ʻO HER2-Positive Breast Cancer Survival rates a me nā helu helu ʻē aʻe

Anter

• He aha nā helu ola?
• He aha ka prevalence o ka maʻi ʻaʻai umauma HER2-maikaʻi?
• Hiki i ka HER2-maikaʻi umauma kanesa maʻi hou?
• He aha nā lapaʻau e loaʻa ai?
• ʻOki kino
• Pāhawewe
• ʻO Chemotherapy
• Nā mālama i kau ʻia
• ʻO Trastuzumab (Herceptin)
• Ado-trastuzumab emtansine (Kadcyla)
• Neratinib (Nerlynx)
• Pertuzumab (Perjeta)
• Lapatinib (Tykerb)
• He aha ka kuanaʻike?

He aha ka maʻi ʻaʻai umauma HER2-maikaʻi?

ʻAʻole maʻi ka maʻi ʻaʻai umauma. He hui maoli ia o nā maʻi. Ke kuhi nei i ka maʻi ʻaʻai o ka umauma, kahi o nā ʻanuʻu mua e ʻike nei i kāu ʻano. Hāʻawi ke ʻano maʻi ʻaʻai umauma i ka ʻike nui e pili ana i ka ʻano o ke kanesa.

Ke loaʻa iā ʻoe kahi biopsy o ka umauma, hoʻāʻo ʻia kaʻiʻo no nā mea loaʻa nā hone (HR). Ua hoʻāʻo pū ʻia no kekahi mea i kapa ʻia he receptor ulu ulu epidermal kanaka (2). Hiki i kēlā me kēia mea ke hoʻopili i ka ulu ʻana o ka maʻi ʻaʻai umauma.

I kekahi mau hōʻike pilikino, hōʻike ʻia ʻo HER2 iā HER2 / neu a i ʻole ERBB2 (Erb-B2 receptor tyrosine kinase 2). Hoʻomaopopo ʻia nā mea loaʻa Hormone me estrogen (ER) a me progesterone (PR).

Hana ka ʻāpana HER2 i nā protein HER2, a i ʻole nā ​​mea loaʻa. Kōkua kēia mau mea loaʻa i ka mālama ʻana i ka ulu a me ka hoʻoponopono ʻana o nā hunaola umauma. ʻO kahi overexpression o ka protein HER2 e kumu i ka hana hou ʻana o nā hunaola umauma.

ʻOi aku ka ikaika o nā maʻi maʻi umauma HER2 ma mua o nā maʻi maʻi umauma HER2-maikaʻi ʻole. Me ke kūlana tumoma a me ke kahua maʻi ʻaʻai, ke kūlana HR a me HER2 e kōkua ai e hoʻoholo i kāu koho lapaʻau.

E hoʻomau i ka heluhelu e aʻo hou aʻe e pili ana i ka HER2-maikaʻi umauma maʻi 'aʻai a me ka mea āu e manaʻo ai.

He aha nā helu ola?

I kēia manawa, ʻaʻohe noiʻi kikoʻī e pili ana i nā helu ola no ka HER2-maikaʻi umauma maʻi ʻaʻai wale. Pili nā loiloi o kēia manawa e pili ana i ke ola ʻana o ka maʻi ʻaʻai umauma i nā ʻano like ʻole.

Wahi a ka National Cancer Institute (NCI), eia nā helu 5 e ola ai no nā wahine i ʻike ʻia ma waena o 2009 a 2015.

• kūloko: 98.8 pakeneka
• āpana: 85.5 pakeneka
• mamao (a metastatic): 27.4 pakeneka
• hui ʻia nā pae āpau: 89.9 pakeneka

He mea nui e hoʻomanaʻo he mau helu helu wale kēia. Hoʻokumu ʻia nā helu helu ola wā lōʻihi i ka poʻe i ʻike ʻia i nā makahiki i hala aku nei, akā ke loli nei ka mālama ʻana me ka wikiwiki.

