Nilotinib

Anter

• Ma mua o ka lawe nilotinib,
• Hiki i ka Nilotinib ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻ sectionlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka:

Hiki iā Nilotinib ke hoʻolōʻihi i ka QT (kahi puʻuwai puʻuwai kūpono ʻole e hiki ai i ka nāwaliwali, nalowale o ka ʻike, hopu ʻia, a make koke paha). E haʻi i kāu kauka inā ʻo ʻoe a i ʻole kekahi o kou ʻohana i loaʻa a loaʻa paha iā QT maʻi lōʻihi (kahi ʻano hoʻoilina e nui ai ka lōʻihi o ka QT) a i ʻole loaʻa paha iā ʻoe nā haʻahaʻa o ka potassium a me ka magnesium i loko o kou koko. , kahi kuʻi puʻuwai kūpono ʻole, a i ʻole maʻi maʻi ate. E haʻi i kāu kauka a me ka kauka inā ʻoe e lawe amiodarone (Nexterone, Pacerone); nā antifungals e like me ketoconazole, itraconazole (Onmel, Sporanox), a i ʻole voriconazole (Vfend); chloroquine (Plaquenil); clarithromycin (Biaxin, i Prevpac); disopyramide (Norpace); erythromycin (E.E.S., Eryc, PCE); kekahi mau lāʻau no ka maʻi pale maʻi (HIV) a i ʻole loaʻa i ka maʻi maʻi maʻi maʻi (AIDS) e like me atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ma Kaletra), a me saquinavir (Invirase); haloperidol (Haldol); methadone (Dolophine, Methadose); moxifloxacin (Avelox); nefazodone; pimozide (Orap); procainamide; quinidine (i Nuedexta); sotalol (Betapace, Betapace AF, nā mea ʻē aʻe); telithromycin (Ketek); a me thioridazine. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e hōʻoki i ka lawe ʻana i ka nilotinib a kāhea koke aku i kāu kauka: wikiwiki, kuʻi, a i ʻole kuʻi puʻuwai maikaʻi ʻole. maule ana; nalowale o ka ʻike; aiʻole ka hopu ʻana.

Mai ʻai i kekahi meaʻai no ka liʻiliʻi ma 2 mau hola ma mua o ka lawe ʻana i ka nilotinib a no 1 hola ma hope o ka lawe ʻana i kēia lāʻau.

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua, e like me nā hoʻokolohua koko a me nā electrocardiograms (EKGs, nā hoʻāʻo e hoʻopaʻa i ka hana uila o ka puʻuwai) ma mua a i kou wā e hoʻomaʻamaʻa ai e mālama pono ia nāu e lawe i ka nilotinib.

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui o ka mea hana (Kauka Lapaʻau) ke hoʻomaka ʻoe i ka lāʻau me nilotinib a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i ka nilotinib.

Hoʻohana ʻia ʻo Nilotinib e mālama i kekahi ʻano o ka leukemia myeloid mau (CML; kahi ʻano maʻi ʻaʻai o nā hunaola keʻokeʻo) i ʻike hou ʻia e loaʻa i kēia ʻano i nā mākua a me nā keiki ʻo 1 mau makahiki a ʻoi paha. Hoʻohana ʻia ia e mālama i kekahi ʻano o CML i hiki ʻole ke mālama kūleʻa ʻia ka maʻi me ka imatinib (Gleevec) a i ʻole nā ​​mākua i hiki ʻole ke lawe i imatinib. Hoʻohana ʻia ʻo Nilotinib e mālama i kekahi ʻano o ka CML i nā keiki 1 makahiki a ʻoi paha o ka makahiki i hiki ʻole ke mālama kūleʻa ʻia i ko lākou maʻi me nā lāʻau kūpoki kinase tyrosine kinase ʻē aʻe. Aia ʻo Nilotinib i kahi papa o nā lāʻau i kapa ʻia nā kinase inhibitors. Hana ia ma ke kāpae ʻana i ka hana o ka protein pono ʻole e hōʻailona ai i nā hunaola maʻi ʻaʻai e hoʻonui. Kōkua kēia i mea e hōʻoki a hoʻolohi ai paha i ka hoʻolaha ʻana o nā hunaola maʻi ʻaʻai.

