Nā Hana RA: DMARDs a me TNF-Alpha Inhibitors

Anter

• Hoʻolauna
• DMARDs: He mea nui i ka mālama mua ʻana
• DMARD me nā mea ʻehaʻeha
• Corticosteroids
• Nā NSAID ma luna o ka counter
• Nā NSAID kuhikuhi
• Nā DMARD a me nā maʻi
• Nā mea kāohi TNF-alpha
• E kamaʻilio me kāu kauka
• Q:
• A:

Hoʻolauna

ʻO Rheumatoid arthritis (RA) kahi maʻi autoimmune mau. Hoʻokomo ia i kāu ʻōnaehana pale pale i nā mea olakino olakino i kou mau hui, e hopena ai i ka ʻeha, ka pehu ʻana, a me ka ʻoʻoleʻa. ʻAʻole like me ka osteoarthritis, nā hopena mai ka maʻamau a me ka waimaka i kou mau makahiki, hiki i ka RA ke hoʻopili i kekahi me nā makahiki āpau. ʻAʻohe mea i ʻike pono i ke kumu.

ʻAʻohe lāʻau a RA, akā hiki i nā lāʻau ke kōkua i ke kōkua ʻana i nā ʻōuli. Hoʻopili kēia mau lāʻau i nā lāʻau anti-inflammatory, corticosteroids, a me nā lāʻau e kāohi i ka ʻōnaehana pale. ʻO kekahi o nā lāʻau lapaʻau maikaʻi loa ka maʻi e hoʻololi ana i nā lāʻau anti-rheumatic (DMARDs), i hoʻopili pū ʻia me nā mea hoʻopaʻa TNF-alpha.

DMARDs: He mea nui i ka mālama mua ʻana

ʻO nā DMARD kahi lāʻau i kuhikuhi pinepine ʻia e ka rheumatologists ma hope pono o ke kuhi ʻana o RA. ʻO ka hapa nui o ka pōʻino hui paʻa mau mai RA i nā makahiki ʻelua i hala, no laila hiki i kēia mau lāʻau ke hana i kahi hopena nui i ka wā o ka maʻi.

Hana nā DMARD ma ka hoʻonāwaliwali ʻana i kāu ʻōnaehana pale. Hoʻoemi kēia hana i ka hoʻouka kaua ʻana a RA i kou mau ami e hoʻēmi ai i ka poino holoʻokoʻa.

ʻO nā laʻana o DMARD me:

• methotrexate (Otrexup)
• hydroxychloroquine (Plaquenil)
• leflunomide (Arava)

DMARD me nā mea ʻehaʻeha

ʻO ka mea nui i ka hoʻohana ʻana i nā DMARD he lohi lākou i ka hana. Hiki iā ia ke hala i mau mahina e ʻike i ka hōʻoluʻolu ʻeha mai kahi DMARD. No kēia kumu, kēnā pinepine nā rheumatologists i nā painkillers hana wikiwiki e like me nā corticosteroids a i ʻole nā ​​lāʻau anti-inflammatory nonsteroidal (NSAIDs) e lawe i ka manawa like. Hiki i kēia mau lāʻau ke kōkua i ka hoʻohaʻahaʻa i ka ʻeha ke kali ʻoe i ka hopena o ka DMARD.

ʻO nā laʻana o nā corticosteroids a i ʻole nā ​​NSAID e hiki ke hoʻohana ʻia me DMARD e hoʻopili ʻia:

Corticosteroids

• prednisone (Rayos)
• methylprednisolone (Depo-Medrol)
• triamcinolone (Aristospan)

Nā NSAID ma luna o ka counter

• aspirin
• ibuprofen
• naproxen sodium

Nā NSAID kuhikuhi

• nabumetone
• celecoxib (Celebrex)
• piroxicam (Feldene)

Nā DMARD a me nā maʻi

Hoʻopili nā DMARD i kāu ʻōnaehana pale pale holoʻokoʻa. Kuhi kēia iā lākou i kahi makaʻu ʻoi aku o nā maʻi.

