Leukemia myelogenous mau (CML)

ʻO ka leukemia myelogenous maʻi (CML) ka maʻi ʻaʻai e hoʻomaka i loko o ka iwi iwi. ʻO kēia nā mea palupalu i waenakonu o nā iwi e kōkua ai e hana i nā hunaola āpau.

Hoʻokumu ʻo CML i kahi ulu ulu ʻole o nā ʻona makua ʻole a oʻo ʻole e hana i kekahi ʻano o ke koko keʻokeʻo i kapa ʻia he mau myeloid. Kūkulu nā hunaola maʻi i ka iwi iwi a me ke koko.

Pili ke kumu o CML i kahi chromosome ʻino i kapa ʻia ʻo chromosome Philadelphia.

Hiki i ka pale uila ke hoʻonui i ka makaʻu o ka hoʻomohala ʻana iā CML. Hiki ke hōʻike i ka radiation mai nā hana radiation i hoʻohana ʻia i ka wā kahiko e mālama i ka maʻi ʻaʻai thyroid a i ʻole ʻo Hodgkin lymphoma a i ʻole mai kahi pōpilikia nuklea.

He mau makahiki ka lōʻihi e hoʻomohala i ka leukemia mai ka pāhawewe. ʻO ka hapa nui o ka poʻe i mālama ʻia no ka maʻi ʻaʻai me ka radiation ʻaʻole hoʻomohala i ka leukemia. A ʻo ka hapa nui o ka poʻe me CML ʻaʻole i hōʻike ʻia i ka radiation.

Hana pinepine ʻo CML i nā mākua waena a me nā keiki.

Hoʻohui ʻia ʻo ka leukemia myelogenous mau i nā pae:

• Maʻamau
• Hoʻoikaika ʻia
• Pilikia pāhū

Hiki ke lōʻihi ke kau mau no nā mahina a mau makahiki paha. He kakaikahi paha a ʻaʻole iki paha nā ʻano maʻi i kēia manawa. Hoʻomaopopo ʻia ka hapa nui o ka poʻe i kēia wā, ke hana ʻia nā hoʻokolohua koko no nā kumu ʻē aʻe.

ʻO ka ʻāpana i hōʻeleu ʻia he pae ʻoi aku ka weliweli. Ulu koke nā leukemia. ʻO nā ʻōuli maʻamau e pili ana i ke kuni (ʻoiai me ka maʻi ʻole), ka ʻeha o ka iwi, a me ka ʻāpā pehu.

Alakaʻi ʻo CML i alakaʻi ʻia i ka wā pilikia pahū. Hiki ke kahe a me ka maʻi ma muli o ka maikaʻi ʻole o ka iwi iwi.

ʻO nā hōʻailona kūpono ʻē aʻe o kahi ulia pōpilikia nā:

• ʻUpala
• Nui ka hou (sweats i ka pō)
• Ka luhi
• Fiva
• Kaomi ma lalo o nā iwi ʻaoʻao hema hema mai kahi ākea pehu
• Rash - nā māka ʻulaʻula pinpoint ma ka ʻili (petechiae)
• Nawaliwali

Hōʻike pinepine kahi hoʻokolohua kino i ka maʻi pehu. Hōʻike kahi helu piha o ke koko (CBC) i ka hoʻonui ʻia o nā hunaola keokeo me nā ʻano makua ʻole he nui a me ka hoʻonui ʻia o nā pā. ʻO kēia nā ʻāpana o ke koko e kōkua i ke kūʻē ʻana i ke koko.

Nā hoʻokolohua ʻē aʻe i hana ʻia e hoʻopili ʻia:

• Biopsy iwi ʻōiwi
• Ke hoʻāʻo nei ke kō a me ka iwi o ka iwi no ka loaʻa ʻana o ka chromosome Philadelphia
• Heluna pāluna

ʻO nā lāʻau i kuhi i ka protein ʻino i hana ʻia e ka Philadelphia chromosome ʻo ia ka lapaʻau mua loa no CML. Hiki ke lawe i kēia mau lāʻau i lāʻau lapaʻau. Hele pinepine ka poʻe i mālama ʻia me kēia mau lāʻau i loko o ke kala wikiwiki a hiki ke noho i ke kala no nā makahiki he nui.

I kekahi manawa, hoʻohana mua ʻia ka chemotherapy e hōʻemi i ka helu keʻokeʻo o ke koko inā kiʻekiʻe loa ia ma ke kuhi.