Hele mai ʻo Nilotinib ma ke ʻano he capsule e lawe ma ka waha. Lawe pinepine ʻia me ka ʻai ʻole ʻelua mau lā i ka lā. Pono e lawe ʻia ʻo Nilotinib ma kahi ʻōpū nele, ma ka liʻiliʻi he 2 mau hola ma mua a i ʻole 1 hola ma hope o ka ʻai ʻana i kekahi meaʻai. Lawe i ka nilotinib ma nā manawa like i kēlā me kēia lā. E hoʻāʻo e hoʻokaʻawale i kāu kau ma kahi o 12 mau hola ke kaʻawale. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono i ka nilotinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E hoʻopau piha i nā capsule me ke kīʻaha wai; mai hoʻokaʻawale, a nau aku, a hoka ʻole iā lākou. Inā ʻaʻole hiki iā ʻoe ke ale i nā capsule holoʻokoʻa, e kāwili i nā ʻike o ka capsule i hoʻokahi teaspoon o ka ʻāpala. E ale koke i ka hui (i loko o 15 mau minuke.) Mai mālama i ka hui ʻana no ka hoʻohana ʻia o ka wā e hiki mai ana.

E hoʻemi paha kāu kauka i kāu lāʻau nilotinib a i ʻole hoʻokū i kāu lāʻau lapaʻau e pili ana i ka maikaʻi o ka hana ʻana o ka lāʻau iā ʻoe a inā ʻoe e ʻike i nā hopena ʻaoʻao. E hoʻomau i ka lawe ʻana i ka nilotinib ʻoiai inā maikaʻi ʻoe. Mai hōʻoki i ka lawe ʻana i ka nilotinib me ke kamaʻilio ʻole ʻana me kāu kauka.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe nilotinib,

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka nilotinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā capsule nilotinib. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, a me nā mea hoʻopihaʻai pono ʻole āu e lawe nei a hoʻolālā paha e lawe. E ʻōlelo pono i nā lāʻau i helu ʻia i ka ʻĀINA WAIWAI nui a me kekahi o kēia mau mea: kekahi blockers angiotensin-receptor blockers e like me irbesartan (Avapro, ma Avalide) a me losartan (Cozaar, ma Hyzaar); anticoagulants ('' nā mea hōʻemi koko '') e like me warfarin (Coumadin, Jantoven); aripiprazole (Abilify); kekahi benzodiazepines e like me alprazolam (Xanax), diazepam (Valium), midazolam, a me triazolam (Halcion); buspirone (Buspar); kekahi mau blockers channel calcium e like me amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, a me nā mea ʻē aʻe), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), a me verapamil (Calan, Verelan, a me nā mea ʻē aʻe) ; kekahi mau lāʻau hoʻohaʻahaʻa kolesterol (statins) me atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin (Altoprev), a me simvastatin (Zocor); chlorpheniramine (Chlor-Trimeton, nā huā a me nā huahana anu); dexamethasone; dihydroergotamine (D.H.E. 45, Migranal); ergotamine (i Cafergot, i Ergomar); fentanyl (Actiq, Duragesic, Subsys); flecainide (Tambocor); kekahi mau lāʻau no ke kaumaha e like me amitriptyline, desipramine (Norpramin); duloxetine (Cymbalta); imipramine (Tofranil); paroxetine (Brisdelle, Paxil, Pexeva); a me ka venlafaxine (Effexor); kekahi mau lāʻau waha no ka maʻi kō e like me glipizide (Glucotrol) a me tolbutamide; kekahi mau lāʻau e kāohi i ka ʻōnaehana pale e like me cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), a me tacrolimus (Prograf); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Equetro, Tegretol, Teril), phenobarbital, a me phenytoin (Dilantin, Phenytek); mexiletine; kekahi mau lāʻau anti-inflammatory nonsteroidal (NSAIDs) e like me celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), a me piroxicam (Feldene); ondansetron (Zofran); propafenone (Rythmol); nā mea pale proton-pump e like me esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), a me rabeprazole (AcipHex); quinine (Qualaquin); rifabutin (Mycobutin); rifampin (Rifadin); rifapentine (Priftin); risperidone (Risperdal); sildenafil (Viagra, Revatio); tamoxifen; testosterone (Androderm, Androgel, Striant, nā mea ʻē aʻe); timolol; kāwīwī; tramadol (Ultram, i Ultracet); trazodone; a me ka vincristine. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Pili pū paha nā lāʻau ʻē aʻe he nui me ka nilotinib, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• inā ʻoe e lawe i nā antacids i loaʻa ka magnesium, aluminika (Maalox, Mylanta, Tums, a me nā mea ʻē aʻe), a i ʻole simethicone, e lawe i ka antacid he 2 mau hola ma mua a ma kahi o 2 mau hola ma hope o kou lawe ʻana i ka nilotinib.
• inā ʻoe e lawe i kahi lāʻau no ka palaka ʻana, ka puʻuwai, a i ʻole nā ​​maʻi ulcer e like me cimetidine (Tagamet), famotidine (Pepcid, in Duexis), nizatidine (Axid), a i ʻole ranitidine (Zantac), lawe ma ka liʻiliʻi he 10 mau hola ma mua a i ʻole 2 paha. mau hola ma hope o kou lawe ʻana i ka nilotinib.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi i kāu kauka inā loaʻa ʻoe i ka maʻi hahau a i ʻole ke ʻoki kino e wehe i ka ʻōpū holoʻokoʻa (gastrectomy āpau). Eia kekahi, e haʻi i kāu kauka inā ua hōʻemi paha ʻoe i ke kahe o ke koko i kou mau wāwae, nā pilikia puʻuwai, nā pilikia kahe ʻana o ke koko, pancreatitis (ka pehu ʻana o ka pancreas, kahi gland ma hope o ka mea e hua ai nā mea e kōkua ai me ka digestion), a i ʻole kekahi ʻano e hana paʻakikī iā ʻoe e ʻeli i ka lactose (kō kō waiū) a i ʻole nā ​​kō ʻē aʻe.
• e haʻi i kāu kauka inā hāpai ʻoe a i ʻole hoʻolālā e hāpai. ʻAʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i ka nilotinib. Pono ʻoe e hoʻohana i ka kaohi hānau kūpono e pale ai i ka hāpai ʻana i kāu mālama ʻana me nilotinib a no 14 mau lā ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Inā hāpai ʻoe i ka lawe ʻana i ka nilotinib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Nilotinib i ka fetus.
• e haʻi i kāu kauka inā ʻoe e hānai umauma ana. ʻAʻole pono ʻoe e hānai i ka umauma ʻoiai ʻoe e lawe nei i ka nilotinib a no 14 mau lā ma hope o kāu hopena hope loa.
• inā ke ʻoki nei ʻoe, e like me ke kaha ʻana o nā niho, e haʻi i ke kauka a i ʻole kauka niho e lawe nei ʻoe i ka nilotinib.

