Hormone therapy no ka maʻi ʻaʻai prostate

Hoʻohana ka Hormone therapy no ka maʻi ʻaʻai prostate i ka ʻoki ʻana a i ʻole nā ​​lāʻau e hoʻohaʻahaʻa ai i nā pae o ke kāne male i loko o ke kino o ke kāne. Kōkua kēia i ka lohi o ka ulu ʻana o ka maʻi ʻaʻai prostate.

ʻO nā Androgens nā kāne moe kāne. ʻO Testostero kekahi ʻano nui o androgen. Hana ʻia ka hapa nui o ka testosterone e nā testicle. Hoʻopuka pū kekahi nā gland adrenal i kahi mea liʻiliʻi.

Hoʻokumu ʻo Androgens i nā ulu maʻi ʻaʻai prostate e ulu. Hoʻohaʻahaʻa ka Hormone therapy no ka maʻi ʻaʻai prostate i ka pae o nā androgens i ke kino. Hiki iā ia ke hana i kēia e:

• Ke kū nei i nā testicle mai ka hana ʻana i androgens me ka hoʻohana ʻana i ke ʻoki a me nā lāʻau
• Ke kāpae nei i ka hana o androgens i ke kino
• Ke kū nei i ke kino mai ka hana ʻana i androgens

ʻAneʻane hoʻohana ʻole ʻia ʻo Hormone therapy no ka poʻe me ka maʻi ʻaʻai prostate Stage I a Stage II paha.

Hoʻohana nui ʻia ia no:

• Ua pālahalaha ka maʻi ʻaʻai holomua ma mua o ka gland prostate
• Ka maʻi ʻaʻai i hōʻole ʻole e pane i ke kahakaha a i ʻole ka radiation
• Ka maʻi ʻaʻai i hoʻi hou

Hiki nō ke hoʻohana:

• Ma mua o ka pāhawewe ʻana a i ʻole ke ʻoki kino e kōkua ai e hōʻemi i nā tumors
• Me ke radiation radiation no ka maʻi ʻaʻai e hoʻi hou ana paha

ʻO ka lapaʻau maʻamau ka lawe ʻana i nā lāʻau i hoʻohaʻahaʻa i ka nui o nā androgens i hana ʻia e nā testicle. Kāhea ʻia lākou he mau analogs (lH-RH) luteinizing hormon-hoʻokuʻu ʻia a me nā anti-androgens (papa waha). Hoʻoiho kēia mau lāʻau i nā pae androgen e like me ke kahakaha ʻana. Kāhea ʻia kēia ʻano lapaʻau i kekahi manawa ʻo "castration kemika."

ʻO nā kāne i loaʻa i ka androgen deprivation therapy e pono e loaʻa nā hoʻokolohua ukali me ke kauka e kuhikuhi nei i nā lāʻau.

• Ma waena o 3 a 6 mau mahina ma hope o ka hoʻomaka ʻana o ka hoʻoponopono
• I hoʻokahi manawa i ka makahiki, e nānā i ke kahe o ke koko a hana i ke kō kō (glucose) a me nā hoʻokolohua kolesterol
• E kiʻi i nā hoʻokolohua koko PSA e nānā i ke ʻano o ka hana ʻana o ka lāʻau

Hāʻawi ʻia nā analogs LH-RH ma ke ʻano he pū a i ʻole he implant liʻiliʻi i hoʻonoho ʻia ma lalo o ka ʻili. Hāʻawi ʻia lākou i kēlā me kēia wahi mai hoʻokahi manawa i ka mahina a hoʻokahi manawa i ka makahiki. Hoʻopili kēia mau lāʻau:

• Leuprolide (Lupron, Eligard)
• ʻO Goserelin (Zoladex)
• ʻO Triptorelin (Trelstar)
• Histrelin (Vantas)

ʻO kekahi lāʻau lapaʻau, degarelix (Firmagon), he mea kūʻē LH-RH. Hoʻoemi ia i nā pae androgen me ka wikiwiki a ʻoi aku ka liʻiliʻi o nā hopena. Hoʻohana ʻia ia i nā kāne me ka maʻi ʻaʻai nui.

Paipai kekahi mau kauka e kū a hoʻomaka hou i ka lāʻau ʻana (intermittent therapy). ʻIke ʻia kēia ala e kōkua i ka hōʻemi ʻana i nā hopena ʻaoʻao o ka hormone therapy. Eia naʻe, ʻaʻole maopopo inā hana ka intermittent therapy a me ka hoʻomau hoʻomau. Hōʻike kekahi mau noiʻi e ʻoi aku ka maikaʻi o ka hoʻomau hoʻomau ʻana a i ʻole e hoʻohana wale ʻia ka lāʻau intermittent no nā ʻano wae o ka maʻi ʻaʻai prostate.

Hoʻokiʻoki ke ʻoki ʻana i nā testicle (castration) i ka hana ʻana o ka hapa nui o nā androgens i ke kino. Hoʻoiho hoʻi kēia a kū i ka maʻi ʻaʻai prostate mai ka ulu ʻana. ʻOiai maikaʻi, ʻaʻole koho ka hapa nui o nā kāne i kēia koho.

ʻO kekahi mau lāʻau e hana nei ma ke kāpae ʻana i ka hopena o androgen ma nā hunaola maʻi ʻaʻai prostate. Kapa ʻia lākou he anti-androgens. Lawe ʻia kēia mau lāʻau e like me nā pila. Hoʻohana pinepine ʻia lākou i ka wā o nā lāʻau e hoʻohaʻahaʻa ai i nā pae o androgen e hana ʻole pū kekahi ana.

