Spironolactone (Aldactone)

Anter

• No ke aha ia
• Pehea e lawe ai
• 1. hypertension pono
• 2. Hōʻaha puʻuwai Congestive
• 3. Ka cirrhosis ate
• 4. Nephrotic Syndrome
• 5. Edema
• 6. Hypokalemia / hypomagnesaemia
• 7. Ka mālama mua ʻana i ka Hyperaldosteronism
• 8. hypertension māinoino
• Mekanism o ka hana
• Nā hopena ʻē aʻe
• Nā Kūʻai Kūʻai

ʻO Spironolactone, ka mea i ʻike kalepa ʻia ʻo Aldactone, hana ma ke ʻano he diuretic, e hoʻonui ana i ka hoʻopau ʻana o ka wai ma o ka mimi, a ma ke ʻano he antihypertensive, a hiki ke hoʻohana ʻia i ka mālama ʻana i ke koko kiʻekiʻe, ka pehu e pili ana i nā pilikia i ka hana ʻana o ka puʻuwai a i ʻole nā ​​maʻi. i ke akepaʻa a me nā puʻupaʻa, hypokalemia a i ʻole i ka mālama ʻana i ka hyperaldosteronism, no ka laʻana.

I kekahi mau hihia, hiki i kēia lāʻau ke kuhikuhi ʻia no ka mālama ʻana i ka huehue a pale aku i ka nalo ʻana o ka lauoho, akā ʻaʻole kēia mau noi i ʻāpana o nā hōʻike nui no spironolactone, ʻaʻole hoʻi i ʻōlelo ʻia i loko o ka ʻāpana hoʻokomo.

Hiki ke kūʻai ʻia ʻo Spironolactone i loko o nā hale kūʻai lāʻau, no ke kumu kūʻai ma kahi o 14 a 45 paha reais, kaukaʻi ʻia inā koho ke kanaka i ka laikini a i ʻole ka generic, e koi ana i ka hōʻike o kahi kuhikuhi.

No ke aha ia

Hōʻike ʻia ʻo Spironolactone no:

• Pono hypertension;
• Hoʻokumu ʻia ka edema e nā pilikia o ka puʻuwai, ka puʻuwai a me ke akepaʻa;
• Edema ʻIdiopathic;
• Kākoʻo kōkua ma ka hypertension malignant;
• Hypokalemia ke manaʻo ʻia nā ana ʻē aʻe he kūpono ʻole ʻole paha;
• Kāohi i ka hypokalemia a me ka hypomagnesaemia i ka poʻe e lawe ana i ka diuretics;
• Kuhi a me ka mālama ʻana i ka hyperaldosteronism.

E aʻo e pili ana i nā ʻano diuretics ʻē aʻe a aʻo pehea e hana ai.

Pehea e lawe ai

Pili ke ana ma muli o ka pilikia e mālama ʻia:

1. hypertension pono

ʻO ka mahele maʻamau he 50 mg / lā a 100 mg / lā, a i nā hihia kūʻē a koʻikoʻi hoʻi hiki ke hoʻonui iki, i nā manawa o ʻelua mau pule, a hiki i ka 200 mg / lā. Pono e hoʻomau i ka mālama ʻana no ka liʻiliʻi o ʻelua mau pule e hōʻoia i ka pane kūpono i ka lāʻau. Pono e hoʻoponopono i ka mahele lāʻau e like me ka mea e pono ai.

2. Hōʻaha puʻuwai Congestive

ʻO ka paipai e hoʻomaka nei i kēlā me kēia lā he 100 mg i ka mahele hoʻokahi a i hoʻokaʻawale ʻia paha, a hiki ke loli ma waena o 25 mg a me 200 mg i kēlā me kēia lā. Pono e hoʻoholo ʻia ka mahele mālama mau no kēlā me kēia kanaka.

3. Ka cirrhosis ate

Inā ʻoi aku ka nui o ka nui o ka urinary sodium / urinary potassium ratio ma mua o 1, ʻo ka mahele maʻamau he 100 mg / lā. Inā ʻoi aku ka liʻiliʻi o kēia lakio ma mua o 1, ʻo ka mahele lāʻau i ʻōlelo ʻia 200 mg / lā a 400 mg / lā. Pono e hoʻoholo ʻia ka mahele mālama mau no kēlā me kēia kanaka.

4. Nephrotic Syndrome

ʻO ka mahele maʻamau i nā mākua he 100 mg / lā a 200 mg / lā.

5. Edema

ʻO ka mahele maʻamau he 100 mg i kēlā me kēia lā no nā mākua a ma kahi o 3.3 mg i kēlā me kēia kg o ke kaupaona i lawelawe ʻia i kahi mahele haʻihaʻi. Pono e hoʻoponopono ʻia ke ana ma muli o ka pane a me ke ahonui o kēlā me kēia kanaka.

6. Hypokalemia / hypomagnesaemia

Hoʻomaopopo ʻia kahi ana o 25 mg / lā a hiki i 100 mg / lā i ka mālama ʻana i ka hypopotassemia a me / a i ʻole hypomagnesemia i hoʻokomo ʻia e nā diuretics, ke lawa ʻole ka pāʻina potassium a me / a i ʻole nā ​​magnesium supplement.

7. Ka mālama mua ʻana i ka Hyperaldosteronism

Ke hoʻokumu maikaʻi ʻia ka diagnostical of hyperaldosteronism e nā hōʻike definitive hou aku, hiki ke lawelawe ʻia ka spironolactone i nā kaona o 100 mg i kēlā me kēia lā no ka hoʻomākaukau no ke ʻoki.

8. hypertension māinoino

Hoʻohana wale ʻia ia ma ke ʻano he kōkua kōkua a ke nui ka hūnā ʻia o aldosterone, hypokalemia a me nā alkalosis metabolic. ʻO ka mahele hoʻomaka he 100 mg / lā, hiki ke hoʻonui ʻia, ke pono, i nā manawa o ʻelua mau pule, a i ka 400 mg / lā.

Mekanism o ka hana

ʻO Spironolactone kahi antagonist aldolone kikoʻī, e hana nui ana i ka sodium a me ka potassium ion exchange site aldosterone, aia i loko o ka tubule i kuhikuhi ʻia o ka puʻupaʻa, e alakaʻi ana i ka hoʻonui ʻia o ka sodium a me ka hoʻopau ʻana o ka wai a hoʻonui i ka paʻa ʻana o ka potassium.

Nā hopena ʻē aʻe

Hiki i kekahi o nā hopena o spironolactone ke komo pū me ka neoplasm umauma maikaʻi, leukopenia, thrombositopenia, nā haunaele electrolyte, nā loli i ka libido, ka huikau, ka palaho, nā maʻi o ka gastrointestinal a me ka nausea, ka hana ate ʻole, Steve-Johnson syndrome, ka lāʻau hemermysis epidermal ka nalowale, hypertrichosis, ka huehue, nā hives, nā wāwae wāwae, nā puʻuwai puʻuwai nui ʻole, ka ʻeha o ka umauma, nā maʻi menstrual, gynecomastia a me nā malaise.

Nā Kūʻai Kūʻai

ʻAʻole pono e hoʻohana ʻia ka Spironolactone e ka poʻe hypersensitive i nā ʻāpana o ke kumumanaʻo, ka poʻe me ka hōʻeha puʻuwai nui, ka hōʻino nui ʻana i ka hana o ka hakuʻala, anuria, ka maʻi ʻo Addison, hyperkalaemia a i ʻole e hoʻohana ana i kahi lāʻau i kapa ʻia ʻo eplerenone.