Ivermectin: he aha ia a pehea e hoʻohana ai
Anter
- No ke aha ia
- Pehea e ho ohana
- 1. ʻO Strongyloidiasis, filariasis, kiki a me nā ʻāpala
- 2. Onchocerciasis
- Nā hopena ʻē aʻe
- ʻO wai ka mea pono ʻole e lawe
- ʻO Ivermectin a me COVID-19
- I ka mālama ʻana iā COVID-19
- I ka pale ʻana iā COVID-19
ʻO Ivermectin kahi lāʻau antiparasitic hiki ke paralyzing a paipai i ka hoʻopau ʻia ʻana o kekahi mau parasite, e hōʻike nui ʻia e ke kauka i ka mālama ʻana i nā onchocerciasis, elephantiasis, pediculosis, ascariasis a me nā scabies.
Hōʻike ʻia kēia lāʻau no nā mākua a me nā keiki ma mua o 5 mau makahiki a hiki ke loaʻa i loko o nā hale kūʻai lāʻau lapaʻau, he mea nui e nīnau i ke kauka e pili ana i ka hoʻohana ʻana, no ka mea, ʻokoʻa paha ka mahele lāʻau e like me ka maʻi infectious e mālama ʻia ai a me ke kaupaona o ka mea i hoʻopilikia ʻia. .
No ke aha ia
ʻO Ivermectin kahi lāʻau antiparasitic i hōʻike nui ʻia i ka mālama ʻana i kekahi mau maʻi, e like me:
- Ikaika ikaika;
- ʻO Filariasis, ʻike nui ʻia ʻo elephantiasis;
- Scabies, i kapa ʻia hoʻi he scabies;
- ʻO Ascariasis, ʻo ia ka maʻi e ka parasite Nā lumbricoides ʻo Ascaris;
- Pediculosis, ʻo ia ka infestation me nā kika;
- ʻO Onchocerciasis, kaulana kaulana ʻia ʻo "blindness river".
He mea nui e hana ʻia ka ivermectin e like me ke alakaʻi a ke kauka, no ka mea hiki ke pale i ke ʻano o nā hopena ʻē aʻe e like me ka diarrhea, ka luhi, ka ʻeha o ka ʻōpū, ka pohō kaumaha, ka paʻa ʻana a me ka luaʻi. I kekahi mau hihia, ʻike paha ka piko, ka hiamoe, ka poni, ka haʻalulu a me ka hives ma ka ʻili.
Pehea e ho ohana
Hoʻohana mau ʻia ʻo Ivermectin i hoʻokahi mahele lāʻau e like me ka maʻi infectious pono e hoʻopau ʻia. Lawe ʻia ka lāʻau i loko o ka ʻōpū nele, hoʻokahi hola ma mua o ka ʻai mua o ka lā. ʻAʻole pono ia e ʻai ʻia me nā lāʻau o ka barbiturate, benzodiazepine a i ʻole ka papa waikawa valproic.
1. ʻO Strongyloidiasis, filariasis, kiki a me nā ʻāpala
E mālama i ka strongyloidiasis, filariasis, lice infestation a i ʻole scabies, pono e hoʻoponopono ʻia ka lāʻau i koi ʻia i kou kaupaona, penei:
Kaona (i kg) | Ka helu o nā papa (6 mg) |
15 a hiki i 24 | . Papa |
25 a 35 | 1 papa |
36 a 50 | 1 ½ papa |
51 a 65 | Nā papa 2 |
66 a 79 | 2 ½ papa |
ma mua o 80 | 200 mcg no kg |
2. Onchocerciasis
E mālama i ka onchocerciasis, ka lāʻau i koi ʻia, kaukaʻi ʻia i ke kaumaha, penei:
Kaona (i kg) | Ka helu o nā papa (6 mg) |
15 a 25 | . Papa |
26 a hiki i 44 | 1 papa |
45 a 64 | 1 ½ papa |
65 a 84 | Nā papa 2 |
ma mua o 85 | 150 mcg no kg |
Nā hopena ʻē aʻe
ʻO kekahi o nā hopena hopena maʻamau e hiki ke hana ʻia i ka wā o ka mālama ʻana me ivermectin ʻo ia ka maʻi diarrhea, nausea, luaʻi, nāwaliwali ākea a me ka nele o ka ikehu, ʻeha o ka ʻōpū, nalowale o ka makemake ʻole a paʻa ʻole paha. ʻAno ʻoluʻolu a kuewa wale kēia mau hopena.
