Safinamide

Anter

• Ma mua o ka lawe safinamide,
• Hoʻokumu paha ʻo Safinamide i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Safinamide me ka hui pū ʻana o ka levodopa a me ka carbidopa (Duopa, Rytary, Sinemet, a me nā mea ʻē aʻe) e mālama ai i nā ʻāpana "off" (nā manawa o ka paʻakikī e neʻe ai, e hele wāwae ana, a e kamaʻilio pū ana paha e hiki ke hana ʻia e like me ka pau ʻana o ka lāʻau lapaʻau a i ʻole koho ʻia) i ka poʻe me ka maʻi ʻo Parkinson (PD; kahi maʻi o ka ʻōnaehana hopohopo e hoʻopilikia ai i ka neʻe ʻana, ka mālama ʻana i nā mākala, a me ke kaulike). Aia ʻo Safinamide i kahi hui o nā lāʻau i kapa ʻia ʻo monoamine oxidase type B (MAO-B) nā mea kāohi. Hana ia ma ka hoʻonui ʻana i ka nui o ka dopamine (kahi mea kūlohelohe e pono ai e kaohi i ka neʻe) i ka lolo.

Hele mai ʻo Safinamide ma ke ʻano he papa e lawe ma ka waha. Lawe mau ʻia me ka ʻai ʻole a ʻai ʻole hoʻokahi manawa i kēlā me kēia lā. Lawe i ka safinamide ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka safinamide e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi haʻahaʻa o ka safinamide a hoʻonui paha i kāu lāʻau ma hope o 2 mau pule o ka mālama ʻana.

Mai hōʻoki i ka lawe ʻana i ka safinamide me ke kamaʻilio ʻole ʻana me kāu kauka. E hoʻemi paha kāu kauka i kāu lāʻau ma mua o ke kū. Inā kū koke ʻoe i ka lawe ʻana i ka safinamide, ʻike paha ʻoe i ka haʻalele ʻana i nā hōʻailona e like me ke kuni; ʻoʻoleʻa o ka mākala; huikau; a i ʻole nā ​​hoʻololi ʻana i ka ʻike. E haʻi i kāu kauka inā ʻike ʻoe i kekahi o kēia mau ʻōuli ke hoʻemi ʻia kāu mahele lāʻau o ka safinamide.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe safinamide,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka safinamide (waha a i ʻole ka ʻōlelo alelo, ka hanu ʻana o ka hanu), nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o ka papa safinamide. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka inā lawe ʻoe i kekahi o kēia mau mea: amphetamines (stimulants, 'uppers') e like me amphetamine (Adderall, Adzenys, Dyanavel XR, ma Adderall), dextroamphetamine (Dexedrine, ma Adderall), a me methamphetamine (Desoxyn); kekahi mau antidepressants e like me amitriptyline (Elavil), amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), mirtazapine (Remeron) a me trazodone; buspirone; cyclobenzaprine (Amrix); methylphenidate (Aptensio, Metadate, Ritalin, nā mea ʻē aʻe); opioids e like me meperidine (Demerol), methadone (Dolophine, Methadose), propoxyphene (ʻaʻole loaʻa hou ma US; Darvon), a i ʻole tramadol (Conzip, Ultram, i Ultracet); selotonin selective a me nā norepinephrine reuptake inhibitors (SSNRIs) e like me duloxetine (Cymbalta) a me venlafaxine (Effexor); a me St. John's wort; E haʻi pū i kāu kauka inā lawe ʻoe i kahi mea hoʻopuka MAO e like me isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), a i ʻole tranylcypromine (Parnate). iā lākou i loko o nā pule ʻelua i hala. E haʻi paha kāu kauka iā ʻoe ʻaʻole pono ʻoe e lawe i ka safinamide me kekahi o kēia mau lāʻau. Inā kū ʻoe i ka lawe ʻana i ka safinamide, pono ʻoe e kali ma ka liʻiliʻi he 14 mau lā ma mua o kou hoʻomaka ʻana e lawe i kekahi o kēia mau lāʻau. Eia kekahi, mai lawe i ka dextromethorphan (i Robitussin DM; i loaʻa i loko o ka nui o nā kūmole nonprescription a me nā huahana anuanu) me ka safinamide.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E ʻōlelo pono i kekahi o kēia mau mea: antipsychotics e like me clozapine (Clozaril, Fazaclo, Versacloz) a me olanzapine (Zyprexa); nā benzodiazepines e like me alprazolam (Xanax), diazepam (Diastat, Valium), lorazepam (Ativan), temazepam (Restoril), a me triazolam (Halcion); nā lāʻau no ke anu a me nā maʻi āpau (decongestants) me nā mea i kau ʻia i ka maka a i ʻole ka ihu; imatinib (Gleevec); irinotecan (Camptosar, Onivyde); isoniazid (Laniazid, ma Rifamate, ma Rifater); lapatinib (Tykerb); methotrexate (Otrexup, Rasuvo); metoclopramide (Reglan); mitoxantrone; rosuvastatin (Crestor); nā mea hoʻoliʻiliʻi serotonin reuptake e like me citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, Symbyax, a me nā mea ʻē aʻe), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), a me sertraline (Zoloft); sulfasalazine (Azulfidine); a me ka topotecan (Hycamtin). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā loaʻa ʻoe i ka maʻi ate. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe iā safinamide.
• e haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi noʻonoʻo e like me schizophrenia (kahi maʻi noʻonoʻo e hoʻonāukiuki ai ka noʻonoʻo, nalowale o ka hoihoi i ke ola, a me nā ʻano ikaika a i ʻole ʻano ʻē), maʻi maʻi bipolar (ʻano e loli mai ke kaumaha i ka pīhoihoi maoli ʻole) , a psychosis paha; aiʻole inā he koko kiʻekiʻe a haʻahaʻa paha kou; dyskinesia (neʻe ʻole); a i ʻole nā ​​pilikia hiamoe. E haʻi pū aku i kāu kauka inā he ʻohana a ʻohana paha kāu a i ʻole he pilikia paha me ka retina o kou mau maka a i ʻole ka albinism (hoʻoilina hoʻoilina e kumu ai ka nele o ke kala i ka ʻili, ka lauoho a me nā maka).
• e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. Inā hāpai ʻoe i ka lawe ʻana i ka safinamide, e kāhea i kāu kauka.
• e haʻi i kāu kauka inā ʻoe e hānai umauma ana a hoʻolālā paha i ka umauma.
• pono ʻoe e ʻike i ka safinamide e hiamoe ai ʻoe a e hiamoe ai paha ʻoe i kāu hana maʻamau o kēlā me kēia lā. ʻAʻole paha ʻoe e hiamoe a i ʻole he hōʻailona hōʻailona ʻē aʻe ma mua o kou hiamoe ʻana.Mai hoʻokele i kahi kaʻa, hana i nā mīkini, hana ma kahi kiʻekiʻe, a i ʻole e komo i nā hana weliweli i ka hoʻomaka ʻana o kāu lapaʻau a ʻike ʻoe i ka hopena o ka lāʻau iā ʻoe. Inā hiamoe ʻoe i ka wā e hana ana ʻoe i kahi mea e like me ka nānā ʻana i ke kīwī, kamaʻilio ʻana, ʻai ʻana, a i ʻole ke kaʻa ʻana i ke kaʻa, a inā hiamoe nui ʻoe, keu hoʻi i ke ao, e kāhea i kāu kauka. Mai kalaiwa, hana ma nā wahi kiʻekiʻe, a hana i nā mīkini a hiki i kou wā e kamaʻilio ai me kāu kauka.
• E hoʻomanaʻo hiki i ka waiʻona ke hoʻohui i ka hiamoe i hoʻokumu ʻia e kēia lāʻau. Mai inu i ka waiʻona i ka wā e lawe nei ʻoe i ka safinamide.
• pono ʻoe e ʻike i kekahi poʻe i lawe i nā lāʻau e like me ka safinamide i ulu i nā pilikia piliwaiwai a i ʻole nā ​​ʻūlū ikaika a i ʻole nā ​​ʻaoʻao koʻikoʻi a koʻikoʻi paha iā lākou, e like me ka hoʻonui ʻana i nā makemake moekolohe a i ʻole nā ​​lawena. Kāhea i kāu kauka inā makemake ʻoe e pāʻani i ka paʻakikī e kaohi, loaʻa iā ʻoe nā koi ikaika, a i ʻole hiki ʻole iā ʻoe ke kaohi i kāu hana. E haʻi aku i nā lālā o kou ʻohana e pili ana i kēia pilikia i hiki iā lākou ke kāhea i ke kauka inā ʻaʻole ʻoe e ʻike he pili pilikia kāu piliwaiwai a i ʻole nā ​​ʻano hoʻoikaika ʻē aʻe a i ʻole nā ​​ʻano hana ʻano ʻē.

