Mea Kākau: Gregory Harris
Lā O Ka Hana: 13 Apelila 2021
HōʻAno Hou I Ka Lā: 17 Nowemapa 2024
Anonim
NOURIANZ™ (istradefylline) Mechanism of Action in Parkinson’s Disease
Wikiō: NOURIANZ™ (istradefylline) Mechanism of Action in Parkinson’s Disease

Anter

Hoʻohana ʻia ʻo Istradefylline me ka hui pū ʻana o ka levodopa a me ka carbidopa (Duopa, Rytary, Sinemet, a me nā mea ʻē aʻe) e mālama ai i nā ʻāpana "off" (nā manawa o ka paʻakikī e neʻe ai, e hele wāwae ana, a e kamaʻilio pū ana paha e hiki ke hana ʻia e like me ka pau ʻana o ka lāʻau lapaʻau a i ʻole koho ʻia) ʻO ka maʻi ʻo Parkinson (PD; kahi maʻi o ka ʻōnaehana hopohopo e pilikia ai i ka neʻe ʻana, ka mālama ʻana i nā mākala, a me ke kaulike). Aia ʻo Istradefylline i kahi papa o nā lāʻau i kapa ʻia adenosine receptor antagonists. Hana ia ma ka hoʻololi ʻana i ka hana o kekahi mau mea kūlohelohe i ka lolo.

Hele mai ʻo Istradefylline ma ke ʻano he papa e lawe ma ka waha. Lawe mau ʻia me ka ʻai ʻole a ʻai ʻole hoʻokahi manawa i kēlā me kēia lā. Lawe iā istradefylline ma kahi o ka manawa like i kēlā me kēia lā. E hāhai pono i nā ʻōkuhi i kāu lepili kuhikuhi, a nīnau i kāu kauka a kauka paha e wehewehe i kahi ʻāpana āu i maopopo ʻole ai. Lawe pololei i istradefylline e like me ke kuhikuhi. Mai lawe i ka mea ʻoi aku a liʻiliʻi paha o ia mea a lawe pinepine iā ia ma mua o ka mea i kauoha ʻia e kāu kauka.

E noi i kāu kauka lāʻau a kauka paha no kahi kope o ka ʻike a ka mea hana no ka mea maʻi.


Kau ʻia kēia lāʻau no nā hoʻohana ʻē aʻe; e noi i kāu kauka a kauka paha no ka ʻike hou aku.

