Mea Kākau: Judy Howell
Lā O Ka Hana: 28 Iulai 2021
HōʻAno Hou I Ka Lā: 18 Nowemapa 2024
Anonim
Diabetes medications - SGLT2 inhibitors - Canagliflozin (Invokana)
Wikiō: Diabetes medications - SGLT2 inhibitors - Canagliflozin (Invokana)

Anter

He aha ia ʻo Invokana?

ʻO Invokana kahi lāʻau hoʻomalu inoa inoa inoa inoa. Ua ʻae ʻia ʻo FDA no ka hoʻohana ʻana i nā mākua me ka maʻi diabetes ʻano 2 i:

  • E hoʻomaikaʻi i nā pae kō kō. No kēia hoʻohana, kauoha ʻia ʻo Invokana i mea hoʻohui i ka papaʻai a me ka hoʻoikaika kino e hoʻohaʻahaʻa i nā pae kō kō.
  • E hoʻemi i ka pilikia o kekahi pilikia o ka maʻi puʻuwai. No kēia hoʻohana, hāʻawi ʻia ʻo Invokana i nā mākua me ka maʻi maʻi maʻi i ʻike ʻia. Hoʻohana ʻia ia e hoʻohaʻahaʻa i ka makaʻi o ka puʻuwai a me ka hahau i alakaʻi ʻole ʻia i ka make. A hoʻohana ʻia ka lāʻau e hōʻemi i ka makaʻu o ka make mai kahi pilikia o ka puʻuwai a i ʻole ke koko.
  • E hoʻemi i ka pilikia o kekahi mau pilikia i ka poʻe i loaʻa i ka nephropathy diabetic me albuminuria. No kēia hoʻohana, hāʻawi ʻia ʻo Invokana i kekahi mau mākua i loaʻa i ka nephropathy diabetic (hōʻino nā hakuʻala i hoʻokumu ʻia e ka maʻi diabetic) me albuminuria * ʻoi aku ma mua o 300 milligrams i kēlā me kēia lā. Hoʻohana ʻia ia e hoʻohaʻahaʻa i ka makaʻu o:
    • hoʻopau pae kahua maʻi maʻi
    • ʻo ka make i hoʻokumu ʻia e ka pilikia o ka puʻuwai a i ʻole ke koko
    • pālua i ke kiʻekiʻe o ka creatinine
    • ka pono i ka haukapila no ka holo pono ʻole o ka naʻau

No ka ʻike hou aku e pili ana i kēia mau hoʻohana o Invokana a me kekahi mau palena o kona hoʻohana ʻana, e ʻike i ka ʻaoʻao ʻo “Invokana” ma lalo nei.


Nā kikoʻī lāʻau

Loaʻa iā Invokana ka lāʻau canagliflozin. Pili ia i kahi papa o nā lāʻau i kapa ʻia ʻo nā sodium-glucose co-transporter 2 (SGLT-2) mea kāohi. (Hoʻohālikelike kahi papa lāʻau i kahi hui o nā lāʻau e hana like.)

Hele mai ʻo Invokana ma ke ʻano he papa i lawe ʻia e ka waha. Loaʻa ia i nā ikaika ʻelua: 100 mg a me 300 mg.

Ka hoʻokō ʻana

No ka ʻike e pili ana i ka pono o Invokana no kāna hoʻohana pono ʻia, e ʻike i ka ʻāpana ʻo “Invokana” ma lalo.

Generokana invokana

Loaʻa i loko o Invokana hoʻokahi mea hana lāʻau lapaʻau: canagliflozin. Loaʻa iā ia ma ke ʻano he lāʻau lapaʻau inoa inoa wale nō. ʻAʻole i loaʻa i kēia manawa i ka palapala generic. (ʻO kahi lāʻau laulā kahi kope pololei o ka lāʻau lapaʻau hana i kahi lāʻau lapaʻau inoa.)

Nā hopena ʻaoʻao Invokana

Hiki i ka Invokana ke hana i nā hopena ʻoluʻolu a koʻikoʻi paha. Loaʻa i ka papa inoa aʻe kekahi o nā hopena ʻē aʻe i hiki ke hana ʻia i ka wā e lawe ana iā Invokana. ʻAʻole pili kēia papa inoa i nā hopena ʻaoʻao āpau.

E aʻo hou aʻe ai e pili ana i nā hopena ʻē aʻe o Invokana a i ʻole pehea e hoʻokele ai iā lākou, e kamaʻilio me kāu kauka a kauka paha.


Kaha: Mālama ka Food and Drug Administration (FDA) i nā hopena o nā lāʻau i ʻae ʻia. Inā makemake ʻoe e hoʻomaopopo iā FDA e pili ana i kahi hopena i loaʻa iā ʻoe me Invokana, hiki iā ʻoe ke hana pēlā ma o MedWatch.

Nā hopena ʻaoʻao hou aʻe

Hiki i nā hopena ʻaoʻao maʻamau o Invokana ke hoʻokomo iā * *:

  • maʻi maʻi urinary tract
  • ka mimiki pinepine ʻana ma mua o ka maʻamau
  • make wai
  • kōpaʻa
  • nausea
  • nā maʻi hū † i nā kāne a me nā wahine
  • ʻume puʻu ʻili

E hala paha ka hapa nui o kēia mau hopena i loko o kekahi mau lā a i ʻole ʻelua mau pule. Inā ʻoi aku ke koʻikoʻi a i ʻole hele aku, e kamaʻilio me kāu kauka a kauka paha.

Pono ʻoe e kāhea i kāu kauka inā manaʻo ʻoe he maʻi urinary tract a i ʻole he maʻi hū.

Nā hopena hopena koʻikoʻi

ʻAʻole maʻamau nā hopena ʻino loa mai Invokana, akā hiki nō ke hanana. Kāhea koke i kāu kauka inā loaʻa nā hopena koʻikoʻi. Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.


Hiki i nā hopena ʻē aʻe a me kā lākou mau hōʻailona ke hoʻohui i kēia:

  • Kahena (haʻahaʻa haʻahaʻa pae), kahi e hiki ai ke hoʻohaʻahaʻa i ke koko. Hiki i nā ʻōuli ke hoʻohui pū:
    • ʻūpā
    • e maule ana
    • ʻālohilohi
    • nāwaliwali, ke kū aʻe ʻoe
  • Hypoglycemia (pae kō kō kō haʻahaʻa). Hiki i nā ʻōuli ke hoʻohui pū:
    • hiamoe
    • ʻeha poʻo
    • huikau
    • nāwaliwali
    • pōloli
    • ukiuki
    • ka houʻu ʻana
    • manao huikau
    • puʻuwai wikiwiki
  • ʻO ka hopena maʻi ahulau. *
  • Hoʻohui o nā lālā o lalo. *
  • Ketoacidosis diabetic (hoʻonui i nā pae o nā ketone i kou koko a i ʻole ka mimi). *
  • ʻO ka gangrene o Fournier (maʻi maʻi kokoke i nā genital). *
  • Poino hakuʻala. *
  • Haki iwi. *

Nā kikoʻī hopena ʻaoʻao

Mahalo paha ʻoe i ka hopena o kekahi mau hopena ʻē aʻe me kēia lāʻau. Eia kekahi kikoʻī ma kekahi mau hopena ʻē aʻe a i ʻole hiki i kēia lāʻau ke kumu.

Ka hopena hoʻowali

E like me ka nui o nā lāʻau, hiki i kekahi poʻe ke loaʻa i kahi hopena maʻi ma hope o ka lawe ʻana iā Invokana. I nā noiʻi hoʻokolohua, a hiki i ka 4.2% o ka poʻe e lawe ana iā Invokana i hōʻike e loaʻa nā hopena maʻi ahonui.

Hiki i nā ʻōuli o ke ʻano ʻāpiki mālie ke hoʻopili pū i:

  • ʻāwīwī o ka ʻili
  • ʻumeʻume
  • flushing (hoʻomehana, pehu, a ʻulaʻula i kou ʻili)

Kākaʻikahi ka hopena maʻi ʻino ʻoi aku ka paʻakikī akā hiki. ʻO kekahi poʻe wale nō i loko o nā noiʻi hoʻokolohua i hōʻike i nā hopena maʻi kūpilikiʻi ʻoiai e lawe ana iā Invokana.

Hiki i nā ʻōuli o ke kūpilikiʻi ʻāpiki loa ke hoʻopili pū me

  • ʻōhū ma lalo o kou ʻili, maʻamau i kou lihilihi, lehelehe, lima, a mau wāwae paha
  • pehu o kou alelo, waha, a ʻāʻī paha
  • pilikia hanu

Kāhea koke i kāu kauka inā loaʻa iā ʻoe kahi maʻi maʻi ʻino i Invokana. Akā kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino.

Hoʻoikaika

Hoʻonui paha ʻo Invokana i kou makaʻi o ka ʻoki ʻana o nā lālā o lalo. (Me ka ʻoki ʻana, wehe ʻia kekahi o kou mau lālā.)

Ua ʻike ʻia he ʻelua mau noiʻi i ka hoʻonui ʻia o ka makaʻu no ka ʻokiʻoki o nā lālā haʻahaʻa i nā poʻe i lawe iā Invokana a loaʻa iā:

  • ʻano 2 diabetes a me ka maʻi puʻuwai, a i ʻole
  • ʻano 2 diabetes a ua makaʻu i ka maʻi maʻi puʻuwai

I loko o nā haʻawina, a he 3.5% o ka poʻe i lawe iā Invokana i ka ʻokiʻoki. Ke hoʻohālikelike ʻia me ka poʻe i lawe ʻole i ka lāʻau, ua pāpālua ʻo Invokana i ka hopena o ka ʻoki. ʻO ka manamana wāwae a me ka midfoot (ʻāpana ākea) nā wahi maʻamau o ka ʻoki ʻana. Ua hōʻike pū ʻia kekahi ʻokiʻoki wāwae.

