E nīnau i ka loea: Dr. Amesh Adalja ma New Hepatitis C

Anter

• He aha ka Hepatitis C, a pehea e ʻokoʻa ai mai nā ʻano ʻē aʻe o ka Hepatitis?
• He aha nā papa maʻamau o ka mālama ʻana?
• He aha nā ʻano hana hou e loaʻa ana i ka honua, a pehea ke ʻano o ka hopena?
• Pehea e hoʻohālikelike ai kēia mau hana hou me nā maʻamau maʻamau?
• Pehea e hana ai nā mea maʻi i kā lākou hoʻoholo hoʻoholo?

Ua nīnauele mākou iā Kauka Amesh Adalja, kahi loea maʻi maʻi me ka University of Pittsburgh Medical Center, e pili ana i kāna mau ʻike i ka mālama ʻana i ka maʻi hepitis C (HCV). ʻO kahi loea i ke kula, hāʻawi ʻo Kauka Adalja i kahi nānā o ka HCV, nā maʻamau maʻamau, a me nā hana hōʻoluʻolu hou i hiki ke hoʻololi i ka pāʻani no nā maʻi hepitis C ma nā wahi āpau.

He aha ka Hepatitis C, a pehea e ʻokoʻa ai mai nā ʻano ʻē aʻe o ka Hepatitis?

ʻO Hepatitis C kahi ʻano hepatitis viral i ʻokoʻa mai kekahi ʻano ʻē aʻe o ka maʻi hepatitis i loaʻa iā ia ka maʻi maʻamau a hiki ke alakaʻi i ka cirrhosis ate, ka maʻi ʻaʻai ate, a me nā maʻi ʻōnaehana ʻē aʻe. Hoʻopili ia ma kahi o ka US a ʻo ia nō hoʻi ke kumu alakaʻi no ka pono no ka lawe ʻana i ke ake. Hoʻolahalaha ʻia ia ma o ke kū ʻana o ke koko e like me ke kahe ʻana o ke koko (ma mua o ka kānana ʻana), hoʻohana ʻana i ka lāʻau hoʻōki a pinepine ʻole i ka pili kolohe. ʻAʻohe o Hepatitis A kahi ʻano mau, hiki ke pale ʻia i ka lāʻau lapaʻau, hoʻolaha ʻia e ke ala fecal-oral, a ʻaʻole ia e alakaʻi i ka cirrhosis ate a me / a i ʻole ka maʻi ʻaʻai. ʻO ka Hepatitis B, lawe pū ʻia i ke koko a hiki nō hoʻi ke hoʻokumu i ka cirrhosis ate a me ka maʻi ʻaʻai, hiki ke pale ʻia ka lāʻau lapaʻau a ʻoi aku ka maʻalahi o ka hoʻolaha ʻana ma o ka pili moekolohe a mai nā makuahine i kā lākou keiki i ka wā hāpai a hānau. ʻO Hepatitis E like loa me ka hepatitis A akā, i nā manawa kakaikahi, hiki ke lilo i mau manawa mau, a he nui hoʻi ka nui o ka make ma nā wahine hāpai.

He aha nā papa maʻamau o ka mālama ʻana?

ʻO nā papa o ka mālama ʻana no ka maʻi hepa C kaukaʻi piha loa i ke ʻano o ka maʻi hepa C e kū nei. ʻEono mau genotypes o ka hepatitis C a ʻoi aku ka maʻalahi o kekahi e mālama ma mua o nā poʻe ʻē aʻe. Ma ka laulaha, ʻo ka mālama ʻana i ka maʻi hepa C e hui pū ʻia ana he ʻelua a ʻekolu paha mau lāʻau, me ka interferon, lawelawe ʻia no 12 mau pule.

He aha nā ʻano hana hou e loaʻa ana i ka honua, a pehea ke ʻano o ka hopena?

ʻO ka hoʻomaʻamaʻa hou hou loa ʻo ka antosirus lāʻau sofosbuvir, i hōʻike ʻia ʻaʻole maikaʻi wale nō, akā hiki nō hoʻi ke hoʻopōkole loa i nā papa o ka therapy mai nā regimens ʻoi aku ka lōʻihi ma mua o ka hoʻolauna ʻia ʻana.

Hana ʻo Sofosbuvir ma ka kāohi ʻana i ka enzyme viral RNA polymerase. ʻO kēia ke ʻano e hiki ai i ka virus ke hana kope iā ia iho. I nā hoʻokolohua hoʻokolohua, ua hōʻike ʻia kēia lāʻau lapaʻau me ka maikaʻi loa ma ke kāohi ʻana i ka maʻi me ka wikiwiki, e ʻae ana i ka hoʻopōkole ʻana i ka regimen lapaʻau. ʻOiai ua hoʻomākaukau nā lāʻau ʻē aʻe i kēia enzyme, ʻo ka hoʻolālā ʻana o kēia lāʻau lapaʻau e like me ka wikiwiki a me ka maikaʻi i hoʻohuli ʻia i kāna ʻano hana i loko o ke kino, e ʻae ana i ka pāpā ikaika i ka enzyme. ʻO Sofosbuvir ʻo ia

Eia kekahi, i kekahi mau hihia, hiki ke hoʻohana ʻia i nā hui lāʻau hoʻowahāwahā i ka interferon-weliweli no kāna ʻaoʻao hopena maikaʻi ʻole. [ʻOiai maikaʻi, kaulana ʻo interferon no ke kaumaha a me nā hōʻailona like flu. ʻO Sofosbuvir ka lāʻau mua i ʻae ʻia e ka FDA no ka hoʻohana ʻana me ka lawelawe ʻole ʻia o interferon i kekahi mau hihia.]

Pehea e hoʻohālikelike ai kēia mau hana hou me nā maʻamau maʻamau?

ʻO ka mea maikaʻi, e like me kaʻu i ʻōlelo ai ma luna, ʻoi aku ka pōkole o nā regimens hou, ʻoi aku ka hoʻomanawanui, a ʻoi aku ka maikaʻi. ʻO ka mea maikaʻi ʻole ke kumu kūʻai o nā lāʻau hou. Eia nō naʻe, inā e nānā kekahi i ka piha o ka pōʻaiapili, e pili ana i nā kumukūʻai hoʻomohala lāʻau i loaʻa, ma muli o ka hiki ke pale aku i nā pōpilikia weliweli loa a me nā koina o ka maʻi hepitis C, ʻo kēia mau lāʻau hou he mea hoʻokipa maikaʻi loa i ka arsenal.

Pehea e hana ai nā mea maʻi i kā lākou hoʻoholo hoʻoholo?

Paipai wau i nā mea maʻi e hoʻoholo i nā hoʻoholo me ka laulima ʻana me kā lākou kauka ma hope o ke kūkākūkā ʻana no ke kūlana o ko lākou maʻi, ke kūlana o ko lākou ake ake, a me ko lākou hiki ke hoʻopaʻa i ka lāʻau.