Ma mua o ka lawe ʻana i istradefylline,

  • e haʻi i kāu kauka a me kāu kauka lāʻau inā he maʻi ʻoe i ka istradefylline, i nā lāʻau ʻē aʻe, a i ʻole kekahi o nā mea hana i loko o nā papa istradefylline. E noi i kāu kauka lāʻau no kahi papa inoa o nā mea hoʻohui.
  • e haʻi i kāu kauka a me ka mea kauka lāʻau i nā lāʻau lapaʻau, nā wikamina, nā mea hoʻopihapiha, a me nā huahana lāʻau āu e lawe nei a hoʻolālā paha e lawe. E haʻi pono i kekahi o kēia mau mea: clarithromycin (Biaxin, i Prevpac); kekahi mau antifungals e like me itraconazole (Onmel, Sporanox) a i ʻole ketoconazole; digoxin (Lanoxin), enzalutamide (Xtandi); kekahi mau lāʻau no ka maʻi pale maʻi (HIV) a i ʻole loaʻa i ka maʻi maʻi maʻi maʻi (AIDS) e like me efavirenz (Sustiva, i Atripla), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, ma Kaletra), a saquinavir (Hoʻokele); modafinil (Provigil); nefazodone; pioglitazone (Actos, ma Duetact, Oseni); rifabutin (Mycobutin); rifampin (Rifadin); kekahi mau lāʻau no ka hopu ʻana e like me ka carbamazepine (Equetro, Tegretol, Teril), oxcarbazepine (Trileptal), phenobarbital, a me phenytoin (Dilantin, Phenytek); nā steroid ʻo waha e like me dexamethasone, methylprednisolone (Medrol), a me prednisone; aiʻole telithromycin (Ketek). Pono paha kāu kauka e hoʻololi i nā kaha o kāu mau lāʻau a nānā pono iā ʻoe no nā hopena ʻaoʻao. Nui paha nā lāʻau ʻē aʻe e launa pū paha me ka istradefylline, no laila e ʻike pono i kāu kauka e pili ana i nā lāʻau a pau āu e lawe nei, a ʻo nā mea ʻaʻole i ʻike ʻia ma kēia papa inoa.
  • e haʻi i kāu kauka a me kāu kauka lāʻau he aha nā huahana lāʻau āu e lawe nei, ʻo ka wort ʻo St. ʻAʻole pono ʻoe e lawe i ka wort a St. John i kou wā e mālama ai me istradefylline.
  • e haʻi i kāu kauka inā loaʻa a loaʻa paha iā ʻoe kahi maʻi psychotic (kahi ʻano e pilikia ai e haʻi i ka ʻokoʻa ma waena o nā mea a i ʻole nā ​​manaʻo maoli a me nā mea a me nā manaʻo ʻaʻole maoli), nā neʻe o ke kino i hiki ʻole iā ʻoe ke kaohi, a i ʻole nā ​​maʻi ate.
  • E haʻi i kāu kauka inā hāpai ʻoe, e hoʻolālā e hāpai, a i ʻole e hānai umauma ana. ʻAʻole pono ʻoe e hāpai i ka wā e lawe ana ʻoe i istradefylline. Pono ʻoe e hoʻohana i ka kaohi hānau kūpono e pale ai i ka hāpai ʻana i kāu wā mālama me istradefylline. Inā hāpai ʻoe i ka lawe ʻana i istradefylline, e kāhea i kāu kauka.
  • e haʻi i kāu kauka inā hoʻohana ʻoe i nā huahana paka (paka, paka, paka paka, a i ʻole paka paka). Hiki i nā huahana puhi paka ke hoʻemi i ka pono o kēia lāʻau.
  • pono ʻoe e ʻike i kekahi poʻe i lawe i nā lāʻau e like me istradefylline i ulu i nā pilikia piliwaiwai a i ʻole nā ​​ʻūlū ikaika a i ʻole nā ​​ʻaoʻao koʻikoʻi a koʻikoʻi ʻole paha no lākou, e like me ka hoʻonui ʻana i nā makemake moekolohe a i ʻole nā ​​lawena, ka hoʻolilo kālā ʻole ʻia ʻana, a i ʻole ka ʻai nui ʻana. Kāhea i kāu kauka inā makemake ʻoe e pāʻani i ka paʻakikī e kaohi, loaʻa iā ʻoe nā koi ikaika, a i ʻole hiki ʻole iā ʻoe ke kaohi i kāu hana. E haʻi aku i nā lālā o kou ʻohana e pili ana i kēia pilikia i hiki iā lākou ke kāhea i ke kauka inā ʻaʻole ʻoe e ʻike he pili pilikia kāu piliwaiwai a i ʻole nā ​​ʻano hoʻoikaika ʻē aʻe a i ʻole nā ​​ʻano hana ʻano ʻē.

Inā ʻaʻole haʻi kāu kauka iā ʻoe, e hoʻomau i kāu papaʻai maʻamau.


E lawe i ka lāʻau i hala i kou wā e hoʻomanaʻo ai. Eia nō naʻe, inā kokoke i ka manawa no ka mahele hope aʻe, e lele i ka lāʻau i hala a hoʻomau i kāu papa hana maʻamau. Mai lawe i kahi lāʻau pālua e pani no kahi mea i hala.

Hiki i ka Istradefylline ke kumu i nā hopena ʻaoʻao. E haʻi i kāu kauka inā koʻikoʻi kekahi o kēia mau ʻōuli a mai hele aku paha:

  • ʻūpā
  • kōpaʻa
  • nalo ʻai ʻole
  • paʻakikī e hiamoe a hiamoe paha

Hiki i kekahi o nā hopena ʻaoʻao ke koʻikoʻi. Inā ʻike ʻoe i kekahi o kēia mau ʻōuli, e kāhea koke i kāu kauka a i ʻole e kiʻi i ka lāʻau olakino olakino.