Ma mua o kou hoʻomaka ʻana e lawe iā Invokana, e kamaʻilio me kāu kauka e pili ana i kou maka o ka ʻoki ʻana. He mea nui loa kēia inā ua nui kou ʻokiʻoki i ka wā i hala. He mea nui pū kekahi inā loaʻa ʻoe i ke kahe o ke koko a i ʻole nā ​​maʻi nerve, a i ʻole nā ​​maʻi maʻi wawae diabetic.

Kāhea koke i kāu kauka a haʻalele i ka lawe ʻana iā Invokana inā ʻoe:

  • ʻeha hou i ka ʻeha o ka wāwae a i ʻole ka palupalu
  • he ʻeha ka wāwae a he ulcer paha
  • loaʻa i kahi maʻi maʻi wāwae

Kāhea iā 911 inā manaʻo kou mau hōʻailona i ka hoʻoweliweli ola a i ʻole inā manaʻo ʻoe e loaʻa ana kahi pilikia olakino. Inā hoʻomohala ʻoe i nā ʻōuli a i ʻole nā ​​kūlana e hoʻonui i kou makaʻu no ka ʻoki ʻana i nā lālā o lalo, malia paha ua hōʻoki kāu kauka iā ʻoe e lawe iā Invokana

Maʻi hū

ʻO ka lawe ʻana iā Invokana e hoʻonui ai i kou makaʻu no ka maʻi hū. Heʻoiaʻiʻo kēia no nā kāne a me nā wahine, e like me ka ʻikepili mai nā hoʻokolohua hoʻokolohua. I nā hoʻāʻo, a hiki i 11.6% o nā wahine a me 4.2% o nā kāne i loaʻa i ka maʻi hū.

E hoʻomohala paha ʻoe i kahi maʻi hū inā loaʻa iā ʻoe i ka wā i hala a i ʻole inā he kāne ʻoki poepoe ʻole ʻia ʻoe.

Inā loaʻa ʻoe i kahi maʻi hū ke lawe ʻo Invokana, e kamaʻilio me kāu kauka. Hiki iā lākou ke hōʻike i nā ala e mālama ai.

Ketoacidosis diabetes

ʻOiai he kākaʻikahi ia, hiki i kekahi poʻe e lawe iā Invokana ke hoʻomohala i kahi kūlana koʻikoʻi i kapa ʻia ʻo ka ketoacidosis diabetic. Kū kēia kēia ke loaʻa ʻole nā ​​kinikini i kou kino i ka glucose (kō) e pono ai no ka ikaika. Me ka ʻole o kēia kō, hoʻohana kou kino i ka momona no ka ikehu. A hiki i kēia ke alakaʻi i nā kiʻekiʻe o nā kemika waikawa i kapa ʻia ketones i kou koko.

Hiki i nā ʻōuli o ka ketoacidosis diabetic ke hoʻopili pū me:

  • make wai nui loa
  • ka mimiki pinepine ʻana ma mua o ka maʻamau
  • nausea
  • ka luaʻi
  • ʻeha ka ʻōpū
  • luhi
  • nāwaliwali
  • pokole o ka hanu
  • hanu ʻaʻala ʻaʻala
  • huikau

I nā hihia koʻikoʻi, hiki i ka ketoacidosis diabetic ke hana i ke koma a i ʻole ka make. Inā manaʻo ʻoe he ketoacidosis diabetic kāu, e kāhea koke aku i kāu kauka. Akā inā koʻikoʻi kāu mau ʻōuli, e kāhea iā 911 a i ʻole e hele i kahi lumi pilikia kokoke loa.

Ma mua o kou hoʻomaka ʻana e lawe iā Invokana, e nānā kāu kauka i kou makaʻu no ka hoʻomōhala ʻana i ka ketoacidosis diabetic. Inā loaʻa ʻoe i ka nui o ka makaʻu o kēia ʻano, hiki i kāu kauka ke nānā pono iā ʻoe i ka wā o ka mālama ʻana. A i kekahi mau hihia, e like me inā e hana ana ʻoe i kahi ʻoki, loaʻa paha iā lākou iā ʻoe no ka manawa pōkole e lawe iā Invokana.

ʻĀpana o Fournier

ʻO Fournier's gangrene kahi maʻi maʻi ʻole i ka wahi ma waena o kāu genital a me kou kiko. Hiki i nā ʻōuli ke hoʻohui pū:

  • ʻeha, palupalu, pehu, a ʻulaʻula paha i kāu genital a i ʻole ka wahi rectal
  • fiva
  • malaise (manaʻo nui o ka hōʻoluʻolu)

ʻAʻole i loaʻa i ka poʻe i nā hoʻokolohua hoʻokolohua o Invokana ka gangrene o Fournier. Akā ma hope o ka ʻae ʻia ʻana o ka lāʻau no ka hoʻohana, ua hōʻike kekahi poʻe i ka loaʻa ʻana o kahi gangrene o Fournier ʻoiai e lawe ana iā Invokana a i ʻole nā ​​lāʻau ʻē aʻe i ka papa lāʻau like. (Hoʻohālikelike kahi papa lāʻau i kahi hui o nā lāʻau e hana like.)

ʻO nā hihia ʻoi aku ka hewa o ka gangrene o Fournier i alakaʻi i ka haukapila, nā ʻoki ʻana he nui, a i ʻole ka make.

Inā manaʻo ʻoe ua hoʻomohala ʻoe i ka gangrene o Fournier, e kāhea koke aku i kāu kauka. Makemake paha lākou iā ʻoe e haʻalele i ka lawe ʻana iā Invokana. E paipai pū lākou i ka lāʻau no ka maʻi.

Poino hakuʻala

Hiki i ka lawe ʻana iā Invokana ke hoʻonui i kou makaʻu i ka hōʻino ʻana o ka hakuʻala. Hiki i nā ʻōuli o ke kī hōʻino ke hoʻopili ʻia:

  • emi ka mimiki ma mua o ka maʻamau
  • ka pehu ʻana i kou mau wāwae, nā kuʻekuʻe wāwae, a me nā wāwae
  • huikau
  • luhi (nele o ka ikaika)
  • nausea
  • ʻeha ka umauma a i ʻole kaomi
  • kuʻi naʻau kaulike ʻole
  • ka hopu ʻana

Ma hope o kaʻae ʻia ʻana o ka lāʻau no ka hoʻohana, ua hōʻike kekahi poʻe e lawe ana iā Invokana i ka maikaʻi ʻole o kā lākou puʻupaʻa. I ka pau ʻana o kēia poʻe i ka lawe ʻana iā Invokana, ua hoʻomaka hou ka hana ʻana o ko lākou mau puʻupaʻa e hana maʻamau.

Hiki paha iā ʻoe ke loaʻa nā pilikia ʻōpū inā ʻoe:

  • make wai (loaʻa kahi pae wai haʻahaʻa)
  • he pilikia puʻuwai a puʻuwai paha
  • lawe i nā lāʻau ʻē aʻe e hoʻopili i kou puʻupaʻa
  • ʻoi aku ma mua o 65 makahiki

Ma mua o kou hoʻomaka ʻana e lawe iā Invokana, e hoʻāʻo kāu kauka i ke ʻano o ka maikaʻi o ka hana o kāu mau puʻupaʻa. Inā loaʻa iā ʻoe nā pilikia ʻōpū, ʻaʻole hiki iā ʻoe ke lawe iā Invokana.

Hiki paha i kāu kauka ke hōʻoia i ka hana o kāu mau puʻupaʻa i kou wā e mālama ai me Invokana. Inā ʻike lākou i kekahi pilikia o ka hakuʻala, hiki iā lākou ke hoʻololi i kāu lāʻau a oki paha i kāu mālama ʻana me ka lāʻau.

Haki iwi

I loko o kahi noiʻi hoʻokolohua, ua ʻike kekahi mau kānaka i lawe iā Invokana i ka haki iwi (kahi iwi haki). ʻAʻole maʻamau ka haki o nā haki.

Hiki i nā ʻōuli o ka haʻi iwi ke:

  • ʻeha
  • pehu
  • palupalu
  • ʻāpala
  • deformity

Inā pilikia nui ʻoe no ka haki a inā hopohopo paha ʻoe no ka haki ʻana i kahi iwi, e kamaʻilio me kāu kauka. Hiki iā lākou ke ʻōlelo i nā ala e pale ai i kēia hopena ʻaoʻao.

Wailele

I nā hoʻokolohua hoʻokolohua ʻeiwa, ua hāʻule i ka 2.1% o ka poʻe i lawe iā Invokana. Ua nui ka makaʻu o ka hāʻule i nā pule mua o ka mālama ʻana.

Inā hāʻule ʻoe i ka lawe ʻana iā Invokana a i ʻole inā hopohopo ʻoe i ka hāʻule ʻana, e kamaʻilio me kāu kauka. Hiki iā lākou ke ʻōlelo i nā ala e pale ai i kēia hopena ʻaoʻao.

ʻO Pancreatitis (ʻaʻole kahi hopena)

ʻO ka Pancreatitis (mumū i kāu pancreas) he laha loa i nā hoʻokolohua hoʻokolohua. Ua like nā uku o ka pancreatitis ma waena o ka poʻe i lawe iā Invokana a me ka poʻe i lawe i kahi placebo (lapaʻau me ka lāʻau ʻole. Ma muli o kēia mau hopena like, ʻaʻole paha ʻo Invokana ka mea i hoʻokumu i ka pancreatitis.

Inā he hopohopo kāu e pili ana i ka hoʻomohala ʻana i ka pancreatitis me Invokana, e kamaʻilio me kāu kauka.

ʻEha hui (ʻaʻole kahi hopena)

ʻAʻole ka ʻeha hui ka hopena o Invokana i nā hoʻokolohua hoʻokolohua.

Eia nō naʻe, hiki i kekahi mau lāʻau diabetes ke kumu i ʻeha pū. I ka ʻoiaʻiʻo, ua hoʻolaha ka Food and Drug Administration (FDA) i kahi hoʻolaha palekana no kahi papa o ka lāʻau diabetes i kapa ʻia nā mea kāohi lāʻau dipeptidyl peptidase-4 (DPP-4). (Hoʻohālikelike kahi papa lāʻau i kahi hui o nā lāʻau e hana like.) Ua ʻōlelo ʻia ka hoʻolaha e hiki i nā mea kāohi DPP-4 ke hōʻeha i nā ʻeha pū.