He paʻakikī loa ka mālama ʻana i ka pōpilikia pahū. ʻO kēia no ka mea aia kahi helu kiʻekiʻe loa o nā hunaola keokeo ʻole (nā leukemia) i kū ʻole i ka lāʻau.

ʻO ka lāʻau hoʻōla iwi wale nō i ʻike ʻia no ka CML kahi transplant o ka iwi iwi, a i ʻole ke transplant cell stem. ʻO ka hapa nui o ka poʻe, ʻaʻole pono i kahi transplant no ka mea ua kūleʻa nā lāʻau i manaʻo ʻia. Kūkākūkā i kāu koho me kāu oncologist.

Pono ʻoe a me kāu mea mālama olakino e hoʻokele i nā pilikia ʻē aʻe a i ʻole nā ​​hopohopo i kāu wā leukemia, e like me:

• Ka mālama ʻana i kāu mau holoholona i ka manawa o ka chemotherapy
• Nā pilikia koko
• ʻO ka ʻai ʻana i ka nui o nā calorie ke maʻi ʻoe
• ʻO ka pehu a me ka ʻeha ma kou waha
• ʻAi palekana i ka wā o ka mālama ʻana i ka maʻi ʻaʻai

Hiki iā ʻoe ke hoʻomāmā i ke koʻikoʻi o ka maʻi ma ke komo ʻana i kahi hui kākoʻo maʻi ʻaʻai. ʻO ke kaʻana ʻana me nā poʻe ʻē aʻe i loaʻa nā ʻike a me nā pilikia maʻamau e hiki ke kōkua iā ʻoe e noʻonoʻo ʻole.

Ua hoʻomaikaʻi maikaʻi nā lāʻau i hoʻomākaukau ʻia i ka nānā no ka poʻe me CML. Ke hele aku nā hōʻailona a me nā ʻōuli o CML a helu ʻia ke koko a me ka biopsy o ka iwi o ka iwi i mea maʻamau, manaʻo ʻia ke kanaka i ke kala. Hiki i ka hapa nui o ka poʻe ke noho i ke kala no nā makahiki he nui ʻoiai kēia lāʻau.

Manaʻo pinepine ʻia ke kāpili iwi a i ʻole ka iwi iwi i ka poʻe i hoʻi ka maʻi a i ʻole e ʻoi aku ka maikaʻi i ka wā e lawe ana i nā lāʻau mua. Koi ʻia paha ka transplant no nā poʻe i ʻike ʻia i ka wā i hōʻeleu ʻia a i ʻole ka pilikia i pohā.

Hiki i nā pilikia pahū ke alakaʻi i nā pilikia, me ka maʻi, ke kahe ʻana o ke koko, ka luhi, ka wela ʻole i wehewehe ʻia, a me nā pilikia o nā puʻupaʻa. Hiki i ka Chemotherapy ke loaʻa i nā hopena koʻikoʻi, kaukaʻi ʻia i nā lāʻau i hoʻohana ʻia.

Hōʻalo i ka pā ʻana i ka pāhawewe ke hiki.

CML; Leukemia myeloid maʻi; CGL; Leukemia granulocytic mau loa; Leukemia - granulocytic mau

• Hoʻoneʻe iwi iwi - hoʻokuʻu

• ʻIʻini iwi iwi
• Leukemia myelocytic mau loa - nānā microscopic
• Leukemia myelocytic mau
• Leukemia myelocytic mau

ʻO Kantarjian H, Cortes J. Chronic myeloid leukemia. I: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. ʻO Oncology Clinical ʻo Abboff. ʻElua huaʻōlelo Piladelapia, PA: Elsevier; 2020: chap 98.

Pūnaewele ʻo National Cancer Institute. ʻO ka hoʻomaʻamaʻa olakino myelogenous leukemia (PDQ) www.cancer.gov/types/leukemia/hp/cml-treatment-pdq. Hoʻohou i Pepeluali 8, 2019. Loaʻa ʻia ma Malaki 20, 2020.

Pūnaewele Pūnaewele Manuahi Manuahi. Nā kulekele hana lapaʻau NCCN i ka oncology: (Nā alakaʻi NCCN). ʻO leukemia myeloid chronic. Mana 3.2020. www.nccn.org/professionals/physician_gls/pdf/cml.pdf. Hoʻohou i Ianuali 30, 2020. Loaʻa iā Malaki 23, 2020.

ʻO Radich J. Chronic myeloid leukemia. I: Goldman L, Schafer AI, eds. ʻO ka lāʻau lapaʻau Goldman-Cecil. 26th ed. Piladelapia, PA: Elsevier; 2020: chap 175.