Eia hou, hiki ke hana i nā hopena maʻi āpau, keu hoʻi i ka lawe ʻana ivermectin no onchocerciasis, i hiki ke hōʻike ʻia me ka ʻeha o ka ʻōpū, ke kuni, ke kino ʻili, nā ʻulaʻula ma ka ʻili, ka pehu ʻana i nā maka a me nā lihilihi maka. Inā kū kēia mau ʻōuli, pono e hōʻoki i ka hoʻohana ʻana i ka lāʻau a noi koke i ke kōkua lapaʻau a i ʻole ke keʻena pilikia kokoke loa.
ʻO wai ka mea pono ʻole e lawe
Hoʻopaʻa ʻia kēia lāʻau no nā wahine hāpai, nā wahine hānai waiū, nā keiki ma lalo o 5 mau makahiki a i ʻole 15 kg a me nā mea maʻi me ka meningitis a me ka hānō. Eia hou, ʻaʻole pono e hoʻohana ʻia i ka poʻe me ka hypersensitivity ivermectin a i ʻole kekahi o nā mea ʻē aʻe i loaʻa i ka mana.
ʻO Ivermectin a me COVID-19
Ua kūkākūkā nui ʻia ka hoʻohana ʻana o ivermectin e kūʻē iā COVID-19 i ke kaiāulu ʻepekema, no ka mea he antiviral kēia antiparasitic e kūʻē i ka maʻi virus no ka maʻi melemele, ZIKA a me dengue, a no laila, ua manaʻo ʻia he hopena kekahi e pili ana iā SARS- CoV-2.
I ka mālama ʻana iā COVID-19
Ua hoʻāʻo ʻia ʻo Ivermectin e nā kānaka noiʻi ma Australia ma kahi moʻomeheu paʻa i loko o vitro, ka mea i hōʻike he maikaʻi kēia mea i ka hoʻopau ʻana i ka maʻi SARS-CoV-2 i loko o 48 mau hola [1] . Eia naʻe, ʻaʻole lawa kēia mau hopena e hōʻike ai i kona hopena i nā kānaka, a pono nā hoʻokolohua hoʻokolohua e hōʻoia i kona pono maoli. i loko o vivo, a hoʻoholo hou inā palekana ka lāʻau lapaʻau therapeutic in humans.
ʻO kahi noiʻi o nā mea maʻi i hōʻola ʻia i Bangladesh[2] i manaʻo ʻia e hōʻoia inā palekana ka hoʻohana ʻana o ivermectin no kēia mau maʻi a aia kekahi hopena e kūʻē iā SARS-CoV-2. No laila, ua waiho ʻia kēia mau mea maʻi i kahi protocol 5-day treatment me ivermectin (12 mg) a i ʻole hoʻokahi mahele lāʻau o ivermectin (12 mg) i hui pū ʻia me nā lāʻau ʻē aʻe no 4 mau lā, a ua hoʻohālikelike ʻia ka hopena me ka hui placebo me nā 72 maʻi. A ʻo kahi hopena, ua ʻike nā kānaka noiʻi he palekana ka hoʻohana ʻana o ivermectin wale nō a maikaʻi ia i ka mālama ʻana i ka COVID-19 māmā i nā mea maʻi makua, akā naʻe e pono ana nā noiʻi hou e hōʻoia i kēia mau hopena.
