Trametinib

Anter

• Ma mua o ka lawe ʻana i ka trametinib,
• Hoʻokumu paha ʻo Trametinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e hōʻoki i ka lawe ʻana i ka trametinib a kāhea koke aku i kāu kauka:
• Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

Hoʻohana hoʻokahi ʻia ʻo Trametinib a i ʻole hui pū ʻia me dabrafenib (Tafinlar) e mālama i kekahi ʻano melanoma (kahi ʻano maʻi ʻaʻai ʻili) ʻaʻole hiki ke mālama ʻia me ke ʻoki a i pāhola paha i nā ʻāpana ʻē aʻe o ke kino. Hoʻohana ʻia ia me ka dabrafenib e mālama a pale i ka hoʻi ʻana o kekahi ʻano melanoma ma hope o ke kaha ʻana e hoʻoneʻe iā ia a me nā lymph node i hoʻopili ʻia. Hoʻohana pū ʻia ʻo Trametinib me ka dabrafenib e mālama i kekahi ʻano maʻi ʻaʻai liʻiliʻi liʻiliʻi (NSCLC) i pālahalaha ʻia i nā mea kokoke a i ʻole nā ​​ʻāpana ʻē aʻe o ke kino Hoʻohana ʻia ia me ka dabrafenib e mālama i kekahi ʻano o ka maʻi ʻaʻai thyroid i pālahalaha ʻia i nā mea kokoke a i ʻole nā ​​ʻāpana ʻē aʻe o ke kino, ʻaʻole hiki ke mālama ʻia me nā lāʻau ʻē aʻe. Aia ʻo Trametinib i kahi papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o kahi protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i ka hōʻoki ʻana i nā hunaola maʻi ʻaʻai.

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Hele mai ʻo Trametinib ma ke ʻano he papa e lawe ma ka waha. Lawe ʻia ia i hoʻokahi manawa i ka lā ma ka ʻōpū hakahaka, ma ka liʻiliʻi he 1 hola ma mua a i ʻole 2 mau hola ma hope o ka pāʻina ʻana. E lawe i ka trametinib ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E lawe i ka trametinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka. Mai hōʻoki i ka lawe ʻana i ka trametinib me ke kamaʻilio ʻole ʻana me kāu kauka.

Hiki i kāu kauka ke hoʻoponopono i kāu mahele lāʻau o trametinib ke kaukaʻi ʻia i kāu pane i ka mālama ʻana a me nā hopena ʻē aʻe āu e ʻike ai. E kamaʻilio me kāu kauka e pili ana i kou ʻano i kāu mālama ʻana.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka trametinib,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka trametinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o ka papa trametinib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe.
• e haʻi i kāu kauka inā loaʻa a loaʻa paha ʻoe i ka maʻi maʻi a i ʻole nā ​​pilikia hanu; mimikō; nā pilikia kahe o ke kahe a i ʻole ke kahe o ke koko; colitis (pehu o ke kolona); nā pilikia o ka ʻōpū; ke koko kiʻekiʻe; ka naʻau, ka maka, ka ate, a i ʻole ka maʻi ʻaʻai. a i ʻole nā ​​ʻano olakino ʻē aʻe.
• e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. ʻAʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i ka trametinib. Pono ʻoe e hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i kāu mālama ʻana me trametinib a no 4 mau mahina ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā hana kaohi hānau e holo pono nāu. Inā hāpai ʻoe i ka lawe ʻana i ka trametinib, e kāhea i kāu kauka. Hoʻopilikia paha ʻo Trametinib i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū a i ʻole hoʻolālā e hānai. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana i ka trametinib a no 4 mau mahina ma hope o kāu hopena hope loa.
• pono ʻoe e ʻike i kēia lāʻau i hoʻemi ʻia ka momona i nā wahine. E kamaʻilio me kāu kauka e pili ana i nā pilikia o ka lawe ʻana i ka trametinib.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā he emi ia ma mua o 12 mau hola a hiki i kāu kau palena hope e hoʻolālā ʻia, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu paha ʻo Trametinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ʻili maloʻo
• ʻeha ma ka waha a me ke elelo
• waha maloo
• ka luaʻi
• nalo ʻai ʻole
• hoʻololi i ka hiki ke ʻono i ka meaʻai
• luhi

