Mea Kākau: Clyde Lopez
Lā O Ka Hana: 20 Iulai 2021
HōʻAno Hou I Ka Lā: 24 Ianuali 2025
Anonim
Joleen White: Evaluation of Peginterferon Beta-1a & IFN Beta-1a PK, PD, and Immunogenicity in MS
Wikiō: Joleen White: Evaluation of Peginterferon Beta-1a & IFN Beta-1a PK, PD, and Immunogenicity in MS

Anter

Hoʻohana ʻia ka injection ʻo Peginterferon beta-1a e mālama i nā mākua me nā ʻano like ʻole o ka sclerosis maha (MS; kahi maʻi kahi e holo pono ʻole ai nā ʻalalā a ʻike paha ka poʻe i ka nāwaliwali, numbness, nalo ʻana o ka hui pū ʻana o nā mākala, a me nā pilikia me ka hihiʻo, ka ʻōlelo, a kāohi bladder) me kēia mau mea:

  • maʻi hoʻokaʻawale clinically (CIS; nā ʻōuli ʻōuli nerve e kū ma ka liʻiliʻi he 24 mau hola),
  • relapsing-remitting forms (papa o ka maʻi kahi e ʻō ai nā ʻōuli mai kēlā me kēia manawa), a i ʻole
  • nā papa holomua holomua (papa o ka maʻi kahi e hoʻi pinepine ai ka hoʻi ʻana).

Aia ʻo Peginterferon beta-1a injection i kahi papa o nā lāʻau i kapa ʻia ʻo nā immunomodulator. Hana ia ma ka hōʻemi ʻana i ka lī a me ka pale ʻana i nā hōʻino o ke aʻalolo e kumu ai nā ʻōuli o ka sclerosis maha.

ʻO Peginterferon beta-1a injection e hele mai ma ke ʻano he hopena (wai) i kahi peni dosing a i ʻole kahi syringe prefilled e hoʻokomo i ka subcutaneously (ma lalo o ka ʻili). Hoʻokomo pinepine ʻia ia i kēlā me kēia lā i nā lā he 14. Hoʻokomo i ka pahu kui peginterferon beta-1a ma kahi o ka manawa like o ka lā i kēlā me kēia manawa e hoʻokomo ʻoe iā ia. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E hoʻohana i ka pahu kui peginterferon beta-1a e like me ke kuhikuhi. Mai hoʻokomo i ka mea ʻoi aku a liʻiliʻi paha o ia mea a ʻaʻole hoʻi e pahu pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.


E hoʻomaka paha kāu kauka iā ʻoe ma kahi lāʻau haahaa o ka pahu kui peginterferon beta-1a i hiki i kou kino ke hoʻomaʻamaʻa i ka lāʻau. E loaʻa paha iā ʻoe kahi packer hoʻomaka o ka peginterferon beta-1a injection i loaʻa i ʻelua syringes me ʻelua mau kaha haʻahaʻa o ka lāʻau e hoʻohana ai no kāu mau kau ʻelua.

Hiki paha i ka pahu kui Peginterferon beta-1a ke kōkua i ka mālama ʻana i nā sclerosis he nui akā ʻaʻole ia e hoʻōla iā ia. E hoʻomau i ka hoʻohana ʻana i ka pahu kui peginterferon beta-1a ʻoiai inā ʻoluʻolu ʻoe. Mai hooki i ka hoʻohana ʻana i ka pahu kui peginterferon beta-1a me ke kamaʻilio ʻole ʻana me kāu kauka.

Hiki iā ʻoe ke hoʻopili iā peginterferon beta-1a iā ʻoe iho, a i ʻole hiki iā ʻoe ke loaʻa i kahi hoaaloha a i ʻole ʻohana pili i ka lāʻau. E heluhelu pono i nā kuhikuhi a ka mea hana ma mua o kou hoʻopili ʻana i ka lāʻau no ka manawa mua. E noi i kāu kauka a kauka paha e hōʻike iā ʻoe pehea e hoʻopili ai i ka lāʻau.