Ke noʻonoʻo nei i kāu nānā, pono i kāu kauka e kālailai i nā kumu he nui. Aia i waena o lākou nā:

• ʻO ke kahua ma ka hōʻoia: ʻOi aku ka maikaʻi o ka nānā ke ʻole ka palahalaha ʻana o ka maʻi ʻaʻai o ka umauma ma waho o ka umauma a i ʻole pālahalaha wale ʻia ka ʻāina ma ka hoʻomaka o ka lapaʻau. ʻO ka maʻi ʻaʻai umauma Metastatic, ʻo ia ka maʻi ʻaʻai i hohola i nā wahi mamao, ʻoi aku ka paʻakikī o ka mālama ʻana.
• Ka nui a me ka papa o ka tumo mua: Hōʻike kēia i ka ikaika o ka maʻi ʻaʻai.
• Komo ke komo ʻana o node lymph: Hiki ke pālahalaha ʻia ka maʻi ʻaʻai mai nā pūnana lymph a i nā meaola a me nā mea mamao.
• HR a me HER2 kūlana: Hiki ke hoʻohana ʻia nā therapeutive target no nā maʻi maʻi umauma HR-maikaʻi a me HER2-maikaʻi.
• ʻO ke olakino holoʻokoʻa: Hiki i nā pilikia olakino ʻē aʻe ke hoʻopili i ka lapaʻau.
• Pane i ka therapy: He paʻakikī e wānana inā pono ka hopena i kahi lāʻau a hana paha i nā hopena ʻaoʻao ʻole.
• Makahiki: ʻOi aku ka maikaʻi o ka nānā ʻana o nā wahine ʻōpio a me nā mea i piha i ka makahiki he 60 ma mua o nā wahine waena, koe wale nō nā mea me ka maʻi ʻaʻai umauma 3.

Ma ʻAmelika Hui Pū ʻIa, ua koho ʻia ma mua o ka 41,000 mau wahine e make i ka maʻi ʻaʻai umauma ma 2019.

He aha ka prevalence o ka maʻi ʻaʻai umauma HER2-maikaʻi?

Ma kahi o 12 pākēneka o nā wahine ma ʻAmelika Hui Pū ʻIa e hoʻomohala i ka maʻi ʻaʻai maʻi maʻi invasive i kekahi manawa. ʻO kēlā me kēia, ʻoiai nā kāne, hiki ke hoʻomohala i ka maʻi ʻaʻai umauma HER2-maikaʻi. Eia naʻe, ʻoi aku ka hopena i nā wahine ʻōpio. Ma kahi o 25 pākēneka o nā maʻi ʻōpū umauma HER2-maikaʻi.

Hiki i ka HER2-maikaʻi umauma kanesa maʻi hou?

ʻOi aku ka huhū o ka HER2-maikaʻi umauma maʻi maʻi a ʻoi aku paha e hoʻi hou ma mua o ka HER2-maʻi maʻi maʻi maʻi maʻi ʻole. Hiki ke hana hou i kēlā me kēia manawa, akā hana mau ia i loko o 5 mau makahiki o ka mālama.

ʻO ka nūhou maikaʻi ʻoi aku ka liʻiliʻi o ka hoʻi hou ʻana i kēia lā ma mua o ka wā ma mua. ʻO kēia ka mea nui ma muli o nā mālama hope loa i hoʻokumu ʻia. I ka ʻoiaʻiʻo, ʻo ka hapa nui o ka poʻe i mālama ʻia no ka pae mua HER2-maikaʻi ʻole ka maʻi ʻaʻai umauma.

Inā HR-maikaʻi kou maʻi kanesa umauma, hiki i ka hoʻomaʻamaʻa hormonal ke kōkua i ka hōʻemi ʻana i ka hopena o ka hoʻi hou ʻana.

Hiki ke hoʻololi i ke kūlana HR a me ke kūlana HER2. Inā piʻi hou ka maʻi ʻaʻai o ka umauma, pono e hoʻāʻo ʻia ka tumo hou i hiki ai ke loiloi hou ʻia ka lapaʻau ʻana.

He aha nā lapaʻau e loaʻa ai?

E hoʻopili paha kāu papahana hoʻolālā i kahi hui o nā therapies e like me:

• ʻoki kino
• pāhawewe
• chemotherapy
• i mālama pono ʻia

ʻO nā hōʻailona Hormone kahi koho no nā kānaka nona ka maʻi ʻaʻaʻi pū kekahi me HR maikaʻi.

ʻOki kino

ʻO ka nui, kahi, a me ka helu o nā puʻupuʻu e kōkua i ka hoʻoholo ʻana i ka pono no ka ʻoki ʻana i ka umauma a i ʻole mastectomy, a inā e hemo i nā lymph node.

Pāhawewe

Hiki i ka radiation radiation ke kuhi i nā hunaola maʻi ʻea e koe ma hope o ke kahakaha ʻana. Hiki nō ke hoʻohana ʻia e hōʻemi i nā hikoko.

ʻO Chemotherapy

ʻO Chemotherapy kahi mālama ʻōnaehana. Hiki i nā lāʻau ikaika ke ʻimi a luku i nā hunaola maʻi ʻaʻai i nā wahi āpau o ke kino. ʻO ka HER2-maikaʻi umauma maʻi 'aʻai pane maʻamau i chemotherapy.

