Selumetinib

Anter

• Ma mua o ka lawe ʻana i ka selumetinib,
• Hoʻokumu ʻo Selumetinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:
• Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

Hoʻohana ʻia ʻo Selumetinib e mālama i ka neurofibromatosis ʻano 1 (NF1; kahi maʻi ʻōnaehana e ulu ai nā tumors ma nā ʻāʻī) i nā keiki 2 makahiki a ʻoi paha i loaʻa nā neurofibromas plexiform (PN; nā pulu palupalu) ʻaʻole hiki ke hoʻopau loa ʻia e ke ʻoki. Aia ʻo Selumetinib i kahi papa o nā lāʻau i kapa ʻia ʻo nā kinase inhibitors. Hana ia ma ka pale ʻana i ka hana o ka protein pono ʻole e hōʻailona i nā tumors e ulu. Kōkua kēia i ka hōʻoki a hoʻolohi i ka ulu ʻana o ka tumo.

Hele mai ʻo Selumetinib ma ke ʻano he capsule e lawe ma ka waha. Lawe ʻia ia i ʻelua mau manawa i ka lā ma ka ʻōpū hakahaka. Mai ʻai i kekahi meaʻai 2 mau hola ma mua a i ʻole no 1 hola ma hope o kēlā me kēia kau. E lawe i ka selumetinib ma kahi o ka manawa like (s) i kēlā me kēia lā, ma kahi o 12 mau hola ke kaʻawale. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. E lawe i ka selumetinib e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E ale i nā capsule a pau i ka wai; mai wehe, nau, a wāwahi paha iā lākou.

Inā luaʻi ʻoe ma hope o ka lawe ʻana i ka selumetinib, mai lawe i kahi lāʻau ʻē aʻe. E hoʻomau i kāu papa hana maʻamau.

Hiki i kāu kauka ke hōʻemi i kāu lāʻau a i ʻole manawa kūmau a paʻa mau paha i kāu lāʻau inā ʻike ʻoe i kekahi mau hopena ʻaoʻao. E haʻi pono i kāu kauka i kou ʻano i kou wā e mālama ai me selumetinib.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.

Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i ka selumetinib,

• e haʻi i kāu kauka a me ka mea kauka lāʻau inā he maʻi ʻoe i ka selumetinib, nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hoʻohui i nā capsule selumetinib. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
• e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E hōʻoia e haʻi i kekahi o kēia mau mea: anticoagulants ('nā mea hōʻemi koko') e like me warfarin (Coumadin, Jantoven); nā antifungals e like me fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), a me voriconazole (Vfend); aprepitant (Emend); clarithromycin (Biaxin, i Prevpac); clopidogrel (Plavix); corticosteroids e like me betamethasone (Celestone), budesonide (Entocort), cortisone (Cortone), dexamethasone (Decadron, Dexpak, Dexasone, a me nā mea ʻē aʻe), hydrocortisone (Cortef, Hydrocortone), methylprednisolone (Medrol, Meprolone, kekahi), prednisolone ), a me prednisone (Rayos); diltiazem (Cardizem, Dilacor, Tiazac, nā mea ʻē aʻe); erythromycin (E.E.S., E-Mycin, Erythrocin); kekahi mau lāʻau no ka maʻi HIV me indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, ma Kaletra), a me saquinavir (Fortovase, Invirase); idelalisib (Zydelig); nefazodone; phenobarbital; rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, ma Rifamate, ma Rifater); verapamil (Calan, Covera); a me nā huaʻai E. Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao.
• e haʻi i kāu kauka i nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St.
• e haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe kahi pilikia ʻike, pilikia i ka ale ʻana, a i ʻole maʻi puʻuwai a i ʻole ate.
• E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a inā ʻoe e hoʻolālā i ka hānau keiki ʻana. Inā he wahine ʻoe, pono ʻoe e lawe i kahi hōʻike hāpai keiki ma mua o kou hoʻomaka ʻana i ka lāʻau lapaʻau a hoʻohana i ka kaohi hānau e pale ai i ka hāpai ʻana i ka wā o kāu lapaʻau a no ka liʻiliʻi he 1 pule ma hope o kāu hopena hope loa Inā he kāne ʻoe, pono ʻoe a me kāu pakanā e hoʻohana i ka kaohi hānau ma kāu mālama ʻana me selumetinib a no 1 hebedoma ma hope o kāu hopena hope loa. E kamaʻilio me kāu kauka e pili ana i nā ʻano hana hānau hiki iā ʻoe ke hoʻohana i kāu wā o kāu mālama ʻana. Inā hāpai ʻoe a ʻo kāu hoa paha i ka lawe ʻana i ka selumetinib, e kāhea koke i kāu kauka. Hoʻopilikia paha ʻo Selumetinib i ka fetus.
• e haʻi i kāu kauka inā e hānai ana ʻoe i ka waiū. ʻAʻole pono ʻoe e hānai i ka wā e lawe nei ʻoe i ka selumetinib a no 1 pule ma hope o ka hopena hope loa.

Hōʻalo i ka ʻai ʻana i ka huaʻikuʻi a i ʻole inu i ka wai huaʻulu i ka wā e lawe ana i kēia lāʻau.

E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā aia i loko o 6 mau hola o ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hoʻokumu ʻo Selumetinib i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

• ka luaʻi
• kōpaʻa
• ʻeha ka ʻōpū
• nausea
• ʻili maloʻo
• ʻeha poʻo
• ulcer waha
• ʻūlili
• ʻulaʻula a puni nā manamana lima
• kahe ʻana ka ihu
• luhi
• nalo ʻai ʻole
• loli ka lauoho a i ʻole ka waihoʻoluʻu o ka lauoho

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

• fiva
• kahe koko ʻole ʻana
• ʻili mae a luhi paha
• ʻike maka ʻole; nalo o ka hihiʻo; mau kiko ʻeleʻele i kāu ʻike; a i ʻole nā ​​loli ʻike hou ʻē aʻe
• pāhoehoe
• ʻehu, ʻili a ʻili paha
• ʻehaʻeha, ʻeha, a nāwaliwali paha; aiʻole mimi ʻeleʻele
• ka puʻu a i ʻole ke kani ʻana; pokole o ka hanu; pehu o nā kuʻekuʻe wāwae a me nā wāwae; aiʻole ka luhi nui loa

Hoʻokumu paha ʻo Selumetinib i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.

Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua. Mai wehe i ka desiccant (ʻāpana liʻiliʻi i hoʻopili ʻia me nā capsule e omo i ka waiū) mai kāu ʻōmole.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Mālama i nā manawa a pau me kāu kauka, kauka maka, a me ka hale hana. E kauoha kāu kauka i kekahi mau hoʻokolohua lab, me nā hoʻokolohua maka, ma mua, i ka manawa, a ma hope o kāu lāʻau e nānā ai i ka pane o kou kino i ka selumetinib.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

• Koselugo^®