E hoʻohana i kahi syringe hou a i ʻole ka peni peni i kēlā me kēia manawa ke hoʻopili ʻoe i kāu lāʻau. Mai hoʻohana hou a kaʻana like i nā syringes a i ʻole nā ​​peni. E hoʻolei i nā nūnū a i ʻole nā ​​peni i loko o kahi pahu kūpaʻa kū ʻole i hiki ʻole i nā keiki. E kamaʻilio me kāu kauka a kauka paha e pili ana i ka hoʻolei ʻana i ka ipu kūpaʻa.


Ma mua o kou mākaukau e hoʻokomo i ka peginterferon beta-1a, pono ʻoe e hemo i ka lāʻau mai ka pahu hau, a ʻae iā ia e hoʻomaha ma kahi o 30 mau minuke i hiki iā ia ke hoʻomehana i ka mahana o ka lumi. Mai hoʻāʻo e hoʻomehana i ka lāʻau i ka hoʻomehana ʻana iā ia i loko o ka hawewe, e waiho ana iā ia i loko o ka wai wela, a i ʻole ma o nā ʻano hana ʻē aʻe.

E nānā mau i ka lāʻau i kāu syringe prefilled a i ʻole ka peni ma mua o kāu hoʻohana ʻana. He akāka a kala ʻole paha akā he mau huʻa ea liʻiliʻi paha. Inā ʻohu ke ao o ka lāʻau, kala, a i ʻole loaʻa nā ʻāpana a i ʻole inā ua hala ka lā palena pau i kaha ʻia ma ka peni a me ke ʻākiʻō, mai hoʻohana i kēlā peni a ʻaʻaki. Inā ʻoe e hoʻohana nei i kahi peni, nānā pū hoʻi e ʻike aia he mau ʻōmaʻomaʻo ʻōmaʻomaʻo i ka puka aniani kūlana. Mai hoʻohana i ka peni inā ʻaʻohe ona ʻōmaʻomaʻo ʻōmaʻomaʻo i loko o ka puka aniani kūlana.

Hiki iā ʻoe ke hoʻopili i ka peginterferon beta-1a ma nā wahi āpau o kou ʻōpū, ke kua o kou mau lima luna, a i ʻole kou mau ʻūhā. Koho i kahi wahi ʻokoʻa i kēlā me kēia manawa e hoʻokomo ʻoe i kāu lāʻau. Mai hoʻokomo i kāu lāʻau i loko o ka ʻili i hoʻonāukiuki ʻia, ʻehaʻula, ʻulaʻula, maʻi, a me nā makaʻu.


Hiki paha iā ʻoe ke ʻike i nā hōʻailona like flu e like me headache, iwi a ʻeha ʻeha, kuni, haʻalulu, a me ka luhi i kou wā e mālama ʻia ai me ka peginterferon beta-1a. Pono ʻoe e inu i ka wai i ka manawa o kāu mālama ʻana e kōkua ai i ka pale ʻana a i ʻole kaohi ʻana i kēia mau ʻōuli. E haʻi paha kāu kauka iā ʻoe e lawe i kahi lāʻau i hōʻike ʻole ʻia e hōʻoluʻolu ai i ka ʻeha a pale aku ai i ka fiva ma mua a ma hope paha o kou hoʻopili ʻana i kāu lāʻau e kōkua ai i ka mālama ʻana a i ʻole pale i kēia mau ʻōuli. E kamaʻilio me kāu kauka e pili ana i kahi mau lāʻau ʻē aʻe āu e lawe ai i kāu wā e mālama ai.

