ʻO ka dysbetalipoproteinemia ʻohana

ʻO ka dysbetalipoproteinemia ʻohana kahi maʻi i hala i nā ʻohana. Hoʻonui ia i ka nui o nā kolesterol a me nā triglycerides i loko o ke koko.

ʻO kahi kīnā kīnā ke kumu o kēia ʻano. Loaʻa nā hemahema i ke kūkulu ʻana i nā ʻāpana lipoprotein nui i loaʻa nā kolesterol a me kahi ʻano momona i kapa ʻia ʻo triglycerides. Pili ka maʻi i nā kīnā o ka ʻāpana no ka apolipoprotein E.

Hiki i ka hypothyroidism, ka momona, a i ʻole ka maʻi kō ke hōʻeha i ke ʻano. ʻO nā kumu pilikia no ka ʻohana dysbetalipoproteinemia me kahi moʻolelo ʻohana o ka maʻi a i ʻole ka maʻi o ke aʻa coronary.

ʻAʻole paha e ʻike ʻia nā ʻōuli a hiki i ka makahiki 20 a ʻoi paha.

Hiki ke waiho ʻia nā waihona melemele o nā mea momona i ka ʻili i kapa ʻia he xanthomas ma nā lihilihi, nā lima, nā wāwae, a i ʻole nā ​​kuʻekuʻe o nā kuli a me nā kuʻe lima.

Hiki i nā ʻōuli ʻē aʻe ke:

• ʻO ka ʻeha o ka umauma (angina) a i ʻole nā ​​hōʻailona ʻē aʻe o ka maʻi coronary artery hiki ke loaʻa i ka wā ʻōpio
• ʻO ka cramping o hoʻokahi a i ʻole ʻelua mau keiki bipi ke hele wāwae
• Nā ʻeha ma nā manamana wāwae e hoʻōla ʻole ai
• ʻO nā ʻōuli e like me nā ʻōuli e like me ka pilikia o ka kamaʻilio ʻana, hāʻule ʻana ma kekahi ʻaoʻao o ka maka, nāwaliwali o ka lima a me ka wāwae, a me ka nalo ʻana o ke kaulike

Nā hoʻokolohua e hana ʻia ai e kuhikuhi i kēia ʻano me:

• ʻO ka hoʻāʻo genetic no apolipoprotein E (apoE)
• Hōʻike koko lipid panel
• Pae Triglyceride
• ʻO ka hoʻāʻo lipoprotein haʻahaʻa haʻahaʻa (VLDL)

ʻO ka pahuhopu o ka mālama ʻana e kaohi i nā kūlana e like me ka momona, hypothyroidism, a me ka maʻi kō.

Hoʻololi ka hoʻololi ʻana i ka papaʻai e hoʻoliʻiliʻi i nā kalori, nā momona momona, a me ka kōkō e kōkua ai i ka hoʻohaʻahaʻa ʻana i ke kōpaʻa koko.

Inā kiʻekiʻe ka pae kolesterol a me nā triglyceride ma hope o kāu hana ʻana i ka loli, pono paha i kāu kauka olakino ke lawe pū i nā lāʻau. ʻO nā lāʻau e hoʻohaʻahaʻa i ke koko triglyceride a me nā pae kolesterol:

• ʻO nā resins acid-sequestering bile.
• Fibrates (gemfibrozil, fenofibrate).
• ʻAkika nikotinikika.
• Statins.
• Nā mea kāohi iā PCSK9, e like me alirocumab (Praluent) a me evolocumab (Repatha). Hōʻike kēia i kahi papa lāʻau hou e mālama i ka cholesterol.

ʻO ka poʻe me kēia ʻano ua hoʻonui i ka makaʻu no ka maʻi o ke aʻa a me nā maʻi vipher peripheral.

Me ka mālama ʻana, hiki i ka hapa nui o ka poʻe ke hōʻemi nui i kā lākou pae o ka kolesterol a me nā triglycerides.

Komo pū nā pilikia:

• Maʻi hohola
• Hahau
• Maʻi maʻi kīnā
• Claudication pākuʻi
• ʻO Gangrene o nā ʻaoʻao haʻahaʻa

Kāhea i kāu mea hāʻawi inā ua hōʻoia ʻia ʻoe me kēia maʻi a:

• Kūkulu nā ʻōuli hou.
• ʻAʻole hoʻomaikaʻi nā ʻōuli me ka lāʻau.
• ʻOi aku ka maikaʻi o nā ʻōuli.

ʻO ke kānana ʻana i nā lālā o ka ʻohana o ka poʻe me kēia ʻano e alakaʻi i ka ʻike mua a me ka mālama ʻana.

ʻO ka mālama ʻana i ka wanaʻao a me ka kaupalena ʻana i nā kumu pilikia ʻē aʻe e like me ka puhipaka ʻana hiki ke kōkua i ka pale ʻana i nā hōʻeha puʻuwai mua, nā hahau, a me nā kīʻaha koko i ālai ʻia.

ʻAno III hyperlipoproteinemia; Apolipoprotein E hemahema a hemahema paha

• Maʻi maʻi ʻaʻai Coronary

ʻO Genest J, Libby P. Nā maʻi lipoprotein a me nā maʻi maʻi ʻōpū. I: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, Braunwald E, eds. ʻO ka maʻi puʻuwai ʻo Braunwald: He puke aʻo no ka lāʻau Cardiovascular. 11th hua. Piladelapia, PA: Elsevier; 2019: chap 48.

Robinson JG. Nā maʻi o ka lipid metabolism. I: Goldman L, Schafer AI, eds. ʻO ka lāʻau lapaʻau Goldman-Cecil. 26th ed. Piladelapia, PA: Elsevier; 2020: chap 195.