Akā ʻaʻole ʻo Invokana i kēlā papa lāʻau. Akā, pili ia i kahi papa o nā lāʻau i kapa ʻia he sodium-glucose co-transporter-2 (SGLT2) mea kāohi.

Inā he hopohopo kāu e pili ana i ka ʻeha pū me ka hoʻohana ʻana o Invokana, e kamaʻilio me kāu kauka.

Lilo ka lauoho (ʻaʻole kahi hopena)

ʻAʻole ka hopena o ka lauoho ka hopena o Invokana i nā hoʻokolohua hoʻokolohua.

Inā hopohopo ʻoe i ka nalo ʻana o ka lauoho, e kamaʻilio me kāu kauka. Hiki iā lākou ke kōkua iā ʻoe e hoʻoholo i ke kumu o ia a me nā ʻano e mālama ai iā ia.

Kauoha invokana

ʻO ka lāʻau Invokana kauka a ke kauka e kuhikuhi ai e hilinaʻi ʻia i nā kumu he nui. Pākuʻi ʻia kēia mau mea:

  • ke ʻano a me ke koʻikoʻi o ke ʻano āu e hoʻohana nei iā Invokana e mālama ai
  • kou mau makahiki
  • nā kūlana olakino ʻē aʻe āu
  • pehea ka maikaʻi o ka hana o kou puʻupaʻa
  • kekahi mau lāʻau ʻē aʻe āu e lawe nei me Invokana

ʻO ka maʻamau, e hoʻomaka kāu kauka iā ʻoe ma kahi lāʻau haʻahaʻa. A laila e hoʻoponopono lākou iā ia i ka manawa e hiki ai i ka nui e kūpono iā ʻoe. E kauoha kauka loa i kāu kauka liʻiliʻi e hāʻawi i ka hopena i makemake ʻia.

Hōʻike ka ʻikepili aʻe i nā lāʻau i hoʻohana pinepine ʻia a koi ʻia paha. Eia nō naʻe, e mālama pono i nā lāʻau a ke kauka i kuhikuhi ai nāu. E hoʻoholo kāu kauka i ke ana ʻoi loa e kūpono i kāu mau pono.

Nā ʻano lāʻau a me nā ikaika

Hele mai ʻo Invokana ma ke ʻano he papa. Loaʻa ia i nā ikaika ʻelua:

  • 100 milligrams (mg), e hiki mai ana ma ke ʻano he papa melemele
  • 300 mg, e hele mai ana ma ke ʻano he papa keʻokeʻo

Nā hana no ka hoʻohaʻahaʻa ʻana i nā pae kō kō

Kuhi ʻia nā lāʻau i manaʻo ʻia o Invokana e hoʻohaʻahaʻa i nā pae kō kō e pili ana i ke ana i kapa ʻia ka helu kānana glomerular (eGFR). Hana ʻia kēia ana me ka hoʻāʻo ʻana i ke koko. A hōʻike ia i ka maikaʻi o ka hana o kāu mau puʻupaʻa.

I ka poʻe me ka:

  • eGFR o ka liʻiliʻi he 60, ʻaʻohe o lākou nalowale o ka puʻuwai hana i ka nalowale ʻana o ka hana puʻupaʻa. ʻO kā lākou mea i koi ʻia no Invokana he 100 mg i kēlā me kēia lā. Hiki i kā lākou kauka ke hoʻonui i kā lākou mea i 300 mg i kēlā me kēia lā inā pono e kōkua i ka mālama ʻana i ka pae kō kō.
  • eGFR o 30 a emi ma mua o 60, loaʻa iā lākou ka nalowale o ka hana o ka hakuʻala. ʻO kā lākou mea i koi ʻia no Invokana he 100 mg i kēlā me kēia lā.
  • eGFR ma lalo o 30, ua nui ko lākou nalo ʻana i ka hana o ka hakuʻala. ʻAʻole ia e koi iā lākou e hoʻomaka me ka hoʻohana ʻana iā Invokana. Akā inā ua hoʻohana mua lākou i ka lāʻau a ke hele nei i kahi pae o albumin (kahi protein) i loko o kā lākou mimi, hiki paha iā lākou ke hoʻomau i ka lawe ʻana iā Invokana. *

Kaha: ʻAʻole pono e hoʻohana ʻia ka invokana e ka poʻe e hoʻohana nei i ka dialysis therapy. (Dialysis kahi kaʻina hana e hoʻohana ai e hoʻomaʻemaʻe i nā huahana neoneo mai kou koko inā ʻaʻole lawa ke olakino o kou puʻupaʻa e hana pēlā.)

Nā hana no ka hōʻemi ʻana i nā pilikia o ka maʻi ʻōpū

Hōʻoia nā lāʻau i manaʻo ʻia e hoʻoliʻiliʻi i nā pilikia o ka maʻi puʻuwai e like me ka hoʻohaʻahaʻa ʻana i nā pae kō kō. E ʻike i ka ʻāpana i luna no nā kikoʻī.

Nā hana no ka hōʻemi ʻana i ka makaʻu o nā pilikia mai ka nephropathy diabetic

Hōʻike ʻia nā lāʻau i makemake ʻia e hoʻohaʻahaʻa i nā pilikia o nā pilikia mai ka nephropathy diabetic e like me ka hoʻohaʻahaʻa ʻana i nā pae kō kō. E ʻike i ka ʻāpana i luna no nā kikoʻī.

He aha inā e haʻo wau i kahi lāʻau?

Inā ʻoe e nalo i kahi mahele lāʻau o Invokana, e lawe ke hoʻomanaʻo koke ʻoe. Inā ʻaneʻane kokoke ka manawa no kāu kaukō aʻe, e lele i ka lāʻau i hala ʻole a lawe i ka lāʻau aʻe i ka manawa maʻamau. Mai hoʻāʻo e hopu i ka lawe ʻana i ʻelua mau lāʻau i ka manawa hoʻokahi. Hiki i kēia ke kumu i nā hopena ʻino weliweli.

ʻO ka hoʻohana ʻana i kahi mea hana hoʻomanaʻo hiki ke kōkua iā ʻoe e hoʻomanaʻo e lawe iā Invokana i kēlā me kēia lā.

E lawe pono iā Invokana e like me ke kauka a kāu kauka.

Pono wau e hoʻohana i kēia lāʻau lōʻihi?

Inā ʻae ʻoe a me kāu kauka e hana maikaʻi ana ʻo Invokana iā ʻoe, e hoʻohana paha ʻoe ia i kahi wā lōʻihi.

Nā koho ʻē aʻe i Invokana

Loaʻa nā lāʻau ʻē aʻe i hiki ke mālama i kou ʻano. Kūpono paha kekahi iā ʻoe ma mua o nā poʻe ʻē aʻe. Inā hoihoi ʻoe i ka ʻimi ʻana i kahi ʻokoʻa i Invokana, e kamaʻilio me kāu kauka e pili ana i nā lāʻau ʻē aʻe e holo pono paha iā ʻoe.

Nā koho ʻē aʻe no ka hoʻohaʻahaʻa ʻana i nā pae kō kō i nā poʻe me ka maʻi diabetes type 2

Nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e hoʻohaʻahaʻa i nā pae kō kō i nā poʻe me ka maʻi diabetes type 2:

  • sodium-glucose co-transporter 2 (SGLT-2) mea hoʻopukapuka, e like me:
    • empagliflozin (Jardiance)
    • dapagflozin (Farxiga)
    • ertugliflozin (Steglatro)
  • ʻo nā mimretics incretin / glucagon-like peptide-1 (GLP-1) agonists reseptor, e like me:
    • dulaglutide (Trulicity)
    • exenatide (Bydureon, Byetta)
    • Luluʻula (Victoza)
    • lixisenatide (Adlyxin)
    • semaglutide (Ozempic)
    • albiglutide (Tanzeum)
  • metformin (Glucophage, Glumetza, Riomet)
  • dipeptidyl peptidase-4 (DPP-4) mea hoʻopukapuka, e like me:
    • alogliptin (Nesina)
    • linagliptin (Tradjenta)
    • saxagliptin (Onglyza)
    • sitagliptin (Januvia)
  • thiazolidinediones, e like me:
    • pioglitazone (Actos)
    • rosiglitazone (Avandia)
  • nā mea kāpae alpha-glucosidase, e like me:
    • acarbose (Kūpono)
    • miglitol (Glyset)
  • sulfonylureas, e like me:
    • chlorpropamide
    • glimepiride (Amaryl)
    • glipizide (Glucotrol)
    • glyburide (Diabeta, Glynase PresTabs)

Nā koho ʻē aʻe no ka hōʻemi ʻana i ka pilikia o nā pilikia o ka maʻi puʻuwai i loko o ka poʻe me ka maʻi diabetes type 2

Nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e hōʻemi i ka makaʻu o kekahi mau pilikia maʻi puʻuwai * i ka poʻe me ka maʻi diabetes type 2:

  • nā mea kūpale SGLT2 ʻē aʻe, e like me empagliflozin (Jardiance)
  • ʻO nā peptide-1 peptide-1 (GLP-1) reseptor agonists, e like me liraglutide (Victoza)
  • lāʻau lāʻau statin, e like me:
    • atorvastatin (Lipitor)
    • rosuvastatin (Crestor)

Nā koho ʻē aʻe no ka hōʻemi ʻana i ka pilikia o nā pilikia mai ka diabetic nephropathy i ka poʻe me ka maʻi diabetes type 2

Nā laʻana o nā lāʻau ʻē aʻe i hiki ke hoʻohana ʻia e hōʻemi i ka makaʻu o nā pilikia * o ka nephropathy diabetic † i ka poʻe me ka maʻi diabetes type 2:

  • ʻo ka angiotensin e hoʻohuli nei i nā mea kūpale enzyme, e like me lisinopril
  • blockers receptor angiotensin, e like me irbesartan

Invokana vs. nā lāʻau ʻē aʻe

Mahalo paha ʻoe i ka hoʻohālikelike ʻana o Invokana i nā lāʻau ʻē aʻe i kuhikuhi ʻia no ka poʻe me ka maʻi kōkō 2. Ma lalo nā hoʻohālikelike ma waena o Invokana a me kekahi mau lāʻau.

