Tolvaptan (maʻi ʻōpū)

Anter

• Ma mua o ka lawe ʻana iā tolvaptan (Jynarque),
• Hiki i Tolvaptan (Jynarque) ke hopena i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻ sectionlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka:
• Pākuʻi ʻia paha nā ʻōuli o ka overdose:

Hiki i ka Tolvaptan (Jynarque) ke hoʻopōʻino i ke ake, i kekahi manawa kūpono kūpono e koi ai i ka lawe ʻana i ke ake a i ʻole e hoʻokau i ka make. E haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe nā pilikia o ke ake, e like me ka maʻi hepitis. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe iā tolvaptan (Jynarque). E kauoha pinepine kāu kauka i nā hoʻokolohua hale loiloi ma mua a i kou wā e ʻike ai inā pili ka tolvaptan (Jynarque) i kou ake. E haʻi paha kāu kauka iā ʻoe ʻaʻole pono e loaʻa iā ʻoe kēia lāʻau inā hōʻike nā hōʻike he pilikia kou i ke ake. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke aku i kāu kauka: nausea, luaʻi, luhi nui loa, kahe ʻana o ke kōkō a ʻeha paha, ka nele o ka ikaika, nalo ʻole o ka makemake, ʻeha ma ka ʻaoʻao ʻākau i luna o ka ʻōpū, melemele o ka ʻili a me nā maka. , mimi ʻeleʻele, ʻeleʻele, ʻili, a me nā hōʻailona like flu.

Ma muli o nā makaʻu me kēia lāʻau, tolvaptan (Jynarque) i loaʻa wale ma o kahi papahana hoʻokaʻawale palena papaha. Ua hoʻonohonoho ʻia kahi papahana i kapa ʻia ʻo Jynarque Risk Evaluation and Mitigation Strategies (REMS) e hoʻēmi i nā makaʻu o ka lawe ʻana i tolvaptan (Jynarque). Pono e kau inoa kāu kauka a me kāu kauka lāʻau me ka papahana Jynarque REMS. E noi i kāu kauka no ka ʻike hou aku e pili ana i kēia papahana a pehea ʻoe e loaʻa ai i kāu lāʻau. E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua ma mua a i kou wā e mālama ai e nānā i ka pane o kou kino iā tolvaptan (Jynarque).

E hāʻawi aku kāu kauka a kauka paha iā ʻoe i ka palapala ʻike hoʻomanawanui a ka mea hana (Ke alakaʻi lāʻau) ke hoʻomaka ʻoe i ka lāʻau me tolvaptan (Jynarque) a i kēlā me kēia manawa e hoʻopiha hou i kāu kauka. E heluhelu pono i ka ʻike a nīnau i kāu kauka a kauka paha inā he nīnau kāu. Hiki iā ʻoe ke kipa aku i ka pūnaewele ʻo Food and Drug Administration (FDA) (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) a i ʻole pūnaewele o ka mea hana e kiʻi i ka Medication Guide.

E kamaʻilio me kāu kauka e pili ana i ka makaʻu o ka lawe ʻana i tolvaptan (Jynarque).

Hoʻohana ʻia ʻo Tolvaptan (Jynarque) e hoʻolohi i ka hōʻino ʻana o ka hana hakuʻala i kekahi mau maʻi me ka maʻi autcyomal polycystic kidney maʻi (ADPKD; kekahi ʻano maʻi maʻi ʻōiwi i hoʻoili ʻia). Aia ʻo Tolvaptan (Jynarque) i kahi papa o nā lāʻau i kapa ʻia vasopressin V₂ ʻenemi antagonists. Hana ia ma ka hoʻonui ʻana i ka nui o ka wai i hoʻokuʻu ʻia mai ke kino e like me ka mimi a hoʻemi i ka ulu ʻana o nā cista i nā puʻupaʻa. ʻO ka wehe ʻana i ka wai mai ke kino a hoʻolohi i ka ulu ʻana o nā cist e kōkua i ka lohi o ka hōʻino ʻana o ka hana o ka hakuʻala.

Loaʻa ʻo Tolvaptan ma ke ʻano he papaha (Samsca) e mālama i nā kiʻekiʻe o ke kōpaʻa o ka sodium i ka poʻe i loaʻa ka puʻuwai a i ʻole kekahi mau ʻano ʻē aʻe. Hāʻawi wale kēia monograp i ka ʻike e pili ana i nā papa tolvaptan (Jynarque) e hoʻolohi i ka hōʻino ʻana o ka hana o ka puʻupaʻa i nā maʻi me ADPKD. Inā ʻoe e hoʻohana ana i kēia lāʻau e mālama i nā pae haʻahaʻa o ka sodium i loko o ke koko, e heluhelu i ka monograph i kapa ʻia ʻo tolvaptan (sodium koko haʻahaʻa).