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e hōʻoki i ka lawe ʻana i ka trametinib a kāhea koke aku i kāu kauka:

• kahe koko ʻole ʻana a palapū paha
• koko a ʻeleʻele paha, noho aliʻi
• ʻū ana a luaʻi paha i ke koko a i ʻole mea e like me ke kumu kope
• ihu ihu
• ʻōpū nui loa
• ʻeha ka ʻōpū
• nausea
• fiva
• haʻalulu
• wikiwiki, kūlike ʻole, a kuʻi paha i ka puʻuwai puʻuwai
• paʻakikī i ka hanu ʻana
• ʻeha ka umauma
• ka pehu o ka maka, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a me nā wāwae
• dizziness, lightheadedness, a nāwaliwali paha
• pokole o ka hanu
• ʻeha ka wāwae, pehu, palupalu, ʻulaʻula, a mehana
• ʻeha poʻo poʻo
• ʻūhā
• ʻike hihi
• loli i ka hihiʻo, me ke ʻike ʻana i ka ʻaneʻane (kahakaha pōuliuli a puni nā mea) a i ʻole nā ​​kiko kala
• nalo o ka hihiʻo
• ʻeha ka maka
• mau maka maloʻo, ʻulaʻula, a pehu paha
• ʻehu, ʻulaʻula, a i ʻole nā ​​pimples
• wart
• he puʻupuʻu ʻulaʻula e hoʻokahe a ʻaʻole hoʻi e hoʻōla
• e hoʻololi i ka nui a me ke kala o kahi mole
• ʻūlili
• pāhū, ulcer, a ʻeha hoʻi ma ka ʻili a me nā kui
• ʻūlū, puhi, ʻulaʻula, ʻōhū, ʻili a i ʻole hehi ʻana, palapū, a ʻeha paha ma nā poho o nā lima a me nā kapuwaʻi o nā wāwae.
• urination pinepine
• hoʻonui ka make wai

Hiki paha i ka Trametinib ke hoʻonui i ka makaʻu e hoʻomohala ʻoe i nā maʻi ʻili hou a i ʻole nā ​​maʻi ʻino ʻē aʻe. E kamaʻilio me kāu kauka e pili ana i ka makaʻu i ka lawe ʻana i kēia lāʻau.

Hoʻokumu paha ʻo Trametinib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo mai ai, pani paʻa ʻia, mai ka pulu a me nā kukui, a mai kahi hiki ʻole o nā keiki. Mai hoʻokomo i nā papa i nā ipu ʻē aʻe, e like me nā pahu pila o kēlā me kēia pule a i ʻole ia pule. E mālama iā ia i loko o ka pahu hau, akā mai hoʻopili. Mai wehe i ka desiccant (ʻāpana liʻiliʻi i hoʻopili ʻia me ka lāʻau e omo ai i ka waiū) mai kāu ʻōmole.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

• pilikia pilikia ʻike

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua hoʻokolohua ma mua a i kou wā o ka mālama ʻana e ʻike inā palekana iā ʻoe e loaʻa trametinib a e nānā i ka pane o kou kino i ka trametinib. E nānā pū kāu kauka i kou ʻili no nā loli ma mua o kou hoʻomaka ʻana i ka lāʻau, i kēlā me kēia 2 mau mahina i kou wā e hoʻomaʻamaʻa ai, a hiki i 6 mau mahina ma hope o ka mālama. E nānā pū kāu kauka i kou kaomi koko mai kēlā manawa a kēia manawa e pono ai.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Mekinist^®