Invokana vs. Jardiance

ʻO Invokana a me Jardiance (empagliflozin) i loko o ka papa like o nā lāʻau lapaʻau: nā mea hana paʻakai sodium-glucose 2 (SGLT-2) mea kāohi. ʻO ke kumu o ka hana like ʻana o lākou i ka mālama ʻana i ka maʻi diabetes type 2.

Loaʻa iā Invokana ka lāʻau canagliflozin. Loaʻa iā Jardiance i ka empagliflozin lāʻau.

Hoʻohana

Ua ʻae ʻia ʻo Invokana a me Jardiance e ka Food and Drug Administration (FDA) iā:

  • hoʻomaikaʻi i nā pae kō kō i nā mākua me ka maʻi diabetes type 2
  • hoʻemi i ka hopena o ka make o ka maʻi puʻuwai ma nā mākua me nā maʻi ʻelua a me nā maʻi puʻuwai

Hoʻohui ʻia, ʻae ʻia ʻo Invokana no ka hōʻemi ʻana i ka makaʻu o:

  • ʻO ka hōʻeha puʻuwai a me ka hahau ʻaʻole e alakaʻi i ka make i nā mākua me ka maʻi diabetes type 2 a me nā maʻi puʻuwai.
  • Kekahi kūpikipiki o ka diabetic nephropathy i nā mākua me ka maʻi diabetes type 2. (Me ka diabetic nephropathy, loaʻa ʻoe i ka hōʻino puʻupaʻa i hoʻokumu ʻia e ka maʻi diabetes.)

No ka ʻike hou aku e pili ana i nā hoʻohana a Invokana i ʻae ʻia a me kāna mau palena o ka hoʻohana, e ʻike i ka mahele ʻo "Invokana" ma luna.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai ʻo Invokana a me Jardiance ma ke ʻano he papa e lawe ai ʻoe ma ka waha i ke kakahiaka.

Hiki iā ʻoe ke lawe i nā lāʻau ʻelua me ka ʻai ʻole, akā ʻoi aku ka maikaʻi o ka lawe ʻana iā Invokana ma mua o ka ʻaina kakahiaka.

Nā hopena a me nā pilikia

ʻO Invokana a me Jardiance no ka papa lāʻau like a hana like i loko o ke kino. Ma muli o kēia, kumu lākou i nā hopena ʻaoʻao like loa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Aia i loko o kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke loaʻa me Invokana, me Jardiance, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Invokana:
    • make wai
    • kōpaʻa
  • Hiki ke hana me Jardiance:
    • ʻeha pū
    • hoʻonui i nā pae kolesterol
  • Hiki ke hana me Invokana a me Jardiance:
    • maʻi maʻi urinary tract
    • ka mimiki pinepine ʻana ma mua o ka maʻamau
    • nausea
    • ʻume puʻu ʻili
    • nā maʻi hū i nā kāne a me nā wahine

Nā hopena hopena koʻikoʻi

Loaʻa i kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana me Invokana, me Jardiance, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Invokana:
    • ʻoki ʻana i kahi lālā o lalo
    • haki iwi
  • Hiki ke hana me Jardiance:
    • kekahi mau hopena koʻikoʻi koʻikoʻi
  • Hiki ke hana me Invokana a me Jardiance:
    • make wai (pae wai haʻahaʻa), hiki ke hoʻohaʻahaʻa i ke koko
    • ketoacidosis diabetic (hoʻonui ʻia nā pae o ketones i ke koko a i ʻole ka mimi)
    • hōʻino kīhāpai *
    • maʻi maʻi urinary tract
    • hypoglycemia (haʻahaʻa kō kō kō)
    • ʻO ka gangrene o Fournier (maʻi maʻi kokoke i nā genital)
    • hopena hopena maʻi ʻino

Ka hoʻokō ʻana

ʻAʻole i hoʻohālikelike ʻia kēia mau lāʻau i ke poʻo i ke poʻo i nā noiʻi maʻi. Akā ua ʻike nā haʻawina i nā Invokana a me Jardiance e maikaʻi no kā lākou hoʻohana i ʻae ʻia.

Nā kumukūʻai

ʻO Invokana a me Jardiance nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe o lākou ʻano generic. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā wānana mai GoodRx.com, Invokana a me Jardiance ma ke ʻano he kumukūʻai like. ʻO ke kumukūʻai maoli āu e uku ai no kēlā me kēia lāʻau e pili ana i kāu hoʻolālā ʻinikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.

Invokana vs. Farxiga

Aia ʻo Invokana a me Farxiga i ka papa like o nā lāʻau: sodium-glucose co-transporter 2 (SGLT-2) mea kāohi. ʻO ke kumu o ka hana like ʻana o lākou i ka mālama ʻana i ka maʻi diabetes type 2.

Loaʻa iā Invokana ka lāʻau canagliflozin. Loaʻa iā Farxiga ka lāʻau dapagliflozin.

Hoʻohana

Ua ʻae ʻia ʻo Invokana a me Farxiga e ka Food and Drug Administration (FDA) e hoʻomaikaʻi i nā pae kō kō i nā mākua me ka maʻi kōkō 2.

ʻAe ʻia ʻo Invokana e hōʻemi i ka makaʻu o:

  • hōʻeha puʻuwai a me ka hahau ʻaʻole e alakaʻi i ka make i ka poʻe me nā maʻi ʻelua a me nā maʻi puʻuwai
  • Ka make ʻana o ka maʻi puʻuwai ma nā kānaka me nā maʻi maʻi ʻelua a me nā maʻi puʻuwai
  • kekahi mau pilikia o ka diabetic nephropathy * i ka poʻe me ka maʻi diabetes type 2

ʻAe ʻia ʻo Farxiga e hōʻemi i ka makaʻu o:

  • haukapila no ka puʻuwai puʻuwai ʻole i ka poʻe me ka maʻi diabetes type 2 a me nā maʻi puʻuwai a i ʻole nā ​​mea pilikia no ka maʻi puʻuwai
  • Ka make ʻana o ka maʻi puʻuwai a me ka haukapila no ka maikaʻi ʻole o ka puʻuwai i nā mākua me kekahi ʻano o ka puʻuwai puʻuwai me ka hapa liʻiliʻi o ka eject

No ka ʻike hou aku e pili ana i nā hoʻohana a Invokana i ʻae ʻia a me nā palena o ka hoʻohana ʻana, e ʻike i ka ʻāpana ʻo "Invokana" ma luna.

Nā ʻano lāʻau a me ka hoʻoponopono ʻana

Hele mai nā Invokana a me Farxiga e like me nā papa āu e lawe ai ma ka waha i ke kakahiaka. Hiki iā ʻoe ke lawe i nā lāʻau ʻelua me ka ʻole o ka meaʻai, akā ʻoi aku ka maikaʻi o ka lawe ʻana iā Invokana ma mua o ka ʻaina kakahiaka.

Nā hopena a me nā pilikia

ʻO Invokana a me Farxiga mai ka papa lāʻau like a hana like i loko o ke kino. Ma muli o kēia, kumu lākou i nā hopena ʻaoʻao like loa. Ma lalo nā hiʻohiʻona o kēia mau hopena ʻaoʻao.

Nā hopena ʻaoʻao hou aʻe

Loaʻa i loko o kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke loaʻa me Invokana, me Farxiga, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Invokana:
    • make wai
  • Hiki ke hana me Farxiga:
    • nā maʻi hanu e like me ke anuanu maʻamau a i ʻole ka flu
    • ʻeha hope a ʻehaʻeha paha
    • hōʻoluʻolu ʻoiai e mimiki ana
  • Hiki ke hana me Invokana a me Farxiga:
    • maʻi maʻi urinary tract
    • ka mimiki pinepine ʻana ma mua o ka maʻamau
    • nausea
    • kōpaʻa
    • ʻume puʻu ʻili
    • nā maʻi hū i nā kāne a me nā wahine

Nā hopena hopena koʻikoʻi

Loaʻa i kēia mau papa inoa nā laʻana o nā hopena ʻino e hiki ke hana me Invokana, me Farxiga, a i ʻole me nā lāʻau ʻelua (ke lawe pākahi ʻia).

  • Hiki ke hana me Invokana:
    • ʻoki ʻana i kahi lālā o lalo
  • Hiki ke hana me Farxiga:
    • kekahi mau hopena koʻikoʻi koʻikoʻi
  • Hiki ke hana me Invokana a me Farxiga:
    • haki iwi
    • make wai (pae wai haʻahaʻa), hiki ke hoʻohaʻahaʻa i ke koko
    • ketoacidosis diabetic (hoʻonui ʻia nā pae o nā ketones i ke koko a i ʻole ka mimi)
    • hakuʻala hōʻino *
    • maʻi maʻi urinary tract
    • hypoglycemia (haʻahaʻa kō kō kō)
    • ʻO ka gangrene o Fournier (maʻi maʻi kokoke i nā genital)
    • hopena hopena maʻi ʻino

Ka hoʻokō ʻana

ʻAʻole i hoʻohālikelike ʻia kēia mau lāʻau i ke poʻo i ke poʻo i nā noiʻi maʻi. Akā ua ʻike nā haʻawina i nā Invokana a me Farxiga i ke kūpono no kā lākou hoʻohana pono ʻia.

Nā kumukūʻai

ʻO Invokana lāua ʻo Farxiga nā lāʻau lapaʻau inoa ʻelua. ʻAʻohe o lākou ʻano generic. ʻOi aku ke kumu kūʻai o nā lāʻau lapaʻau inoa inoa ma mua o nā generics.

Wahi a nā wānana mai GoodRx.com, Invokana a me Farxiga ma ke kumu kūʻai he nui. ʻO ke kumukūʻai maoli āu e uku ai no kēlā me kēia lāʻau e pili ana i kāu hoʻolālā ʻinikua, kou wahi, a me ka lāʻau kūʻai āu e hoʻohana ai.

