Biologics a me PsA: He aha kāu koho?

Anter

• He aha nā meaolaolaola?
• Pehea e hoʻohana ai nā biologics e mālama iā PsA?
• He aha kaʻu mau koho e mālama iā PsA me kahi biologic?
• Nā mea kāohi TNF-alpha
• Nā mea hoʻopukapuka IL-12, IL-23, a me IL-17
• Nā mea hoʻowahawaha T-cell
• Mea kāohi iā JAK kinase
• Palekana anei nā biologics i kēlā me kēia me PsA?
• He aha nā hopena o ka lawe ʻana i kahi biologic?
• ʻO ka lawe lawe ʻana

Hōʻike Overview

ʻO Psoriatic arthritis, a ʻo PsA paha, ke kumu o ka pehu, ʻoʻoleʻa, a me nā ʻeha pū. ʻAʻohe mea ola no PsA, akā hiki i nā loli nohona a me nā lāʻau ke kōkua i ka mālama ʻana i nā ʻōuli.

ʻO nā lāʻau i hoʻohana mau ʻia nā lāʻau anti-inflammatory nonsteroidal (NSAIDs), nā lāʻau antirheumatic (DMARDs) e hoʻololi nei i nā maʻi (a me nā biologics.

ʻAʻole hou nā biologics, akā hāʻawi lākou i ka ʻoi aku ka holomua holomua i kēia manawa ma mua o ka wā ma mua. Paipai nā kulekele hou i kēia mau lāʻau i hoʻokahi o nā koho lapaʻau lālani mua no PsA.

He aha nā meaolaolaola?

ʻO nā lāʻau lapaʻau kuʻuna nā mea synthetic. Hana ʻia lākou mai nā kemika i loaʻa ʻole i ke kūlohelohe.

Hana ʻia nā lāʻau lapaʻau maʻamau a ka poʻe ʻike a hilinaʻi hoʻi ma kahi keʻena hoʻokolohua mai nā mea nonbiological. ʻO Aspirin, no ka laʻana, hoʻohālikelike ʻia ma hope o kahi mea i loko o ka wilow bark, akā i kēia manawa ua hana ʻia mai nā mea synthetic.

ʻO Biologics, ma ka ʻaoʻao ʻē aʻe, hana ʻia i nā mea olaola. Hoʻohana nā kānaka ʻepekema i nā hunaola holoʻokoʻa, nā ʻenemika, nā mea ʻohā, a me nā mea ʻē aʻe e hana i kahi lāʻau me kahi hana kikoʻī loa.

Ua ʻike ʻia nā manawa kūpono i ka ʻenehana ʻenehana i hana ʻia mai nā mea i loaʻa i ke kūlohelohe. Inā ua loaʻa ʻoe i kahi lāʻau āpau a i ʻole i loaʻa i ka hoʻololi o ke koko, ua loaʻa iā ʻoe kahi lāʻau lapaʻau i hana ʻia ma muli o nā mea olaola.

No ka mea ʻoi aku ka pololei o nā biologics i ka māka ʻana i nā hunaola, a mimic i nā mole i loaʻa kūlohelohe i ke kino, ʻoi aku ka maikaʻi o ka hopena. Loaʻa iā lākou nā hopena ʻē aʻe ma mua o nā lāʻau i hana ʻia mai nā kinikona.

Pehea e hoʻohana ai nā biologics e mālama iā PsA?

Hoʻokumu pinepine ka mumū i ka pehu, ʻoʻoleʻa, a me ka ʻeha pū kekahi e wehewehe ai iā PsA. Hoʻohana ʻia nā Biologics e mālama iā PsA kikoʻī i nā ala like ʻole i loko o ke kino e hana i ka mumū. He ʻokoʻa kēia mai nā lāʻau kūlohelohe, kahi e māka ai nā ʻanuʻu he nui i ka ʻōnaehana paleʻea.

Kaukaʻi ʻia i kāu hōʻailona psoriatic arthritis a me ka mōʻaukala olakino, hiki i kāu kauka ke koi aku i kekahi o nā biologics no ke kōkua.

He aha kaʻu mau koho e mālama iā PsA me kahi biologic?

Nui a hewahewa nā koho e mālama i kāu PsA me kahi biologic. Hiki ke hōʻiliʻili ʻia kēia mau lāʻau e kāu kauka e pili ana i ka hana a lākou e pili ana i ka ʻōnaehana pale.

Nā mea kāohi TNF-alpha

Tumor nekrosis factor-alpha (TNF-alpha) kahi protein e alakaʻi ai i ka mumū. Loaʻa ka nui o nā TNF-alpha i ka poʻe me PsA i ko lākou ʻili a i ʻole i ko lākou hui.

Hoʻolālā ʻia kēia mau lāʻau ʻelima e pale i kēia protein.

• Cimzia (certolizumab pegol)
• ʻO Enbrel (etanercept)
• Humira (adalimumab)
• Remicade (infliximab)
• Simponi (golimumab)

Hana lākou ma ka hoʻōki ʻana i ka ulu nui ʻana o nā hunaola ʻili a me ka hoʻowali ʻana i hiki ke alakaʻi i ka hōʻino ʻia o nā hui pū.