Nā mālama i kau ʻia

Nā hana i mālama ʻia no ka maʻi maʻi umauma HER2-maikaʻi pū me:

ʻO Trastuzumab (Herceptin)

Kōkua ʻo Trastuzumab i nā poloka ʻaila mai ka loaʻa ʻana o nā hōʻailona kemika e hoʻoulu i ka ulu ʻana.

Ua hōʻike kahi noiʻi ma 2014 ma mua o 4,000 mau wahine i ka hoʻoliʻiliʻi nui o ka trastuzumab a me ka hoʻomaikaʻi ʻana i ke ola ke hoʻohui ʻia i ka chemotherapy i ka wā mua o ka maʻi ʻaʻai umauma HER2-maikaʻi. ʻO ka regima chemotherapy ka paclitaxel ma hope o doxorubicin a me cyclophosphamide.

Ua hoʻonui ka ola o 10 mau makahiki mai 75.2 pakeneka me ka chemotherapy wale nō i 84 pakeneka me ka hoʻohui o trastuzumab. Hoʻomau ka hoʻomaikaʻi ʻana i nā helu o ke ola me ka hoʻi ʻole. Ua hoʻonui ka ola ola manuahi 10 makahiki mai ka 62.2 pakeneka a i ka 73.7 pakeneka.

Ado-trastuzumab emtansine (Kadcyla)

Hoʻohui kēia lāʻau i ka trastuzumab me kahi lāʻau chemotherapy i kapa ʻia ʻo emtansine. Hāʻawi pololei ʻo Trastuzumab i ka emtansine i nā hunaola maʻi ʻaʻai HER2-maikaʻi. Hiki ke hoʻohana ʻia e hōʻemi i nā ʻōpū a hoʻonui i ke ola i nā wahine me ka maʻi kanulau umauma metastatic.

Neratinib (Nerlynx)

ʻO Neratinib kahi mālama makahiki hoʻokahi i hoʻohana ʻia i nā wā mua o ka maʻi maʻi umauma HER2-maikaʻi. Hāʻawi ʻia i nā mākua i pau i ka hoʻopau i kahi regimen lapaʻau e hoʻopili ana me trastuzumab. ʻO ka pahuhopu o neratinib ka mea e hōʻemi i ka likelika o ka hoʻi hou ʻana.

Hana maʻamau nā mea i hoʻomākaukau ʻia ma waho o ka cell e pale i nā hōʻailona kemika e hāpai i ka ulu ʻana o ka tumo. ʻO Neratinib, ma ka ʻaoʻao ʻē aʻe, e hoʻopili i nā hōʻailona kemika mai loko mai o ke kele.

Pertuzumab (Perjeta)

He lāʻau ʻo Pertuzumab e hana like me trastuzumab. Eia nō naʻe, hoʻopili ʻia i kekahi ʻāpana ʻokoʻa o ka protein HER2.

Lapatinib (Tykerb)

Palaka ʻo Lapatinib i nā protein i kumu e ulu i ka ulu paʻapū ʻole. Hiki iā ia ke kōkua e hoʻolohi i ka holomua o ka maʻi ke lilo ke kanesa umauma metastatic i mea kū i ka trastuzumab.

He aha ka kuanaʻike?

Wahi a nā koho, aia ma mua o 3.1 miliona mau wahine i ʻAmelika Hui Pū ʻIa i loaʻa kahi moʻolelo o ka maʻi ʻaʻai umauma.

ʻO ke kuanaʻike no ka HER2-maikaʻi umauma maʻi 'aʻai loli aʻe i kēlā me kēia kanaka. ʻO nā holomua i nā therapies i hoʻomākaukau ʻia e hoʻomau i ka hoʻomaikaʻi i ka nānā no nā pae mua a me nā maʻi metastatic.

Ke pau ka lapaʻau ʻana no ka maʻi ʻaʻai nonmetastatic umauma, pono ʻoe i ka hoʻokolohua manawa no nā hōʻailona o ka hoʻi hou ʻana. ʻO ka hapa nui o nā hopena o ka hoʻomaʻamaʻa e hoʻomaikaʻi i ka holo ʻana o ka manawa, akā ʻo kekahi (e like me nā pilikia momona) mau paha.

ʻAʻole manaʻo ʻia ka maʻi ʻaʻai umauma Metastatic curable. Hiki ke hoʻomau i ka mālama ʻana ke hana ʻo ia. Inā kū kekahi hana lapaʻau, hiki iā ʻoe ke hoʻololi i kahi ʻē aʻe.