Leukemia lymphocytic mau (CLL)

ʻO ka leukemia lymphocytic mau (CLL) ka maʻi ʻaʻai o kekahi ʻano o nā aʻa koko keʻokeʻo i kapa ʻia he lymphocytes. Loaʻa kēia mau hunaola i ka iwi iwi a me nā ʻāpana ʻē aʻe o ke kino. ʻO ka iwi iwi ka mea palupalu i waenakonu o nā iwi e kōkua ai i ke kūkulu ʻana i nā hunaola āpau.

Ma muli o ka CLL ka hoʻonui lohi o kekahi ʻano o nā hunaola keokeo i kapa ʻia ʻo B lymphocytes, a i ʻole B cells. Hoʻolahalaha nā hunaola maʻi ʻaʻai ma o ke koko a me ka iwi o ka iwi. Hiki i ka CLL ke hoʻopili i nā lymph node a i ʻole nā ​​mea ʻē aʻe e like me ke ake a me ka iwi. Hiki i ka CLL ke hana i ka iwi o ka iwi e nalo i kāna hana.

ʻAʻole ʻike ʻia ke kumu o CLL. ʻAʻohe loulou i ka pāhawewe. ʻAʻole maopopo inā hiki i kekahi mau kemika ke kumu iā CLL. ʻO ka hōʻike ʻana iā Agent Orange i ka wā o ke Kaua Vietnam ua hoʻopili ʻia i kahi piʻi iki o ka hoʻomohala ʻana iā CLL.

Hoʻololi pinepine ka CLL i ka poʻe ʻelemakule, ʻo ka mea hoʻi ma luna o nā makahiki he 60. ʻO ka poʻe ma lalo o ka makahiki 45 ʻaʻole hoʻoulu pinepine iā CLL. ʻOi aku ka maʻamau o CLL i nā keʻokeʻo ma mua o nā lāhui ʻē aʻe. ʻOi aku ka maʻamau i nā kāne ma mua o ka wahine. ʻO kekahi poʻe me CLL he lālā ʻohana me ka maʻi.

Hoʻonui mālie nā ʻōuli. ʻAʻole kumu pinepine ʻo CLL i nā ʻōuli ma ka mua. ʻIke ʻia paha e nā hoʻokolohua koko i hana ʻia i ka poʻe no nā kumu ʻē aʻe.

Pākuʻi ʻia paha nā ʻōuli o CLL:

• Hoʻonui i nā lymph node, ke ake, a i ʻole ke kakā
• Hoʻoulu nui, sweats i ka pō
• Ka luhi
• Fiva
• Nā maʻi e hoʻi hou ana (recur), ʻoiai me ka mālama ʻana
• Loaʻa ka ʻai a lilo i piha wikiwiki paha (satiety wanaʻao)
• Kaumaha emi

E hana ka mea mālama ola i kahi hoʻokolohua kino a nīnau e pili ana i kāu mau hōʻailona.

Hoʻokomo ʻia paha nā hoʻāʻo e kuhikuhi iā CLL:

• Helu piha ke koko (CBC) me ka hoʻokaʻawale ʻana o ke koko.
• ʻO ka hoʻāʻo cytometry kahe o nā hunaola keʻokeʻo.
• Hoʻohana ʻia ka fluorescent in situ hybridization (FISH) e nānā a helu i nā genes a chromosome paha. Kōkua paha kēia hōʻike i ka diagnose CLL a i ʻole alakaʻi alakaʻi i ka mālama ʻana.
• Hiki ke kōkua i ka hoʻāʻo ʻana no nā loli ʻē aʻe e wānana i ke ʻano o ka pane ʻana o ka maʻi ʻaʻai i ka lāʻau.

Loaʻa i nā kānaka me CLL ka helu o ke koko kiʻekiʻe keʻokeʻo kiʻekiʻe.

ʻO nā hoʻāʻo e nānā i nā loli i ka DNA i loko o nā hunaola maʻi ʻaʻai e hana pū ʻia paha. Nā hualoaʻa mai kēia mau hoʻāʻo a mai nā hoʻokolohua hoʻokau e kōkua i kāu mea lawelawe e hoʻoholo i kāu mālama.

Inā loaʻa iā ʻoe kahi CLL ma mua, e nānā pono kāu mea iā ʻoe. ʻAʻole hāʻawi pinepine ʻia ka mālama ʻana no ka CLL pae mua, ke ʻole ʻoe:

• Nā maʻi e hoʻi mau ana
• Leukemia e piʻi wikiwiki nei i ka ʻino
• Helu ke koko ʻulaʻula haʻahaʻa a i ʻole helu platelet
• Māluhiluhi, nalo o ka makemake ʻole, hoʻemi kaumaha, a i ʻole nā ​​sweats o ka pō
• Nā pehu lymph pehu

Hoʻohana ʻia ʻo Chemotherapy, me nā lāʻau i manaʻo ʻia e mālama iā CLL. E hoʻoholo kāu mea hāʻawi i ke ʻano o nā lāʻau e kūpono iā ʻoe.