Uku invokana

E like me nā lāʻau a pau, hiki ke hoʻololi ke kumukūʻai o Invokana.

ʻO ke kumukūʻai maoli āu e uku ai ma muli o kāu ʻinikua uhi a me ka hale kūʻai lāʻau lapaʻau āu e hoʻohana ai.

Kōkua kālā a me nā ʻinikua

Inā makemake ʻoe i kākoʻo kālā e uku ai no Invokana, loaʻa ke kōkua.

Hāʻawi ʻo Janssen Pharmaceuticals, Inc., ka mea hana i Invokana, i kahi papahana i kapa ʻia ʻo Janssen CarePath Savings Program. No ka ʻike hou aku a e ʻike inā ua kūpono ʻoe no ke kākoʻo, kāhea iā 877-468-6526 a i ʻole kipa i ka pūnaewele pūnaewele.

Hoʻohana ʻo Invokana

Ua ʻae ka Food and Drug Administration (FDA) i nā lāʻau i kuhikuhi ʻia e like me Invokana e mālama i kekahi mau ʻano.

Invokana i ka poʻe me ka maʻi diabetes type 2

Ua ʻae ʻia ʻo Invokana no ka hoʻohana ʻana i ka poʻe mākua me ka maʻi diabetes type 2 i:

  • E hoʻomaikaʻi i nā pae kō kō. No kēia hoʻohana, kauoha ʻia ʻo Invokana i mea hoʻohui i ka papaʻai a me ka hoʻoikaika kino e hoʻohaʻahaʻa i nā pae kō kō.
  • E hoʻemi i ka pilikia o kekahi pilikia o ka maʻi puʻuwai. No kēia hoʻohana, hāʻawi ʻia ʻo Invokana i nā mākua me ka maʻi maʻi maʻi i ʻike ʻia. Hoʻohana ʻia ia e hoʻohaʻahaʻa i ka makaʻi o ka puʻuwai a me ka hahau i alakaʻi ʻole ʻia i ka make. A hoʻohana ʻia ka lāʻau e hōʻemi i ka makaʻu o ka make mai kahi pilikia o ka puʻuwai a i ʻole ke koko.
  • E hoʻemi i ka pilikia o kekahi mau pilikia i ka poʻe me ka nephropathy diabetic. No kēia hoʻohana, hāʻawi ʻia ʻo Invokana i kekahi mau mākua me ka nephropathy diabetic (hōʻino nā hakuʻala i hoʻokumu ʻia e ka maʻi diabetic) me albuminuria * ʻoi aku ma mua o 300 milligrams i kēlā me kēia lā. Hoʻohana ʻia ia e hoʻohaʻahaʻa i ka makaʻu o:
    • hoʻopau pae kahua maʻi maʻi
    • ʻo ka make i hoʻokumu ʻia e ka pilikia o ka puʻuwai a i ʻole ke koko
    • pālua i ke kiʻekiʻe o ka creatinine
    • ka pono i ka haukapila no ka holo pono ʻole o ka naʻau

ʻO ka maʻamau, ʻo kahi hōmona i kapa ʻia ʻo ka insulin e hoʻoneʻe i ke kō mai kou koko i loko o kāu mau hunaola. A hoʻohana kāu mau pūnaewele i kēlā kō no ka ikehu. Akā me ka maʻi diabetes ʻano 2, ʻaʻole hana kino kou kino i ka insulin pono.

Ke holo nei ka manawa, pau paha kou kino i ka hana ʻana i ka nui o ka insulin. No laila, me ka maʻi diabetes ʻano 2, ʻaʻole e neʻe ʻia ke kō mai kou koko e like me ka maʻamau. A alakaʻi kēia i ka hoʻonui ʻia o nā kō kō.

ʻO ka hoʻonui ʻia o nā kō kō i hiki ke hōʻino i kāu kīʻaha koko, a he mea paha ia e pilikia ai i kou puʻuwai a me nā puʻupaʻa.

Hana ʻo Invokana e hoʻohaʻahaʻa i kāu mau kō kō a me ka hoʻēmi i ka makaʻu o kekahi mau pilikia me kou kīʻaha koko, naʻau, a me nā puʻupaʻa.

Nā palena o ka hoʻohana

He mea nui e hoʻomaopopo ʻaʻole i ʻae ʻia ʻo Invokana no ka hoʻohana ʻana i ka poʻe me ka maʻi diabetes type 1. Akā, ʻae wale ʻia no ka hoʻohana ʻana i ka poʻe me ka maʻi diabetes type 2. Manaʻo ʻia he hiki i ka poʻe me ka maʻi diabetes type 1 ke hoʻonui i ka makaʻu no ka ketoacidosis diabetic inā hoʻohana lākou iā Invokana. (Me ka ketoacidosis diabetic, ua hoʻonui ʻoe i nā pae ketone i loko o kou koko a mimi paha.) I mea e aʻo hou ai e pili ana i kēia ʻano, e ʻike i ka ʻaoʻao ʻo “Invokana effects” ma luna.

Hoʻohui ʻia, ʻaʻole pono e hoʻohana ʻia ʻo Invokana e kōkua i ka hoʻohaʻahaʻa ʻana i nā pae kō kō i nā poʻe me ka maʻi maʻisā ʻano 2 ka poʻe i hoʻopilikia loa i ka hana puʻuwai. Kahi kikoʻī, ʻaʻole pono e hoʻohana ʻia ka lāʻau i loko o ka poʻe me ka helu kānana glomerular i koho ʻia (eGFR) ma lalo o 30 (eGFR kahi ana i hana ʻia me ka hoʻāʻo ʻana i ke koko. Hōʻike ia i ka maikaʻi o ka hana o kāu mau puʻupaʻa.) Manaʻo ʻia ʻAʻole maikaʻi paha ʻo Invokana no ka hoʻohana ʻana i ka poʻe me kēia ʻano.

Ka hoʻokō ʻana

Ua aʻo ʻia ʻo Invokana wale nō a me ka hoʻohui pū ʻana me nā lāʻau ʻē aʻe i ka hoʻohaʻahaʻa ʻana i nā pae kō kō i nā poʻe me ka maʻi diabetes type 2. I kēia mau noiʻi, ua loaʻa ʻo Invokana e hoʻohaʻahaʻa i ka pae hemoglobin A1c (HbA1c) o ka poʻe, ʻo ia ke ana o ka pae awelika o nā kō kō.

Ua aʻo ʻia ʻo Invokana i ka hoʻohaʻahaʻa ʻana i ka pilikia o kekahi mau pilikia maʻi puʻuwai i loko o ka poʻe me ka maʻi diabetes type 2. I kēia mau noiʻi, hoʻohaʻahaʻa ka lāʻau i kekahi mau ʻano o ka puʻuwai a me ka hahau a me ka make ma muli o ka pilikia o ka puʻuwai a i ʻole ke kīʻaha koko.

Eia kekahi, ua aʻo ʻia ʻo Invokana i ka poʻe me ka nephropathy diabetic ma ke ʻano he lāʻau e hoʻohaʻahaʻa ai i ka pilikia o kekahi mau pilikia. I loko o kēia noi ʻana, ua hoʻemi ka poʻe i lawe ʻia iā Invokana i nā helu o ka maʻi maʻi kidney end end, a ua pāpālua ʻia ka pae creatinine i loko o ko lākou koko, a me nā pilikia ʻē aʻe.

No ka ʻike hou aku e pili ana i ka pono o Invokana no kāna hoʻohana pono ʻia, e ʻike i ka ʻike o ka lāʻau.

Eia hou, kuhikuhi nā alakaʻi mai ka American Diabetes Association:

  • me ka hoʻohana ʻana i kahi mea hōʻoki SGLT2, e like me Invokana, ma ke ʻano he ʻāpana o ka lāʻau lapaʻau no ka mālama ʻana i ke kō kō i nā mākua me ka maʻi diabetes type 2 i loaʻa pū ka maʻi puʻuwai a puʻuwai paha.
  • me ka hoʻohana ʻana i kahi mea kāohi SGLT2 i ka poʻe me ka maʻi diabetes type 2 i loaʻa nā pilikia pilikia no nā pilikia o ka maʻi puʻuwai

Hoʻohana inoa lepe no Invokana

Ma waho aʻe o ka hoʻohana ʻana no ka maʻi diabetes type 2, hoʻohana ʻia ʻo Invokana i kahi lepili inoa no kekahi kumu ʻē aʻe. ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau i waho ke hoʻohana ʻia kahi lāʻau i ʻae ʻia no hoʻokahi hoʻohana no kahi ʻokoʻa ʻae ʻole ʻia.

ʻO Invokana no ka maʻi diabetes type 1

ʻOiai ua paipai ka mea hana e hoʻohana ʻole ʻia ʻo Invokana no ka maʻi diabetes type 1, hoʻohana ʻia ka lāʻau i kekahi manawa i ka lepili e mālama i ke ʻano.

I hoʻokahi hoʻokolohua hoʻokolohua, ua lawe ka poʻe me ka maʻi diabetes type 1 iā Invokana a me ka insulin. No ka poʻe i loko o ke aʻo ʻana, ua hoʻemi kēia hana.

  • ko lākou pae kō kō
  • kā lākou pae hemoglobin A1c (HbA1c)
  • ka huina nui o ka insulin a lākou e lawe ai i kēlā me kēia lā

Inā he mau nīnau kāu e pili ana i nā koho lapaʻau no ka maʻi diabetes type 1, e kamaʻilio me kāu kauka.

Invokana no ka hōʻemi kino

ʻOiai ʻaʻole i ʻae ʻia ʻo Invokana ma ke ʻano he lāʻau hoʻohaʻahaʻa kaumaha, ʻo ka pohō kaumaha ka hopena o ka lāʻau.