ʻO nā maʻi maʻamau i loaʻa i nā maʻi RA he:

• maʻi maʻi ʻili
• luna maʻi hanu maʻi
• pulumonia
• maʻi maʻi urinary tract

I mea e pale aku ai i nā maʻi, pono ʻoe e hoʻomaʻemaʻe i ka hoʻomaʻemaʻe maikaʻi, e like me ka holoi pinepine ʻana i kou mau lima a me ka ʻauʻau ʻana i kēlā me kēia lā a i kēlā me kēia lā ʻē aʻe. E haʻalele ʻoe i ka poʻe maʻi.

Nā mea kāohi TNF-alpha

Tumor nekrosis factor alpha, a i ʻole TNF alpha, kahi mea e kūlohelohe i kou kino. I RA, ʻo nā pūnaewele ʻōnaehana pale i hoʻouka i nā hono e hana i nā kiʻekiʻe kiʻekiʻe o ka TNF alpha. Hoʻokumu kēia mau pae kiʻekiʻe i ka ʻeha a me ka pehu. ʻOiai nā mea ʻē aʻe e hoʻohui i ka hōʻino o RA i nā hono, ʻo TNF alpha ka mea pāʻani nui i ke kaʻina.

Ma muli o ka pilikia nui o ka TNF alpha ma RA, ʻo nā mea kāohi TNF-alpha kekahi o nā ʻano nui o nā DMARD ma ka mākeke i kēia manawa.

Aia he ʻelima ʻano o nā mea kāohi TNF-alpha:

• adalimumab (Humira)
• etanercept (Enbrel)
• certolizumab pegol (Cimzia)
• golimumab (Simponi)
• infliximab (Remicade)

Kāhea ʻia kēia mau lāʻau lapaʻau he blockers TNF-alpha no ka mea ālai lākou i ka hana o TNF alpha. Hoʻoemi lākou i nā pae alpf TNF i kou kino e kōkua i ka hōʻemi ʻana i nā hōʻailona RA. Hoʻomaka pū lākou e hana ʻoi aku ka wikiwiki ma mua o nā DMARD ʻē aʻe. Hoʻomaka paha lākou i ka hopena ma waena o ʻelua pule a hoʻokahi mahina.

E kamaʻilio me kāu kauka

ʻO ka hapa nui o ka poʻe me RA e pane maikaʻi i nā mea kāohi TNF-alpha a me nā DMARD ʻē aʻe, akā no kekahi poʻe, ʻaʻole holo pono paha kēia mau koho. Inā ʻaʻole lākou e hana nāu, e haʻi aku i kāu rheumatologist. E kuhikuhi paha lākou i kahi mea kāohi TNF-alpha ʻokoʻa ma ke ʻano he pae hou aʻe, a i ʻole e ʻōlelo paha lākou i kahi ʻano DMARD ʻokoʻa.

E hōʻano hou i kāu rheumatologist i kou ʻano a pehea kou manaʻo i kāu lāʻau. Hiki iā ʻoe a me kāu kauka ke loaʻa i kahi hoʻolālā hoʻomalu RA e holo pono no ʻoe.

Q:

Hiki i kaʻu papaʻai ke hoʻololi i kaʻu RA?

A:

Ae. Nui nā meaʻai e hiki ke kōkua i ka hōʻemi ʻana i ka mumū i kou kino. Inā makemake ʻoe e hoʻāʻo i nā hoʻololi o ka papaʻai e hoʻomaikaʻi ai i kāu mau hōʻailona RA, e hoʻomaka me ka ʻai ʻana i nā meaʻai i loaʻa nā omega-3 fatty acid, antioxidants, a me nā fiber, e like me nā nati, nā iʻa, nā hua, nā mea kanu, a me nā tī tī. ʻO kahi ala maikaʻi e lawe i kēia mau meaʻai i kāu hana maʻamau i kēlā me kēia lā e ukali i ka papaʻai Mediterranean. No ka ʻike hou aku e pili ana i kēia papaʻai a me nā meaʻai ʻē aʻe e kōkua ai i ka hōʻoluʻolu i nā hōʻailona RA, e nānā i ka papa anti-inflammatory no RA.