Selpercatinib

Anter

• Ma mua o ka lawe ʻana iā selpercatinib,
• Hoʻokumu ʻo Selpercatinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Selpercatinib e mālama i kekahi ʻano maʻi ʻaʻai liʻiliʻi liʻiliʻi liʻiliʻi (NSCLC) i nā mākua i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino i ka poʻe mākua. Hoʻohana ʻia ia e mālama i kekahi ʻano o ka maʻi ʻaʻai thyroid i nā mākua a me nā keiki he 12 mau makahiki a ʻoi paha i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino. Hoʻohana ʻia ʻo Selpercatinib e mālama i kahi ʻano ʻē aʻe o ka maʻi ʻaʻai thyroid i pāhola ʻia i nā ʻāpana ʻē aʻe o ke kino i nā mākua a me nā keiki he 12 mau makahiki a ʻoi paha i mālama maikaʻi ʻole ʻia me ka iodine radioactive. Aia ʻo Selpercatinib i kahi papa o nā lāʻau i kapa ʻia nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kahi protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hoʻolohi a hoʻopau paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Selpercatinib ma ke ʻano he capsule e lawe ma ka waha. Lawe ʻia ia i ʻelua mau manawa i kēlā me kēia lā (i kēlā me kēia 12 hola) me ka ʻai ʻole a me ka ʻole. E lawe iā selpercatinib ma nā manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E lawe i selpercatinib kikoʻī e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā capsule holoʻokoʻa; mai wehe, nau, a wāwahi paha iā lākou.

Inā ʻoe e luaʻi ma hope o ka lawe ʻana i selpercatinib, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau, a hoʻopau paha a hoʻopau paha i kāu lāʻau. Aia kēia i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a me nā hopena ʻē aʻe āu e ʻike ai. E kamaʻilio me kāu kauka e pili ana i kou ʻano i kāu mālama ʻana. E hoʻomau i ka lawe iā selpercatinib inā ʻoe e manaʻo maikaʻi. Mai hōʻoki i ka lawe ʻana i selpercatinib me ka walaʻau ʻole ʻana me kāu kauka.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana iā selpercatinib,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka selpercatinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hoʻohui i loko o nā capsule selpercatinib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E haʻi pono i kekahi o kēia mau mea: antifungals e like me fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, a me voriconazole (Vfend); aprepitant (Emend); carbamazepine (Carbatrol, Tegretol, Equetro, nā mea ʻē aʻe); clarithromycin (Biaxin, i Prevpac); diltiazem (Cardizem, Cartia, Tiazac, nā mea ʻē aʻe); erythromycin (E.E.S., E-Mycin, Erythrocin); kekahi mau lāʻau no ka maʻi pale maʻi (HIV) a i ʻole loaʻa i ka maʻi maʻi maʻi maʻi (AIDS) me efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ma Kaletra), a me saquinavir (Invirase) ; nefazodone; phenobarbital; phenytoin (Dilantin, Phenytek); pioglitazone (Actos); quinidine (i Nuedexta); repaglinide (Prandin); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ma Rifamate, ma Rifater); and verapamil (Calan, Verelan, kekahi). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Hiki ke launa pū kekahi me nā lāʻau ʻē aʻe he nui me selpercatinib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• inā ʻoe e lawe ana i kahi H₂ ka lāʻau blocker no ka hoʻoinu ʻole, ka puʻuwai, a i ʻole nā ​​maʻi ulcer e like me cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), a i ʻole ranitidine (Zantac), e lawe i ka selpercatinib ma kahi o 2 mau hola ma mua a i ʻole 10 mau hola ma hope o ka lawe ʻana i kekahi o kēia mau lāʻau.
• inā ʻoe e lawe i kahi antacid i loaʻa ka aluminika, magnesium, calcium, a i ʻole simethicone; aiʻole nā ​​lāʻau lapaʻau buffered e like me buffer aspirin, lawe selpercatinib ma ka liʻiliʻi he 2 mau hola ma mua a ma ka liʻiliʻi 2 mau hola ma hope o kou lawe ʻana i kekahi o kēia mau lāʻau.
• inā ʻoe e lawe i kahi mea pale proton-pump e like me esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), a me rabeprazole (AcipHex), e lawe i kēlā me kēia kau o selpercatinib me ka meaʻai.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole loaʻa paha iā ʻoe kahi puʻuwai lohi, wikiwiki, a i ʻole maʻamau. kahi wā QT hoʻolōʻihi (kahi pilikia puʻuwai laha ʻole e hiki ai ke hōʻeha i ka puʻuwai ʻole, maʻule, a make koke paha); ke koko kiʻekiʻe; nā pilikia koko; aiʻole ka maʻi puʻuwai a i ʻole ate.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i ka hānau keiki ʻana. ʻAʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i selpercatinib. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o kou hoʻomaka ʻana i ka mālama ʻana a hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu wā lapaʻau me selpercatinib a no 1 pule ma hope o kāu hopena hope loa. Inā he kāne ʻoe, pono ʻoe a me kāu pakanā wahine e hoʻohana i ka kaohi hānau ma kāu mālama ʻana me selpercatinib a no 1 hebedoma ma hope o kāu hopena hope loa. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana iā selpercatinib, e kāhea koke i kāu kauka. Hiki i Selpercatinib ke hōʻeha i ka fetal.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana ʻoe i selpercatinib a no 1 pule ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike i kēia lāʻau i hoʻemi ai i ka momona i nā kāne a me nā wahine. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana i selpercatinib.
• inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho paha e lawe nei ʻoe iā selpercatinib. E haʻi paha kāu kauka iā ʻoe mai lawe i ka selpercatinib 7 mau lā ma mua o kou ʻoki ʻana a i ʻole ke kaʻina hana a e haʻi wau iā ʻoe ke hoʻomaka hou ʻoe e lawe i ka lāʻau.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā aia i loko o 6 mau hola o kāu kau ma hope, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu ʻo Selpercatinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• waha maloo
• pāhoehoe
• kōpaʻa
• nausea
• ka luaʻi
• ʻeha ka ʻōpū
• ʻeha poʻo
• luhi
• ʻūhā
• pokole o ka hanu
• ka pehu ʻana o kou mau lima, nā wāwae, nā lima a me nā wāwae