Ma nā noiʻi hoʻokolohua, ua lilo ka poʻe i lawe iā Invokana i 9 mau paona ma mua o 26 mau pule o ka lapaʻau. Ma muli o kēia hopena ʻaoʻao, makemake paha kāu kauka iā ʻoe e lawe iā Invokana inā loaʻa iā ʻoe ka ʻano diabetes 2 a ʻoi aku kou kaumaha.

Hoʻokumu ʻo Invokana i ka pohō kaumaha ma o ka hoʻouna ʻana i ke kō (ke kō) he nui i kou koko i kāu mimi. Haʻalele nā ​​calorie mai ka glucose i kou kino i loko o kou mimi, ka mea e alakaʻi ai iā ʻoe e lilo kaupaona.

E lawe pono iā Invokana e like me ke kauka a kāu kauka. Mai lawe i ka lāʻau e lilo i ka paona a i ʻole no kekahi kumu ʻē aʻe me ka kamaʻilio ʻole mua ʻole ʻana me kāu kauka.

ʻO Invokana a me ka waiʻona

E hōʻalo i ka inu rama loa i ka wā e lawe ana iā Invokana. Hiki i ka waiʻona ke hoʻololi i kāu pae kō kō a hoʻonui i kou makaʻi no:

  • hypoglycemia (haʻahaʻa kō kō kō)
  • ketoacidosis diabetic (hoʻonui ʻia nā pae o ketones i ke koko a me ka mimi)
  • pancreatitis (inflamed pancreas)

Inā inu ʻoe i ka waiʻona, e kamaʻilio me kāu kauka no ka nui o ka palekana o ka wai ʻona iā ʻoe i ka wā e lawe ai iā Invokana.

Nā hana pilina Invokana

Hiki i ka Invokana ke launa pū me nā lāʻau ʻē aʻe. Hiki iā ia ke launa pū me kekahi mau mea hoʻopihapiha a me nā meaʻai.

Hiki i nā launa like ʻole ke kumu i nā hopena like ʻole. ʻO kahi laʻana, hiki i kekahi mau pilina ke hoʻololi i ka maikaʻi o ka hana ʻana o ka lāʻau, ʻoiai ʻo nā mea ʻē aʻe e hoʻonui i nā hopena ʻaoʻao.

Invokana a me nā lāʻau ʻē aʻe

Ma lalo nā papa inoa o nā lāʻau i hiki ke launa pū me Invokana. ʻAʻole i loko o kēia mau papa inoa nā lāʻau āpau e launa pū paha me Invokana.

Ma mua o ka lawe ʻana iā Invokana, e ʻike pono e haʻi aku i kāu kauka a me ka kauka lāʻau e pili ana i nā kauka a pau, ma ka ʻaiʻē, a me nā lāʻau ʻē aʻe āu e lawe ai. E haʻi pū iā lākou e pili ana i nā wikamina, nā mea kanu, a me nā mea hoʻopiha āu e hoʻohana ai. Hiki ke kōkua i ka hāʻawi ʻana i kēia ʻike iā ʻoe e hōʻalo i nā launa ʻole.

Inā he mau nīnau kāu e pili ana i nā launa lāʻau e hoʻopili iā ʻoe, e nīnau i kāu kauka a kauka paha.

ʻO Invokana a me nā lāʻau i hiki ke hoʻonui i ka makaʻu o ka hypoglycemia

Lawe iā Invokana me kekahi mau lāʻau i hiki ke hoʻonui i kou makaʻu no ka hypoglycemia (pae kō kō kō haʻahaʻa). Inā ʻoe e lawe i kēia mau lāʻau, pono ʻoe e nānā pinepine i ke kiʻekiʻe o ke kō o kou kō. Eia kekahi, pono paha i kāu kauka e hoʻololi i ke ana o kāu mau lāʻau.

ʻO nā laʻana o kēia mau lāʻau:

  • nā lāʻau diabetes ʻē aʻe, e like me:
    • dulaglutide (Trulicity)
    • linagliptin (Tradjenta)
    • Luluʻula (Victoza)
    • sitagliptin (Januvia)
    • glyburide (DiaBeta, Glynase, Micronase)
    • glimepiride (Amaryl)
    • glipizide (Glucotrol)
    • insulins-ʻai manawa (Humalog, Novolog)
    • metformin (Glucophage)
    • nateglinide (Starlix)
    • repaglinide (Prandin)
  • kekahi mau lāʻau lapaʻau kiʻekiʻe, e like me:
    • benazepril (Lotensin)
    • candesartan (Atacand)
    • enalapril (Vasotec)
    • irbesartan (Avapro)
    • lisinopril (Zestril)
    • losartan (Cozaar)
    • olmesartan (Benicar)
    • valsartan (Diovan)
  • nā lāʻau ʻē aʻe i hiki ke hoʻohaʻahaʻa i nā pae kō kō, e like me:
    • disopyramide (Norpace)
    • kekahi mau lāʻau kolesterol, e like me fenofibrate (Tricor, Triglide) a me gemfibrozil (Lopid)
    • kekahi antidepressants, e like me fluoxetine (Prozac, Sarafem) a me selegiline (Emsam, Zelapar)
    • octreotide (Sandostatin)
    • sulfamethoxazole-trimethoprim (Bactrim, Septra)

ʻO Invokana a me nā lāʻau i hiki ke hoʻonui i nā pae kō kō

Hiki i kekahi mau lāʻau ke hoʻonui i ke kiʻekiʻe o ke kō i kou kino. Inā ʻoe e lawe i kēia mau lāʻau, pono ʻoe e nānā pinepine i ke kiʻekiʻe o ke kō o kou kō. Hiki i kēia ke kōkua i ka pale ʻana i ka hyperglycemia (pae kō kō kiʻekiʻe). Eia kekahi, pono paha i kāu kauka e hoʻololi i kāu kau ʻana.

ʻO nā laʻana o kēia mau lāʻau:

  • albuterol (ProAir, Proventil, Ventolin HFA)
  • kekahi mau antivirals, e like me atazanavir (Reyataz) a me lopinavir / ritonavir (Kaletra)
  • kekahi mau steroid, e like me:
    • budesonide (Entocort EC, Pulmicort, Uceris)
    • prednisone
    • fluticasone (Flonase, Flovent)
  • kekahi diuretics, e like me chlorothiazide (Diuril) a me hydrochlorothiazide (Microzide)
  • kekahi antipsychotics, e like me clozapine (Clozaril, Fazaclo) a me olanzapine (Zyprexa)
  • kekahi mau hormoni, e like me:
    • danazol (Danazol)
    • levothyroxine (Levoxyl, Synthroid)
    • somatropin (Genotropin)
  • glucagon (GlucaGen)
  • niacin (Niaspan, Slo-Niacin, kekahi)
  • ʻōpū oral (pills kaohi hānau)

ʻO Invokana a me nā lāʻau i hiki ke hoʻohaʻahaʻa i ke kahe o ke koko

ʻO ka lawe ʻana iā Invokana me kekahi mau lāʻau e hōʻemi ai i ke kahe o ke koko e hoʻohaʻahaʻa loa ai i kou kaʻe koko. Hiki paha iā ia ke hoʻonui i kou makaʻu no ka hōʻino ʻana o ka hakuʻala.

ʻO nā laʻana o kēia mau lāʻau:

  • benazepril (Lotensin)
  • candesartan (Atacand)
  • enalapril (Vasotec)
  • irbesartan (Avapro)
  • lisinopril (Zestril)
  • losartan (Cozaar)
  • olmesartan (Benicar)
  • valsartan (Diovan)

ʻO Invokana a me nā lāʻau i hiki ke hoʻonui a hoʻēmi paha i nā hopena o Invokana

Hiki i kekahi mau lāʻau ke hoʻololi i ka hana a Invokana i kou kino. Inā ʻoe e lawe i kēia mau lāʻau, pono ʻoe e nānā pinepine i ke kiʻekiʻe o ke kō o kou kō. Eia kekahi, pono paha i kāu kauka e hoʻololi i kāu kau ʻana.

ʻO nā laʻana o kēia mau lāʻau:

  • rifampin (Rifadin, Rimactane)
  • phenytoin (Dilantin)
  • phenobarbital
  • ritonavir (Norvir)
  • digoxin (Lanoxin)

ʻO Invokana a me nā mea kanu a me nā mea hoʻopili

Lawe i kekahi mau mea kanu a me nā mea hoʻopihapiha me Invokana i mea e hoʻonui ai i kou makaʻi no ka hypoglycemia (pae kō kō kō haʻahaʻa). ʻO nā laʻana o kēia mau mea:

  • ʻakika alpha-lipoic
  • melon ʻawaʻawa
  • chomium
  • hale haʻuki
  • kālika ʻiʻo prickly

Hoʻohana ʻo Invokana me nā lāʻau ʻē aʻe

ʻAe ʻia ʻo Invokana no kekahi mau hoʻohana i ka poʻe me ka maʻi kōkō ʻelua. (E aʻo hou ai e pili ana i kēia mau hoʻohana i ʻāpono ʻia, e ʻike i ka ʻāpana ʻo "Invokana" ma luna.)

I kekahi manawa, hoʻohana ʻia ʻo Invokana me nā lāʻau ʻē aʻe e hoʻohaʻahaʻa i nā pae kō kō. Ma lalo, wehewehe mākou i kēia kūlana kūpono.

ʻO Invokana me nā lāʻau ʻē aʻe e hoʻohaʻahaʻa i nā pae kō kō

Hiki i nā kauka ke kauoha aku iā Invokana wale a i ʻole me nā lāʻau ʻē aʻe e hoʻomaikaʻi i nā pae kō kō i nā poʻe me ka maʻi diabetes type 2.

I ka mālama ʻana i ka maʻi diabetes, i kekahi manawa ʻaʻole hoʻomaikaʻi maikaʻi kahi lāʻau kō i ke koko. I kēia mau hihia, ʻano maʻamau ka poʻe e lawe i nā lāʻau iʻoi aku ma mua o hoʻokahi i mea e kaohi ai i ko lākou mau kō kō.