E hāʻawi aku kāu kauka a mea kauka paha iā ʻoe i ka pepa ʻikepili a ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me peginterferon beta-1a a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka hoʻopili ʻana i ka pahu paʻi peginterferon beta-1a,

  • e haʻi aku i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻino ʻoe i ka pahu kui peginterferon beta-1a, nā lāʻau lapaʻau beta interferon ʻē aʻe (Avonex, Betaseron, Extavia, Rebif), nā lāʻau ʻē aʻe ʻē aʻe, a i ʻole kekahi o nā mea hana i ka injection ʻo peginterferon beta-1a. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻai, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi i kāu kauka inā loaʻa iā ʻoe a i ʻole i loaʻa i kekahi mau mai ʻo ka hopu ʻana; kahi maʻi noʻonoʻo e like me ke kaumaha, keu hoʻi inā ʻoe i noʻonoʻo e pepehi iā ʻoe iho a hoʻāʻo paha e hana pēlā; nā pilikia koko; nā helu haʻahaʻa o kēlā me kēia ʻano keena koko; a i ʻole ka puʻuwai, ka ate, ka thyroid, a i ʻole nā ​​maʻi hakuʻala.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i ka inikua ʻo peginterferon beta-1a, e kāhea i kāu kauka.
  • inā ke hana ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho ʻo ʻoe ke lawe nei i ka injection peginterferon beta-1a.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

Kāhea i kāu kauka inā hoʻopoina ʻoe e hoʻopili i kahi lāʻau o kēia lāʻau. E haʻi aku kāu kauka iā ʻoe i ka wā e pīkī ai i ka lāʻau i hala ʻole a i ka wā e hoʻokomo ai i kāu lāʻau i hoʻonohonoho ʻia aʻe. Mai hoʻokomo i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ka injection Peginterferon beta-1a i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • ʻeha poʻo
  • ʻehaʻeha a ʻeha pū paha
  • fiva
  • haʻalulu
  • nāwaliwali

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli e kāhea koke i kāu kauka a i ʻole e loaʻa i ka lāʻau lapaʻau olakino.

  • melemele o ka ʻili a me nā maka
  • mimi ʻeleʻele
  • noho hākea
  • nausea
  • ka luaʻi
  • nalo ʻai ʻole
  • ʻāpā ʻaʻano ʻole a hoʻokahe koko paha
  • luhi nui loa
  • huikau
  • ukiuki
  • hopohopo
  • me ka manaʻo hopohopo ʻole a maikaʻi ʻole paha e pili ana iā ʻoe iho
  • ke noʻonoʻo nei e pili ana i ka hōʻino a pepehi paha iā ʻoe iho a i ʻole ke hoʻolālā ʻana a hoʻāʻo ʻana paha e hana pēlā
  • ka hopu ʻana
  • pokole o ka hanu
  • ʻili mae
  • wikiwiki a i ʻole kūpikipiki puʻuwai
  • ʻeha ka umauma
  • hūwī
  • hives
  • ʻūlili
  • ka pehu o nā maka, ka maka, ka waha, ke elelo, ka ʻāʻī, nā lima, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
  • hulahula
  • pilikia i ka hanu ʻana a i ʻole ke ale ʻana
  • ʻulaʻula, mehana, ʻōhū, ʻeha, a maʻi ʻole paha ma kahi āu i hōʻino ai i ka lāʻau i ola ʻole i loko o kekahi mau lā
  • nā noho ʻulaʻula a koko paha a me nā diarrhea
  • ʻeha ka ʻōpū
  • ʻolelo lohi a paʻakikī paha
  • nā pale poni a i ʻole nā ​​kiko kiko (pehu) ma ka ʻili
  • hoʻemi i ka urination a i ʻole ke koko i ka mimi

ʻO Peginterferon beta-1a injection ke kumu o nā hopena ʻē aʻe. Kāhea i kāu kauka inā loaʻa iā ʻoe kekahi pilikia maʻamau i ka loaʻa ʻana o kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i loko o ka pahu hau, akā mai hoʻopili. Inā ʻaʻole hiki iā ʻoe ke mālama i ka lāʻau i loko o ka pahu hau, hiki iā ʻoe ke mālama iā ia i ka mahana wela, mai ka wela, ka mālamalama, a me ka hou a 30 mau lā. E hoʻolei i nā lāʻau i hoʻopaʻa ʻia a i ʻole i hala ʻole a i ʻole pono hou.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino i ka injection o peginterferon beta-1a.

Mai ʻae i kekahi e hoʻohana i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe.Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

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