōʻoia. Akā ʻo kēlā me kēia maʻi pili hoʻopili, ʻo ka gen-single a i ʻole autoimmune-e pili ana, hiki ke loaʻa i kahi wānana ʻoi loa ka maikaʻi.