ʻO Invokana lāua ʻo Victoza

Mālama pū ʻo Invokana lāua ʻo Victoza i ka maʻi diabetes ʻano 2, akā hana lāua i nā ʻano like ʻole. Pili nā lāʻau ʻelua i nā papa lāʻau ʻokoʻa. ʻO Invokana kahi mea paʻakai sodium-glucose 2 (SGLT-2) mea kāohi. ʻO Victoza kahi like me ka peptide-1 (GLP-1) agagonist reseptor.

Kauoha paha nā kauka i kekahi SGLT-2 mea kāohi a me GLP-1 mau agonist receptor pū. Hiki ke kōkua i kēia hui ʻana i nā pae kō kō a hoʻoliʻiliʻi i ka make o ka maʻi puʻuwai.

ʻO nā agonists reseptor GLP-1 ʻē aʻe:

  • dulaglutide (Trulicity)
  • exenatide (Bydureon, Byetta)
  • Luluʻula (Victoza)
  • lixisenatide (Adlyxin)
  • semaglutide (Ozempic)

ʻO Invokana a me nā lāʻau diabetes

ʻO nā laʻana o nā lāʻau maʻi diabetes ʻē aʻe i hiki ke hoʻohana ʻia me Invokana:

  • glimepiride (Amaryl)
  • glipizide (Glucotrol)
  • glyburide (DiaBeta, Glynase)
  • metformin (Glucophage, Glumetza, Riomet - ʻike ma lalo)
  • pioglitazone (Actos)

Loaʻa ʻo Invokana a me metformin ma ke ʻano he lāʻau hoʻohui like i kapa ʻia Invokamet a i ʻole Invokamet XR. ʻO Invokana kahi mea paʻakai sodium-glucose 2 (SGLT-2) mea kāohi. ʻO Metformin kahi mea nui.

ʻAe ʻia ʻo Invokamet a me Invokamet XR e hoʻomaikaʻi i nā pae kō kō i nā mākua me ka maʻi kōkō 2. Kauoha nā kauka i kēia mau lāʻau i ka hoʻohui i ka papaʻai a me ka hoʻoikaika kino.

Pehea e lawe ai iā Invokana

E lawe iā Invokana e like me ka ʻōlelo a ke kauka a mea lawelawe olakino paha.

I ka manawa hea e lawe ai

ʻOi aku ka maikaʻi e lawe iā Invokana i ke kakahiaka, ma mua o ka ʻaina kakahiaka.

Lawe ana iā Invokana me ka meaʻai

Hiki iā ʻoe ke lawe iā Invokana me ka ʻole o ka meaʻai, akā ʻoi aku ka maikaʻi o ka lawe ʻana ma mua o ka ʻaina kakahiaka.Kōkua kēia iā ʻoe e hōʻalo i nā kui kō kō ma hope o ka ʻai ʻana.

Hiki iā Invokana ke haki?

No. ʻOi aku ka maikaʻi o ka lawe ʻana iā Invokana holoʻokoʻa.

Pehea e hana ai ʻo Invokana

ʻAe ʻia ʻo Invokana no kekahi mau hoʻohana i nā mākua me ka maʻi kōkō ʻano 2. (No ka ʻike e pili ana i kēia mau hoʻohana i ʻāpono ʻia, e ʻike i ka ʻāpana ʻo “Invokana” ma luna.)

He aha ka hana me ka maʻi kō?

ʻO ka maʻamau, ʻo kahi hōmona i kapa ʻia ʻo ka insulin e hoʻoneʻe i ke kō mai kou koko i loko o kāu mau hunaola. A hoʻohana kāu mau pūnaewele i kēlā kō no ka ikehu. Akā me ka maʻi diabetes ʻano 2, ʻaʻole hana kino kou kino i ka insulin pono.

Ke holo nei ka manawa, pau paha kou kino i ka hana ʻana i ka nui o ka insulin. No laila, me ka maʻi diabetes ʻano 2, ʻaʻole e neʻe ʻia ke kō mai kou koko e like me ka maʻamau. A alakaʻi kēia i ka hoʻonui ʻia o nā kō kō.

ʻO ka hoʻonui ʻia o nā kō kō i hiki ke hōʻino i kāu kīʻaha koko, a he mea paha ia e pilikia ai i kou puʻuwai a me nā puʻupaʻa.

He aha ka hana a Invokana

Hana ʻo Invokana ma ka hoʻohaʻahaʻa ʻana i ka nui o ka glucose i kou koko. Ma ke ʻano he sodium-glucose co-transporter 2 (SGLT2), pale ʻo Invokana i ke kō mai ke komo ʻana i loko o ke kino. Ma kahi o, kōkua ʻo Invokana i ke kō e waiho i kou kino ma o kou mimi.

Ma ka hana ʻana i kēia, kōkua pū ʻo Invokana e hōʻemi i ka pilikia o kekahi mau pilikia me kou kīʻaha koko, ka puʻuwai, a me nā puʻupaʻa.

Pehea ka lōʻihi o ka hana?

Hoʻomaka ka hana a Invokana ma hope o kāu lawe ʻana. Akā ka hopena maikaʻi loa ia i ka hoʻohaʻahaʻa ʻana i kāu pae kō kō e pili ana i 1 a 2 mau hola ma hope o kou lawe ʻana i ka lāʻau.

ʻO Invokana a me ka hāpai keiki

ʻAʻole lawa nā noiʻi i loko o nā kānaka e ʻike inā palekana ʻo Invokana e hoʻohana i ka wā hāpai. Ua hōʻike ʻia nā hopena o nā noiʻi holoholona i kahi pilikia o nā pilikia ʻōpū i nā fetus ke hāʻawi ʻia nā wahine hāpai i ka lāʻau.

Ma muli o kēia mau aʻo ʻana, ʻaʻole pono e hoʻohana ʻia ʻo Invokana i ka manawa o ka lua a me ke kolu o ka trimesters o ka hāpai keiki. Eia nō naʻe, e noʻonoʻo i nā ʻike holoholona ʻaʻole e wānana i nā mea e hiki mai ana i nā kānaka.

Inā hāpai ʻoe a hoʻolālā paha ʻoe e hāpai, e kamaʻilio me kāu kauka. Hiki iā ʻoe ke kaupaona i nā pilikia a me nā pono kūpono o ka lawe ʻana iā Invokana ʻoiai e hāpai ana.

Invokana a me ka waiū hānai

ʻAʻole maopopo inā hele ʻo Invokana i ka waiū umauma kanaka. Eia nō naʻe, ʻoi aku ka maikaʻi ke kali a hiki i ka pau ʻana o kou hānai ʻana ma mua o kou lawe ʻana iā Invokana.

Ua hōʻike ʻia nā noiʻi holoholona e hele i ka lāʻau i loko o ka waiū o nā ʻiole wahine lactating. E hoʻomanaʻo i kēlā me kēia manawa ʻaʻole i wānana nā holoholona i nā mea e hiki mai ana i nā kānaka. Akā no ka mea hiki paha i ka Invokana ke hoʻopili i ka ulu ʻana o ka puʻupaʻa i kahi keiki i hānai ʻia, ʻaʻole pono ʻoe e lawe iā ia ke hānai ʻoe.

Inā ʻoe e hoʻolālā ana i ka umauma, e kamaʻilio me kāu kauka. Hiki iā ʻoe ke hoʻoholo inā pono ʻoe e lawe iā Invokana a i ʻole ka umauma.

Nā nīnau maʻamau e pili ana iā Invokana

Eia nā pane i kekahi o nā nīnau e nīnau pinepine ʻia e pili ana iā Invokana.

He aha ka ʻokoʻa ma waena o Invokana a me Invokamet?

Aia i loko o Invokana ka lāʻau canagliflozin, ʻo ia ka mea hana kūpaʻa sodium-glucose 2. Hoʻohana ʻia ʻo Invokana me ka papaʻai a me ka hoʻoikaika kino e hoʻomaikaʻi ai i nā pae kō kō i nā mākua me ka maʻi diabetes type 2. Hoʻohana ʻia ia e hōʻemi i ka hopena o ka puʻuwai puʻuwai, hahau ʻana, a me ka make i nā mākua me ka maʻi diabetes type 2 a me nā maʻi puʻuwai. Hoʻohui ʻia, hoʻohana ʻia ia e hōʻemi i ka hopena o kekahi mau pilikia o ka diabetic nephropathy (hōʻino nā hakuʻala i hoʻokumu ʻia e ka maʻi diabetes).

Loaʻa i loko o Invokamet nā lāʻau ʻelua: canagliflozin (ka lāʻau i Invokana) a me metformin, kahi biguanide. E like me Invokana, Hoʻohana ʻia ʻo Invokamet me ka papaʻai a me ka hoʻoikaika kino e hoʻomaikaʻi ai i nā pae kō kō i nā mākua me ka maʻi kōkō 2. Eia naʻe, ʻaʻole ʻae ʻia e hōʻemi i ka pilikia o nā pilikia pili i ka puʻuwai e like me ka puʻuwai puʻuwai a i ʻole ka hahau ʻana i ka poʻe me ka maʻi diabetes type 2 a me nā maʻi puʻuwai.

Pehea wau e ʻike ai inā e hana ana ʻo Invokana?

ʻOiai e lawe ana iā Invokana, e nānā pinepine i kāu pae kō kō e ʻike pono ai i loko o nā pahuhopu āu a kāu kauka i hoʻonoho ai. Hiki iā ʻoe ke hahai i kāu holomua lapaʻau me kēia mau kaha a me nā hoʻokolohua koko ʻē aʻe, e like me nā pae hemoglobin A1C (HbA1C). Hiki i nā hopena ke hōʻike i ka hana ʻana o Invokana a me nā lāʻau diabetes ʻē aʻe āu e lawe ai e hoʻohaʻahaʻa i kāu mau kō kō.

Hiki iā Invokana ke kōkua iaʻu e lilo i ka paona?

ʻAe, hiki nō. ʻOiai ʻaʻole i ʻae ʻia ʻo Invokana ma ke ʻano he lāʻau hoʻohaʻahaʻa kaumaha, ua hōʻike ʻia nā hopena o ka noiʻi ʻana ʻo ka lilo ʻana o ka paona kahi hopena ʻē aʻe.