Koi ʻia ke kōpili a i ʻole ka platelet transfusions inā haʻahaʻa nā helu o ke koko.

Hiki ke hoʻohana ʻia ka iwi iwi a i ʻole ke koʻokoʻo o ke koʻokoʻo i nā ʻōpio me ka CLL kiʻekiʻe a kiʻekiʻe paha. ʻO kahi transplant ka lāʻau lapaʻau wale nō e hāʻawi i kahi hiki ke hoʻōla ʻia no CLL, akā he pilikia pū kekahi ia. E kūkākūkā kāu mea hoʻolako i nā pilikia a me nā pōmaikaʻi me ʻoe.

Pono ʻoe a me kāu mea lawelawe e mālama i nā hopohopo ʻē aʻe i kāu mālama leukemia, e like me:

• Ka mālama ʻana i kāu mau holoholona i ka manawa o ka chemotherapy
• Nā pilikia koko
• Waha maloo
• ʻO ka ʻai ʻana i ka nui o nā calories
• ʻAi palekana i ka wā o ka mālama ʻana i ka maʻi ʻaʻai

Hiki iā ʻoe ke hoʻomāmā i ke koʻikoʻi o ka maʻi ma ke komo ʻana i kahi hui kākoʻo maʻi ʻaʻai. ʻO ke kaʻana ʻana me nā poʻe ʻē aʻe i loaʻa nā ʻike a me nā pilikia maʻamau e hiki ke kōkua iā ʻoe e noʻonoʻo ʻole.

Hiki i kāu mea hāʻawi ke kūkākūkā me ʻoe i ka nānā o kāu CLL e pili ana i kāna pae a pehea ke ʻano o ka pane ʻana i ka lāʻau.

Komo pū nā pilikia o CLL a me kāna mālama ʻana:

• ʻO ke anemia hemolytic autoimmune, kahi ʻano e luku ʻia nā hunaola ʻulaʻula e ka ʻōnaehana pale
• Kahe ʻana mai ka helu platelet haʻahaʻa
• ʻO ka hypogammaglobulinemia, kahi ʻano i loaʻa kahi pae haʻahaʻa o nā mea ʻākena ma mua o ka maʻamau, kahi e hoʻonui ai i ka makaʻu o ka maʻi.
• Idiopathic thrombocytopenic purpura (ITP), kahi maʻi koko
• Nā maʻi e hoʻi hou ana (recur)
• Ka luhi hiki ke hele mai ke akahai a i ke koʻikoʻi
• Nā maʻi ʻino ʻē aʻe, me kahi lymphoma ʻoi aku ka nui o ka hakakā (Richter transformation)
• Nā hopena o ka chemotherapy

Kāhea i kahi mea hoʻolako inā hoʻomohala ʻoe i nā lymph node hoʻonui ʻia a i ʻole ka luhi ʻole i wehewehe ʻole ʻia, palapū, sweating nui, a me ka pohō kaumaha.

CLL; Leukemia - lymphocytic mau (CLL); Ka maʻi ʻaʻai koko - leukemia lymphocytic maʻi mau; Maʻi ʻaʻai iwi iwi - leukemia lymphocytic maʻi mau; Lymphoma - leukemia lymphocytic mau

• Hoʻoneʻe iwi iwi - hoʻokuʻu

• ʻIʻini iwi iwi
• Auer koʻokoʻo
• ʻO ka leukemia lymphocytic mau loa - ka nānā ʻana i microscopic
• Nā Antibodies

Awan FT, Byrd JC. Leukemia lymphocytic mau. I: Niederhuber JE, Armitage JO, Kastan MB, Doroshow JH, Tepper JE, eds. ʻO Oncology Clinical ʻo Abboff. ʻElua huaʻōlelo Piladelapia, PA: Elsevier; 2020: chap 99.

Pūnaewele ʻo National Cancer Institute. ʻO ka mālama ʻana i ka leukemia lymphocytic mau (PDQ) - mana ʻoihana olakino. www.cancer.gov/types/leukemia/hp/cll-treatment-pdq. Hoʻohou i Ianuali 22, 2020. Loaʻa iā Pepeluali 27, 2020.

Pūnaewele Pūnaewele Manuahi Manuahi. Nā kulekele hana lapaʻau NCCN o ka oncology. Leukemia lymphocytic maʻi mau / lymphocytic lymphocytic liʻiliʻi. Mana 4.2020. www.nccn.org/professionals/physician_gls/pdf/cll.pdf. Hoʻohou i Kēkēmapa 20, 2019. Loaʻa iā Pepeluali 27, 2020.