Ua mālama ʻia kahi noiʻi ʻē aʻe ma India e hōʻoia inā loaʻa ka hopena anti-inflammatory e kūʻē i ka hoʻohana ʻana o ivermectin e ka COVID-19 [3], ʻoiai he hiki i kēia lāʻau ke hoʻopilikia i ka lawe ʻana o kahi hanana SARS-CoV-2 i ka pūliki o nā huna kanaka, e hopena ai i ka hopena antiviral. Eia nō naʻe, hiki ke hana ʻia kēia hopena me nā kiʻekiʻena o ivermectin (ʻoi aku ma mua o ka lāʻau i koi ʻia no ka mālama ʻana i nā parasites), a ʻo ia ka hopena i nā hopena ʻino o ke ake. No laila, ma ke ʻano he koho ʻē aʻe i nā kiʻekiʻena o ka ivermectin, ua noi nā mea noiʻi i ka hoʻohana ʻana o kēia lāʻau i ka inhalation, kahi mea i ʻoi aku ka maikaʻi o ka hana e kūʻē iā SARS-CoV-2, akā naʻe, pono e aʻo maikaʻi ʻia kēia ala o ka hoʻokele.
E aʻo hou aʻe e pili ana i nā lāʻau e mālama ai i ka maʻi me ka coronavirus hou.
I ka pale ʻana iā COVID-19
Ma waho aʻe o ke aʻo ʻia ʻana o ivermectin ma ke ʻano he ʻano lapaʻau no COVID-19, ua hoʻokō ʻia kekahi mau noiʻi ʻē aʻe me ka manaʻo e hōʻoia inā e kōkua ka hoʻohana ʻana i kēia lāʻau i pale i ka maʻi.
Ua nānā ʻia kahi noiʻi e nā mea noiʻi ma ʻAmelika Hui Pū ʻIa e nānā i ke kumu o ka loaʻa ʻana o nā kumu like ʻole o COVID-19 i kekahi mau ʻāina [5]. Ma ke ʻano he hopena o kēia hoʻokolokolo ʻana, ua ʻike lākou he haʻahaʻa haʻahaʻa ko nā ʻāina ʻApelika ma muli o ka hoʻohana ʻia ʻana o nā lāʻau nui, ka nui o nā lāʻau antiparasitic, e like me ivermectin, ma muli o ka hoʻonui ʻia o ka maka o nā parasites ma kēia mau ʻāina.
No laila, manaʻo ka poʻe noiʻi he hiki i ka hoʻohana ʻana o ivermectin ke hoʻemi i ka helu o ke kope ʻana i ka maʻi a pale i ka ulu ʻana o ka maʻi, akā pili wale kēia hopena i nā hoʻopili ʻana, a ʻaʻole i lawe ʻia nā hoʻokolohua hoʻokolohua.
Ua hōʻike ʻia kahi noiʻi ʻē aʻe i ka hoʻohana ʻia ʻana o nā nanoparticle e pili pū ana me ivermectin i hiki ke hoʻēmi i ka ʻōlelo o nā mea loaʻa ma nā huna kanaka, ACE2, ka mea e paʻa ai i ka maʻi, a me nā protein i loaʻa ma ka ʻili o ka maʻi, e hoʻēmi nei i ka makaʻu o ka maʻi. [6]. Eia nō naʻe, pono i nā noiʻi vivo hou e hōʻoia i ka hopena, a me nā noiʻi ʻino e hōʻoia i ka palekana o ka hoʻohana ʻana o nā nanoparticle ivermectin.
E pili ana i ka hoʻohana ʻana o ivermectin me ka pale ʻana, ʻaʻohe ʻike hope loa. Eia nō naʻe, i mea e hiki ai i ivermectin ke hana ma o ka pale ʻana a hōʻemi ʻana paha i ke komo ʻana o nā maʻi i loko o nā hunaola, pono ia aia kahi amo viral, no ka mea pēlā e hiki ai ke hana i ka antiviral o ka lāʻau.