Amyloidosis kumu

ʻO ka amyloidosis mua he maʻi maʻamau ia e kūkulu ai nā protein āpau i nā aʻa a me nā meaola. Kapa ʻia nā ʻōpala o nā protein pono ʻole i nā waihona amyloid.

ʻAʻole maopopo maikaʻi ke kumu o ka amyloidosis mua. He pāʻani paha kā Genes.

Pili ke kūlana i ka hana ʻino a me ka nui o nā protein. Kūkulu nā ʻōpala o nā protein āpau i kekahi o nā ʻola. Hana kēia i mea paʻakikī no ka hana pono ʻana o nā meaola.

Hiki i ka amyloidosis mua ke alakaʻi i nā ʻano i hoʻopili ʻia:

• Carpal tunnel maʻi maʻi
• ʻO ka hōʻino puʻuwai puʻuwai (cardiomyopathy) e alakaʻi ai i ka puʻuwai puʻuwai congestive
• Malabsorption ʻōpū
• Hū ka ʻū a me ka hana pono ʻole
• Hewa ʻole nā ​​hakuʻala
• ʻO ka maʻi nephotic (ka hui o nā ʻōuli e pili pū me ka protein i ka mimi, nā pae protein o ke koko haʻahaʻa i loko o ke koko, nā pae kolesterol kiʻekiʻe, nā pae triglyceride kiʻekiʻe, a me ka pehu a puni ke kino)
• Nā pilikia nerve (neuropathy)
• Orthostatic hypotension (hāʻule i ke kahe o ke koko ke kū ʻoe)

Pili nā ʻōuli i nā ʻokana i hoʻopili ʻia. Hiki i kēia maʻi ke hoʻopili i nā ʻōnaehana a me nā ʻaʻa, e like me ke alelo, nā ʻōpū, nā iwi iwi a me nā ʻene, nā ʻalolo, ka ʻili, nā liga, ka puʻuwai, ke ake, nā aʻa, a me nā puʻupaʻa.

Pākuʻi ʻia paha nā ʻōuli i kekahi o kēia mau mea:

• Rhythm puʻuwai maʻamau
• Ka luhi
• Numbness o nā lima a me nā wāwae paha
• Pokole o ka hanu
• Hoʻololi ka ʻili
• Pilikia i nā pilikia
• ʻO ka pupuhi ma nā lima a me nā wāwae
• Alelo pehu
• Paʻa lima nāwaliwali
• ʻO ka hōʻemi kaumaha a me ka loaʻa kaumaha

Nā ʻōuli ʻē aʻe i hiki ke loaʻa me kēia maʻi.

• Hoʻoemi i ka puka mimi
• Pohā
• Hoarseness a hoʻololi paha i ka leo
• ʻEha hui
• Nawaliwali

E nānā ka mea mālama ola iā ʻoe. E nīnau ʻia ʻoe e pili ana i kāu mōʻaukala olakino a me nā ʻōuli. Hōʻike paha kahi hoʻokolohua kino he akepau kou ake a palupalu paha, a he mau hōʻailona paha o ka ʻino nerve.

ʻO ka hana mua i ke kuhi ʻana i ka amyloidosis he koko a me nā hoʻokolo mimi e nānā i nā protein pono ʻole.

Aia nā hoʻokolohua ʻē aʻe i kāu mau ʻōuli a me ka ʻokia e hiki ke hoʻopili ʻia. Aia kekahi mau hoʻokolohua me:

• ʻO ke ultrasound ʻōpū e nānā i ke ake a me ka pelu
• Nā hōʻike naʻau, e like me ECG, a i ʻole echocardiogram, a i ʻole MRI
• ʻO nā hoʻokolohua hana kīwī e nānā no nā hōʻailona o ke kō ʻole (nephrotic Syndrome)

ʻO nā hoʻāʻo e hiki ke kōkua i ka hōʻoia ʻana i ka hōʻailona me:

• ʻImi o ka momona momona ʻōpū
• Biopsy iwi ʻōiwi
• ʻO ka biopsy puʻuwai puʻuwai
• ʻO Biopsy mucosa kūpono

Hiki ke hoʻopili ʻia i ka mālama ʻana:

• ʻO Chemotherapy
• Ke kuʻi ʻana o ke koʻokoʻo
• Ke kuʻi ʻōhua

Inā kumu ʻia ke ʻano e kekahi maʻi ʻē aʻe, pono e mālama ʻino ʻia kēlā maʻi. Hiki i kēia ke hoʻomaikaʻi i nā hōʻailona a hoʻolohi paha i ka maʻi mai ka ʻino ʻana. Hiki ke mālama ʻia nā pilikia e like me ka puʻuwai puʻuwai, kō ʻole o ka hakuʻala, a me nā pilikia ʻē aʻe i kekahi manawa, ke pono.

Maikaʻi kāu hilinaʻi ʻana i nā mea ola i hoʻohuli ʻia. ʻO ke komo ʻana o ka puʻuwai a me ka hakuʻala i ke kumu o ke kūleʻa ʻana o ka ʻokena a me ka make. Hiki i ke amyloidosis ākea (ʻōnaehana) ke alakaʻi i ka make i loko o 2 mau makahiki.

Kāhea i kāu mea hāʻawi inā loaʻa iā ʻoe nā ʻōuli o kēia maʻi. Kāhea pū inā ua ʻike ʻia ʻoe me kēia maʻi a loaʻa iā:

• Mimi emi
• Hanu paʻakikī
• ʻO ka pehu ʻana o nā kuʻekuʻe wāwae a i ʻole nā ​​ʻāpana kino ʻē aʻe i hele ʻole

ʻAʻohe pale e ʻike ʻia no ka amyloidosis mua.

ʻO Amyloidosis - kumu mua; Amyloidosis kaulahao kukui Immunoglobulin; Amyloidosis ʻōnaehana mua

• ʻO Amyloidosis o nā manamana lima
• ʻO Amyloidosis o ka maka

Gertz MA, Buadi FK, Lacy MQ, Hayman SR. Amyloidosis lahui kukui Immunoglobulin (amyloidosis mua). I: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Nā Kumumanaʻo a me ka Hoʻomeheu. ʻEpekema 7 Piladelapia, PA: Elsevier; 2018: chap 88.

ʻO Hawkins PN. ʻO Amyloidosis.I: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, eds. Rheumatology. ʻEpekema 7 Piladelapia, PA: Elsevier; 2019: chap 177.