Hoʻopili nā anti-androgens i:

• Flutamide (Eulexin)
• Enzalutamide (Xtandi)
• Abiraterone (Zytiga)
• ʻO Bicalutamide (Casodex)
• Nilutamide (Nilandron)

Hiki ke hana i nā Androgens ma nā wahi ʻē aʻe o ke kino, e like me nā adrenal glands. Hiki i kekahi mau hunaola maʻi ʻaʻai prostate ke hana i androgens. ʻEkolu mau lāʻau e kōkua i ka hoʻōki ʻana i ke kino mai ka hana ʻana i nā androgens mai nā mea ʻē aʻe ma mua o nā testicle.

ʻElua mau lāʻau, ketoconazole (Nizoral) a me aminoglutethimide (Cytradren), mālama i nā maʻi ʻē aʻe akā hoʻohana ʻia i kekahi manawa e mālama i ka maʻi ʻaʻai prostate. ʻO ke kolu, ʻo abiraterone (Zytiga) mālama i ka maʻi ʻaʻai prostate holomua i hoʻolaha ʻia i nā wahi ʻē aʻe o ke kino.

I ka hala ʻana o ka manawa, lilo ka maʻi ʻaʻai prostate i mea pale i ka hoʻōla hormonone. ʻO kēia ke kumu o ka maʻi ʻaʻai e pono ai i nā pae haʻahaʻa o androgen e ulu. Ke kū kēia, hiki ke hoʻohui ʻia i nā lāʻau hou aʻe a i ʻole nā ​​mālama ʻē aʻe.

Loaʻa nā hopena o Androgens i ke kino holoʻokoʻa. No laila, hiki i nā mālama e hoʻohaʻahaʻa i kēia mau hormones ke hana i nā hopena ʻē aʻe he nui. ʻO ka lōʻihi o kou lawe ʻana i kēia mau lāʻau, ʻo ka nui o ka hopena o ka hopena.

Pākuʻi ʻia lākou:

• Ka pilikia i ke kūkulu ʻana i ka hale a ʻaʻole hoihoi i ka moekolohe
• Hoʻopiʻi i nā testicle a me nā peni
• ʻO nā kukuna wela
• Nā iwi nāwaliwali a haki paha
• ʻO nā mākala liʻiliʻi, nāwaliwali hoʻi
• Hoʻololi i nā momona o ke koko, e like me ka cholesterol
• Nā loli i ke kō kō
• Kaumaha hoʻonui
• Swings hāhuli
• Ka luhi
• ʻO ka ulu ʻana o kaʻiʻo o ka umauma, palupalu ka umauma

Hiki i ka hoʻowalewale Androgen therapy ke hoʻonui i nā pilikia no ka maʻi diabetes a me ka maʻi puʻuwai.

Ke hoʻoholo nei i ka hoʻokolohua hormonal no ka maʻi ʻaʻai prostate hiki ke lilo i hoʻoholo paʻakikī a paʻakikī hoʻi. Pili paha ke ʻano o ka mālama ʻana i:

• ʻO kou makaʻi no ka maʻi ʻaʻai e hoʻi nei
• Pehea kou neʻe ʻana i kou maʻi ʻaʻai
• Inā paha ua oki ka hana ʻana i nā lāʻau ʻē aʻe
• Inā ua pālahalaha ka maʻi ʻaʻai

ʻO ke kamaʻilio pū ʻana me kāu mea hāʻawi e pili ana i kāu mau koho a me nā pono a me nā pōpilikia o kēlā me kēia lapaʻau hiki ke kōkua iā ʻoe e hoʻoholo pono loa iā ʻoe.

Hoʻoiho Androgen therapy; ADT; Androgen suppression therapy; Pākuʻi androgen hoʻohui ʻia; Orchiectomy - maʻi ʻaʻai prostate; Castration - maʻi ʻaʻai prostate

• Anatomia hānau kāne

Pūnaewele ʻAmelika Hui Pū ʻIa ʻAmelika. Hormone therapy no ka maʻi ʻaʻai prostate. www.cancer.org/cancer/prostate-cancer/treating/hormone-therapy.html. Hoʻohou i Kēkēmapa 18, 2019. Loaʻa iā Malaki 24, 2020.

Pūnaewele ʻo National Cancer Institute. Hormone therapy no ka maʻi ʻaʻai prostate. www.cancer.gov/types/prostate/prostate-hormone-therapy-fact-sheet. Hoʻohou i Pepeluali 28, 2019. Loaʻa iā Kēkēmapa 17, 2019.

Pūnaewele ʻo National Cancer Institute. Hoʻomaʻo Prostate cancer (PDQ) - mana loea olakino. www.cancer.gov/types/prostate/hp/prostate-treatment-pdq. Hoʻohou i Ianuali 29, 2020. Loaʻa iā Malaki 24, 2020.

Pūnaewele Pūnaewele Manuahi Manuahi. Nā kulekele hana hoʻokolohua NCCN i ka oncology (nā alakaʻi NCCN): ka maʻi ʻaʻai prostate. Mana 1.2020. www.nccn.org/professionals/physician_gls/pdf/prostate.pdf. Hoʻohou ʻia Malaki 16, 2020. Loaʻa iā Malaki 24, 2020.

ʻO Eggener S. Hormonal therapy no ka maʻi ʻaʻai prostate. I: Partin AW, Dmochowski RR, Kavoussi LR, Peters CA, eds. Campbell-Walsh Urology. 12th ed. Piladelapia, PA: Elsevier; 2021: chap 161.

• Kanesa Prostate