Mea Kākau: Gregory Harris
Lā O Ka Hana: 7 Apelila 2021
HōʻAno Hou I Ka Lā: 26 Ianuali 2025
Anonim
Pharmacology 386 a BisPhosphonates Osteoporosis Treatment Calcium Alendronate Etidronate Pamidronate
Wikiō: Pharmacology 386 a BisPhosphonates Osteoporosis Treatment Calcium Alendronate Etidronate Pamidronate

Anter

Hoʻohana ʻia ʻo Etidronate e mālama i ka maʻi o Paget o ka iwi (kahi ʻano palupalu a nāwaliwali nā iwi a hemahema paha, ʻeha, a haki paha) a pale a mālama i ka osterification heterotopic (ka ulu ʻana o nā iwi iwi i kahi o ke kino ʻē aʻe. ma mua o ka iwi) i ka poʻe i loaʻa i ka huina o ke kīʻaha pani hakahaka (ʻoki e hoʻololi i ka hui pūhaka me kahi ami synthetic) a i ʻole i ka poʻe i ʻeha i ka iwi kuamoʻo. Aia ʻo Etidronate i ka papa o nā lāʻau i kapa ʻia bisphosphonates. Hana ia me ka hoʻolohi i ka haki o ka iwi kahiko a me ka hoʻokumu ʻana o ka iwi hou.

Hele mai ʻo Etidronate ma ke ʻano he papa e lawe ma ka waha. Lawe ʻia ia i hoʻokahi manawa i ka lā ma ka ʻōpū hakahaka. Hiki ke hana hou i ka mālama ʻana no ka maʻi o Paget inā hoʻi mai nā ʻōuli a i ʻole ʻino hoʻi ma hope o ka hala ʻana o kekahi manawa. Lawe i ka etidronate ma kahi o ka manawa like (s) i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe i ka etidronate e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia a i ʻole no kahi manawa lōʻihi ʻoi aku ka manawa i kau ʻia e kāu kauka.


ʻAʻole hiki ke hana pono ʻo Etidronate a hōʻino paha i ka esophagus (paipu e hoʻopili i ka waha a me ka ʻōpū) a i ʻole ke kumu e ʻeha ai ka waha inā ʻaʻole e lawe ʻia e like me nā ʻōlelo aʻoaʻo aʻe. E haʻi i kāu kauka inā ʻaʻole ʻoe e maopopo, ʻaʻole ʻoe e noʻonoʻo e hoʻomanaʻo ʻoe, a i ʻole hiki ʻole iā ʻoe ke hāhai i kēia mau ʻōlelo aʻo.

  • E hoʻopau i nā papa me ke kīʻaha piha (6 a 8 auneke [180 a 240 mL]) o ka wai maʻamau ʻoiai ʻoe e noho ana a i ʻole e kū ana.
  • Noho a kū pololei paha ma hope o ka lawe ʻana i ka etidronate.
  • Mai ʻai, inu, a lawe i nā lāʻau ʻē aʻe (e like me nā vitamina a i ʻole antacids) no 2 mau hola ma mua a me 2 mau hola ma hope o kou lawe ʻana i ka etidronate.

Inā ʻoe e lawe i ka etidronate e mālama i ka maʻi o Paget o ka iwi a i ʻole e pale a mālama ʻana i ka ossification heterotopic, e liʻuliʻu paha kou manawa no ka hoʻomaikaʻi. Mai hōʻoki i ka lawe ʻana i ka etidronate me ke kamaʻilio ʻole ʻana me kāu kauka.

Hoʻohana ʻia ʻo Etidronate i kekahi manawa e mālama a pale aku i ka osteoporosis (ke ʻano a lahilahi a nāwaliwali nā iwi a haki maʻalahi paha) i hoʻokumu ʻia e nā corticosteroids (kahi ʻano o ka lāʻau e hiki ai i ka osteoporosis). E kamaʻilio me kāu kauka e pili ana i nā pilikia e hiki ke hoʻohana i kēia lāʻau no kāu maʻi.


Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka etidronate,

  • e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka etidronate, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o ka papa etidronate. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau he aha nā lāʻau lapaʻau a me nā lāʻau ʻole i kuhikuhi ʻia, nā wikamina, nā mea hoʻopihaʻai, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe E hoʻomaopopo pono e haʻi i kekahi o kēia mau mea: angiogenesis nā mea kāohi e like me bevacizumab (Avastin), everolimus (Afinitor, Zortress), pazopanib (Votrient), sorafenib (Nexavar), a sunitinib (Sutent); anticoagulants ('blood thinners') e like me warfarin (Coumadin, Jantoven); chemotherapy maʻi ʻaʻai; a me nā steroid oral e like me dexamethasone, methylprednisolone (Medrol), a me prednisone (Rayos). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • inā ʻoe e lawe i nā mea hoʻoluʻu a me nā mea minamina e like me ka hao, a i ʻole inā ʻoe e lawe i nā antacids i loko o ka calcium, magnesium, a i ʻole alumini (Maalox, Mylanta, Tums, a me nā mea ʻē aʻe), lawe iā lākou i 2 mau hola ma mua a i ʻole 2 mau hola ma hope o kou lawe ʻana i ka etidronate.
  • e haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe nā pilikia me kāu esophagus e like me ka esophageal strikure (hoʻoliʻiliʻi o ka esophagus e hana i nā pilikia o ka ale ʻana) a i ʻole achalasia (maʻi e pili ana i ka hiki i ka esophagus ke neʻe i ka meaʻai i ka ʻōpū), a i ʻole osteomalacia (palupalu o nā iwi ma muli o ka nele o nā minelala). E haʻi paha kāu kauka iā ʻoe mai lawe i ka etidronate.
  • e haʻi i kāu kauka inā ʻaʻole hiki iā ʻoe ke noho a kū i luna a inā he anemia a i ʻole loaʻa paha iā ʻoe (kahi e lawe ʻole ai nā hunaola ʻulaʻula i nā oxygen āpau i nā ʻāpana āpau o ke kino); kahi pae haʻahaʻa o ka puna i loko o kou koko; pilikia i ka ale ʻana, ʻehaʻeha puʻuwai, ulcer, a i ʻole nā ​​ʻōpū ʻōpū ʻē aʻe; maʻi ʻaʻai; enterocolitis (ʻōhū i loko o nā ʻōpū); kekahi ʻano maʻi, ʻoi loa i kou waha; nā pilikia me kou waha, nā niho, a i ʻole nā ​​gum; i kekahi ʻano e hōʻoki i kou koko mai ka hoʻopili ʻana maʻamau; a maʻi maʻi ʻōpae paha. Pono paha kāu kauka e hoʻololi i ka mahele lāʻau o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
  • e haʻi i kāu kauka inā hāpai ʻoe, hoʻolālā e hāpai, a i ʻole e hānai umauma ana. E haʻi aku i kāu kauka inā ʻoe e hoʻolālā e hāpai i kēlā me kēia manawa i ka wā e hiki mai ana no ka mea e noho ka etidronate i kou kino no nā makahiki he nui ma hope o kou haʻalele ʻana. Kāhea i kāu kauka inā hāpai ʻoe i ka wā a ma hope paha o kāu mālama ʻana me etidronate.
  • pono ʻoe e ʻike he hiki i ka etidronate ke kumu i ka osteonecrosis o ka iwi ā (ONJ, kahi kūlana koʻikoʻi o ka iwi ā), keu hoʻi inā he ʻoki niho ʻoe a i ʻole ke mālama ʻana ʻoiai ʻoe e lawe nei i ka lāʻau. Pono kahi kauka niho e nānā i kou mau niho a hana i nā hana e pono ai, e like me ka hoʻomaʻemaʻe a me ke hoʻoponopono ʻana i nā niho pono ʻole, ma mua o kou hoʻomaka ʻana e lawe i ka etidronate. E mālama pono i kou niho a hoʻomaʻemaʻe i kou waha pono ʻoiai ʻoe e lawe nei i ka etidronate. E kamaʻilio me kāu kauka ma mua o ka loaʻa ʻana o nā lāʻau lapaʻau iā ʻoe e lawe nei i kēia lāʻau.
  • pono ʻoe e ʻike ʻo ka etidronate ke kumu o ka iwi nui, nā mākala, a me nā ʻeha pū. E hoʻomaka paha ʻoe e ʻike i kēia ʻeha i loko o nā lā, mau mahina, a mau makahiki paha ma hope o kou lawe mua ʻana i ka etidronate. ʻOiai ʻo kēia ʻano ʻeha e hoʻomaka paha ma hope o kou lawe ʻana i ka etidronate no kekahi manawa, he mea nui ia no ʻoe a me kāu kauka e hoʻomaopopo ai no etidronate paha ia. Kāhea koke i kāu kauka inā ʻike ʻoe i ka ʻehaʻeha loa i kēlā me kēia manawa i ka wā o kāu mālama ʻana me etidronate. E haʻi paha kāu kauka iā ʻoe e haʻalele i ka lawe ʻana i ka etidronate a hele aku paha kou ʻeha ma hope o kou hoʻōki ʻana i ka lāʻau.

He mea nui e loaʻa iā ʻoe ka nui o ka puna a me ka wikamina D a ʻai i ka papaʻai kaulike ʻoiai ʻoe e lawe ana i ka etidronate. E haʻi aku kāu kauka iā ʻoe i nā meaʻai nā kumu waiwai maikaʻi o kēia mau meaola a me ka nui o nā lawelawe āu e pono ai i kēlā me kēia lā. Inā paʻakikī ʻoe e ʻai lawa i kēia mau meaʻai, e haʻi i kāu kauka. I kēlā hihia, hiki i kāu kauka ke kauoha a koi paha i kahi mea kōkua.


Inā ʻaʻole ʻoe i ʻai, e lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Inā ʻoe i ʻai mua, e lawe i ka mahele lāʻau i hala i 2 mau hola ma hope o kāu ʻai ʻana. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i ka Etidronate ke hana i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • nausea
  • pāhoehoe

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻoe e ʻike i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka:

  • puʻuwai puʻuwai hou a ʻoi aku paha
  • ʻeha ke ale ʻana
  • ʻeha ka umauma
  • ka pehu o ka maka, ka ʻāʻī, ke alelo, nā lehelehe, nā maka, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
  • hulahula
  • paʻakikī i ka ale ʻana
  • pāhū ma ka ʻili

Hiki i ka Etidronate ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Hiki i nā ʻōuli o ka overdose ke hoʻopili i kēia mau mea:

  • ka luaʻi
  • ʻōpū o ka ʻōpū
  • pāhoehoe
  • ʻeha, puhi ʻana, numbness, a ʻūlū paha i nā lima a me nā wāwae
  • nā spasms Muscle a me nā ʻūlū

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino i ka etidronate.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • ʻO Didronel®
  • EHDP
Nānā Hou - 08/15/2017

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