Lenvatinib

Anter

• Ma mua o ka lawe ʻana i lenvatinib,
• Hoʻokumu ʻo Lenvatinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Lenvatinib e mālama i kekahi ʻano o ka maʻi ʻaʻai thyroid i hoʻi mai a i ʻole pālahalaha ʻia i nā ʻāpana ʻē aʻe o ke kino a ʻaʻole hiki ke mālama ʻia me ka iodine radioactive. Hoʻohana pū ʻia ʻo Lenvatinib me everolimus (Afinitor, Zortress) e mālama ai i ka maʻi puʻuwai puʻuwai puʻupaʻa (RCC, kahi ʻano maʻi ʻaʻai e hoʻomaka i ka puʻupaʻa) i ka poʻe i loaʻa i ka lāʻau ma mua me kekahi lāʻau chemotherapy. Hoʻohana ʻia ʻo Lenvatinib e mālama i ka carcinoma hepatocellular (HCC; kahi ʻano maʻi ʻaʻai ate) hiki ʻole ke mālama ʻia me ke ʻoki kino. Hoʻohana pū ʻia ʻo Lenvatinib me ka pembrolizumab (Keytruda) e mālama ai i kekahi ʻano maʻi ʻaʻai o ka endometrium (ka uhi ʻana o ka uterus) i pālahalaha ʻia i nā ʻāpana ʻē aʻe o ke kino a i ʻole nā ​​wā ʻino a i ʻole ma hope o ka mālama ʻana me nā lāʻau chemotherapy a i ʻole hiki ʻole ke mālama ʻoki kino a i ʻole radiation radiation. Aia ʻo Lenvatinib i ka papa o nā lāʻau i kapa ʻia nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kahi protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hōʻoki ʻana i nā hunaola maʻi ʻaʻai.

Hele mai ʻo Lenvatinib ma ke ʻano he capsule e lawe ma ka waha. Lawe ʻia ia i hoʻokahi manawa i kēlā me kēia lā me ka ʻai ʻole. Lawe iā lenvatinib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka lenvatinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā capsule holoʻokoʻa; mai wehe, nau, a wāwahi paha iā lākou.

Inā hiki ʻole iā ʻoe ke ale i nā capsule, hahao iā lākou i loko o ke aniani liʻiliʻi a hoʻohui e pili ana i hoʻokahi punetune o ka wai a i ʻole ka wai ʻāpala. Mai wāwahi a wāwahi paha i nā capsule. E waiho i nā capsule i loko o ka wai a ma ka liʻiliʻi he 10 mau minuke a laila e hoʻoulu i nā ʻike no 3 mau minuke. Inu ka huikau. Ma hope o ka inu ʻana i ka hoʻohuihui, e hoʻomoʻi i hoʻokahi punetune o ka wai a i ʻole ka wai ʻoma i ke kīʻaha. Hoʻopili i nā mea i loko o kekahi mau manawa a ale i ka hui.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau o lenvatinib a i ʻole e haʻi iā ʻoe e hōʻoki i ka lawe ʻana i ka lāʻau no kekahi manawa a mau loa paha inā ʻike ʻoe i nā hopena ʻino. E mālama pono i kāu kauka e pili ana i kou ʻano i kou wā e mālama ai me ka lenvatinib.