Nā mea hoʻopukapuka IL-12, IL-23, a me IL-17

ʻO Interleukin-12, interleukin-17, a me interleukin-23 he mau protein ʻokoʻa e pili ana i ka mumū. ʻElima mau biologics e loaʻa i kēia manawa e hoʻopilikia i ka hana a i ʻole me ka receptor kūlike o kēia mau protein.

Hoʻonohonoho ʻia kēia mau lāʻau e pale i ka mumū.

• Stelara (ustekinumab): IL-12/23
• Cosentyx (secukinumab): IL-17
• ʻO Taltz (ixekizumab): IL-17
• Siliq (brodalumab): IL-17
• Tremfya (guselkumab): IL-23

Nā mea hoʻowahawaha T-cell

I ka poʻe i loaʻa i ka maʻi kō, ua hoʻā ʻia nā pūnaewele T-lymphocyte, a i ʻole nā ​​T-cells, i hiki ke alakaʻi i ka hoʻonui ʻana o kēia mau hunaola. ʻO kekahi poʻe me ka maʻi kōwao e hoʻomohala maoli i kahi keu o nā T-cells.

ʻO kēia nā pūnaewele pale, a mākou a pau e pono ai. Akā i ka nui, hana lākou i nā kemika e alakaʻi i ka hōʻino pū, ʻeha, a me ka pehu.

ʻO Orencia (abatacept) kahi lāʻau e hoʻopili i nā T-cells. ʻAʻole hoʻemi ʻo Orencia i ka helu o nā pūnaewele T, akā paʻa ia i ka hoʻokuʻu ʻia ʻana o ke kemika i kumu i nā ʻōuli ma ke kāpae ʻana i ka hoʻāʻo T-cell.

Mea kāohi iā JAK kinase

ʻO Xeljanz (tofacitinib) kahi lāʻau ʻē aʻe i ʻae ʻia no PsA. He mea kāohi ʻo JAK kinase, e kuhikuhi nei i kahi mole liʻiliʻi e ālai i kahi ala e pili ana i ka pane o ka ʻōnaehana pale.

ʻAʻole kēia lāʻau lapaʻau he biologic, akā hiki i kāu kauka ke kamaʻilio pū me ʻoe e pili ana. Hoʻohui pinepine ʻia me nā biologics i nā kūkā kamaʻilio e pili ana i nā mea i māka ʻia no ka autoimmunity.

Palekana anei nā biologics i kēlā me kēia me PsA?

Paipai ʻia nā meaolaola no kēlā poʻe e noho nei me ka PsA kaulike a koʻikoʻi. Akā ʻaʻole kekahi moho i moho biologics.

ʻO ia no ka mea ʻoi aku ka hopena o ka hopena o ka lāʻau ma mua o ka maikaʻi. ʻAʻole pono ka poʻe me nā ʻōnaehana pale i hōʻino ʻia a i ʻole nā ​​maʻi ʻino e lawe i nā biologics no kā lākou PsA. Hoʻopau kēia mau lāʻau i ka ʻōnaehana pale a hiki ʻole ke palekana inā hoʻopilikia ʻia kāu i kekahi ʻano.

ʻO ke kumukūʻai a me nā lilo o waho o ka ʻeke no ka biologics hiki ke lilo i mea pale no kekahi poʻe.

He aha nā hopena o ka lawe ʻana i kahi biologic?

ʻOkoʻa kēlā me kēia biologic PsA. Loaʻa i kēlā me kēia mea nā hopena ʻaoʻao ponoʻī. Eia nō naʻe, aia kekahi mau mea like i kēia papa o nā lāʻau. ʻO ka hopena maʻa mau loa no nā biologics āpau ka hoʻonui ʻia o ka makaʻu o nā maʻi maʻamau ʻole, a i ʻole oha manawa.

Inā hoʻoholo ʻoe a me kāu kauka e hoʻāʻo i kēia papa hana me kahi biologic, ʻike paha ʻoe i nā hōʻailona like flu a i ʻole nā ​​maʻi hanu. No ka hāʻawi ʻia ʻana o nā biologics e ka hoʻopili ʻana a i ʻole IV, hiki paha iā ʻoe ke ʻike i ka hōʻoluʻolu kahi e kuʻi ai ka nila i kou ʻili.

Hiki i nā biologics ke alakaʻi i nā hopena ʻino ʻoi aku ka hewa, e like me nā maʻi o ke koko a i ʻole ke kanesa. No kēia mau kumu, he mea maikaʻi e hoʻomohala i kahi pilina ikaika me kāu kauka. Hiki pū, hiki iā ʻoe ke hoʻoholo inā he biologic ka lāʻau kūpono no kāu psoriatic arthritis.

ʻO ka lawe lawe ʻana

Ua hoʻolauna nā Biologics i nā koho lapaʻau i pahuhopu ʻia no ka poʻe e noho ana me ka PsA kūlike a koʻikoʻi. ʻAʻole hou nā mea āpau, akā ua manaʻo ʻia lākou i kēia manawa he lalani mua no ka mālama ʻana iā PsA.