Hiki paha iā ʻoe ke ʻike i kahi hopena koʻikoʻi inā ʻai ʻoe i nā meaʻai i kiʻekiʻe i ka tyramine i kou wā e mālama ai me ka safinamide. Loaʻa ʻo Tyramine i nā meaʻai a me nā mea inu he nui, e like me ka ʻiʻo, nā moa, nā iʻa, a me nā tīhi i puhi ʻia, ʻelemakule, mālama kūpono ʻole ʻia, a i hōʻino ʻia paha. kekahi mau huaʻai, nā lau, a me nā pī; mea inu ʻona; a me nā huahana hū i hū. E haʻi aku kāu kauka a mea ʻaʻai paha i nā meaʻai āu e pale pono ai, a me nā meaʻai āu e ʻai ai i nā liʻiliʻi. Inā ʻoe e ʻai i kahi meaʻai kiʻekiʻe i ka tyramine ʻoiai ke lawe nei iā safinamide, e kāhea i kāu kauka.

Hōʻalo i ka lāʻau i hala a lawe i kāu kau ma hope i ka manawa maʻamau i ka lā aʻe. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Safinamide i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• nausea
• paʻakikī e hiamoe a hiamoe paha

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• ke kaumaha a i ʻole ka neʻe pinepine ʻana o ke kino i hiki ʻole iā ʻoe ke kaohi
• loli ka hihiʻo
• hallucination (ke ʻike nei i nā mea a i ʻole ka lohe ʻana i nā leo i ʻole ola)
• hilinaʻi kuhihewa (ka manaʻoʻiʻo ʻana i nā mea ʻaʻole maoli)
• ka hoʻonāukiuki, nā haʻalulu, ke kuni, ka hou ʻana, ka huikau, ka puʻuwai puʻuwai wikiwiki, ka haʻalulu, ka ʻāʻī nui a i ʻole ka mimiki ʻana, ka nalowale ʻana o ke kuʻikahi, nausea, ka luaʻi, a i ʻole ka palahī

Hoʻokumu paha ʻo Safinamide i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Mālama i nā manawa āpau me kāu kauka.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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