  • ke kaumaha a i ʻole ka neʻe pinepine ʻana o ke kino i hiki ʻole iā ʻoe ke kaohi
  • hallucination (ke ʻike nei i nā mea a i ʻole ka lohe ʻana i nā leo i ʻole ola)
  • ke kānalua nei a manaʻo paha i ka makemake o nā poʻe e hana ʻino iā ʻoe
  • ka manaʻoʻiʻo ʻana i nā mea maoli ʻole
  • hana kūpikipiki, hoʻonāukiuki, a huikau paha

Hiki i ka Istradefylline ke kumu i nā hopena ʻē aʻe. Kāhea i kāu kauka inā he pilikia ʻokoʻa kāu i ka lawe ʻana i kēia lāʻau.


Inā ʻoe e ʻike i kahi hopena koʻikoʻi, e hoʻouna ʻoe a i ʻole kāu kauka i kahi hōʻike i ka papahana hōʻike ʻino a MedWatch Adverse Event Food (FDA) ma ka pūnaewele (http://www.fda.gov/Safety/MedWatch) a i ʻole kelepona. 1-800-332-1088).

E mālama i kēia lāʻau i loko o ka pahu i komo ai, pani paʻa ʻia, a ʻaʻole hiki i nā kamaliʻi. E mālama iā ia i ka mahana wela o ka lumi a ma kahi o ka wela a me ka momona (ʻaʻole i ka lua.

He mea nui e mālama i nā lāʻau āpau mai ka maka a hiki i nā keiki e like me nā ipu (e like me nā minder pill i kēlā me kēia pule a me nā mea no nā kulu maka, nā kalima, nā pākuʻi, a me nā inhalers) ʻaʻole pale keiki a hiki i nā keiki ʻōpio ke wehe maʻalahi iā lākou. No ka pale ʻana i nā keiki ʻōpio mai ka lāʻau make, laka mau i nā pāpale palekana a kau koke i ka lāʻau i kahi palekana - kahi i luna a mamao a mai ko lākou alo a hiki. http://www.upandaway.org

Pono e hoʻolei ʻia nā lāʻau i koi ʻole ʻia i nā ala kūikawā e hōʻoia i ka hiki ʻole i nā holoholona, ​​nā keiki, a me nā poʻe ʻē aʻe ke hoʻopau iā lākou. Eia nō naʻe, ʻaʻole pono ʻoe e kaomi i kēia lāʻau i ka lua. Akā, ʻo ke ala ʻoi loa e hoʻolilo i kāu lāʻau i loko o kahi papahana hoʻihoʻi lāʻau. E kamaʻilio me kāu kauka lāʻau a kāhea paha i kāu ʻōpala a me nā hana hoʻopōʻaiapuni kūloko e aʻo e pili ana i nā papahana hoʻihoʻi i kou kaiāulu. E ʻike i ka pūnaewele palekana o kā FDA's Disposal of Medicines (http://goo.gl/c4Rm4p) no ka ʻike hou aku inā ʻaʻohe ou komo i kahi papahana hoʻihoʻi.

I ke kumu o ka overdose, e kāhea i ka helpline kaohi lāʻau make ma 1-800-222-1222. Loaʻa ka ʻike ma ka pūnaewele ma https://www.poisonhelp.org/help. Inā ua hina ka mea i hoʻomāinoino ʻia, loaʻa ka hopu ʻana, pilikia i ka hanu ʻana, a i ʻole hiki ʻole ke ala aʻe, e kāhea koke i nā lawelawe kūikawā ma 911.

Mālama i nā manawa āpau me kāu kauka.

Mai ʻae i kahi mea ʻē aʻe e lawe i kāu lāʻau. E nīnau i kāu kauka lāʻau i nā nīnau āu e pili ana i ka hoʻopiha hou ʻana i kāu kuhikuhi.

He mea nui iā ʻoe e mālama i kahi papa inoa i kākau ʻia a me nā lāʻau lapaʻau ʻole (over-the-counter) lāʻau āu e lawe nei, a me nā huahana e like me nā huaora, nā minelala, a i ʻole nā ​​mea hoʻopiliʻai aʻe. Pono ʻoe e lawe i kēia papa inoa me ʻoe i kēlā me kēia manawa ke kipa ʻoe i ke kauka a i ʻole inā ʻae ʻia ʻoe i kahi haukapila. He ʻike nui nō hoʻi ia e lawe pū me ʻoe inā pilikia ʻo ka pilikia.

  • Nourianz®
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