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• ʻeha ma ka ʻaoʻao ʻākau i luna o ka ʻōpū; ʻehaʻeha a hoʻokahe koko paha; mimi ʻeleʻele; a melemele paha o ka ʻili a me ka maka
• palpitations puʻuwai
• dizziness a i ʻole ʻālohilohi
• maule ana
• ka ʻū ʻana a i ʻole ka luaʻi ʻana i ke koko a i ʻole nā ​​mea like e like me ke kope; kahe ʻole ke kahe ʻana a ʻeha paha, ʻulaʻula; mimi ʻulaʻula, a i ʻole ʻeleʻele eleele; a ʻulaʻula a hoʻolōʻihi paha i ka neʻe ʻana o ka ʻōpū
• nausea; ka luaʻi; pokole o ka hanu; ʻūpī mākala; nāwaliwali; ka hopu ʻana; aiʻole ka pehu ʻana o nā lima a me nā wāwae
• fiva, ʻehu, a ʻeha pū a ʻeha paha

Hiki iā Selpercatinib ke hoʻōki i ka ulu ʻana o nā iwi i ka ulu koke ʻana i nā ʻōpio e ulu mau nei. E kamaʻilio me kāu kauka o kāu keiki e pili ana i ka makaʻu o ka hāʻawi ʻana i kēia lāʻau i kāu keiki.

Hoʻokumu paha ʻo Selpercatinib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E nānā pinepine kāu kauka i kou kaomi koko a kauoha i kekahi mau hoʻokolohua lab ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino i selpercatinib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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