Eia nō naʻe, e noʻonoʻo pono e lawe iā Invokana e like me ke kauka a kāu kauka. Mai lawe i ka lāʻau e lilo i ka paona a i ʻole no kekahi kumu ʻē aʻe me ka kamaʻilio ʻole mua ʻole ʻana me kāu kauka.

Ua hoʻokumu ʻo Invokana i nā ʻoki?

ʻAe, i nā hihia koʻikoʻi, ua hōʻoki ʻia. I loko o ʻelua mau noiʻi, a hiki i ka 3.5% o ka poʻe i lawe iā Invokana i ka ʻoki. Hoʻohālikelike ʻia i ka poʻe i loaʻa ʻole ka lāʻau, ua pāpālua ʻo Invokana i ka hopena o ka ʻoki. ʻO ka manamana wāwae a me ka midfoot (ʻāpana ākea) nā wahi maʻamau o ka ʻoki ʻana. Ua hōʻike pū ʻia kekahi ʻokiʻoki wāwae.

Inā hopohopo ʻoe i kēia hopena a i ʻole he nīnau e pili ana iā Invokana, e kamaʻilio me kāu kauka.

Inā kū wau i ka lawe ʻana iā Invokana, e loaʻa anei iaʻu nā ʻōuli no ka haʻalele ʻana?

ʻAʻole kū ka Invokana kumu o ka haʻalele ʻana i nā ʻōuli. Eia nō naʻe, hiki iā ia ke hoʻonui i kou kiʻekiʻe o ke kō kō, e hiki ai ke hōʻeha i kāu hōʻailona diabetes.

Mai hōʻoki i ka lawe ʻana iā Invokana me ka walaʻau ʻole ʻana me kāu kauka. A inā hoʻoholo ʻolua e hōʻoki i ka lawe ʻana iā Invokana a laila loaʻa iā ʻoe nā ʻōuli e pili ana iā ʻoe, e haʻi pono i kāu kauka. Hiki iā lākou ke loiloi i ke kumu o lākou a kōkua iā ʻoe e hoʻokuʻu a mālama iā lākou.

Nā hana hoʻohoka invokana

Ma mua o ka lawe ʻana iā Invokana, e kamaʻilio me kāu kauka e pili ana i kāu mōʻaukala olakino. ʻAʻole kūpono paha ʻo Invokana iā ʻoe inā loaʻa iā ʻoe kekahi ʻano olakino. Pākuʻi ʻia kēia mau mea:

Kaha: No ka ʻike e pili ana i nā hopena maikaʻi ʻole o Invokana, e ʻike i ka ʻaoʻao ʻo “Invokana” ma luna.

Inokā overdose

ʻO ka lawe ʻana i ka nui o kēia lāʻau i hiki ke hoʻonui i kou makaʻu no nā hopena ʻino.

Nā hōʻailona overdose

Heʻuʻuku loa ka ʻike e pili ana i nā hōʻailona inā loaʻa iā Invokana ka nui. Pākuʻi ʻia paha nā ʻōuli o ka overdose:

  • hypoglycemia koʻikoʻi (pae haʻahaʻa kō kō i ke kiʻekiʻe), kahi e hiki ai ke hoʻoluliluli, hopohopo, a huikau hoʻi
  • nā pilikia o ka gastrointestinal, hiki i ke kīpē, kahe, a me ka luaʻi
  • hōʻino kīhāpai

He aha e hana ai inā he overdose

Inā manaʻo ʻoe ua lawe nui ʻoe i kēia lāʻau, e kāhea i kāu kauka. Hiki iā ʻoe ke kāhea i ka ʻAmelika Hui Pū ʻIa o nā Poison Control ma 800-222-1222 a i ʻole hoʻohana i kā lākou mea hana pūnaewele. Akā inā koʻikoʻi kāu mau ʻōuli, e kāhea iā 911 a i ʻole e hele koke i kahi lumi pilikia kokoke.

Pau ʻole ʻo Invokana

Ke kiʻi ʻoe iā Invokana mai ka hale kūʻai lāʻau, e hoʻohui ka kauka i kahi lā palena pau i ka lepili ma ka ʻōmole. ʻO kēia lā maʻamau hoʻokahi makahiki mai ka lā a lākou i hāʻawi ai i ka lāʻau.

Kōkua kēia mau lā palena i ka hōʻoia ʻana i ka maikaʻi o nā lāʻau i kēia manawa. ʻO ke kūlana o ka Food and Drug Administration (FDA) i kēia manawa e hōʻalo i ka hoʻohana ʻana i nā lāʻau i make.

Pehea ka lōʻihi o ka maikaʻi o ka lāʻau e hiki ai ke hilinaʻi i nā kumu he nui, e like me pehea a ma hea ʻoe e mālama ai.

E mālama pono i kāu mau pila Invokana i ka mahana wela ma kahi o 77 ° F (25 ° C) i loko o kahi pahu paʻa paʻa.

Inā loaʻa iā ʻoe kahi lāʻau i hoʻohana ʻole ʻia i hala i ka lā palena pau, e nīnau i kāu kauka lāʻau inā paha hiki iā ʻoe ke hoʻohana.

ʻO ka ʻike ʻoihana no Invokana

Hāʻawi ʻia ka ʻike aʻe no nā kauka lapaʻau a me nā ʻoihana ola.

Nā Hōʻike

Ua ʻae ʻia ʻo Invokana no ka hoʻohana ʻana i nā mākua me ka maʻi diabetes type 2 i:

  • E hoʻomaikaʻi i nā pae glucose koko, i ka huipū pū me ka papaʻai a me ka hoʻoikaika kino.
  • E hoʻohaʻahaʻa i ka pilikia o nā pilikia nui o ka maʻi puʻuwai, i ka poʻe me ka maʻi o ka maʻi maʻi. ʻO ke kikoʻī, hoʻohaʻahaʻa ka lāʻau i ka make o ka maʻi maʻi maʻi, ka infoccial myocardial nonfatal, a me ka maʻi nonfatal.
  • E hoʻemi i ka pilikia o kekahi mau pilikia o ka diabetic nephropathy i ka poʻe me ka albuminuria. ʻO ke kikoʻī, hoʻohaʻahaʻa ka lāʻau i ka makaʻu o ka creatinine i pāpālua ʻia i ke koko, ka maʻi hōʻino hope loa, ka haukapila ma muli o ka maikaʻi ʻole o ka puʻuwai, ka make ʻana o ka puʻuwai.

Mekanism o ka hana

Hoʻopaʻa ʻo Invokana i ka sodium-glucose co-transporter 2 (SGLT-2) i nā tubula renal proximal. Pale kēia i ka reabsorption o ke kōkō i kānana ʻia mai nā tubula o ka puʻupaʻa. ʻO ka hopena he osmotic diuresis ma muli o ka nui o ka excretion o ka urinary glucose.

Pharmacokinetics a me ka metabolism

Ma hope o ka hoʻoponopono waha, ʻoi aku ka nui o ka noʻonoʻo ma waena o 1 a 2 mau hola. Hiki ke lawe ʻia ʻo Invokana me ka ʻole o ka meaʻai. ʻO ka lawe ʻana iā Invokana me kahi pāʻina i piha i ka momona momona ʻaʻohe ona hopena i nā lāʻau lapaʻau lāʻau lapaʻau. Eia nō naʻe, ʻo ka lawe ʻana iā Invokana ma mua o ka pāʻina e hoʻoliʻiliʻi i nā loli glucose postprandial ma muli o ka hoʻopaneʻe ʻana o ka glucose i loko o nā ʻōpū. Ma muli o kēia, lawe ʻia ʻo Invokana ma mua o ka pāʻina mua o ka lā.

ʻO ka bioavailability waha o Invokana 65%.

Hoʻokomo mua ʻia ʻo Invokana e O-glucuronidation ma o UGT1A9 a me UGT2B4. ʻO ka Metabolism ma o CYP3A4 i manaʻo ʻia he ala liʻiliʻi.

ʻO ka hapalua o ke ola o Invokana ma kahi o 10.6 mau hola no ka lāʻau 100-mg. ʻO ka hapalua o ke ola e pili ana iā 3.1 mau hola no ka mahele lāʻau 300-mg.

Hana duke

No nā mea maʻi me ka eGFR ma lalo o 60 mL / min / 1.73 ka m2, hoʻoponopono i ka mahele lāʻau Invokana. Nānā pinepine i kā lākou hana kōpaʻa.

Nā Kūʻai Kūʻai

Hoʻopiʻi ʻia ʻo Invokana i ka poʻe nāna:

  • Loaʻa i ka hopena hypersensitivity koʻikoʻi iā Invokana
  • aia ma ka dialysis therapy

Waihona

Pono e mālama ʻia ʻo Invokana ma 77 ° F (25 ° C).

Hoʻolaha: Nūhou Lapaʻau i kēia lā ua hana i nā hana āpau e hōʻoia i ka pololei o nā ʻike āpau, laulā, a me kēia manawa. Eia nō naʻe, ʻaʻole pono e hoʻohana i kēia ʻatikala i pani no ka ʻike a me ka mākaukau o kahi loea mālama ola laikini. E nīnau mau ʻoe i kāu kauka a i ʻole ʻoihana olakino ʻē aʻe ma mua o ka lawe ʻana i nā lāʻau. Hiki ke loli i ka ʻike o ka lāʻau i loko a ʻaʻole i manaʻo ʻia e uhi i nā hoʻohana a pau, nā kuhikuhi, ka makaʻala, nā ʻōlelo aʻoaʻo, nā launa lāʻau, nā hopena maʻi ʻaʻai, a me nā hopena maikaʻi ʻole. ʻO ka loaʻa ʻole o nā ʻōlelo aʻoaʻo a i ʻole nā ​​ʻike ʻē aʻe no kahi lāʻau i hāʻawi ʻia ʻaʻole ia e hōʻike i ka palekana o ka lāʻau a lāʻau paha i kūpono no nā mea maʻi āpau a i ʻole nā ​​hoʻohana kikoʻī āpau.

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