Aia ka lōʻihi o kāu mālama ʻana i ka maikaʻi o kāu pane ʻana i ka lāʻau a me nā hopena āu e ʻike ai. E hoʻomau i ka lawe ʻana i ka lenvatinib ʻoiai inā maikaʻi ʻoe. Mai hōʻoki i ka lawe ʻana i ka lenvatinib me ke kamaʻilio ʻole ʻana me kāu kauka.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i lenvatinib,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i lenvatinib, i nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā capsule lenvatinib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe.E ʻōlelo pono i kekahi o kēia mau mea: kekahi mau lāʻau no ka puʻuwai puʻuwai ʻole e like me amiodarone (Nexterone, Pacerone), disopyramide (Norpace), procainamide, quinidine (i Nuedexta), a me sotalol (Betapace, Betapace AF, Sorine, Sotylize). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka inā loaʻa paha ʻoe i ka hopu ʻana, ke koko kiʻekiʻe, ka hahau, ka puʻuwai puʻuwai, ʻeha poʻo, hoʻololi i ka hihi, ʻo ia hoʻi nā mea no ke kahe o ke koko, kahi fistula (ka pilina maʻamau ma waena o nā mea ʻelua i loko o kou kino a i ʻole ma waena o ʻoki a me waho o kou kino), kahi waimaka i ka paia o kou ʻōpū a i ʻole ʻōpū, hoʻolōʻihi wā QT (kahi puʻuwai puʻuwai kūpono ʻole e hiki ai i ka nāwaliwali, nalowale o ka ʻike, hopu ʻana, a make koke paha), ʻole ka puʻuwai, nā haʻahaʻa haʻahaʻa o ka kalipuna, potassium, a i ʻole magnesium i loko o kou koko, nā pilikia kahe ʻana o ke koko, a i ʻole ka puʻuwai, nā puʻupaʻa, a me nā maʻi ate. E haʻi aku i kāu kauka inā ua mālama ʻia ʻoe me ka radiation radiation.
• pono ʻoe e ʻike e hōʻemi paha ka lenvatinib i ka momona i nā kāne a me nā wahine. Eia nō naʻe, ʻaʻole pono ʻoe e kuhi ʻaʻole hiki iā ʻoe a i ʻole kāu pakanā ke hāpai. E haʻi i kāu kauka inā hāpai ʻoe a hoʻolālā paha e hāpai. Pono ʻoe e loaʻa i kahi hōʻike hāpai ma mua o kou hoʻomaka ʻana i ka lāʻau me lenvatinib. Inā hiki iā ʻoe ke hāpai, pono ʻoe e hoʻohana i ka kaohi hānau ma kāu mālama ʻana me lenvatinib a no 4 mau pule ma hope o kāu hopena hope loa. Inā hāpai ʻoe i kou lawe ʻana i lenvatinib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Lenvatinib i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū a i ʻole hoʻolālā e hānai. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana iā lenvatinib
• e haʻi i kāu kauka inā ʻoe e hoʻolālā e hana i kahi ʻoki, me ke kīʻaha niho. E haʻi paha kāu kauka iā ʻoe e hōʻoki i kāu hana me lenvatinib ma kahi o 6 mau lā ma mua o kāu hana i hoʻonohonoho ʻia no ka mea hiki ke hoʻopili i ka hōʻeha ʻana i ka ʻeha E haʻi aku kāu kauka iā ʻoe i ka manawa e hoʻomaka ai e lawe hou i ka lenvatinib ma hope o kāu ʻoki ʻana.
• pono ʻoe e ʻike e hoʻonui paha kou kahe koko i kou wā e mālama ai me ka lenvatinib. E nānā paha kāu kauka i kou kaomi koko i kou wā e lapaʻau ai.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Inā loaʻa kāu mahele lāʻau aʻe i 12 mau hola a ʻoi paha, e lawe i ka lāʻau i hala i kou hoʻomanaʻo ʻana iā ia. Eia nō naʻe, inā e lawe ʻia ka lāʻau aʻe ma lalo o 12 mau hola, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu ʻo Lenvatinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• luhi a luhi paha
• ʻehu, ʻulaʻula, ʻili, a me ka ʻili ʻana o ka ʻili ma nā poho lima a me nā wāwae o ka wāwae
• nausea
• kōpaʻa
• puʻuwai puʻuwai
• hoʻēmi ʻai
• Kaumaha emi
• hoʻololi i ka hiki ke ʻono i ka meaʻai
• ʻūhā
• hulahula
• ʻeha nā waha
• waha maloo
• ʻeha poʻo
• ʻeha puʻupuʻu a me nā ʻeha
• paʻakikī e hiamoe a hiamoe paha
• poho lauoho
• fiva
• puhi ʻana i ka wā urination
• hūwī

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• pokole o ka hanu
• pehu o nā wāwae a me nā kuʻekuʻe wāwae
• ʻeha ka umauma
• numbness a nāwaliwali paha o ka maka, ka lima, a me ka wāwae ma kekahi ʻaoʻao o kou kino
• ʻeha ma nā lima, kua, ʻāʻī, a ʻāʻā
• hikiwawe, ʻeha ke poʻo
• ʻolelo lohi a paʻakikī paha
• hoʻololi koke i ka hihiʻo
• ʻōpū nui loa
• melemele o ka ʻili a me nā maka
• ʻeha ka ʻōpū
• mimi ʻeleʻele
• nā noho waihoʻoluʻu kukui
• ka hopu ʻana
• nāwaliwali
• huikau
• kahe a kūpaʻa ka ihu
• luaʻi koko
• ʻeleʻele, hoʻolōʻihi, a i ʻole nā ​​noho noho koko
• ke kuʻi nei i ke koko a i ʻole ke koko
• kahe nui ke haehae
• ka luaʻi, diarrhea, a i ʻole nā ​​hōʻailona o ka make wai
• nā palapū hoola ʻole

Hoʻokumu paha ʻo Lenvatinib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino iā lenvatinib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Lenvima^®