Antigen HLA-B27

HLA-B27 kahi hoʻāʻo o ke koko e nānā no kahi protein i loaʻa ma ka ʻili o nā hunaola keokeo. Kapa ʻia ka protein i ke kanaka leukositte antigen B27 (HLA-B27).

ʻO nā antigens leukocyte kanaka (HLAs) he mau polokina ia e kōkua ai i ka pale o ke kino e haʻi i ka ʻokoʻa ma waena o kāna mau huna ponoʻī a me nā haole, nā mea ʻino. Hana ʻia lākou i nā ʻōlelo aʻo e nā ʻāpana hoʻoilina.

Pono kahi laʻana koko. ʻO ka hapanui o nā manawa, huki ʻia ke koko mai kahi aa i waiho ʻia ma loko o ka kuʻe lima a i ʻole ka hope o ka lima.

I ka hapanui o nā hihia, ʻaʻole pono nā hanana kūikawā e hoʻomākaukau ai no ka hōʻike.

Ke hoʻokomo ʻia ke kui kele e huki i ke koko, ʻike paha ʻoe i ka ʻehaʻeha o ka ʻeha, a i ʻole ka prick a i ʻole ka nau ʻana o ka naʻau. Ma hope, aia paha kekahi ʻōkā.

E kauoha paha kāu mea mālama mālama ola i kēia hoʻāʻo e kōkua ai i ka hoʻoholo ʻana i ke kumu o ka ʻeha pū, ka ʻoʻoleʻa, a me ka pehu ʻana. E hana ʻia paha ka hōʻike me nā hōʻike ʻē aʻe, e like me:

• Pūmua C-reactive
• Ka helu sedimentation ʻErythrocyte (ESR)
• ʻLelo Rheumatoid
• Nā kukuna X

Hoʻohana pū ʻia ka hoʻokolohua HLA e kūlike me nā kiko i manawaleʻa ʻia me nā kiko o ke kanaka e loaʻa nei kahi transplant organ. ʻO kahi laʻana, hiki ke hana ʻia i ka wā e pono ai ke kanaka i kahi transplant kidney a i ʻole ke kuʻi iwi o ka iwi.

ʻO kahi hopena maʻamau (maikaʻi ʻole) ʻo ia ka HLA-B27 ʻaʻole i hele.

Kuhi ʻia kahi hōʻike maikaʻi ʻo HLA-B27 i kēia manawa. Hōʻike ia i kahi ʻoi aku ka maikaʻi ma mua o ka awelika no ka hoʻomohala ʻana a i ʻole loaʻa kekahi mau maʻi autoimmune. ʻO kahi maʻi autoimmune kahi ʻano i kū ke kuhi hewa ka ʻōnaehana pale a hoʻopau i nā kino o ke kino olakino.

Hiki i kahi hopena maikaʻi ke kōkua i kāu mea hāʻawi e hana i kahi ʻano o kahi ʻano o ka maʻi o ka maʻi i kapa ʻia ʻo spondyloarthritis. Hoʻopili kēia ʻano ʻānō i kēia mau maʻi:

• Spondylitis Ankylosing
• ʻO ka maʻi e pili ana i ka maʻi Crohn a i ʻole colitis ulcerative
• Psoriatic arthritis (arthritis e pili ana me psoriasis)
• Pākuʻi reactive
• Sacroiliitis (hoʻāhu o ka sacroiliac ami)
• Uveitis

Inā loaʻa iā ʻoe nā hōʻailona a i ʻole nā ​​hōʻailona o spondyloarthritis, hiki i kahi hōʻike HLA-B27 maikaʻi ke hōʻoia i ka ʻike. Eia nō naʻe, loaʻa ʻo HLA-B27 i kekahi mau kānaka maʻamau a ʻaʻole ia he kumu he maʻi kou.

ʻO nā pōʻino mai ke kahe ʻana o ke koko he liʻiliʻi, akā hiki ke hoʻopili ʻia:

• Kahe nui ke koko
• Pāleʻale a ʻoluʻolu paha
• Hematoma (hōʻiliʻili koko ma lalo o ka ʻili)
• Maʻiʻaʻai (i iki kamepiula i kēlā me kēia manawa ka ʻili i haki)

Kanaka leukocyte antigen B27; Ankylosing spondylitis-HLA; Psoriatic arthritis-HLA; Reactive arthritis-HLA

• Hōʻaʻo koko

Chernecky CC, Berger BJ. Kanaka Leukocyte Antigen (HLA) B-27 - koko. I: Chernecky CC, Berger BJ, hua. Nā Hoʻokolohua Laboratory a me nā kaʻina hana Diagnostic. ʻElua huaʻōlelo St Louis, MO: Elsevier Saunders; 2013: 654-655.

Fagoaga OR. Antigen leukocyte kanaka: ka paʻakikī histocompatibility nui o ke kanaka. I: McPherson RA, Pincus MR, hua. ʻO kā Henry's Clinical Diagnosis a me Management e nā Laboratory Methods. 23rd Ed. St Louis, MO: Elsevier; 2017: chap 49.

Inman RD. ʻO nā spondyloarthropathies. I: Goldman L, Schafer AI, eds. ʻO ka lāʻau lapaʻau Goldman-Cecil. 25th hua. Piladelapia, PA: Elsevier Saunders; 2016: chap 265.

ʻO McPherson RA, ʻo Massey HD. ʻO ka nānā ākea o ka ʻōnaehana pale a me nā maʻi immunologic. I: McPherson RA, Pincus MR, hua. ʻO kā Henry's Clinical Diagnosis a me Management e nā Laboratory Methods. 23rd Ed. St Louis, MO: Elsevier; 2017: chap 43.

Reveille JD. ʻO Spondyloarthritis. I: Rich RR, Fleisher TA, Shearer WT, Schroeder HW, Kakaʻu AJ, Weyand CM, hua. ʻO Immunology Haumāna: Nā Kumu a me nā Haʻawina. 5th lā. Piladelapia, PA: Elsevier; 2019: chap 57.