Hōʻaʻo koko TBG

Hoʻopili ke kīʻaha koko TBG i ke kiʻekiʻe o kahi protein e hoʻoneʻe i ka hormone thyroid ma loko o kou kino. Kapa ʻia kēia protein ʻo thyroxine binding globulin (TBG).

Lawe ʻia kahi laʻana koko a laila hoʻouna ʻia i kahi keʻena hoʻokolohua no ka hoʻāʻo ʻana.

Hiki i kekahi mau lāʻau a me nā lāʻau ke hoʻololi i nā hopena hōʻike. E haʻi paha kāu mea mālama ola iā ʻoe e haʻalele i ka lawe ʻana i kekahi lāʻau no kekahi manawa pōkole ma mua o ka hoʻāʻo ʻana. Mai hōʻoki i ka lawe ʻana i ka lāʻau me ka kamaʻilio mua ʻole ʻana i kāu mea hāʻawi.

Hiki i kēia mau lāʻau a me nā lāʻau ke hoʻonui i ka pae TBG:

• ʻO Estrogens, i loaʻa i nā kaola kaohi hānau a me ka estrogen replacement therapy
• Heroin
• Methadone
• Phenothiazines (kekahi mau lāʻau antipsychotic)

Hiki i nā lāʻau aʻe ke hōʻemi i nā pae TBG:

• ʻO Depakote a i ʻole depakene (i kapa ʻia hoʻi ʻo valproic acid)
• ʻO Dilantin (i kapa ʻia ʻo phenytoin)
• ʻO nā kaha kiʻekiʻe o salicylates, me aspirin
• Nā homone kāne, e like me androgens a me testosterone
• Prednisone

Ke hoʻokomo ʻia ke kui kele e huki i ke koko, manaʻo kekahi poʻe i ka ʻeha kaulike. ʻIke wale kekahi i kahi ʻōniʻu a i ʻole kui. Ma hope, loaʻa paha i kahi kūpikipiki a i ʻole ʻeha iki. Hele koke kēia.

Hana ʻia paha kēia hōʻike e hōʻike i nā pilikia me kāu thyroid.

ʻO ka pae maʻamau he 13 a 39 mau microgram no ka deciliter (mcg / dL), a i ʻole 150 a 360 mau nanomoles i kēlā me kēia lita (nmol / L).

Hiki ke loli iki nā pae waiwai maʻamau i waena o nā hale hana ʻokoʻa. Hoʻohana kekahi mau labs i nā ana like ʻole a i ʻole hoʻokolohua i nā laʻana like ʻole. E kamaʻilio i kāu mea hāʻawi e pili ana i ke ʻano o kāu mau hopena hōʻike.

Loaʻa paha kahi pae TBG hoʻonui ʻia ma muli o:

• ʻO porphyria intermittent huikau (kahi maʻi metabolik laha ʻole)
• Hypothyroidism (underactive thyroid)
• Maʻi maʻi ate
• Hāpai keiki (TBG pae maʻamau hoʻonui i ka wā hāpai keiki)

Kaha: kiʻekiʻe nā pae TBG i nā keiki hānau hou.

ʻO nā pae TBG i hōʻemi ʻia ma muli o:

• Maʻi maʻi koʻikoʻi
• Acromegaly (maʻi i hoʻokumu ʻia e ka nui o ka ulu ʻana o ka hormone)
• Hyperthyroidism (overactive thyroid)
• Kaʻai pono ʻole
• Nephrotic Syndrome (nā hōʻailona e hōʻike nei i ka hōʻino ʻana o ka hakuʻala i kēia manawa)
• Kaumaha mai ke ʻoki kino

Hiki i nā pae TBG kiʻekiʻe a haʻahaʻa paha ke hoʻopili i ka pilina ma waena o ka nui o nā T4 a me nā hōʻike T4 manuahi. Hiki i kahi loli i nā kiʻekiʻe o ke koko TBG ke hoʻololi i ka mahele kūpono o ka pani hou ʻana o levothyroxine no nā poʻe me ka hypothyroidism.

ʻAʻohe pilikia iki i ka lawe ʻia ʻana o kou koko. ʻOkoʻa nā aʻa a me nā aʻa i ka nui mai kekahi kanaka a i kekahi ʻē aʻe a mai kekahi ʻaoʻao o ke kino i kekahi. ʻOi aku ka paʻakikī o ka loaʻa ʻana o kahi laʻana koko mai kekahi poʻe ma mua o nā poʻe ʻē aʻe.

ʻOi aku nā mea ʻino ʻē aʻe o ke kaʻi ʻia ʻana o ke koko, akā hiki ke hoʻopili ʻia:

• Kahe nui ke koko
• Pāleʻale a ʻoluʻolu paha
• Nā punctures he nui e ʻimi i nā uaua
• Hematoma (kūkulu koko ma lalo o ka ʻili)
• Maʻiʻaʻai (i iki kamepiula i kēlā me kēia manawa ka ʻili i haki)

Serum thyroxine hoopaa globulin; Pae TBG; Pae Serum TBG; Hypothyroidism - TBG; Hyperthyroidism - TBG; Thyroid underactive - TBG; ʻO ka nui o ka thyroid - TBG

• Hōʻaʻo koko

ʻO Guber HA, Farag AF. ʻO ka loiloi o ka hana endocrine. I: McPherson RA, Pincus MR, hua. ʻO kā Henry's Clinical Diagnosis a me Management e nā Laboratory Methods. 23rd Ed. St Louis, MO: Elsevier; 2017: chap 24.

Kruse JA. Nā maʻi thyroid. I: Parrillo JE, Dellinger RP, eds. Lapaʻau mālama koʻikoʻi: nā loina o ka ʻike a me ka hoʻokele i ka makua. 5th lā. Piladelapia, PA: Elsevier; 2019: chap 57.

ʻO Salvatore D, Cohen R, Kopp PA, Larsen PR. ʻO ka thyroid pathophysiology a me ka loiloi diagnostic. I: Melmed S, Auchus RJ, Goldfine AB, Koenig RJ, Rosen CJ, eds. ʻO Williams Textbook of Endocrinology. 14th ed. Piladelapia, PA: Elsevier; 2020: chap 11.