Hele mai ʻo Tolvaptan (Jynarque) ma ke ʻano he papa e lawe ma ka waha. Lawe ʻia ia i ʻelua mau manawa i ka lā, hoʻokahi papa i ke kakahiaka a hoʻokahi papa 8 mau hola ma hope, me ka ʻai a me ka ʻole. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pono iā tolvaptan (Jynarque) e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E hoʻomaka paha kāu kauka iā ʻoe ma kahi haʻahaʻa o tolvaptan (Jynarque) a hoʻonui iki i kāu lāʻau.

Pono paha kāu kauka e hōʻemi i kāu lāʻau inā ʻike ʻoe i kekahi hopena. He mea nui iā ʻoe e haʻi i kāu kauka i kou ʻano i kou wā e mālama ai.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana iā tolvaptan (Jynarque),

• e haʻi i kāu kauka a me ka kauka inā he maʻi ʻoe i ka tolvaptan (Jynarque, Samsca), nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i nā papa tolvaptan. E noi i kāu kauka lāʻau a nānā i ke alakaʻi lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka inā lawe ʻoe i kekahi antifungals e like me ketoconazole (Nizoral) a i ʻole itraconazole (Sporanox); clarithromycin (Biaxin); a i ʻole kekahi mau lāʻau no ka HIV e like me indinavir (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir), a i ʻole saquinavir (Invirase); konivaptan (Vaprisol); aiʻole nefazodone. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe i ka tolvaptan (Jynarque) inā ʻoe e lawe i hoʻokahi aʻoi aku paha o kēia mau lāʻau.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E haʻi pono i kekahi o kēia mau mea: atorvastatin (Lipitor, ma Caduet), bosentan (Tracleer), desmopressin (dDAVP, Minirin, Noctiva), digoxin (Lanoxin), fluconazole (Diflucan); furosemide (Lasix), glyburide (Diabeta, Glynase), lovastatin (Altoprev), methotrexate (Otrexup, Rasuvo, Trexall, Xatmep), nateglinide (Starlix), pravastatin (Pravachol), repaglinide (Prandin), rifampin (Rifadin) ), rosuvastatin (Crestor), a me simvastatin (Zocor, i Vytorin). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Hiki paha i nā lāʻau ʻē aʻe ke launa pū me tolvaptan (Jynarque), no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
• e haʻi aku i kāu kauka inā loaʻa iā ʻoe kekahi o nā ʻano i ʻōlelo ʻia i ka ʻARlelo Aʻo IMPORTANT, inā loaʻa a i ʻole loaʻa i kahi pae kiʻekiʻe o ka sodium i loko o kou koko, inā paʻakikī ʻoe i ka mimiki a i ʻole hiki ʻole ke mimī, inā ua nui kou luaʻi. aiʻole ka diarrhea a noʻonoʻo paha e make wai ʻoe, a inā ʻaʻole hiki iā ʻoe ke ʻike he make wai ʻoe. E haʻi paha kāu kauka iā ʻoe ʻaʻole e lawe iā tolvaptan (Jynarque).
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. Inā hāpai ʻoe i ka lawe ʻana i tolvaptan (Jynarque), e kāhea i kāu kauka. ʻAʻole pono ʻoe e hānai i ka wā e lawe ana ʻoe i ka tolvaptan (Jynarque).

Pono ʻoe e inu i ka wai lawa ke lawe ʻoe i tolvaptan (Jynarque) no laila ʻaʻole ʻoe e make wai a make wai.

Mai ʻai i ka hua waina a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

E haʻalele i ka lāʻau i haʻalele ʻia a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i Tolvaptan (Jynarque) ke hopena i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• make wai
• waha maloo
• pinepine, urination nui loa
• puʻuwai puʻuwai
• hoʻēmi ʻai

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli a i ʻole nā ​​mea i helu ʻia i ka ʻ sectionlelo Aʻo IMPORTANT, e kāhea koke i kāu kauka:

• pāhoehoe
• hiki ʻole ke inu maʻamau
• ʻūpā
• maule
• hoʻemi urination
• nāwaliwali
• hiamoe
• huikau
• Kaumaha emi
• wikiwiki a kuʻi paha i nā puʻuwai puʻuwai
• ka pehu o ka maka, ka ʻāʻī, ke alelo, nā lehelehe, nā maka, nā lima, nā wāwae, nā kuʻekuʻe wāwae, a me nā wāwae lalo
• hulahula
• hives

Hiki i Tolvaptan (Jynarque) ke hana i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Pākuʻi ʻia paha nā ʻōuli o ka overdose:

• urination nui loa
• make wai nui loa
• ʻūpā
• maule

E mālama i nā manawa a pau me kāu kauka a me ka hale hana. E kauoha paha kāu kauka i kekahi mau hoʻokolohua lab e nānā i ka pane o kou kino iā tolvaptan (Jynarque).

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• ʻO Jynarque^®