Mai ʻai i ka huaʻulu, inu i ka wai wai, a i ʻole lawe i nā waihona i loko o ka huaʻulu grapefruit i ka lawe ʻana i kēia lāʻau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i ka Nilotinib ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• hūwī
• ʻūlili
• nausea
• ka luaʻi
• pāhoehoe
• kōpaʻa
• puʻuwai puʻuwai
• ʻenekini
• nalo ʻai ʻole
• ʻeha poʻo
• ʻūpā
• luhi
• paʻakikī e hiamoe a hiamoe paha
• puhū pō
• ʻūpē mākala
• kua, iwi, pili, lālā, a ʻeha ʻeha hoʻi
• poho lauoho
• ʻili maloʻo a ʻulaʻula paha
• numbness, puhi ʻana, a i ʻole ka ʻūlū ʻana i nā lima a me nā wāwae paha

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻ sectionlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka:

• kahe koko ʻole ʻana a palapū paha
• koko i ka mimi
• koko a ʻeleʻele paha, noho aliʻi
• ʻeha poʻo, huikau, a i ʻole hoʻololi i ka hihiʻo
• luhi ʻole a nawaliwali paha
• ʻeha o ka umauma a hōʻoluʻolu ʻole paha
• nā pilikia e hele wāwae ana a i ʻole ke kamaʻilio ʻana
• ʻōlohelohe
• hoʻololi i ka ʻili o ka ʻili wāwae
• ʻeha a i ʻole ke anuanu i nā wāwae
• ʻeha o ka ʻōpū me ka nausea a me ka luaʻi
• ke kuni, ke anu, ka ʻāʻī, ka ʻū a me ka paʻa mau, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• ʻili mae
• pokole o ka hanu
• loaʻa kaupaona
• pehu o nā lima, nā kuʻekuʻe wāwae, nā wāwae, a i ʻole ke alo
• ʻeha a hōʻoluʻolu ʻole paha ma ka ʻaoʻao ʻōpū o luna pono
• melemele o ka ʻili a me nā maka
• mimi ʻeleʻele
• urencing emi pinepine ma mua o mau

Na Nilotinib paha e hoʻoulu lohi i nā keiki. E nānā ke kauka o kāu keiki i ka ulu pono o kāu keiki ʻoiai ke lawe nei kāu keiki i ka nilotinib. E kamaʻilio me kāu kauka o kāu keiki e pili ana i ka makaʻu o ka hāʻawi ʻana i kēia lāʻau i kāu keiki.

Hiki i ka Nilotinib ke hana i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Pākuʻi ʻia paha nā ʻōuli o ka overdose:

• fiva, ʻeha ka ʻāʻī, haʻalulu, a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi
• ka luaʻi
• hiamoe

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Tasigna^®